Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats

Psychopharmacology

Volumn 200, Issue 3, 2008, Pages 367-380

  Homberg, Judith R ^a,e   De Boer, Sietse F ^c   Raasø, Halfdan S ^b   Olivier, Jocelien D A ^e   Verheul, Mark ^a   Ronken, Eric ^f   Cools, Alexander R ^e   Ellenbroek, Bart A ^e,g   Schoffelmeer, Anton N M ^b   Vanderschuren, Louk J M J ^d   De Vries, Taco J ^b   Cuppen, Edwin ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^f Solvay Pharmaceuticals Inc   (Netherlands)

^g Neuropharmacology   (Germany)

Author keywords

5 HT 1A receptor; Cocaine self administration; Knockout rat; Postsynaptic; Serotonin transporter; Somatodendritic

Indexed keywords

1 (1,4 BENZODIOXAN 5 YL) 4 (2 INDANYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; COCAINE; LIGAND; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR; PSYCHOSTIMULANT AGENT; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER;

ADAPTATION; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRUG SELECTIVITY; DRUG SELF ADMINISTRATION; GENE EXPRESSION; HYPERACTIVITY; HYPERTHERMIA; LOCOMOTION; MALE; MOTIVATION; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REWARD; STRESS; TELEMETRY; WILD TYPE;

ANIMALS; AUTORADIOGRAPHY; CHOICE BEHAVIOR; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; GENE KNOCKOUT TECHNIQUES; GENOTYPE; INFUSIONS, INTRAVENOUS; MOTIVATION; MOTOR ACTIVITY; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SELF ADMINISTRATION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ENVIRONMENT;

EID: 51849123246     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1212-x     Document Type: Article

References (67)

1. JI Acosta FA Boynton KF Kirschner JL Neisewander 2005 Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behaviour Pharmacol Biochem Behav 80 297 307
2. CM Andrews HF Kung I Lucki 2005 The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens Eur J Pharmacol 508 123 130
3. DA Baker LT-L Tran-Nguyen RA Fuchs JL Neisewander 2001 Influence of individual differences and chronic fluoxetine treatment on cocaine-seeking behavior in rats Psychopharmacology 155 18 26
4. D Bengel DL Murphy AM Andrews CH Wichems D Feltner A Heils R Mössner H Westphal KP Lesch 1998 Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice Mol Pharmacol 53 649 655
5. DJ Bill M Knight EA Forster A Fletcher 1991 Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia Br J Pharmacol 103 1857 1864
6. P Blier C de Montigny Y Chaput 1990 A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence J Clin Psychiatry 51 14 20
7. P Blier B Seletti F Gilbert SN Young C Benkelfat 2002 Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation Neuropsychopharmacology 27 301 308
8. JJ Burmeister EM Lungren KF Kirschner JL Neisewander 2004 Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behaviour in rats Neuropsychopharmacology 29 660 668
9. 1A receptor and behavioural stimulation in the rat: effects of 8-OHDPAT on spontaneous and cocaine-induced behaviour Psychopharmacology 177 46 54
10. RJ Carey G DePalma E Damianopoulos A Shanahan CP Muller JP Huston 2005 Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioural stimulant effects Brain Res 1034 162 171
11. Carr GD, Fibiger HC, Phillips AG (1989) In: Liebman JM, Cooper SJ The neuropharmacological basis of reward. Oxford, Clarendon, pp 265-319
12. ME Carroll ST Lac M Ascencio R Kragh 1990 Fluoxetine reduces intravenous cocaine self-administration in rats Pharmacol Biochem Behav 35 237 244
13. 1A receptor binding in humans J Neurosci 25 2586 2590
14. SF De Boer M Lesourd E Mocaer JM Koolhaas 2000 Somatodendritic 5-HT1A autoreceptors mediate the antiaggressive actions of 5-HT1A receptor agonists in rats: an ethopharmacological study with S-15535, Alenspirone and WAY-100635 Neuropsychopharmacology 23 20 33
15. A Dekeyne M Brocco A Adhumeau A Gobert MJ Millan 2000 The selective serotonin (5-HT)1A receptor ligand, S-15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents Psychopharmacology 152 55 66
16. R De La Garza 2nd KA Cunnigham 2000 The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioural sensitization: a microanalysis of locomotor activity J Pharmacol Exp Ther 292 610 617
17. JM Deminiere PV Piazza M Le Moal H Simon 1989 Experimental approach to individual vulnerability to psychostimulant addiction Neurosci Biobehav Rev 13 141 147
18. L De Visser R van den Bos B Spruit 2005 Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion Behav Brain Res 160 382 388
19. TJ De Vries ANM Schoffelmeer R Binnekade AH Mulder LJMJ Vanderschuren 1998 Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization Eur J Neurosci 10 3565 3571
20. V Fabre C Beaufour A Evrard A Rioux N Hanoun KP Lesch DL Murphy L Lanfumey M Hamon MP Martres 2000 Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter Eur J Neurosci 12 2299 2310
21. PA Forcelli SC Heinrichs 2008 Teratogenic effects of maternal antidepressant exposure on neural substrates of drug-seeking behavior in offspring Addiction Biol 13 52 62
22. G Gerra A Zaimovic L Garofano F Ciusa G Moi P Avanzini E Talarico F Gardini F Brambilla M Manfredini 2007 Perceived parenting behaviour in the childhood of cocaine users: relationship with genotype and personality traits Am J Med Genet B Neuropsychiatr Genet 144 52 57
23. G Gobbi DL Murphy K Lesch P Blier 2001 Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study J Pharmacol Exp Ther 296 987 995
24. GM Goodwin RJ De Souza AR Green 1985 Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock Nature 317 531 533
25. GM Goodwin RJ De Souza AR Green DJ Heal 1987 The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) Psychopharmacology 91 506 511
26. Griffith RR, Bigelow GE, Henningfield JE (1980) Similarities in animal and human drug-taking behaviour. In: Mello NK (ed) Advances in substance abuse vol 1. JAI, Greenwich, Connecticut, pp 1-90 1980
27. FS Hall XF Li I Sora F Xu M Caron KP Lesch DL Murphy GR Uhl 2002 Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions Neuroscience 115 153 161
28. 3H]dopamine in rat brain tissue slices Biochem Pharmacol 24 847 852
29. A Heils A Teufel S Petri G Stöber P Riederer D Bengel KP Lesch 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 2621 2624
30. S Herges DA Taylor 1999 Modulation of cocaine-induced locomotor activity, rears and head bobs by application of WAY-100635 into the dorsal and median raphe nuclei of the rat Naunyn-Schmiedeberg's Arch Pharmacol 360 129 134
31. GA Higgins AJ Bradbury BJ Jones NR Oakley 1988 Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphe nucleus of the rat Neuropharmacology 27 993 1001
32. JD Highley M Linnoila 1997 Low central nervous system serotonergic activity is traitlike and correlates with impulsive behaviour Ann NY Acad Sci USA 836 39 56
33. V Hillegaart 1991 Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat Psychopharmacology 103 291 296
34. W Hodos 1961 Progressive ratio as a measure of reward strength Science 134 943 944
35. JR Homberg JDA Olivier BMG Smits JD Mul J Mudde M Verheul OFM Nieuwenhuizen E Ronken T Cremers ANM Schoffelmeer BA Ellenbroek E Cuppen 2007 Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system Neuroscience 146 1662 1676
36. GF Koob 1992 Drugs of abuse: anatomy, pharmacology and function of reward pathways Trends Pharmacol Sci 13 177 184
37. JM Lauder 1990 Ontogeny of the serotonin system in the rat: serotonin as a developmental signal Ann N Y Acad Sci 600 297 313
38. Q Li C Wichems A Heils LD Van de Kar KP Lesch DL Murphy 1999 Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice J Pharmacol Exp Ther 291 999 1007
39. P Mannelli AA Patkar K Peindl H Tharwani R Gopalakrishnan KP Hill WH Berrettini 2006 Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls Psychiatry Res 144 99 108
40. KF Martin I Phillips M Hearson MR Prow DJ Heal 1992 Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants Br J Pharmacol 107 15 21
41. P Meerlo A Sgoifo SF De Boer JM Koolhaas 1999 Long-lasting consequences of a social conflict in rats: behaviour during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity Behav Neurosci 113 1283 1290
42. MJ Millan JM Rivet H Canton F Lejeune A Gobert P Widdowson K Bervoets M Brocco JL Peglion 1993 S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively Eur J Pharmacol 230 99 102
43. MJ Millan JM Rivet H Canton S le marmouille-Girardon A Gobert 1993 Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists J Pharmacol Exp Ther 264 1364 1376
44. DL Murphy AM Andrews CH Wichems Q Li M Tohda B Greenberg 1998 Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the action of serotonergic drugs J Clin Psychiatry 59 suppl 15 4 12
45. CP Müller RJ Carey MA De Souza Silva G Jocham JP Huston 2002 Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1A-receptor antagonism blocks behavioural but potentiates serotonergic activation Synapse 45 66 67
46. 1A-receptor agonism attenuates the cocaine-induced increased serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo midrodialysis study Neuropharmacology 44 592 603
47. 1A receptors Prog Neurobiol 81 133 178
48. A Newman-Tancredi J Rivet C Chaput M Touzard L Verriele MJ Millan 1999 The 5HT(1A) receptor ligand, S-15535, antagonises G-protein activation: a [35S] GTPgammaS and [3H]S-15535 autoradiography study Eur J Pharmacol 384 111 121
49. R Peltier S Schenk 1993 Effects of serotonergic manipulations on cocaine self-administration in rats Psychopharmacology 110 390 394
50. L Pezawas A Meyer-Lindenberg EM Drabant BA Verchinski KE Munoz BS Kolachana MF Egan VS Mattay AR Hariri DR Weinberger 2005 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression Nat Neurosci 8 828 834
51. LJ Porrino MC Ritz NL Goodman LG Sharpe MJ Kuhar SR Goldberg 1989 Differential effects of the pharmacological manipulation of serotonin systems on cocaine and amphetamine self-administration in rats Life Sciences 45 1529 1535
52. 3H]cocaine binding in central nervous system of mouse Life Sci 27 1055 1062
53. NR Richardson DCS Roberts 1991 Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat Life Sciences 49 833 840
54. NR Richardson DCS Roberts 1996 progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy J Neurosci Meth 66 1 11
55. A Serretti l Mandelli C Lorenzi S Landoni R Calati C Insacco CR Cloninger 2006 Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms Neuropsychobiology 53 9 16
56. HW Shen Y Hagino H Kobayashi K Shinohara-Tanaka K Ikeda H Yamamoto T Yamamoto KP Lesch DL Murphy FS Hall GR Uhl I Sora 2004 Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters Neuropsychopharmacology 29 1790 1799
57. BM Smits JB Mudde J van de Belt M Verheul J Olivier J Homberg V Guryev AR Cools BA Ellenbroek RH Plasterk E Cuppen 2006 Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis Pharmacogenet Genomics 16 159 169
58. I Sora C Wichems N Takahashi XF Li Z Zeng R Revay K-P Lesch GR Murphy DL Uhl 1998 Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice Proc Natl Acad Sci 13 7699 7704
59. I Sora FS Hall AM Andrews M Itokawa XF Li HB Wei C Wichems KP Lesch DL Murphy GR Uhl 2001 Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference Proc Natl Acad Sci 98 5300 5305
60. LT Tran-Nguyen JG Bellew KA Grote JL Neisewander 2001 Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats Psychopharmacology 157 340 348
61. TM Tzschentke 1998 Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues Prog Neurobiol 56 613 672
62. SR Tella 1995 Effects of monoamine reuptake inhibitors on cocaine self-administration in rats Pharmacol Biochem Behav 51 687 692
63. GR Uhl RW Grow 2004 The burden of complex genetics in brain disorders Arch Gen Psychiatry 61 223 229
64. SL Walsh KA Cunningham 1997 Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine Psychopharmacology 130 41 58
65. Wichems CH, Andrews AM, Heils A, Li Q, Lesch KP, Murphy DL (1998) Spontaneous behaviour differences and altered responses to psychomotor stimulants in mice lacking the serotonin transporter. 28th Annual Meeting of the society for Neuroscience
66. J Yamada Y Sugimoto K Horisaka 1988 The behavioural effects of 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) in mice Eur J Pharmacol 154 299 304
67. K Yoshimoto WJ McBride 1992 Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat Neurochem Res 17 401 407