메뉴 건너뛰기




Volumn 120, Issue 5, 2010, Pages 567-584

Molecular diagnostics of gliomas: State of the art

Author keywords

1p 19q deletion; BRAF duplication; Glioma; IDH1 mutation; MGMT promoter methylation; Molecular diagnostics

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; B RAF KINASE; CARMUSTINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MOLECULAR MARKER; NITROSOUREA; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 78149405879     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0736-4     Document Type: Review
Times cited : (227)

References (141)
  • 3
    • 52649172327 scopus 로고    scopus 로고
    • Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
    • 1:CAS:528:DC%2BD1cXhtFKisb3P 18716556
    • EE Bar A Lin T Tihan PC Burger CG Eberhart 2008 Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma J Neuropathol Exp Neurol 67 878 887 1:CAS:528:DC%2BD1cXhtFKisb3P 18716556
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 878-887
    • Bar, E.E.1    Lin, A.2    Tihan, T.3    Burger, P.C.4    Eberhart, C.G.5
  • 5
    • 77953608893 scopus 로고    scopus 로고
    • Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
    • 1:CAS:528:DC%2BC3cXntlCru7k%3D 20304625
    • JP Bayley P Devilee 2010 Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree? Curr Opin Genet Dev 20 324 329 1:CAS:528:DC%2BC3cXntlCru7k%3D 20304625
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 324-329
    • Bayley, J.P.1    Devilee, P.2
  • 6
    • 34249332411 scopus 로고    scopus 로고
    • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    • 1:CAS:528:DC%2BD2sXltVyku74%3D 17483311
    • D Beier P Hau M Proescholdt A Lohmeier J Wischhusen PJ Oefner L Aigner A Brawanski U Bogdahn CP Beier 2007 CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles Cancer Res 67 4010 4015 1:CAS:528:DC%2BD2sXltVyku74%3D 17483311
    • (2007) Cancer Res , vol.67 , pp. 4010-4015
    • Beier, D.1    Hau, P.2    Proescholdt, M.3    Lohmeier, A.4    Wischhusen, J.5    Oefner, P.J.6    Aigner, L.7    Brawanski, A.8    Bogdahn, U.9    Beier, C.P.10
  • 10
    • 0842325802 scopus 로고    scopus 로고
    • Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
    • 1:CAS:528:DC%2BD2cXhtFCgtbk%3D 14871821
    • DJ Brat AA Castellano-Sanchez SB Hunter M Pecot C Cohen EH Hammond SN Devi B Kaur EG Van Meir 2004 Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population Cancer Res 64 920 927 1:CAS:528:DC%2BD2cXhtFCgtbk%3D 14871821
    • (2004) Cancer Res , vol.64 , pp. 920-927
    • Brat, D.J.1    Castellano-Sanchez, A.A.2    Hunter, S.B.3    Pecot, M.4    Cohen, C.5    Hammond, E.H.6    Devi, S.N.7    Kaur, B.8    Van Meir, E.G.9
  • 11
    • 2342588221 scopus 로고    scopus 로고
    • Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma
    • 1:CAS:528:DC%2BD2cXmtF2itrw%3D 14990981
    • DJ Brat EG Van Meir 2004 Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma Lab Invest 84 397 405 1:CAS:528:DC%2BD2cXmtF2itrw%3D 14990981
    • (2004) Lab Invest , vol.84 , pp. 397-405
    • Brat, D.J.1    Van Meir, E.G.2
  • 16
    • 33745575716 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402
    • 1:CAS:528:DC%2BD28XntV2hurg%3D 16782910
    • G Cairncross B Berkey E Shaw R Jenkins B Scheithauer D Brachman J Buckner K Fink L Souhami N Laperierre M Mehta W Curran 2006 Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402 J Clin Oncol 24 2707 2714 1:CAS:528:DC%2BD28XntV2hurg%3D 16782910
    • (2006) J Clin Oncol , vol.24 , pp. 2707-2714
    • Cairncross, G.1    Berkey, B.2    Shaw, E.3    Jenkins, R.4    Scheithauer, B.5    Brachman, D.6    Buckner, J.7    Fink, K.8    Souhami, L.9    Laperierre, N.10    Mehta, M.11    Curran, W.12
  • 18
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 1061 1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 20
    • 0036681993 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner
    • 1:CAS:528:DC%2BD38XlvFeltbY%3D 12154034
    • A Chakravarti A Chakladar MA Delaney DE Latham JS Loeffler 2002 The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner Cancer Res 62 4307 4315 1:CAS:528: DC%2BD38XlvFeltbY%3D 12154034
    • (2002) Cancer Res , vol.62 , pp. 4307-4315
    • Chakravarti, A.1    Chakladar, A.2    Delaney, M.A.3    Latham, D.E.4    Loeffler, J.S.5
  • 24
    • 34948892058 scopus 로고    scopus 로고
    • Diffuse glioma growth: A guerilla war
    • 17805551
    • A Claes AJ Idema P Wesseling 2007 Diffuse glioma growth: a guerilla war Acta Neuropathol 114 443 458 17805551
    • (2007) Acta Neuropathol , vol.114 , pp. 443-458
    • Claes, A.1    Idema, A.J.2    Wesseling, P.3
  • 28
    • 78149410082 scopus 로고    scopus 로고
    • In vivo and in vitro selection of infiltrating glioma cells: A comprehensive, multi-dimensional molecular analysis of the invasive phenotype of human glioblastomas
    • (Meeting Abstract)
    • S Delic N Schmidt N Lottmann A Stefanski K Stuhler G Reifenberger MJ Riemenschneider 2009 In vivo and in vitro selection of infiltrating glioma cells: a comprehensive, multi-dimensional molecular analysis of the invasive phenotype of human glioblastomas Acta Neuropathol 118 437 437 (Meeting Abstract)
    • (2009) Acta Neuropathol , vol.118 , pp. 437-437
    • Delic, S.1    Schmidt, N.2    Lottmann, N.3    Stefanski, A.4    Stuhler, K.5    Reifenberger, G.6    Riemenschneider, M.J.7
  • 31
    • 1942440046 scopus 로고    scopus 로고
    • Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma
    • 1:CAS:528:DC%2BD2cXktlCiu7s%3D 15029256
    • M Ebinger L Senf O Wachowski W Scheurlen 2004 Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma Pathol Oncol Res 10 17 21 1:CAS:528:DC%2BD2cXktlCiu7s%3D 15029256
    • (2004) Pathol Oncol Res , vol.10 , pp. 17-21
    • Ebinger, M.1    Senf, L.2    Wachowski, O.3    Scheurlen, W.4
  • 35
    • 77953028158 scopus 로고    scopus 로고
    • Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing
    • 1:CAS:528:DC%2BC3cXjs1aisr8%3D 20131059
    • J Felsberg M Wolter H Seul B Friedensdorf M Goppert MC Sabel G Reifenberger 2010 Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing Acta Neuropathol 119 501 507 1:CAS:528:DC%2BC3cXjs1aisr8%3D 20131059
    • (2010) Acta Neuropathol , vol.119 , pp. 501-507
    • Felsberg, J.1    Wolter, M.2    Seul, H.3    Friedensdorf, B.4    Goppert, M.5    Sabel, M.C.6    Reifenberger, G.7
  • 36
    • 77955508065 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH: From mechanism to potential therapy
    • 1:CAS:528:DC%2BC3cXotVChtbk%3D 20510884
    • Y Fu R Huang J Du R Yang N An A Liang 2010 Glioma-derived mutations in IDH: from mechanism to potential therapy Biochem Biophys Res Commun 397 127 130 1:CAS:528:DC%2BC3cXotVChtbk%3D 20510884
    • (2010) Biochem Biophys Res Commun , vol.397 , pp. 127-130
    • Fu, Y.1    Huang, R.2    Du, J.3    Yang, R.4    An, N.5    Liang, A.6
  • 38
    • 67349137902 scopus 로고    scopus 로고
    • The EGFRvIII variant in glioblastoma multiforme
    • 1:CAS:528:DC%2BD1MXltl2lu7o%3D 19324552
    • HK Gan AH Kaye RB Luwor 2009 The EGFRvIII variant in glioblastoma multiforme J Clin Neurosci 16 748 754 1:CAS:528:DC%2BD1MXltl2lu7o%3D 19324552
    • (2009) J Clin Neurosci , vol.16 , pp. 748-754
    • Gan, H.K.1    Kaye, A.H.2    Luwor, R.B.3
  • 39
    • 1942469956 scopus 로고    scopus 로고
    • MGMT: Its role in cancer aetiology and cancer therapeutics
    • 1:CAS:528:DC%2BD2cXis1Gmt70%3D 15057289
    • SL Gerson 2004 MGMT: its role in cancer aetiology and cancer therapeutics Nat Rev Cancer 4 296 307 1:CAS:528:DC%2BD2cXis1Gmt70%3D 15057289
    • (2004) Nat Rev Cancer , vol.4 , pp. 296-307
    • Gerson, S.L.1
  • 40
    • 44649088238 scopus 로고    scopus 로고
    • Anaplastic oligodendroglial tumors: Refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402
    • 18371182
    • C Giannini PC Burger BA Berkey JG Cairncross RB Jenkins M Mehta WJ Curran K Aldape 2008 Anaplastic oligodendroglial tumors: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402 Brain Pathol 18 360 369 18371182
    • (2008) Brain Pathol , vol.18 , pp. 360-369
    • Giannini, C.1    Burger, P.C.2    Berkey, B.A.3    Cairncross, J.G.4    Jenkins, R.B.5    Mehta, M.6    Curran, W.J.7    Aldape, K.8
  • 45
    • 33644836724 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours
    • 1:CAS:528:DC%2BD28XisFOqtL8%3D 16488082
    • ME Halatsch U Schmidt J Behnke-Mursch A Unterberg CR Wirtz 2006 Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours Cancer Treat Rev 32 74 89 1:CAS:528: DC%2BD28XisFOqtL8%3D 16488082
    • (2006) Cancer Treat Rev , vol.32 , pp. 74-89
    • Halatsch, M.E.1    Schmidt, U.2    Behnke-Mursch, J.3    Unterberg, A.4    Wirtz, C.R.5
  • 47
    • 0037345970 scopus 로고    scopus 로고
    • Molecular diagnosis of oligodendroglioma in paraffin sections
    • 1:CAS:528:DC%2BD3sXhvF2qurs%3D 12649342
    • KJ Hatanpaa PC Burger JR Eshleman KM Murphy KD Berg 2003 Molecular diagnosis of oligodendroglioma in paraffin sections Lab Invest 83 419 428 1:CAS:528:DC%2BD3sXhvF2qurs%3D 12649342
    • (2003) Lab Invest , vol.83 , pp. 419-428
    • Hatanpaa, K.J.1    Burger, P.C.2    Eshleman, J.R.3    Murphy, K.M.4    Berg, K.D.5
  • 50
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • 1:CAS:528:DC%2BD2MXhvVSrsb4%3D 15746047
    • AB Heimberger R Hlatky D Suki D Yang J Weinberg M Gilbert R Sawaya K Aldape 2005 Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients Clin Cancer Res 11 1462 1466 1:CAS:528:DC%2BD2MXhvVSrsb4%3D 15746047
    • (2005) Clin Cancer Res , vol.11 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3    Yang, D.4    Weinberg, J.5    Gilbert, M.6    Sawaya, R.7    Aldape, K.8
  • 51
    • 67650688162 scopus 로고    scopus 로고
    • The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients
    • 1:CAS:528:DC%2BD1MXotlOksr0%3D 19591631
    • AB Heimberger JH Sampson 2009 The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients Expert Opin Biol Ther 9 1087 1098 1:CAS:528:DC%2BD1MXotlOksr0%3D 19591631
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 1087-1098
    • Heimberger, A.B.1    Sampson, J.H.2
  • 52
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • 1:CAS:528:DyaK28XlsFeht7Y%3D 8790415
    • JG Herman JR Graff S Myohanen BD Nelkin SB Baylin 1996 Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 9821 9826 1:CAS:528:DyaK28XlsFeht7Y%3D 8790415
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3    Nelkin, B.D.4    Baylin, S.B.5
  • 54
    • 13444294190 scopus 로고    scopus 로고
    • Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets
    • 1:CAS:528:DC%2BD2MXit1Gnsb8%3D 15720813
    • DB Hoelzinger L Mariani J Weis T Woyke TJ Berens WS McDonough A Sloan SW Coons ME Berens 2005 Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets Neoplasia 7 7 16 1:CAS:528:DC%2BD2MXit1Gnsb8%3D 15720813
    • (2005) Neoplasia , vol.7 , pp. 7-16
    • Hoelzinger, D.B.1    Mariani, L.2    Weis, J.3    Woyke, T.4    Berens, T.J.5    McDonough, W.S.6    Sloan, A.7    Coons, S.W.8    Berens, M.E.9
  • 55
    • 77954357852 scopus 로고    scopus 로고
    • Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies
    • 1:CAS:528:DC%2BC3cXhtVehurrF 20431032
    • C Horbinski L Kelly YE Nikiforov MB Durso MN Nikiforova 2010 Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies J Mol Diagn 12 487 492 1:CAS:528:DC%2BC3cXhtVehurrF 20431032
    • (2010) J Mol Diagn , vol.12 , pp. 487-492
    • Horbinski, C.1    Kelly, L.2    Nikiforov, Y.E.3    Durso, M.B.4    Nikiforova, M.N.5
  • 56
    • 73349109131 scopus 로고    scopus 로고
    • Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues
    • 1:CAS:528:DC%2BD1MXhsVOhtLvE 19915484
    • C Horbinski J Kofler LM Kelly GH Murdoch MN Nikiforova 2009 Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues J Neuropathol Exp Neurol 68 1319 1325 1:CAS:528:DC%2BD1MXhsVOhtLvE 19915484
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1319-1325
    • Horbinski, C.1    Kofler, J.2    Kelly, L.M.3    Murdoch, G.H.4    Nikiforova, M.N.5
  • 58
    • 68349116524 scopus 로고    scopus 로고
    • IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
    • 1:CAS:528:DC%2BD1MXhtV2qur%2FF 19435942
    • K Ichimura DM Pearson S Kocialkowski LM Backlund R Chan DT Jones VP Collins 2009 IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas Neuro Oncol 11 341 347 1:CAS:528: DC%2BD1MXhtV2qur%2FF 19435942
    • (2009) Neuro Oncol , vol.11 , pp. 341-347
    • Ichimura, K.1    Pearson, D.M.2    Kocialkowski, S.3    Backlund, L.M.4    Chan, R.5    Jones, D.T.6    Collins, V.P.7
  • 60
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • International Cancer Genome Consortium
    • International Cancer Genome Consortium 2010 International network of cancer genome projects Nature 464 993 998
    • (2010) Nature , vol.464 , pp. 993-998
  • 61
    • 0031595389 scopus 로고    scopus 로고
    • Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis- chloroethylnitrosourea: A Southwest Oncology Group study
    • 1:CAS:528:DyaK1cXmvFGrtbw%3D 9779706
    • KA Jaeckle HJ Eyre JJ Townsend S Schulman HM Knudson M Belanich DB Yarosh SI Bearman DJ Giroux SC Schold 1998 Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study J Clin Oncol 16 3310 3315 1:CAS:528:DyaK1cXmvFGrtbw%3D 9779706
    • (1998) J Clin Oncol , vol.16 , pp. 3310-3315
    • Jaeckle, K.A.1    Eyre, H.J.2    Townsend, J.J.3    Schulman, S.4    Knudson, H.M.5    Belanich, M.6    Yarosh, D.B.7    Bearman, S.I.8    Giroux, D.J.9    Schold, S.C.10
  • 63
    • 33745407500 scopus 로고    scopus 로고
    • Multiplex ligation-dependent probe amplification: A diagnostic tool for simultaneous identification of different genetic markers in glial tumors
    • 1:CAS:528:DC%2BD28XpvFClurw%3D 16931583
    • J Jeuken S Cornelissen S Boots-Sprenger S Gijsen P Wesseling 2006 Multiplex ligation-dependent probe amplification: a diagnostic tool for simultaneous identification of different genetic markers in glial tumors J Mol Diagn 8 433 443 1:CAS:528:DC%2BD28XpvFClurw%3D 16931583
    • (2006) J Mol Diagn , vol.8 , pp. 433-443
    • Jeuken, J.1    Cornelissen, S.2    Boots-Sprenger, S.3    Gijsen, S.4    Wesseling, P.5
  • 64
  • 65
    • 34548760880 scopus 로고    scopus 로고
    • MS-MLPA: An attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas
    • 1:CAS:528:DC%2BD2sXhtVCrtLjF 17700563
    • JW Jeuken SJ Cornelissen M Vriezen MM Dekkers A Errami A Sijben SH Boots-Sprenger P Wesseling 2007 MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas Lab Invest 87 1055 1065 1:CAS:528:DC%2BD2sXhtVCrtLjF 17700563
    • (2007) Lab Invest , vol.87 , pp. 1055-1065
    • Jeuken, J.W.1    Cornelissen, S.J.2    Vriezen, M.3    Dekkers, M.M.4    Errami, A.5    Sijben, A.6    Boots-Sprenger, S.H.7    Wesseling, P.8
  • 68
    • 9144230112 scopus 로고    scopus 로고
    • Molecular pathogenesis of oligodendroglial tumors
    • 15674476
    • JW Jeuken A von Deimling P Wesseling 2004 Molecular pathogenesis of oligodendroglial tumors J Neurooncol 70 161 181 15674476
    • (2004) J Neurooncol , vol.70 , pp. 161-181
    • Jeuken, J.W.1    Von Deimling, A.2    Wesseling, P.3
  • 69
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • 1:CAS:528:DC%2BD1cXhtlSktbfM 18974108
    • DT Jones S Kocialkowski L Liu DM Pearson LM Backlund K Ichimura VP Collins 2008 Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas Cancer Res 68 8673 8677 1:CAS:528:DC%2BD1cXhtlSktbfM 18974108
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Backlund, L.M.5    Ichimura, K.6    Collins, V.P.7
  • 70
    • 67349219657 scopus 로고    scopus 로고
    • Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    • 1:CAS:528:DC%2BD1MXksVeluro%3D 19363522
    • DT Jones S Kocialkowski L Liu DM Pearson K Ichimura VP Collins 2009 Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma Oncogene 28 2119 2123 1:CAS:528:DC%2BD1MXksVeluro%3D 19363522
    • (2009) Oncogene , vol.28 , pp. 2119-2123
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Ichimura, K.5    Collins, V.P.6
  • 71
    • 67449099808 scopus 로고    scopus 로고
    • Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
    • 1:CAS:528:DC%2BD1MXms1amu70%3D 19378339
    • MR Kang MS Kim JE Oh YR Kim SY Song SI Seo JY Lee NJ Yoo SH Lee 2009 Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers Int J Cancer 125 353 355 1:CAS:528:DC%2BD1MXms1amu70%3D 19378339
    • (2009) Int J Cancer , vol.125 , pp. 353-355
    • Kang, M.R.1    Kim, M.S.2    Oh, J.E.3    Kim, Y.R.4    Song, S.Y.5    Seo, S.I.6    Lee, J.Y.7    Yoo, N.J.8    Lee, S.H.9
  • 72
    • 70449708940 scopus 로고    scopus 로고
    • A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation
    • 1:CAS:528:DC%2BD1MXhsVKgtLfO 19818334
    • Y Kato G Jin CT Kuan RE McLendon H Yan DD Bigner 2009 A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation Biochem Biophys Res Commun 390 547 551 1:CAS:528:DC%2BD1MXhsVKgtLfO 19818334
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 547-551
    • Kato, Y.1    Jin, G.2    Kuan, C.T.3    McLendon, R.E.4    Yan, H.5    Bigner, D.D.6
  • 73
    • 0032601166 scopus 로고    scopus 로고
    • Primary and secondary glioblastomas: From concept to clinical diagnosis
    • 1:STN:280:DC%2BD3MrgtFCktg%3D%3D 11550301
    • P Kleihues H Ohgaki 1999 Primary and secondary glioblastomas: from concept to clinical diagnosis Neuro-oncol 1 44 51 1:STN:280: DC%2BD3MrgtFCktg%3D%3D 11550301
    • (1999) Neuro-oncol , vol.1 , pp. 44-51
    • Kleihues, P.1    Ohgaki, H.2
  • 74
    • 77952375723 scopus 로고    scopus 로고
    • O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation is significantly less frequent in ependymal tumours as compared to malignant astrocytic gliomas
    • 1:CAS:528:DC%2BC3cXot1artL0%3D 20202118
    • B Koos S Peetz-Dienhart B Riesmeier MC Fruhwald M Hasselblatt 2010 O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation is significantly less frequent in ependymal tumours as compared to malignant astrocytic gliomas Neuropathol Appl Neurobiol 36 356 358 1:CAS:528: DC%2BC3cXot1artL0%3D 20202118
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 356-358
    • Koos, B.1    Peetz-Dienhart, S.2    Riesmeier, B.3    Fruhwald, M.C.4    Hasselblatt, M.5
  • 75
    • 68349088073 scopus 로고    scopus 로고
    • Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma
    • 1:CAS:528:DC%2BD1MXptVGjt7c%3D 19543740
    • A Korshunov J Meyer D Capper A Christians M Remke H Witt S Pfister A von Deimling C Hartmann 2009 Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma Acta Neuropathol 118 401 405 1:CAS:528:DC%2BD1MXptVGjt7c%3D 19543740
    • (2009) Acta Neuropathol , vol.118 , pp. 401-405
    • Korshunov, A.1    Meyer, J.2    Capper, D.3    Christians, A.4    Remke, M.5    Witt, H.6    Pfister, S.7    Von Deimling, A.8    Hartmann, C.9
  • 78
    • 33646061363 scopus 로고    scopus 로고
    • Progressive low-grade oligodendrogliomas: Response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression
    • 1:CAS:528:DC%2BD28XksFCku7Y%3D 16541434
    • N Levin I Lavon B Zelikovitsh D Fuchs F Bokstein Y Fellig T Siegal 2006 Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression Cancer 106 1759 1765 1:CAS:528:DC%2BD28XksFCku7Y%3D 16541434
    • (2006) Cancer , vol.106 , pp. 1759-1765
    • Levin, N.1    Lavon, I.2    Zelikovitsh, B.3    Fuchs, D.4    Bokstein, F.5    Fellig, Y.6    Siegal, T.7
  • 79
    • 51349139499 scopus 로고    scopus 로고
    • EGF receptor variant III as a target antigen for tumor immunotherapy
    • 18767947
    • G Li AJ Wong 2008 EGF receptor variant III as a target antigen for tumor immunotherapy Expert Rev Vaccines 7 977 985 18767947
    • (2008) Expert Rev Vaccines , vol.7 , pp. 977-985
    • Li, G.1    Wong, A.J.2
  • 80
    • 77950964436 scopus 로고    scopus 로고
    • Commentary on Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466)
    • 20151424
    • U Linz 2010 Commentary on Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466) Cancer 116 1844 1846 20151424
    • (2010) Cancer , vol.116 , pp. 1844-1846
    • Linz, U.1
  • 81
  • 84
    • 77954358148 scopus 로고    scopus 로고
    • PTEN loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors
    • 1:CAS:528:DC%2BC3cXot1Wks7w%3D 20530668
    • B McEllin CV Camacho B Mukherjee B Hahm N Tomimatsu RM Bachoo S Burma 2010 PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors Cancer Res 70 5457 5464 1:CAS:528:DC%2BC3cXot1Wks7w%3D 20530668
    • (2010) Cancer Res , vol.70 , pp. 5457-5464
    • McEllin, B.1    Camacho, C.V.2    Mukherjee, B.3    Hahm, B.4    Tomimatsu, N.5    Bachoo, R.M.6    Burma, S.7
  • 87
    • 34548147443 scopus 로고    scopus 로고
    • Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
    • 1:CAS:528:DC%2BD2sXot1Kqsrc%3D 17591937
    • T Mikeska C Bock O El-Maarri A Hubner D Ehrentraut J Schramm J Felsberg P Kahl R Buttner T Pietsch A Waha 2007 Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis J Mol Diagn 9 368 381 1:CAS:528:DC%2BD2sXot1Kqsrc%3D 17591937
    • (2007) J Mol Diagn , vol.9 , pp. 368-381
    • Mikeska, T.1    Bock, C.2    El-Maarri, O.3    Hubner, A.4    Ehrentraut, D.5    Schramm, J.6    Felsberg, J.7    Kahl, P.8    Buttner, R.9    Pietsch, T.10    Waha, A.11
  • 88
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • 15455350
    • M Mollemann M Wolter J Felsberg VP Collins G Reifenberger 2005 Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors Int J Cancer 113 379 385 15455350
    • (2005) Int J Cancer , vol.113 , pp. 379-385
    • Mollemann, M.1    Wolter, M.2    Felsberg, J.3    Collins, V.P.4    Reifenberger, G.5
  • 90
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • 1:CAS:528:DC%2BD1MXhtF2ltbbL 19755387
    • S Nobusawa T Watanabe P Kleihues H Ohgaki 2009 IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas Clin Cancer Res 15 6002 6007 1:CAS:528:DC%2BD1MXhtF2ltbbL 19755387
    • (2009) Clin Cancer Res , vol.15 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 93
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • 1:CAS:528:DC%2BD2sXlvFCns74%3D 17456751
    • H Ohgaki P Kleihues 2007 Genetic pathways to primary and secondary glioblastoma Am J Pathol 170 1445 1453 1:CAS:528:DC%2BD2sXlvFCns74%3D 17456751
    • (2007) Am J Pathol , vol.170 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 94
    • 58249121980 scopus 로고    scopus 로고
    • Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells
    • 1:CAS:528:DC%2BD1MXotl2itg%3D%3D 19116135
    • R Papait L Magrassi D Rigamonti E Cattaneo 2009 Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells Biochem Biophys Res Commun 379 434 439 1:CAS:528:DC%2BD1MXotl2itg%3D%3D 19116135
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 434-439
    • Papait, R.1    Magrassi, L.2    Rigamonti, D.3    Cattaneo, E.4
  • 100
    • 33746860420 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: Results from the CCG-945 cohort
    • 1:CAS:528:DC%2BD28Xot1KisLo%3D 16849758
    • IF Pollack RL Hamilton RW Sobol J Burnham AJ Yates EJ Holmes T Zhou JL Finlay 2006 O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 cohort J Clin Oncol 24 3431 3437 1:CAS:528:DC%2BD28Xot1KisLo%3D 16849758
    • (2006) J Clin Oncol , vol.24 , pp. 3431-3437
    • Pollack, I.F.1    Hamilton, R.L.2    Sobol, R.W.3    Burnham, J.4    Yates, A.J.5    Holmes, E.J.6    Zhou, T.7    Finlay, J.L.8
  • 102
    • 0037317982 scopus 로고    scopus 로고
    • Oligodendroglioma: Toward molecular definitions in diagnostic neuro-oncology
    • 1:CAS:528:DC%2BD3sXhsFaiurs%3D 12578221
    • G Reifenberger DN Louis 2003 Oligodendroglioma: toward molecular definitions in diagnostic neuro-oncology J Neuropathol Exp Neurol 62 111 126 1:CAS:528:DC%2BD3sXhsFaiurs%3D 12578221
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 111-126
    • Reifenberger, G.1    Louis, D.N.2
  • 103
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
    • 1:CAS:528:DC%2BC3cXptlegs7c%3D 20513808
    • ZJ Reitman H Yan 2010 Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism J Natl Cancer Inst 102 932 941 1:CAS:528:DC%2BC3cXptlegs7c%3D 20513808
    • (2010) J Natl Cancer Inst , vol.102 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 104
    • 75849146316 scopus 로고    scopus 로고
    • MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
    • 1:CAS:528:DC%2BC3cXotFKitb8%3D 20150378
    • AL Rivera CE Pelloski MR Gilbert H Colman C De La Cruz EP Sulman BN Bekele KD Aldape 2010 MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma Neuro Oncol 12 116 121 1:CAS:528:DC%2BC3cXotFKitb8%3D 20150378
    • (2010) Neuro Oncol , vol.12 , pp. 116-121
    • Rivera, A.L.1    Pelloski, C.E.2    Gilbert, M.R.3    Colman, H.4    De La Cruz, C.5    Sulman, E.P.6    Bekele, B.N.7    Aldape, K.D.8
  • 105
    • 24344447265 scopus 로고    scopus 로고
    • Molecular classification of human gliomas using matrix-based comparative genomic hybridization
    • 1:CAS:528:DC%2BD2MXhtVaht7vO 15880582
    • P Roerig M Nessling B Radlwimmer S Joos G Wrobel C Schwaenen G Reifenberger P Lichter 2005 Molecular classification of human gliomas using matrix-based comparative genomic hybridization Int J Cancer 117 95 103 1:CAS:528:DC%2BD2MXhtVaht7vO 15880582
    • (2005) Int J Cancer , vol.117 , pp. 95-103
    • Roerig, P.1    Nessling, M.2    Radlwimmer, B.3    Joos, S.4    Wrobel, G.5    Schwaenen, C.6    Reifenberger, G.7    Lichter, P.8
  • 107
    • 51349083585 scopus 로고    scopus 로고
    • Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma
    • 1:CAS:528:DC%2BD1cXhtlyhtbfL 18539480
    • JH Sampson GE Archer DA Mitchell AB Heimberger DD Bigner 2008 Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma Semin Immunol 20 267 275 1:CAS:528:DC%2BD1cXhtlyhtbfL 18539480
    • (2008) Semin Immunol , vol.20 , pp. 267-275
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3    Heimberger, A.B.4    Bigner, D.D.5
  • 111
    • 3543023204 scopus 로고    scopus 로고
    • Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification
    • 12060695
    • JP Schouten CJ McElgunn R Waaijer D Zwijnenburg F Diepvens G Pals 2002 Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification Nucleic Acids Res 30 e57 12060695
    • (2002) Nucleic Acids Res , vol.30 , pp. 57
    • Schouten, J.P.1    McElgunn, C.J.2    Waaijer, R.3    Zwijnenburg, D.4    Diepvens, F.5    Pals, G.6
  • 112
    • 77957268198 scopus 로고    scopus 로고
    • Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: Evidence for molecular subtypes
    • 1:CAS:528:DC%2BC3cXotVKnsbo%3D 20514489
    • M Seiz J Tuettenberg J Meyer M Essig K Schmieder C Mawrin A von Deimling C Hartmann 2010 Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes Acta Neuropathol 120 261 267 1:CAS:528:DC%2BC3cXotVKnsbo%3D 20514489
    • (2010) Acta Neuropathol , vol.120 , pp. 261-267
    • Seiz, M.1    Tuettenberg, J.2    Meyer, J.3    Essig, M.4    Schmieder, K.5    Mawrin, C.6    Von Deimling, A.7    Hartmann, C.8
  • 118
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • 1:CAS:528:DyaK3MXhvVKntQ%3D%3D 2236070
    • N Sugawa AJ Ekstrand CD James VP Collins 1990 Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas Proc Natl Acad Sci USA 87 8602 8606 1:CAS:528:DyaK3MXhvVKntQ%3D%3D 2236070
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 119
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • 1:CAS:528:DC%2BD3sXovVOnsrY%3D 14614022
    • L Tentori C Leonetti M Scarsella G D'Amati M Vergati I Portarena W Xu V Kalish G Zupi J Zhang G Graziani 2003 Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma Clin Cancer Res 9 5370 5379 1:CAS:528:DC%2BD3sXovVOnsrY%3D 14614022
    • (2003) Clin Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3    D'Amati, G.4    Vergati, M.5    Portarena, I.6    Xu, W.7    Kalish, V.8    Zupi, G.9    Zhang, J.10    Graziani, G.11
  • 121
    • 34247399452 scopus 로고    scopus 로고
    • Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors
    • 1:CAS:528:DC%2BD2sXksFSktbo%3D 17285580
    • D Trost M Ehrler R Fimmers J Felsberg MC Sabel L Kirsch J Schramm OD Wiestler G Reifenberger RG Weber 2007 Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors Int J Cancer 120 2368 2376 1:CAS:528:DC%2BD2sXksFSktbo%3D 17285580
    • (2007) Int J Cancer , vol.120 , pp. 2368-2376
    • Trost, D.1    Ehrler, M.2    Fimmers, R.3    Felsberg, J.4    Sabel, M.C.5    Kirsch, L.6    Schramm, J.7    Wiestler, O.D.8    Reifenberger, G.9    Weber, R.G.10
  • 129
    • 65349150503 scopus 로고    scopus 로고
    • IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    • 1:CAS:528:DC%2BD1MXksVOksLY%3D 19246647
    • T Watanabe S Nobusawa P Kleihues H Ohgaki 2009 IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas Am J Pathol 174 1149 1153 1:CAS:528:DC%2BD1MXksVOksLY%3D 19246647
    • (2009) Am J Pathol , vol.174 , pp. 1149-1153
    • Watanabe, T.1    Nobusawa, S.2    Kleihues, P.3    Ohgaki, H.4
  • 130
    • 67349220062 scopus 로고    scopus 로고
    • Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
    • 1:CAS:528:DC%2BD1MXlvFOksb8%3D 19340432
    • T Watanabe A Vital S Nobusawa P Kleihues H Ohgaki 2009 Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome Acta Neuropathol 117 653 656 1:CAS:528:DC%2BD1MXlvFOksb8%3D 19340432
    • (2009) Acta Neuropathol , vol.117 , pp. 653-656
    • Watanabe, T.1    Vital, A.2    Nobusawa, S.3    Kleihues, P.4    Ohgaki, H.5
  • 133
    • 75149166496 scopus 로고    scopus 로고
    • MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
    • 1:CAS:528:DC%2BC3cXisV2gtA%3D%3D 19997073
    • M Weller R Stupp G Reifenberger AA Brandes MJ van den Bent W Wick ME Hegi 2010 MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 6 39 51 1:CAS:528:DC%2BC3cXisV2gtA%3D%3D 19997073
    • (2010) Nat Rev Neurol , vol.6 , pp. 39-51
    • Weller, M.1    Stupp, R.2    Reifenberger, G.3    Brandes, A.A.4    Van Den Bent, M.J.5    Wick, W.6    Hegi, M.E.7
  • 134
    • 34250201533 scopus 로고    scopus 로고
    • Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance
    • 1:CAS:528:DC%2BD2sXmsFKhsbw%3D 17512071
    • SA Weppler Y Li L Dubois N Lieuwes B Jutten P Lambin BG Wouters G Lammering 2007 Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance Radiother Oncol 83 333 339 1:CAS:528: DC%2BD2sXmsFKhsbw%3D 17512071
    • (2007) Radiother Oncol , vol.83 , pp. 333-339
    • Weppler, S.A.1    Li, Y.2    Dubois, L.3    Lieuwes, N.4    Jutten, B.5    Lambin, P.6    Wouters, B.G.7    Lammering, G.8
  • 138
    • 37649000645 scopus 로고    scopus 로고
    • Molecular diagnostic testing in malignant gliomas: A practical update on predictive markers
    • 1:CAS:528:DC%2BD1cXhtlyjurY%3D 18091559
    • S Yip AJ Iafrate DN Louis 2008 Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers J Neuropathol Exp Neurol 67 1 15 1:CAS:528:DC%2BD1cXhtlyjurY%3D 18091559
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1-15
    • Yip, S.1    Iafrate, A.J.2    Louis, D.N.3
  • 139
    • 68049095262 scopus 로고    scopus 로고
    • MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
    • 1:CAS:528:DC%2BD1MXosV2ltL8%3D 19584161
    • S Yip J Miao DP Cahill AJ Iafrate K Aldape CL Nutt DN Louis 2009 MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance Clin Cancer Res 15 4622 4629 1:CAS:528: DC%2BD1MXosV2ltL8%3D 19584161
    • (2009) Clin Cancer Res , vol.15 , pp. 4622-4629
    • Yip, S.1    Miao, J.2    Cahill, D.P.3    Iafrate, A.J.4    Aldape, K.5    Nutt, C.L.6    Louis, D.N.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.