-
1
-
-
0028147196
-
Metabotropic glutamate receptors are differentially regulated during development
-
Catania M.V., Landwehrmeyer G.B., Testa C.M., Standaert D.G., Penny J.B. Jr., Young A.B. Metabotropic glutamate receptors are differentially regulated during development. Neuroscience. 61:1994;481-495.
-
(1994)
Neuroscience
, vol.61
, pp. 481-495
-
-
Catania, M.V.1
Landwehrmeyer, G.B.2
Testa, C.M.3
Standaert, D.G.4
Penny J.B., Jr.5
Young, A.B.6
-
2
-
-
0000994406
-
Analysis of combined drug effects: A new look at a very old problem
-
Chou T.-C., Talalay P. Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol. Sci. 11:1983;450-454.
-
(1983)
Trends Pharmacol. Sci.
, vol.11
, pp. 450-454
-
-
Chou, T.-C.1
Talalay, P.2
-
3
-
-
0025037594
-
Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate
-
Desai M.A., Conn P.J. Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate. Neurosci. Lett. 109:1990;157-162.
-
(1990)
Neurosci. Lett.
, vol.109
, pp. 157-162
-
-
Desai, M.A.1
Conn, P.J.2
-
4
-
-
0028874812
-
Cloning and expression of a human metabotropic glutamate receptor 1a: Enhanced coupling on co-transfection with a glutamate transporter
-
Desai M.A., Burnett J.P., Mayne N.G., Schoepp D.D. Cloning and expression of a human metabotropic glutamate receptor 1a: enhanced coupling on co-transfection with a glutamate transporter. Molec. Pharmacol. 48:1995;648-657.
-
(1995)
Molec. Pharmacol.
, vol.48
, pp. 648-657
-
-
Desai, M.A.1
Burnett, J.P.2
Mayne, N.G.3
Schoepp, D.D.4
-
5
-
-
0029416950
-
3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a
-
3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br. J. Pharmacol. 116:1995;3279-3287.
-
(1995)
Br. J. Pharmacol.
, vol.116
, pp. 3279-3287
-
-
Ericksen, L.1
Thomsen, C.2
-
6
-
-
0029034143
-
Cloning, expression and pharmacological characterization of a human glutamate receptor: HGluR4
-
Fletcher E.J., Nutt S.L., Hoo K.H., Elliott C.E., Korcazk B., McWhinnie E.A., Kamboj R.K. Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. Recep. Channels. 3:1995;21-31.
-
(1995)
Recep. Channels
, vol.3
, pp. 21-31
-
-
Fletcher, E.J.1
Nutt, S.L.2
Hoo, K.H.3
Elliott, C.E.4
Korcazk, B.5
McWhinnie, E.A.6
Kamboj, R.K.7
-
7
-
-
0026596478
-
Molecular neurobiology of glutamate receptors
-
Gasic G.P., Hollman M. Molecular neurobiology of glutamate receptors. Ann. Rev. Physiol. 54:1992;507-536.
-
(1992)
Ann. Rev. Physiol.
, vol.54
, pp. 507-536
-
-
Gasic, G.P.1
Hollman, M.2
-
8
-
-
0019441262
-
Improved patch clamp technique for high resolution current recordings from cells and cell free membrane patches
-
Hamill O., Marty A., Neher E., Sakmann B., Sigworth F. Improved patch clamp technique for high resolution current recordings from cells and cell free membrane patches. Pflügers Arch. 391:1981;85-100.
-
(1981)
Pflügers Arch.
, vol.391
, pp. 85-100
-
-
Hamill, O.1
Marty, A.2
Neher, E.3
Sakmann, B.4
Sigworth, F.5
-
9
-
-
0026756866
-
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells
-
Hayashi Y., Tanabe Y., Aramori I., Masu M., Shimamoto K., Ohfune Y., Nakanishi S. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 107:1992;539-543.
-
(1992)
Br. J. Pharmacol.
, vol.107
, pp. 539-543
-
-
Hayashi, Y.1
Tanabe, Y.2
Aramori, I.3
Masu, M.4
Shimamoto, K.5
Ohfune, Y.6
Nakanishi, S.7
-
10
-
-
0027732539
-
Role of metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb
-
Hayashi Y., Momiyama A., Takahashi T., Ohishi H., Ogawa-Meguro R., Shigemoto R., Mizuno N., Nakanishi S. Role of metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366:1993;681-690.
-
(1993)
Nature
, vol.366
, pp. 681-690
-
-
Hayashi, Y.1
Momiyama, A.2
Takahashi, T.3
Ohishi, H.4
Ogawa-Meguro, R.5
Shigemoto, R.6
Mizuno, N.7
Nakanishi, S.8
-
11
-
-
0028350739
-
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes
-
Hayashi Y., Sekiyama N., Nakanishi S., Jane D.E., Sunter D.C., Birse E.F., Udvarhelyi P.M., Watkins J.C. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J. Neurosci. 14:1994;3370-3377.
-
(1994)
J. Neurosci.
, vol.14
, pp. 3370-3377
-
-
Hayashi, Y.1
Sekiyama, N.2
Nakanishi, S.3
Jane, D.E.4
Sunter, D.C.5
Birse, E.F.6
Udvarhelyi, P.M.7
Watkins, J.C.8
-
12
-
-
0028656406
-
Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: A kainate selective channel subunit
-
Hoo K., Nutt S., Fletcher E.F., Elliot C., Korzack B., Deverill M., Rampersand V., Fantaske R.P., Kamboj R.K. Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit. Recep. Channels. 2:1994;327-337.
-
(1994)
Recep. Channels
, vol.2
, pp. 327-337
-
-
Hoo, K.1
Nutt, S.2
Fletcher, E.F.3
Elliot, C.4
Korzack, B.5
Deverill, M.6
Rampersand, V.7
Fantaske, R.P.8
Kamboj, R.K.9
-
13
-
-
0029144223
-
Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1a and mGluR5a subtypes
-
Kingston A.E., Burnett J.P., Mayne N.G., Lodge D. Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1a and mGluR5a subtypes. Neuropharmacology. 8:1995;887-894.
-
(1995)
Neuropharmacology
, vol.8
, pp. 887-894
-
-
Kingston, A.E.1
Burnett, J.P.2
Mayne, N.G.3
Lodge, D.4
-
14
-
-
0000682752
-
Metabotropic glutamate receptors: Potential drug targets
-
Knopfel T., Gasparini F. Metabotropic glutamate receptors: potential drug targets. Drug Discov. Today. 1:1996;103-108.
-
(1996)
Drug Discov. Today
, vol.1
, pp. 103-108
-
-
Knopfel, T.1
Gasparini, F.2
-
15
-
-
0029071927
-
CDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration
-
Korczak B., Nutt S.L., Fletcher E.J., Hoo K.H., Elliot C.E., Rampersand V., McWhinnie E.A., Kamboj R.K. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. Recep. Channels. 3:1995;41-49.
-
(1995)
Recep. Channels
, vol.3
, pp. 41-49
-
-
Korczak, B.1
Nutt, S.L.2
Fletcher, E.J.3
Hoo, K.H.4
Elliot, C.E.5
Rampersand, V.6
McWhinnie, E.A.7
Kamboj, R.K.8
-
16
-
-
8944234853
-
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC): Identification of a potent, highly selective and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase
-
Monn J.A., Valli M.J., Johnson B.G., Salhoff C.R., Wright R.A., Howe T., Bond A., Lodge D., Spangle L.A., Paschal J.W., Campbell J.B., Griffey K., Tizzano J.P., Schoepp D.D. Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC): identification of a potent, highly selective and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J. Med. Chem. 39:1996;2990-3000.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2990-3000
-
-
Monn, J.A.1
Valli, M.J.2
Johnson, B.G.3
Salhoff, C.R.4
Wright, R.A.5
Howe, T.6
Bond, A.7
Lodge, D.8
Spangle, L.A.9
Paschal, J.W.10
Campbell, J.B.11
Griffey, K.12
Tizzano, J.P.13
Schoepp, D.D.14
-
17
-
-
15644369847
-
Design, synthesis and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: A potent, selective, systemically active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
-
In press
-
Monn J.A., Valli M.J., Massey S.M., Wright R.A., Salhoff C. R., Johnson B.G., Howe T., Alt C.A., Rhodes G.A., Robey R.L., Griffey K.R., Tizzano J.P., Kallman M.J., Helton D. R. and Schoepp D.D. Design, synthesis and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: a potent, selective, systemically active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J. Med. Chem. In press.
-
J. Med. Chem.
-
-
Monn, J.A.1
Valli, M.J.2
Massey, S.M.3
Wright, R.A.4
Salhoff, C.R.5
Johnson, B.G.6
Howe, T.7
Alt, C.A.8
Rhodes, G.A.9
Robey, R.L.10
Griffey, K.R.11
Tizzano, J.P.12
Kallman, M.J.13
Helton, D.R.14
Schoepp, D.D.15
-
18
-
-
0026437728
-
Molecular diversity of glutamate receptors and implications for brain function
-
Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
-
(1992)
Science
, vol.258
, pp. 597-603
-
-
Nakanishi, S.1
-
19
-
-
0030029427
-
Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
-
Nicoletti F., Bruno V., Copani A., Casabona G., Knopfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
-
(1996)
Trends Neurosci.
, vol.19
, pp. 267-271
-
-
Nicoletti, F.1
Bruno, V.2
Copani, A.3
Casabona, G.4
Knopfel, T.5
-
20
-
-
0027534340
-
Synthesis of L-2-(2,3-dicarboxycyclopropyl)glycines. Novel conformationally restricted glutamate analogues
-
Ohfune Y., Shimamoto K., Ishida M., Shinozaki H. Synthesis of L-2-(2,3-dicarboxycyclopropyl)glycines. Novel conformationally restricted glutamate analogues. Bioorgan. Med. Chem. Lett. 3:1993;15-18.
-
(1993)
Bioorgan. Med. Chem. Lett.
, vol.3
, pp. 15-18
-
-
Ohfune, Y.1
Shimamoto, K.2
Ishida, M.3
Shinozaki, H.4
-
21
-
-
0024335555
-
Trans-ACPD, a selective agonist to the PI-coupled excitatory amino acid receptor
-
Palmer E., Monaghan D.T., Cotman C.W. Trans-ACPD, a selective agonist to the PI-coupled excitatory amino acid receptor. Eur. J. Pharmacol. 166:1989;585-587.
-
(1989)
Eur. J. Pharmacol.
, vol.166
, pp. 585-587
-
-
Palmer, E.1
Monaghan, D.T.2
Cotman, C.W.3
-
22
-
-
0028912822
-
The metabotropic glutamate receptors: Structure and functions
-
Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
-
(1995)
Neuropharmacology
, vol.34
, pp. 1-26
-
-
Pin, J.-P.1
Duvoisin, R.2
-
24
-
-
0028243862
-
Novel functions for subtypes of metabotropic glutamate receptors
-
Schoepp D.D. Novel functions for subtypes of metabotropic glutamate receptors. Neurochem. Int. 24:1994;439-449.
-
(1994)
Neurochem. Int.
, vol.24
, pp. 439-449
-
-
Schoepp, D.D.1
-
25
-
-
0027395275
-
Metabotropic glutamate receptors in brain function and pathology
-
Schoepp D.D., Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 14:1993;13-20.
-
(1993)
Trends Pharmacol. Sci.
, vol.14
, pp. 13-20
-
-
Schoepp, D.D.1
Conn, P.J.2
-
26
-
-
0029019890
-
Second-messenger responses in brain slices to elucidate novel glutamate receptors
-
Schoepp D.D., Johnson B.G., Salhoff C.R., Wright R.A., Goldsworthy J.S., Baker S.R. Second-messenger responses in brain slices to elucidate novel glutamate receptors. J. Neurosci. Meth. 59:1995;105-110.
-
(1995)
J. Neurosci. Meth.
, vol.59
, pp. 105-110
-
-
Schoepp, D.D.1
Johnson, B.G.2
Salhoff, C.R.3
Wright, R.A.4
Goldsworthy, J.S.5
Baker, S.R.6
-
27
-
-
0030483690
-
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a synergistic interaction between group 1 and group 2 receptors
-
Schoepp D.D., Salhoff C.R., Wright R.A., Johnson B.G., Burnett J.P., Mayne N.G., Belagaje R., Wu S., Monn J.A. The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors. Neuropharmacology. 35:1996;1661-1672.
-
(1996)
Neuropharmacology
, vol.35
, pp. 1661-1672
-
-
Schoepp, D.D.1
Salhoff, C.R.2
Wright, R.A.3
Johnson, B.G.4
Burnett, J.P.5
Mayne, N.G.6
Belagaje, R.7
Wu, S.8
Monn, J.A.9
-
29
-
-
0029097032
-
Induction or protection of limbic seizures in mice by mGluR subtype selective agonists
-
Tizzano J.P., Griffey K.I., Schoepp D.D. Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology. 34:1995;1063-1067.
-
(1995)
Neuropharmacology
, vol.34
, pp. 1063-1067
-
-
Tizzano, J.P.1
Griffey, K.I.2
Schoepp, D.D.3
-
30
-
-
0029556126
-
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice
-
Tizzano J.P., Griffey K.I., Schoepp D.D. Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice. Ann. N.Y. Acad. Sci. 765:1995;230-235.
-
(1995)
Ann. N.Y. Acad. Sci.
, vol.765
, pp. 230-235
-
-
Tizzano, J.P.1
Griffey, K.I.2
Schoepp, D.D.3
-
31
-
-
0028177284
-
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family
-
Thomsen C., Boel E., Suzdak P.D. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur. J. Pharmacol. 267:1994;77-84.
-
(1994)
Eur. J. Pharmacol.
, vol.267
, pp. 77-84
-
-
Thomsen, C.1
Boel, E.2
Suzdak, P.D.3
-
32
-
-
0030026587
-
(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)pentane-1,5-dioic acid: A potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase
-
Wermuth C.G., Mann A., Schoenfelder A., Wright R.A., Johnson B.G., Burnett J.P., Mayne N.G., Schoepp D.D. (2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase. J. Med. Chem. 39:1996;814-816.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 814-816
-
-
Wermuth, C.G.1
Mann, A.2
Schoenfelder, A.3
Wright, R.A.4
Johnson, B.G.5
Burnett, J.P.6
Mayne, N.G.7
Schoepp, D.D.8
-
33
-
-
0028025658
-
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons
-
Wilsch V.W., Pidoplichko V.I., Opitz T., Shinozaki H., Reymann K.G. Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons. Eur. J. Pharmacol. 262:1994;287-291.
-
(1994)
Eur. J. Pharmacol.
, vol.262
, pp. 287-291
-
-
Wilsch, V.W.1
Pidoplichko, V.I.2
Opitz, T.3
Shinozaki, H.4
Reymann, K.G.5
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