A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 3, 2005, Pages 1181-1187

  Galici, Ruggero ^a,b   Echemendia, Nicholas G ^a   Rodriguez, Alice L ^a   Conn, P Jeffrey ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Janssen Research and Development LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 OXA 4 AMINOBICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLATE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; AMPHETAMINE; LY 487379; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N [4 (2 METHOXYPHENOXY)PHENYL] N (2,2,2 TRIFLUOROETHYLSULFONYL)PYRID 3 YLMETHYLAMINE; PHENCYCLIDINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; LOCOMOTION; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; STARTLE REFLEX;

ALLOSTERIC REGULATION; AMINO ACIDS; ANIMALS; ANTIPSYCHOTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; KINETICS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PREDICTIVE VALUE OF TESTS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; REFLEX, ACOUSTIC; SCHIZOPHRENIA; SULFONAMIDES;

EID: 27744597869     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.091074     Document Type: Article

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