Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6- dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 6, 1999, Pages 1027-1040

  Monn, James A ^a   Valli, Matthew J ^a   Massey, Steven M ^a   Hansen, Marvin M ^a   Kress, Thomas J ^a   Wepsiec, James P ^a   Harkness, Allen R ^a   Grutsch Jr , John L ^a   Wright, Rebecca A ^a   Johnson, Bryan G ^a   Andis, Sherri L ^a   Kingston, Ann ^a   Tomlinson, Rosemarie ^a   Lewis, Richard ^a   Griffey, Kelly R ^a   Tizzano, Joseph P ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4 AMINO 2 THIABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; EGLUMETAD; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COMPLEX PARTIAL SEIZURE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; SECOND MESSENGER;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CELL LINE; CYCLIC AMP; EXCITATORY AMINO ACID AGONISTS; HUMANS; MICE; MODELS, MOLECULAR; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS; SEIZURES; STEREOISOMERISM;

EID: 0033602516     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980616n     Document Type: Article

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