-
1
-
-
0242712188
-
1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex
-
DOI 10.1016/S0028-3908(03)00304-6
-
Y. Ago, Y. Koyama, A. Baba, and T. Matsuda Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex Neuropharmacology 45 8 2003 1050 1056 (Pubitemid 37412250)
-
(2003)
Neuropharmacology
, vol.45
, Issue.8
, pp. 1050-1056
-
-
Ago, Y.1
Koyama, Y.2
Baba, A.3
Matsuda, T.4
-
2
-
-
0030247182
-
Acceleration of the effect of selected antidepressants drugs in major depression by 5-HT(1A) antagonists
-
DOI 10.1016/S0166-2236(96)10037-0
-
F. Artigas, L. Romero, C. de Montigny, and P. Blier Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonist Trends Neurosci. 19 9 1996 378 383 (Pubitemid 26270513)
-
(1996)
Trends in Neurosciences
, vol.19
, Issue.9
, pp. 378-383
-
-
Artigas, F.1
Romero, L.2
De Montigny, C.3
Blier, P.4
-
3
-
-
0032970989
-
A review of central 5-HT receptors and their function
-
DOI 10.1016/S0028-3908(99)00010-6, PII S0028390899000106
-
N.M. Barnes, and T. Sharp A review of central 5-HT receptors and their function Neuropharmacology 38 8 1999 1083 1152 (Pubitemid 29292403)
-
(1999)
Neuropharmacology
, vol.38
, Issue.8
, pp. 1083-1152
-
-
Barnes, N.M.1
Sharp, T.2
-
4
-
-
0024394663
-
A model to measure anticipatory anxiety in mice?
-
DOI 10.1007/BF00444693
-
F. Borsini, A. Lecci, G. Volterra, and A. Meli A model to measure anticipatory anxiety in mice? Psychopharmacology 98 1989 207 211 (Pubitemid 19137733)
-
(1989)
Psychopharmacology
, vol.98
, Issue.2
, pp. 207-211
-
-
Borsini, F.1
Lecci, A.2
Volterra, G.3
Meli, A.4
-
5
-
-
0034648051
-
Stress-induced hyperthermia in mice: Effects of flesinoxan on heart rate and body temperature
-
DOI 10.1016/S0014-2999(00)00387-3, PII S0014299900003873
-
J.A. Bouwknecht, T.H. Hijzen, J. van der Gugten, R.A.A. Maes, and B. Olivier Stress-induced hyperthermia in mice: effects of flesinoxan on heart rate and body temperature Eur. J. Pharmacol. 400 2000 59 66 (Pubitemid 30412109)
-
(2000)
European Journal of Pharmacology
, vol.400
, Issue.1
, pp. 59-66
-
-
Bouwknecht, J.A.1
Hijzen, T.H.2
Van Der Gugten, J.3
Maes, R.A.A.4
Olivier, B.5
-
6
-
-
33845309162
-
The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: A review of pharmacological and genetic studies in the mouse
-
DOI 10.1016/j.neubiorev.2006.02.002, PII S0149763406000145, Neurogenetics and Behavior
-
A.J. Bouwknecht, B. Olivier, and E.R. Paylor The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse Neurosci. Biobehav. Rev. 31 2007 41 59 (Pubitemid 44880072)
-
(2007)
Neuroscience and Biobehavioral Reviews
, vol.31
, Issue.1
, pp. 41-59
-
-
Adriaan Bouwknecht, J.1
Olivier, B.2
Paylor, R.E.3
-
7
-
-
57649112566
-
Promise of mGlu2/3 activators in psychiatry
-
J.P. Conn, and C.K. Jones Promise of mGlu2/3 activators in psychiatry Neuropsychopharmacology 34 1 2009 248 249
-
(2009)
Neuropsychopharmacology
, vol.34
, Issue.1
, pp. 248-249
-
-
Conn, J.P.1
Jones, C.K.2
-
9
-
-
4243086935
-
B receptor-positive modulator GS39783 (N,N′-dicyclopentyl-2-methylsulfanyl- 5-nitro- pyrimidine-4,6-diamine): Anxiolytic-like activity without side effects associated with baclofen or benzodiazepines
-
DOI 10.1124/jpet.104.066753
-
B receptor-positive modulator GS39783 (N, N′-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6- diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines J. Pharmacol. Exp. Ther. 310 2004 952 963 (Pubitemid 39108915)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.310
, Issue.3
, pp. 952-963
-
-
Cryan, J.F.1
Kelly, P.H.2
Chaperon, F.3
Gentsch, C.4
Mombereau, C.5
Lingenhoehl, K.6
Froestl, W.7
Bettler, B.8
Kaupmann, K.9
Spooren, W.P.J.M.10
-
11
-
-
0033838084
-
Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice
-
DOI 10.1016/S0028-3908(00)00050-2, PII S0028390800000502
-
G. De Sarro, E. Palma, N. Costa, R. Marra, S. Gratteri, A. De Sarro, and D. Rotiroti Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice Neuropharmacology 39 11 2000 2147 2161 (Pubitemid 30645638)
-
(2000)
Neuropharmacology
, vol.39
, Issue.11
, pp. 2147-2161
-
-
De Sarro, G.1
Palma, E.2
Costa, N.3
Rosario Marra4
Gratteri, S.5
De Sarro, A.6
Rotiroti, D.7
-
12
-
-
43649087034
-
Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder
-
DOI 10.1038/sj.npp.1301531, PII 1301531
-
E. Dunayevich, J. Erickson, L. Levine, R. Landbloom, D.D. Schoepp, and G.D. Tollefson Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder Neuropsychopharmacology 33 2008 1603 1610 (Pubitemid 351684700)
-
(2008)
Neuropsychopharmacology
, vol.33
, Issue.7
, pp. 1603-1610
-
-
Dunayevich, E.1
Erickson, J.2
Levine, L.3
Landbloom, R.4
Schoepp, D.D.5
Tollefson, G.D.6
-
13
-
-
78650769933
-
N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl) -1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: In vivo profiling suggests a link between behavioral and central nervous system neurochemical changes
-
M.J. Fell, J.M. Witkin, J.F. Falcone, J.S. Katner, K.W. Perry, J. Hart, L. Rorick-Kehn, C.D. Overshiner, K. Rasmussen, S.F. Chaney, M.J. Benvenga, X. Li, D.L. Marlow, L.K. Thompson, S.K. Luecke, K.A. Wafford, W.F. Seidel, D.M. Edgar, A.T. Quets, C.C. Felder, X. Wang, B.A. Heinz, A. Nikolayev, M.S. Kuo, D. Mayhugh, A. Khilevich, D. Zhang, P.J. Ebert, J.A. Eckstein, B.L. Ackermann, S.P. Swanson, J.T. Catlow, R.A. Dean, K. Jackson, S. Tauscher-Wisniewski, G.J. Marek, J.M. Schkeryantz, and K.A. Svensson N-(4-((2-(trifluoromethyl)-3-hydroxy- 4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes J. Pharmacol. Exp. Ther. 336 2011 165 177
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 165-177
-
-
Fell, M.J.1
Witkin, J.M.2
Falcone, J.F.3
Katner, J.S.4
Perry, K.W.5
Hart, J.6
Rorick-Kehn, L.7
Overshiner, C.D.8
Rasmussen, K.9
Chaney, S.F.10
Benvenga, M.J.11
Li, X.12
Marlow, D.L.13
Thompson, L.K.14
Luecke, S.K.15
Wafford, K.A.16
Seidel, W.F.17
Edgar, D.M.18
Quets, A.T.19
Felder, C.C.20
Wang, X.21
Heinz, B.A.22
Nikolayev, A.23
Kuo, M.S.24
Mayhugh, D.25
Khilevich, A.26
Zhang, D.27
Ebert, P.J.28
Eckstein, J.A.29
Ackermann, B.L.30
Swanson, S.P.31
Catlow, J.T.32
Dean, R.A.33
Jackson, K.34
Tauscher-Wisniewski, S.35
Marek, G.J.36
Schkeryantz, J.M.37
Svensson, K.A.38
more..
-
14
-
-
0030070276
-
Electrophysiological, biochemical, neurohormonal and behavioral studies with WAY100635, a potent, selective and silent 5-HT1A receptor antagonist
-
A. Fletcher, E.A. Forster, D.J. Bill, G. Brown, I.A. Cliffe, J.E. Hartley, D.E. Jones, A. McLeachan, K.J. Stanhope, D.J. Critchley, K.J. Childs, V.C. Middlefell, L. Lanfumey, R. Corradetti, A.M. Lapore, H. Gozlan, M. Hamon, and C.T. Douris Electrophysiological, biochemical, neurohormonal and behavioral studies with WAY100635, a potent, selective and silent 5-HT1A receptor antagonist Behav. Brain Res. 73 1996 337 353
-
(1996)
Behav. Brain Res.
, vol.73
, pp. 337-353
-
-
Fletcher, A.1
Forster, E.A.2
Bill, D.J.3
Brown, G.4
Cliffe, I.A.5
Hartley, J.E.6
Jones, D.E.7
McLeachan, A.8
Stanhope, K.J.9
Critchley, D.J.10
Childs, K.J.11
Middlefell, V.C.12
Lanfumey, L.13
Corradetti, R.14
Lapore, A.M.15
Gozlan, H.16
Hamon, M.17
Douris, C.T.18
-
15
-
-
27744597869
-
A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity
-
DOI 10.1124/jpet.105.091074
-
R. Galici, N.G. Echemendia, A.L. Rodriguez, and P.J. Conn A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity J. Pharmacol. Exp. Ther. 315 2005 1181 1187 (Pubitemid 41635406)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.315
, Issue.3
, pp. 1181-1187
-
-
Galici, R.1
Echemendia, N.G.2
Rodriguez, A.L.3
Conn, P.J.4
-
16
-
-
40449139964
-
Identification of a serotonin/glutamate receptor complex implicated in psychosis
-
DOI 10.1038/nature06612, PII NATURE06612
-
J. González-Maeso, R.L. Ang, T. Yuen, P. Chan, N.V. Weisstaub, J.F. López-Giménez, M. Zhou, Y. Okawa, L.F. Callado, G. Milligan, J.A. Gingrich, M. Filizola, J.J. Meana, and S.C. Sealfon Identification of a serotonin/glutamate receptor complex implicated in psychosis Nature 452 2008 93 97 (Pubitemid 351355090)
-
(2008)
Nature
, vol.452
, Issue.7183
, pp. 93-97
-
-
Gonzalez-Maeso, J.1
Ang, R.L.2
Yuen, T.3
Chan, P.4
Weisstaub, N.V.5
Lopez-Gimenez, J.F.6
Zhou, M.7
Okawa, Y.8
Callado, L.F.9
Milligan, G.10
Gingrich, J.A.11
Filizola, M.12
Meana, J.J.13
Sealfon, S.C.14
-
17
-
-
39149083048
-
Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition
-
G. Gu, D.S. Lorrain, H. Wei, R.L. Cole, X. Zhang, L.P. Daggett, H.J. Schaffhauser, L.J. Bristow, and S.M. Lechner Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: implication in emotional responses and central disinhibition Brain Res. 1197 2008 47 62
-
(2008)
Brain Res.
, vol.1197
, pp. 47-62
-
-
Gu, G.1
Lorrain, D.S.2
Wei, H.3
Cole, R.L.4
Zhang, X.5
Daggett, L.P.6
Schaffhauser, H.J.7
Bristow, L.J.8
Lechner, S.M.9
-
18
-
-
0022906235
-
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat
-
G.A. Gudelsky, J.I. Koenig, and H.Y. Meltzer Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Neuropharmacology 25 1986 1307 1313
-
(1986)
Neuropharmacology
, vol.25
, pp. 1307-1313
-
-
Gudelsky, G.A.1
Koenig, J.I.2
Meltzer, H.Y.3
-
19
-
-
0017840874
-
Central actions of benzodiazepines: General introduction
-
W.E. Haefely Central actions of benzodiazepines: general introduction Br. J. Psychiatry 133 1978 231 238 (Pubitemid 8392307)
-
(1978)
British Journal of Psychiatry
, vol.133
, Issue.9
, pp. 231-238
-
-
Haefely, W.E.1
-
20
-
-
0031933951
-
Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors
-
D.R. Helton, J.P. Tizzano, J.A. Monn, D.D. Schoepp, and M.J. Kallman Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors J. Pharmacol. Exp. Ther. 284 1998 651 660 (Pubitemid 28086655)
-
(1998)
Journal of Pharmacology and Experimental Therapeutics
, vol.284
, Issue.2
, pp. 651-660
-
-
Helton, D.R.1
Tizzano, J.P.2
Monn, J.A.3
Schoepp, D.D.4
Kallman, M.J.5
-
21
-
-
0030921751
-
Stress-induced hyperthermia in singly housed mice
-
DOI 10.1016/S0031-9384(97)00157-1, PII S0031938497001571
-
J.A. van der Heyden, T.J. Zethof, and B. Olivier Stress-induced hyperthermia in singly housed mice Physiol. Behav. 62 1997 463 470 (Pubitemid 27376279)
-
(1997)
Physiology and Behavior
, vol.62
, Issue.3
, pp. 463-470
-
-
Van Der Heyden, J.A.M.1
Zethof, T.J.J.2
Olivier, B.3
-
22
-
-
51849123246
-
Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats
-
J.R. Homberg, S.F. De Boer, H.S. Raasø, J.D. Olivier, M. Verheul, E. Ronken, A.R. Cools, B.A. Ellenbroek, A.N. Schoffelmeer, L.J. Vanderschuren, T.J. De Vries, and E. Cuppen Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats Psychopharmacology (Berl.) 200 3 2008 367 380
-
(2008)
Psychopharmacology (Berl.)
, vol.200
, Issue.3
, pp. 367-380
-
-
Homberg, J.R.1
De Boer, S.F.2
Raasø, H.S.3
Olivier, J.D.4
Verheul, M.5
Ronken, E.6
Cools, A.R.7
Ellenbroek, B.A.8
Schoffelmeer, A.N.9
Vanderschuren, L.J.10
De Vries, T.J.11
Cuppen, E.12
-
23
-
-
0028183017
-
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
-
D. Hoyer, D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, E.J. Mylecharane, P.R. Saxena, and P.P. Humphrey International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin) Pharmacol. Rev. 46 1994 157 203 (Pubitemid 24185150)
-
(1994)
Pharmacological Reviews
, vol.46
, Issue.2
, pp. 157-203
-
-
Hoyer, D.1
Clarke, D.E.2
Fozard, J.R.3
Hartig, P.R.4
Martin, G.R.5
Mylecharane, E.J.6
Saxena, P.R.7
Humphrey, P.P.A.8
-
24
-
-
33845745734
-
Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice
-
DOI 10.1007/s00213-006-0618-6
-
M. Iijima, T. Shimazaki, A. Ito, and S. Chaki Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice Psychopharmacology (Berl.) 190 2 2007 233 239 (Pubitemid 46011183)
-
(2007)
Psychopharmacology
, vol.190
, Issue.2
, pp. 233-239
-
-
Iijima, M.1
Shimazaki, T.2
Ito, A.3
Chaki, S.4
-
25
-
-
36849059148
-
The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268
-
DOI 10.1111/j.1527-3458.2007.00024.x
-
G. Imre The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268 CNS Drug Rev. 13 2007 444 464 (Pubitemid 350233471)
-
(2007)
CNS Drug Reviews
, vol.13
, Issue.4
, pp. 444-464
-
-
Imre, G.1
-
26
-
-
40849083238
-
B receptor positive modulator CGP7930 in rodents
-
B receptor positive modulator CGP7930 in rodents Neuropharmacology 54 2008 854 862
-
(2008)
Neuropharmacology
, vol.54
, pp. 854-862
-
-
Jacobson, L.H.1
Cryan, J.F.2
-
27
-
-
20944447548
-
-
Johnson, M.P., Barda, D., Britton, T.C., Emkey, R., Hornback, W.J., Jagdmann, G.E., McKinzie, D.L., Nisenbaum, E.S., Tizzano, J.P., Schoepp, D.D., 2005. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). 179, 271-283.
-
(2005)
Metabotropic Glutamate 2 Receptor Potentiators: Receptor Modulation, Frequency-dependent Synaptic Activity, and Efficacy in Preclinical Anxiety and Psychosis Model(s)
, vol.179
, pp. 271-283
-
-
Johnson, M.P.1
Barda, D.2
Britton, T.C.3
Emkey, R.4
Hornback, W.J.5
Jagdmann, G.E.6
McKinzie, D.L.7
Nisenbaum, E.S.8
Tizzano, J.P.9
Schoepp, D.D.10
-
28
-
-
0038155299
-
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N- (2,2,2-trifluoroethylsulfonyl)pyrid-3- ylmethylamine
-
DOI 10.1021/jm034015u
-
M.P. Johnson, M. Baez, G.E. Jagdmann Jr., T.C. Britton, T.H. Large, D.O. Callagaro, J.P. Tizzano, J.A. Monn, and D.D. Schoepp Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl) pyrid-3-ylmethylamine J. Med. Chem. 46 2003 3189 3192 (Pubitemid 36842403)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.15
, pp. 3189-3192
-
-
Johnson, M.P.1
Baez, M.2
Jagdmann Jr., G.E.3
Britton, T.C.4
Large, T.H.5
Callagaro, D.O.6
Tizzano, J.P.7
Monn, J.A.8
Schoepp, D.D.9
-
29
-
-
0344980107
-
Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models
-
DOI 10.1016/S0028-3908(99)00066-0, PII S0028390899000660
-
A. Kłodzińska, E. Chojnacka-Wójcik, A. Pałucha, P. Brański, P. Popik, and A. Pilc Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models Neuropharmacology 38 1999 1831 1839 (Pubitemid 29509721)
-
(1999)
Neuropharmacology
, vol.38
, Issue.12
, pp. 1831-1839
-
-
Klodzinska, A.1
Chojnacka-Wojcik, E.2
Palucha, A.3
Branski, P.4
Popik, P.5
Pilc, A.6
-
30
-
-
3042683441
-
A signaling
-
DOI 10.1016/j.neuropharm.2004.04.013, PII S0028390804001121
-
A. Klodzinska, E. Tatarczyńska, E. Chojnacka-Wójcik, G. Nowak, N.D. Cosford, and A. Pilc Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling Neuropharmacology 47 3 2004 342 350 (Pubitemid 38953225)
-
(2004)
Neuropharmacology
, vol.47
, Issue.3
, pp. 342-350
-
-
Klodzinska, A.1
Tatarczynska, E.2
Chojnacka-Wojcik, E.3
Nowak, G.4
Cosford, N.D.P.5
Pilc, A.6
-
31
-
-
0025004323
-
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice
-
A. Lecci, F. Borsini, A. Mancinelli, V. D'Aranno, M.A. Stasi, G. Volterra, and A. Meli Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice J. Neural Trans. [Gen. Sec.] 82 1990 219 230 (Pubitemid 20319406)
-
(1990)
Journal of Neural Transmission - General Section
, vol.82
, Issue.3
, pp. 219-230
-
-
Lecci, A.1
Borsini, F.2
Mancinelli, A.3
D'Aranno, V.4
Stasi, M.A.5
Volterra, G.6
Meli, A.7
-
32
-
-
0025267004
-
Pharmacological validation of a novel animal model of anticipatory anxiety in mice
-
A. Lecci, F. Borsini, G. Volterra, and A. Meli Pharmacological validation of a novel animal model of anticipatory anxiety in mice Psychopharmacology 101 1990 255 261 (Pubitemid 20140228)
-
(1990)
Psychopharmacology
, vol.101
, Issue.2
, pp. 255-261
-
-
Lecci, A.1
Borsini, F.2
Volterra, G.3
Meli, A.4
-
33
-
-
33846177868
-
Metabotropic glutamate receptor targets for neuropsychiatric disorders
-
DOI 10.1016/j.ddstr.2006.10.018, PII S1740677306000842
-
A.M. Linden, and D.D. Schoepp Metabotropic glutamate receptor targets for neuropsychiatric disorders Drug Discovery Today Therapeut. Strat. 3 4 2006 507 517 (Pubitemid 46076174)
-
(2006)
Drug Discovery Today: Therapeutic Strategies
, vol.3
, Issue.4
, pp. 507-517
-
-
Linden, A.-M.1
Schoepp, D.D.2
-
34
-
-
0030704241
-
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites
-
DOI 10.1016/S0891-0618(97)00051-3, PII S0891061897000513
-
R. Lujan, J.D. Roberts, R. Shigemoto, H. Ohishi, and P. Somogyi Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites J. Chem. Neuroanat. 13 1997 219 241 (Pubitemid 27499502)
-
(1997)
Journal of Chemical Neuroanatomy
, vol.13
, Issue.4
, pp. 219-241
-
-
Lujan, R.1
Roberts, J.D.B.2
Shigemoto, R.3
Ohishi, H.4
Somogyi, P.5
-
35
-
-
0142216081
-
The neurobiology and control of anxious states
-
DOI 10.1016/S0301-0082(03)00087-X
-
M.J. Millan The neurobiology and control of anxious states Prog. Neurobiol. 70 2 2003 83 244 (Pubitemid 37309295)
-
(2003)
Progress in Neurobiology
, vol.70
, Issue.2
, pp. 83-244
-
-
Millan, M.J.1
-
36
-
-
0033602516
-
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6- dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors
-
DOI 10.1021/jm980616n
-
J.A. Monn, M.J. Valli, S.M. Massey, M.M. Hansen, T.J. Kress, J.P. Wepsiec, A.R. Harkness, J.L. Grutsch Jr., R.A. Wright, B.G. Johnson, S.L. Andis, A. Kingston, R. Tomlinson, R. Lewis, K.R. Griffey, J.P. Tizzano, and D.D. Schoepp Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors J. Med. Chem. 42 1999 1027 1040 (Pubitemid 29153432)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.6
, pp. 1027-1040
-
-
Monn, J.A.1
Valli, M.J.2
Massey, S.M.3
Hansen, M.M.4
Kress, T.J.5
Wepsiec, J.P.6
Harkness, A.R.7
Grutsch Jr., J.L.8
Wright, R.A.9
Johnson, B.G.10
Andis, S.L.11
Kingston, A.12
Tomlinson, R.13
Lewis, R.14
Griffey, K.R.15
Tizzano, J.P.16
Schoepp, D.D.17
-
37
-
-
15644369847
-
Design, synthesis, and pharmacological characterization of (+)-2- aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
-
DOI 10.1021/jm9606756
-
J.A. Monn, M.J. Valli, S.M. Massey, R.A. Wright, C.R. Salhoff, B.G. Johnson, T. Howe, C.A. Alt, G.A. Rhodes, R.L. Robey, K.R. Griffey, J.P. Tizzano, M.J. Kallman, D.R. Helton, and D.D. Schoepp Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6- dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties J. Med. Chem. 40 1997 528 537 (Pubitemid 27080033)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.4
, pp. 528-537
-
-
Monn, J.A.1
Valli, M.J.2
Massey, S.M.3
Wright, R.A.4
Salhoff, C.R.5
Johnson, B.G.6
Howe, T.7
Alt, C.A.8
Rhodes, G.A.9
Robey, R.L.10
Griffey, K.R.11
Tizzano, J.P.12
Kallman, M.J.13
Helton, D.R.14
Schoepp, D.D.15
-
38
-
-
48049122651
-
Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: A study in SERT knockout rats
-
J.D. Olivier, A.R. Cools, B. Olivier, J.R. Homberg, E. Cuppen, and B.A. Ellenbroek Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats Eur. J. Pharmacol. 590 1-3 2008 190 197
-
(2008)
Eur. J. Pharmacol.
, vol.590
, Issue.13
, pp. 190-197
-
-
Olivier, J.D.1
Cools, A.R.2
Olivier, B.3
Homberg, J.R.4
Cuppen, E.5
Ellenbroek, B.A.6
-
39
-
-
0032567711
-
Anxiolytic effects of flesinoxan in the stress-induced hyperthermia paradigm in singly-housed mice are 5-HT(1A) receptor mediated
-
DOI 10.1016/S0014-2999(97)01482-9, PII S0014299997014829
-
B. Olivier, T.J. Zethof, E. Ronken, and J.A. van der Heyden Anxiolytic effects of flesinoxan in the stress-induced hyperthermiaparadigm in singly-housed mice are 5-HT1A mediated Eur. J. Pharmacol. 342 1998 177 182 (Pubitemid 28149966)
-
(1998)
European Journal of Pharmacology
, vol.342
, Issue.2-3
, pp. 177-182
-
-
Olivier, B.1
Zethof, T.J.J.2
Ronken, E.3
Van Der Heyden, J.A.M.4
-
40
-
-
34347241277
-
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
-
DOI 10.1016/j.pharmthera.2007.04.007, PII S0163725807000848
-
A. Palucha, and A. Pilc Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs Pharmacol. Ther. 115 2007 116 147 (Pubitemid 46992810)
-
(2007)
Pharmacology and Therapeutics
, vol.115
, Issue.1
, pp. 116-147
-
-
Palucha, A.1
Pilc, A.2
-
41
-
-
77956257563
-
The Antidepressant-like action of mGlu7 receptor agonist, N, N′-Bis (Diphenylmethyl)-1,2-ethanediamine (AMN082), is serotonin-dependent
-
A. Pałucha-Poniewiera, P. Brański, T. Lenda, and A. Pilc The Antidepressant-like action of mGlu7 receptor agonist, N, N′-Bis (Diphenylmethyl)-1,2-ethanediamine (AMN082), is serotonin-dependent J. Pharmacol. Exp. Ther. 334 2010 1066 1074
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.334
, pp. 1066-1074
-
-
Pałucha-Poniewiera, A.1
Brański, P.2
Lenda, T.3
Pilc, A.4
-
42
-
-
78651343705
-
On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
-
A. Pałucha-Poniewiera, J.M. Wierońska, P. Brański, K. Stachowicz, S. Chaki, and A. Pilc On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039 Psychopharmacology (Berl.) 212 4 2010 523 535
-
(2010)
Psychopharmacology (Berl.)
, vol.212
, Issue.4
, pp. 523-535
-
-
Pałucha-Poniewiera, A.1
Wierońska, J.M.2
Brański, P.3
Stachowicz, K.4
Chaki, S.5
Pilc, A.6
-
43
-
-
0029874694
-
The metabotropic glutamate receptors, MGLUR2 and MGLUR3, show unique postsynaptic, presynaptic and glial localizations
-
DOI 10.1016/0306-4522(95)00533-1
-
R.S. Petralia, Y.X. Wang, A.S. Niedzielski, and R.J. Wenthold The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations Neuroscience 71 1996 949 976 (Pubitemid 26090013)
-
(1996)
Neuroscience
, vol.71
, Issue.4
, pp. 949-976
-
-
Petralia, R.S.1
Wang, Y.-X.2
Niedzielski, A.S.3
Wenthold, R.J.4
-
44
-
-
0028912822
-
The metabotropic glutamate receptors: Structure and functions
-
J.P. Pin, and R. Duvoisin The metabotropic glutamate receptors: structure and functions Neuropharmacology 34 1995 1 26
-
(1995)
Neuropharmacology
, vol.34
, pp. 1-26
-
-
Pin, J.P.1
Duvoisin, R.2
-
45
-
-
0034050583
-
Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex
-
M. Sakaue, P. Somboonthum, B. Nishihara, Y. Koyama, H. Hashimoto, A. Baba, and T. Matsuda Postsynaptic 5-hydroxytryptamine (1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex Br. J. Pharmacol. 129 2000 1028 1034 (Pubitemid 30142918)
-
(2000)
British Journal of Pharmacology
, vol.129
, Issue.5
, pp. 1028-1034
-
-
Sakaue, M.1
Somboonthum, P.2
Nishihara, B.3
Koyama, Y.4
Hashimoto, H.5
Baba, A.6
Matsuda, T.7
-
46
-
-
48049095987
-
Pharmacol. effects metabotropic glutamate receptor 1 antagonist compared those metabotropic glutamate receptor 5 antagonist metabotropic glutamate receptor 2/3 agonist rodents: Detailed Invest. with selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3- yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine- 1(2H)-carboxamide]
-
A. Satow, S. Maehara, S. Ise, H. Hikichi, M. Fukushima, G. Suzuki, T. Kimura, T. Tanak, S. Ito, H. Kawamoto, and H. Ohta Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3- yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine- 1(2H)-carboxamide] J. Pharmacol. Exp. Ther. 326 2008 577 586
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.326
, pp. 577-586
-
-
Satow, A.1
Maehara, S.2
Ise, S.3
Hikichi, H.4
Fukushima, M.5
Suzuki, G.6
Kimura, T.7
Tanak, T.8
Ito, S.9
Kawamoto, H.10
Ohta, H.11
-
47
-
-
0034811597
-
Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
-
D.D. Schoepp Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J. Pharmacol. Exp. Ther. 299 2001 12 20 (Pubitemid 32905113)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.299
, Issue.1
, pp. 12-20
-
-
Schoepp, D.D.1
-
48
-
-
0031055985
-
LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors
-
DOI 10.1016/S0028-3908(96)00160-8, PII S0028390896001608
-
D.D. Schoepp, B.G. Johnson, R.A. Wright, C.R. Salhoff, N.G. Mayne, S. Wu, S.L. Cockerman, J.P. Burnett, R. Belegaje, D. Bleakman, and J.A. Monn LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors Neuropharmacology 36 1997 1 11 (Pubitemid 27115837)
-
(1997)
Neuropharmacology
, vol.36
, Issue.1
, pp. 1-11
-
-
Schoepp, D.D.1
Johnson, B.G.2
Wright, R.A.3
Salhoff, C.R.4
Mayne, N.G.5
Wu, S.6
Cockerham, S.L.7
Paul Burnett, J.8
Belegaje, R.9
Bleakman, D.10
Monn, J.A.11
-
50
-
-
0037169165
-
Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)
-
DOI 10.1016/S0014-2999(01)01562-X, PII S001429990101562X
-
W.P. Spooren, P. Schoeffter, F. Gasparini, R. Kuhn, and C. Gentsch Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608) Eur. J. Pharmacol. 435 2002 161 170 (Pubitemid 34131696)
-
(2002)
European Journal of Pharmacology
, vol.435
, Issue.2-3
, pp. 161-170
-
-
Spooren, W.P.J.M.1
Schoeffter, P.2
Gasparini, F.3
Kuhn, R.4
Gentsch, C.5
-
51
-
-
33846266524
-
Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent
-
DOI 10.1016/j.neuropharm.2006.08.002, PII S0028390806002668
-
K. Stachowicz, E. Chojnacka-Wójcik, K. Kłak, and A. Pilc Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent Neuropharmacology 52 2007 306 312 (Pubitemid 46123350)
-
(2007)
Neuropharmacology
, vol.52
, Issue.2
, pp. 306-312
-
-
Stachowicz, K.1
Chojnacka-Wojcik, E.2
Klak, K.3
Pilc, A.4
-
52
-
-
67650656649
-
The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems
-
K. Stachowicz, A. Kłodzińska, A. Palucha-Poniewiera, S. Schann, P. Neuville, and A. Pilc The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems Neuropharmacology 57 2009 227 234
-
(2009)
Neuropharmacology
, vol.57
, pp. 227-234
-
-
Stachowicz, K.1
Kłodzińska, A.2
Palucha-Poniewiera, A.3
Schann, S.4
Neuville, P.5
Pilc, A.6
-
53
-
-
14044258729
-
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
-
DOI 10.1038/nrd1630
-
C.J. Swanson, M. Bures, M.P. Johnson, A.M. Linden, J.A. Monn, and D.D. Schoepp Metabotropic glutamate receptors as novel targets for anxiety and stress disorders Nat. Rev. Discov. 4 2005 131 144 (Pubitemid 40277494)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.2
, pp. 131-144
-
-
Swanson, C.J.1
Bures, M.2
Johnson, M.P.3
Linden, A.-M.4
Monn, J.A.5
Schoepp, D.D.6
-
54
-
-
0035996365
-
The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam
-
DOI 10.1016/S0091-3057(02)00850-X, PII S009130570200850X
-
J.P. Tizzano, K.I. Griffey, and D.D. Schoepp The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam Pharmacol. Biochem. Behav. 73 2002 367 374 (Pubitemid 34773438)
-
(2002)
Pharmacology Biochemistry and Behavior
, vol.73
, Issue.2
, pp. 367-374
-
-
Tizzano, J.P.1
Griffey, K.I.2
Schoepp, D.D.3
-
55
-
-
70349651963
-
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants
-
J.M. Uslaner, S.M. Smith, S.L. Huszar, R. Pachmerhiwala, R.M. Hinchliffe, J.D. Vardigan, and P.H. Hutson Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants Psychopharmacology (Berl.) 206 4 2009 641 651
-
(2009)
Psychopharmacology (Berl.)
, vol.206
, Issue.4
, pp. 641-651
-
-
Uslaner, J.M.1
Smith, S.M.2
Huszar, S.L.3
Pachmerhiwala, R.4
Hinchliffe, R.M.5
Vardigan, J.D.6
Hutson, P.H.7
-
56
-
-
77955470047
-
5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia
-
C.H. Vinkers, R. van Oorschot, S.M. Korte, B. Olivier, and L. Groenink 5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia Psychopharmacology (Berl.) 211 2 2010 123 130
-
(2010)
Psychopharmacology (Berl.)
, vol.211
, Issue.2
, pp. 123-130
-
-
Vinkers, C.H.1
Van Oorschot, R.2
Korte, S.M.3
Olivier, B.4
Groenink, L.5
-
57
-
-
46849104861
-
A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices - Immunohistochemical studies
-
K. Wedzony, A. Chocyk, and M. Maćkowiak A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices-immunohistochemical studies J. Physiol. Pharmacol. 59 2 2008 229 238 (Pubitemid 351955749)
-
(2008)
Journal of Physiology and Pharmacology
, vol.59
, Issue.2
, pp. 229-238
-
-
Wedzony, K.1
Chocyk, A.2
Mackowiak, M.3
-
59
-
-
77958084765
-
Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
-
J.M. Wierońska, K. Stachowicz, A. Pałucha-Poniewiera, F. Acher, P. Brański, and A. Pilc Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems Neuropharmacology 59 2010 627 634
-
(2010)
Neuropharmacology
, vol.59
, pp. 627-634
-
-
Wierońska, J.M.1
Stachowicz, K.2
Pałucha-Poniewiera, A.3
Acher, F.4
Brański, P.5
Pilc, A.6
-
60
-
-
64949091023
-
Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs
-
J.M. Wierońska, and A. Pilc Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs Neurochem. Int. 55 1-3 2009 85 97
-
(2009)
Neurochem. Int.
, vol.55
, Issue.13
, pp. 85-97
-
-
Wierońska, J.M.1
Pilc, A.2
-
61
-
-
12144289648
-
In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling
-
DOI 10.1038/sj.npp.1300322
-
A signaling Neuropsychopharmacology 29 2004 514 521 (Pubitemid 38365927)
-
(2004)
Neuropsychopharmacology
, vol.29
, Issue.3
, pp. 514-521
-
-
Wieronska, J.M.1
Smialowska, M.2
Branski, P.3
Gasparini, F.4
Klodzinska, A.5
Szewczyk, B.6
Palucha, A.7
Chojnacka-Wojcik, E.8
Pilc, A.9
-
62
-
-
78349301654
-
Metabotropic glutamate receptors:potential drug targets for psychiatric disorders
-
A. Yasuhara, and S. Chaki Metabotropic glutamate receptors:potential drug targets for psychiatric disorders Open Med. Chem. J. 4 2010 20 36
-
(2010)
Open Med. Chem. J.
, vol.4
, pp. 20-36
-
-
Yasuhara, A.1
Chaki, S.2
|