The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems

Neuropharmacology

Volumn 57, Issue 3, 2009, Pages 227-234

  Stachowicz, K ^a   Klodzinska A ^a   Palucha Poniewiera, A ^a   Schann, S ^c   Neuville, P ^c   Pilc, A ^a,b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c BioParc Bld Sebastien Brandt   (France)

Author keywords

ACPT I; Anxiety; Depression; Diazepam; Elevated plus maze test; Forced swim test; GABA; Group mGlu III receptors; Imipramine; mGlu4 receptors; mGlu8 receptors; Mice; Rats; Serotonin; Stress induced hyperthermia; Tail suspension test; Vogel test

Indexed keywords

1 AMINOCYCLOPENTANE 1,3,4 TRICARBOXYLIC ACID; DIAZEPAM; FLUMAZENIL; METABOTROPIC RECEPTOR AGONIST; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RITANSERIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; FORCED SWIMMING TEST; GABAERGIC SYSTEM; HYPERTHERMIA; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; CYCLOPENTANES; DEPRESSION; FLUMAZENIL; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAPERITONEAL; MALE; PIPERAZINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RITANSERIN; SEROTONIN; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; SEROTONIN ANTAGONISTS; STRESS, PSYCHOLOGICAL; TRICARBOXYLIC ACIDS;

EID: 67650656649     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.06.005     Document Type: Article

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