Virus infections and type 1 diabetes risk

Current Diabetes Reports

Volumn 10, Issue 5, 2010, Pages 350-356

  Roivainen, Merja ^a   Klingel, Karin ^b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Cell destruction; Chronic infection; Coxsackievirus; Detection of viral RNA; Diabetogenic enteroviruses; Diabetogenic mechanism; Echovirus; Enterovirus; Enterovirus 5 D8 1 antibody; Enterovirus detection; Environmental factor; Immunostaining; In situ hybridization; Pancreatic islets; Prolonged infection; RT PCR; Type 1 diabetes; Virus; VP1 immunostaining

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN; VIRUS RNA;

COXSACKIE VIRUS; CYTOKINE PRODUCTION; DIABETOGENESIS; DISEASE PREDISPOSITION; ECHO VIRUS; ENTEROVIRUS INFECTION; ENVIRONMENTAL FACTOR; HUMAN; IMMUNOGLOBULIN DEFICIENCY; IN SITU HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE INFECTION; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; PANCREAS ISLET; REGULATORY T LYMPHOCYTE; REVIEW; SENSITIVITY AND SPECIFICITY; VIRUS CELL INTERACTION; VIRUS DETECTION; VIRUS INFECTION; VIRUS RECOMBINATION; VIRUS REPLICATION;

DIABETES MELLITUS, TYPE 1; ENTEROVIRUS INFECTIONS; HUMANS; ISLETS OF LANGERHANS; RISK FACTORS; RNA, VIRAL; VIRAL PROTEINS;

EID: 77956262741     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-010-0139-x     Document Type: Review

References (50)

1. D Hober P Sauter 2010 Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host Nat Rev Endocrinol 6 279 289 10.1038/nrendo.2010. 27 20351698
2. M Roivainen 2006 Enteroviruses: new findings on the role of enteroviruses in type 1 diabetes Int J Biochem Cell Biol 38 721 725 10.1016/j.biocel.2005.08. 019 1:CAS:528:DC%2BD28Xit1Ohtbs%3D 16226050
3. Tauriainen S, Oikarinen S, Oikarinen M, Hyoty H: Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol 2010 Apr 28 [Epub ahead of print].
4. MJ Richer MS Horwitz 2009 Coxsackievirus infection as an environmental factor in the etiology of type 1 diabetes Autoimmun Rev 8 611 615 10.1016/j.autrev.2009.02.006 1:CAS:528:DC%2BD1MXovFaqsLk%3D 19393207
5. MJ Richer MS Horwitz 2009 The innate immune response: an important partner in shaping coxsackievirus-mediated autoimmunity J Innate Immun 1 421 434 10.1159/000226247 1:CAS:528:DC%2BD1MXpt1Kjtb0%3D 20375600
6. CM Filippi MG von Herrath 2010 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: viruses, autoimmunity and immunoregulation Clin Exp Immunol 160 113 119 10.1111/j.1365-2249.2010.04128.x 1:CAS:528:DC%2BC3cXltFGisbg%3D 20415860
7. King AM, Brown F, Christian P, et al.: Picornaviridae. In Virus Taxonomy: Seventh Report of the International Committee on Taxonomy of Viruses. Edited by Van Regenmortel MH, Fauquet, CM, Bishop DH, et al. San Diego, CA: Academic Press; 2000:657-678.
8. MS Oberste K Maher DR Kilpatrick, et al. 1999 Typing of human enteroviruses by partial sequencing of VP1 J Clin Microbiol 37 1288 1293 1:CAS:528:DyaK1MXivFyhsbY%3D 10203472
9. JW Yoon M Austin T Onodera AL Notkins 1979 Isolation of a virus from the pancreas of a child with diabetic ketoacidosis N Engl J Med 300 1173 1179 10.1056/NEJM197905243002102 1:STN:280:DyaE1M7ls1Ogsg%3D%3D 219345
10. JW Yoon AL Notkins 1983 Virus-induced diabetes in mice Metabolism 32 37 40 10.1016/S0026-0495(83)80009-2 1:CAS:528:DyaL3sXkvVGqsbs%3D 6306392
11. K Klingel S Stephan M Sauter, et al. 1996 Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets J Virol 70 8888 8895 1:CAS:528:DyaK28XmvVGqurs%3D 8971018
12. P Ylipaasto K Klingel AM Lindberg, et al. 2004 Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells Diabetologia 47 225 239 10.1007/s00125-003-1297-z 1:STN:280:DC%2BD2c7gtValsg%3D%3D 14727023
13. F Dotta S Censini AG van Halteren, et al. 2007 Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients Proc Natl Acad Sci U S A 104 5115 5120 10.1073/pnas. 0700442104 1:CAS:528:DC%2BD2sXjvFChu7o%3D 17360338 This paper provides evidence for the presence of enteroviruses in pancreatic islets
14. SJ Richardson A Willcox AJ Bone, et al. 2009 The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes Diabetologia 52 1143 1151 10.1007/s00125-009-1276-0 1:CAS:528:DC%2BD1MXlt1Gqu70%3D 19266182 This paper provides evidence for the presence of enteroviruses in pancreatic islets
15. M Oikarinen S Tauriainen T Honkanen, et al. 2008 Analysis of pancreas tissue in a child positive for islet cell antibodies Diabetologia 51 1796 1802 10.1007/s00125-008-1107-8 1:STN:280:DC%2BD1crot1Khtw%3D%3D 18696046 This paper provides evidence for the presence of enteroviruses in pancreatic islets
16. •• Shibasaki S, Imagawa A, Tauriainen S, et al.: Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes. Endocr J 57:211-219. This paper provides evidence for the presence of enteroviruses in pancreatic islets.
17. S Tanaka Y Nishida K Aida, et al. 2009 Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes Diabetes 58 2285 2291 10.2337/db09-0091 1:CAS:528:DC%2BD1MXht1yku7bJ 19641142 This paper provides evidence for the presence of enteroviruses in pancreatic islets
18. Klingel K: Molecular biologic detection of virus infection in myocarditis and dilated cardiomyopathy. In Myocarditis. Edited by Cooper LT. Totowa, NJ: Humana Press; 2002:295-324.
19. Oikarinen M, Tauriainen S, Penttila P, et al.: Evaluation of immunohistochemistry and in situ hybridization methods for the detection of enteroviruses using infected cell culture samples. J Clin Virol 47:224-228.
20. K Klingel M Sauter CT Bock, et al. 2004 Molecular pathology of inflammatory cardiomyopathy Med Microbiol Immunol 193 101 107 10.1007/s00430-003-0190-1 1:CAS:528:DC%2BD2cXjslOku7g%3D 12920583
21. M Roivainen K Klingel 2009 Role of enteroviruses in the pathogenesis of type 1 diabetes Diabetologia 52 995 996 10.1007/s00125-009-1332-9 1:STN:280:DC%2BD1Mzht1Sqsw%3D%3D 19322560 This paper provides evidence for the presence of enteroviruses in pancreatic islets
22. T Harkonen H Lankinen B Davydova, et al. 2002 Enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase IA-2/IAR J Med Virol 66 340 350 10.1002/jmv.2151 1:CAS:528:DC%2BD38Xht1yltLo%3D 11793386
23. T Harkonen M Puolakkainen M Sarvas, et al. 2000 Picornavirus proteins share antigenic determinants with heat shock proteins 60/65 J Med Virol 62 383 391 10.1002/1096-9071(200011)62:3<383::AID-JMV11>3.0.CO;2-# 1:CAS:528:DC%2BD3cXns1OlsLY%3D 11055249
24. G Bussolati E Leonardo 2008 Technical pitfalls potentially affecting diagnoses in immunohistochemistry J Clin Pathol 61 1184 1192 10.1136/jcp.2007.047720 1:STN:280:DC%2BD1cnos1yksw%3D%3D 18326011
25. P Ylipaasto B Kutlu S Rasilainen, et al. 2005 Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets Diabetologia 48 1510 1522 10.1007/s00125-005-1839-7 1:CAS:528: DC%2BD2MXnslyrtL4%3D 15991020
26. Ortis F, Naamane N, Flamez D, et al.: Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes 59:358-374.
27. • Schulte BM, Kramer M, Ansems M, et al.: Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes 59:1182-1191. This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D.
28. • Schulte BM, Bakkers J, Lanke KH, et al.: Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunol 23:99-104. This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D.
29. S Skarsvik J Puranen J Honkanen, et al. 2006 Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes Diabetes 55 996 1003 10.2337/diabetes.55.04.06.db05-0630 1:CAS:528: DC%2BD28XjsVGmtLw%3D 16567521
30. D Hober W Chehadeh A Bouzidi P Wattre 2001 Antibody-dependent enhancement of coxsackievirus B4 infectivity of human peripheral blood mononuclear cells results in increased interferon-alpha synthesis J Infect Dis 184 1098 1108 10.1086/323801 1:CAS:528:DC%2BD3MXotlKitLY%3D 11598831
31. W Chehadeh PE Lobert P Sauter, et al. 2005 Viral protein VP4 is a target of human antibodies enhancing coxsackievirus B4- and B3-induced synthesis of alpha interferon J Virol 79 13882 13891 10.1128/JVI.79.22.13882-13891.2005 1:CAS:528:DC%2BD2MXht1ShsL3O 16254324
32. P Sauter W Chehadeh PE Lobert, et al. 2008 A part of the VP4 capsid protein exhibited by coxsackievirus B4 E2 is the target of antibodies contained in plasma from patients with type 1 diabetes J Med Virol 80 866 878 10.1002/jmv.21171 1:CAS:528:DC%2BD1cXltFCrsrg%3D 18366069 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
33. Ylipaasto P, Eskelinen M, Salmela K, et al.: Vitronectin receptors, alpha v integrins, are recognized by several non-RGD-containing echoviruses in a continuous laboratory cell line and also in primary human Langerhans' islets and endothelial cells. J Gen Virol 91:155-165.
34. M Oikarinen S Tauriainen T Honkanen, et al. 2008 Detection of enteroviruses in the intestine of type 1 diabetic patients Clin Exp Immunol 151 71 75 10.1111/j.1365-2249.2007.03529.x 1:STN:280:DC%2BD2sjkt1Gkug%3D%3D 17991291 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
35. O Vaarala 2008 Leaking gut in type 1 diabetes Curr Opin Gastroenterol 24 701 706 10.1097/MOG.0b013e32830e6d98 19122519 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
36. P Minor 2009 Vaccine-derived poliovirus (VDPV): impact on poliomyelitis eradication Vaccine 27 2649 2652 10.1016/j.vaccine.2009.02.071 19428874 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
37. M Roivainen P Ylipaasto C Savolainen, et al. 2002 Functional impairment and killing of human beta cells by enteroviruses: the capacity is shared by a wide range of serotypes, but the extent is a characteristic of individual virus strains Diabetologia 45 693 702 10.1007/s00125-002-0805-x 1:CAS:528: DC%2BD38XlsVWktLw%3D 12107750
38. H Al-Hello B Davydova T Smura, et al. 2005 Phenotypic and genetic changes in coxsackievirus B5 following repeated passage in mouse pancreas in vivo J Med Virol 75 566 574 10.1002/jmv.20303 1:CAS:528:DC%2BD2MXivFSgu7w%3D 15714484
39. H Al-Hello A Paananen M Eskelinen, et al. 2008 An enterovirus strain isolated from diabetic child belongs to a genetic subcluster of echovirus 11, but is also neutralised with monotypic antisera to coxsackievirus A9 J Gen Virol 89 1949 1959 10.1099/vir.0.83474-0 1:CAS:528:DC%2BD1cXpvVOqsL8%3D 18632967 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
40. H Al-Hello P Ylipaasto T Smura, et al. 2009 Amino acids of Coxsackie B5 virus are critical for infection of the murine insulinoma cell line, MIN-6 J Med Virol 81 296 304 10.1002/jmv.21391 1:CAS:528:DC%2BD1MXhsFSls7w%3D 19107967 This paper provides evidence for the mechanisms by which enterovirus infections might be involved in the pathogenesis of T1D
41. Y Kang NK Chatterjee MJ Nodwell JW Yoon 1994 Complete nucleotide sequence of a strain of coxsackie B4 virus of human origin that induces diabetes in mice and its comparison with nondiabetogenic coxsackie B4 JBV strain J Med Virol 44 353 361 10.1002/jmv.1890440408 1:CAS:528:DyaK2MXjs1ynu70%3D 7897366
42. A Paananen P Ylipaasto E Rieder, et al. 2003 Molecular and biological analysis of echovirus 9 strain isolated from a diabetic child J Med Virol 69 529 537 10.1002/jmv.10341 1:CAS:528:DC%2BD3sXisVOit7o%3D 12601761
43. PA Titchener O Jenkins TM Szopa, et al. 1994 Complete nucleotide sequence of a beta-cell tropic variant of coxsackievirus B4 J Med Virol 42 369 373 10.1002/jmv.1890420408 1:CAS:528:DyaK2MXht1ShtQ%3D%3D 8046427
44. CH Williams S Oikarinen S Tauriainen, et al. 2006 Molecular analysis of an echovirus 3 strain isolated from an individual concurrently with appearance of islet cell and IA-2 autoantibodies J Clin Microbiol 44 441 448 10.1128/JCM.44.2.441-448.2006 1:CAS:528:DC%2BD28XitFShuro%3D 16455897
45. Blomqvist S, Klemola P, Kaijalainen S, et al.: Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J Clin Virol 48:49-54.
46. S Blomqvist A Paananen C Savolainen-Kopra, et al. 2008 Eight years of experience with molecular identification of human enteroviruses J Clin Microbiol 46 2410 2413 10.1128/JCM.00313-08 18463218
47. G Palacios MS Oberste 2005 Enteroviruses as agents of emerging infectious diseases J Neurovirol 11 424 433 10.1080/13550280591002531 1:STN:280: DC%2BD2MnhtFSgtA%3D%3D 16287683
48. ME Wikswo N Khetsuriani AL Fowlkes, et al. 2009 Increased activity of Coxsackievirus B1 strains associated with severe disease among young infants in the United States, 2007-2008 Clin Infect Dis 49 e44 51 10.1086/605090 19622041
49. M Cabrerizo JE Echevarria A Otero, et al. 2008 Molecular characterization of a coxsackievirus A24 variant that caused an outbreak of acute haemorrhagic conjunctivitis in Spain, 2004 J Clin Virol 43 323 327 10.1016/j.jcv.2008.07.017 1:CAS:528:DC%2BD1cXht1Kgs7vF 18786853
50. NZ Ding XM Wang SW Sun, et al. 2009 Appearance of mosaic enterovirus 71 in the 2008 outbreak of China Virus Res 145 157 161 10.1016/j.virusres.2009.06. 006 1:CAS:528:DC%2BD1MXhtV2qsr%2FI 19540282