Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants

Psychopharmacology

Volumn 206, Issue 4, 2009, Pages 641-651

  Uslaner, Jason M ^a   Smith, Sean M ^a   Huszar, Sarah L ^a   Pachmerhiwala, Rashida ^a   Hinchliffe, Richard M ^a   Vardigan, Joshua D ^a   Hutson, Pete H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amphetamine; Antipsychotic; Dopamine; Locomotor activity; MK 801; Norepinephrine; Psychostimulant; Schizophrenia

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; AMPHETAMINE; DIZOCILPINE; DOPAMINE; MONOAMINE; NORADRENALIN; PSYCHOSTIMULANT AGENT; VOLINANSERIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOPAMINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; HABITUATION; MALE; NEUROCHEMISTRY; NONHUMAN; NORADRENALIN RELEASE; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT;

AMINO ACIDS; AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; DIZOCILPINE MALEATE; DOPAMINE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EXCITATORY AMINO ACID AGONISTS; FLUOROBENZENES; MALE; MOTOR ACTIVITY; NOREPINEPHRINE; NUCLEUS ACCUMBENS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, METABOTROPIC GLUTAMATE; SEROTONIN ANTAGONISTS;

EID: 70349651963     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1644-y     Document Type: Article

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