Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal

British Journal of Pharmacology

Volumn 164, Issue 4, 2011, Pages 1335-1356

  Ripley, Tamzin L ^a   Stephens, David N ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

alcohol dependence; animal model; pharmacological treatment

Indexed keywords

2 BENZHYDRYL 3 (2 IODOBENZYLAMINO)QUINUCLIDINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ACAMPROSATE; BROMOCRIPTINE; CARBAMAZEPINE; CHLORDIAZEPOXIDE; CLOMETHIAZOLE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; DIAZEPAM; DISULFIRAM; ENDOCANNABINOID; FLUOXETINE; GLUTAMIC ACID; LORAZEPAM; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; NALMEFENE; NALTREXONE; NERAMEXANE; NORBINALTROPHIMINE; ONDANSETRON; PLACEBO; RIMONABANT; RITANSERIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SUBSTANCE P; TOPIRAMATE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANHEDONIA; ANIMAL BEHAVIOR; COGNITIVE THERAPY; CONTROLLED CLINICAL TRIAL (TOPIC); DETOXIFICATION; DISEASE MODEL; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG MECHANISM; EXPERIMENTAL ANIMAL; GENETIC POLYMORPHISM; HUMAN; IMPULSIVENESS; INSTRUMENTAL CONDITIONING; NONHUMAN; PATIENT COMPLIANCE; PLACE PREFERENCE; PRIORITY JOURNAL; RELAPSE; REVIEW; REWARD; RISK FACTOR; RODENT;

ALCOHOLISM; ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; HUMANS; MICE; RATS; RODENTIA; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 80053324184     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01406.x     Document Type: Review

References (276)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Press: Washington, DC.
2. Anton RF, Moak DH, Waid LR, Latham PK, Malcolm RJ, Dias JK, (1999). Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. Am J Psychiatry 156: 1758-1764. (Pubitemid 29517569)
3. Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, et al,. (2006). Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 295: 2003-2017. (Pubitemid 44794003)
4. Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, et al,. (2008). An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 65: 135-144. (Pubitemid 351222547)
5. Arnone M, Maruani J, Chaperon F, Thiebot MH, Poncelet M, Soubrie P, et al,. (1997). Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology (Berl) 132: 104-106. (Pubitemid 27303746)
6. Atkinson RC, Shiffrin RM, (1971). The control of short-term memory. Sci Am 225: 82-90.
7. Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R, (2005). The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology 30: 1104-1110. (Pubitemid 40720968)
8. Backstrom P, Bachteler D, Koch S, Hyytia P, Spanagel R, (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928. (Pubitemid 38526792)
9. Badia-Elder NE, Kiefer SW, (1999). Taste reactivity in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol 18: 159-163. (Pubitemid 29368323)
10. Ballenger JC, Post RM, (1978). Kindling as a model for alcohol withdrawal syndromes. Br J Psychiatry 133: 1-14. (Pubitemid 8371124)
11. Bardo MT, Bevins RA, (2000). Conditioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology (Berl) 153: 31-43. (Pubitemid 32127902)
12. Becker RE, Greig NH, (2010). Lost in translation: neuropsychiatric drug development. Sci Transl Med 2: 61-66.
13. Berridge KC, (2000). Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns. Neurosci Biobehav Rev 24: 173-198. (Pubitemid 30100443)
14. Besheer J, Faccidomo S, Grondin JJ, Hodge CW, (2008). Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol Clin Exp Res 32: 209-221.
15. Bice PJ, Kiefer SW, (1990). Taste reactivity in alcohol preferring and nonpreferring rats. Alcohol Clin Exp Res 14: 721-727. (Pubitemid 20354996)
16. Bienkowski P, Kostowski W, Koros E, (1999). Ethanol-reinforced behaviour in the rat: effects of naltrexone. Eur J Pharmacol 374: 321-327. (Pubitemid 29313444)
17. Bizarro L, Patel S, Stolerman IP, (2003). Comprehensive deficits in performance of an attentional task produced by co-administering alcohol and nicotine to rats. Drug Alcohol Depend 72: 287-295. (Pubitemid 37485906)
18. Blednov YA, Harris RA, (2008). Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. Int J Neuropsychopharmacol 11: 775-793.
19. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG, et al,. (1996). The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med 89: 396-400. (Pubitemid 26245635)
20. Boettiger CA, Kelley EA, Mitchell JM, D'Esposito M, Fields HL, (2009). Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Pharmacol Biochem Behav 93: 291-299.
21. Booth C, Hasking P, (2009). Social anxiety and alcohol consumption: the role of alcohol expectancies and reward sensitivity. Addict Behav 34: 730-736.
22. Borlikova GG, Elbers NA, Stephens DN, (2006). Repeated withdrawal from ethanol spares contextual fear conditioning and spatial learning but impairs negative patterning and induces over-responding: evidence for effect on frontal cortical but not hippocampal function? Eur J Neurosci 24: 205-216. (Pubitemid 44050680)
23. Bouza C, Angeles M, Munoz A, Amate JM, (2004). Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction 99: 811-828. (Pubitemid 38869838)
24. Brown PL, Jenkins HM, (1968). Auto-shaping of the pigeon's key-peck. J Exp Anal Behav 11: 1-8.
25. Brown G, Stephens DN, (2002). Effects of cocaine on responding for ethanol or sucrose under a progressive ratio schedule. Behav Pharmacol 13: 157-162. (Pubitemid 34450701)
26. Brown G, Jackson A, Stephens DN, (1998). Effects of repeated withdrawal from chronic ethanol on oral self-administration of ethanol on a progressive ratio schedule. Behav Pharmacol 9: 149-161. (Pubitemid 28186511)
27. Brownell KD, Marlatt GA, Lichtenstein E, Wilson GT, (1986). Understanding and preventing relapse. Am Psychol 41: 765-782.
28. Buzsaki G, (1982). The 'where is it?' reflex: autoshaping the orienting response. J Exp Anal Behav 37: 461-484.
29. Cano-Cebrian MJ, Zornoza-Sabina T, Guerri C, Polache A, Granero L, (2003). Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus. Naunyn Schmiedebergs Arch Pharmacol 368: 324-327. (Pubitemid 37372557)
30. Chen JP, Paredes W, Li J, Smith D, Lowinson J, Gardner EL, (1990). Delta 9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology (Berl) 102: 156-162. (Pubitemid 20264653)
31. Chick J, Gough K, Falkowski W, Kershaw P, Hore B, Mehta B, et al,. (1992). Disulfiram treatment of alcoholism. Br J Psychiatry 161: 84-89.
32. Ciccocioppo R, Martin-Fardon R, Weiss F, (2002). Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology 27: 391-399. (Pubitemid 35256145)
33. Ciccocioppo R, Economidou D, Cippitelli A, Cucculelli M, Ubaldi M, Soverchia L, et al,. (2006). Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism. Addict Biol 11: 339-355. (Pubitemid 46696907)
34. Cloninger CR, (1987). Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410-416. (Pubitemid 17071986)
35. Cole JC, Littleton JM, Little HJ, (2000). Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology (Berl) 147: 403-411. (Pubitemid 30048488)
36. Colombo G, Serra S, Brunetti G, Gomez R, Melis S, Vacca G, et al,. (2002). Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats. Psychopharmacology (Berl) 159: 181-187. (Pubitemid 34146562)
37. Colombo G, Vacca G, Serra S, Carai MA, Gessa GL, (2004). Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats. Eur J Pharmacol 498: 119-123. (Pubitemid 39208070)
38. Corbit LH, Janak PH, (2007). Ethanol-associated cues produce general pavlovian-instrumental transfer. Alcohol Clin Exp Res 31: 766-774. (Pubitemid 46587656)
39. Cowen MS, Adams C, Kraehenbuehl T, Vengeliene V, Lawrence AJ, (2005). The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system. Addict Biol 10: 233-242. (Pubitemid 41306326)
40. Cox WM, Hogan LM, Kristian MR, Race JH, (2002). Alcohol attentional bias as a predictor of alcohol abusers' treatment outcome. Drug Alcohol Depend 68: 237-243. (Pubitemid 35232559)
41. Cunningham CL, (1995). Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology (Berl) 120: 28-41.
42. Cunningham CL, Henderson CM, (2000). Ethanol-induced conditioned place aversion in mice. Behav Pharmacol 11: 591-602.
43. Cunningham CL, Patel P, (2007). Rapid induction of Pavlovian approach to an ethanol-paired visual cue in mice. Psychopharmacology (Berl) 192: 231-241. (Pubitemid 46669205)
44. Cunningham CL, Niehus JS, Noble D, (1993). Species difference in sensitivity to ethanol's hedonic effects. Alcohol 10: 97-102. (Pubitemid 23096837)
45. Cunningham CL, Smith R, McMullin C, (2003). Competition between ethanol-induced reward and aversion in place conditioning. Learn Behav 31: 273-280. (Pubitemid 37214581)
46. Cunningham CL, Gremel CM, Groblewski PA, (2006). Drug-induced conditioned place preference and aversion in mice. Nat Protoc 1: 1662-1670. (Pubitemid 46773287)
47. Cunningham CL, Gremel CM, Groblewski PA, (2008). Genetic influences on conditioned taste aversion. In:, Reilly S, Schachtman TR, (eds). Conditioned Taste Aversion: Behavioral and Neural Processe. Oxford University Press: New York, pp. 387-421.
48. Czachowski CL, Legg BH, Samson HH, (2001). Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 25: 344-350. (Pubitemid 32221813)
49. Davidson D, Swift R, Fitz E, (1996). Naltrexone increases the latency to drink alcohol in social drinkers. Alcohol Clin Exp Res 20: 732-739. (Pubitemid 26186942)
50. Davidson D, Palfai T, Bird C, Swift R, (1999). Effects of naltrexone on alcohol self-administration in heavy drinkers. Alcohol Clin Exp Res 23: 195-203. (Pubitemid 29100390)
51. De Sousa A, (2004). A one-year pragmatic trial of naltrexone vs disulfiram in the treatment of alcohol dependence. Alcohol Alcohol 39: 528-531. (Pubitemid 39534536)
52. De Sousa A, (2010). The role of topiramate and other anticonvulsants in the treatment of alcohol dependence: a clinical review. CNS Neurol Disord Drug Targets 9: 45-49.
53. De Sousa AA, De Sousa J, Kapoor H, (2008). An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence. J Subst Abuse Treat 34: 460-463. (Pubitemid 351609293)
54. De Witte P, Littleton J, Parot P, Koob G, (2005). Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action. CNS Drugs 19: 517-537. (Pubitemid 41058377)
55. Diehl A, Ulmer L, Mutschler J, Herre H, Krumm B, Croissant B, et al,. (2010). Why is disulfiram superior to acamprosate in the routine clinical setting? A retrospective long-term study in 353 alcohol-dependent patients. Alcohol Alcohol 45: 271-277.
56. Dole VP, Gentry RT, (1984). Toward an analogue of alcoholism in mice: scale factors in the model. Proc Natl Acad Sci U S A 81: 3543-3546. (Pubitemid 14122710)
57. Doty P, de Wit H, (1995). Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. Behav Pharmacol 6: 386-394.
58. Dougherty DM, Moeller FG, Steinberg JL, Marsh DM, Hines SE, Bjork JM, (1999). Alcohol increases commission error rates for a continuous performance test. Alcohol Clin Exp Res 23: 1342-1351. (Pubitemid 29409348)
59. Dougherty DM, Marsh DM, Moeller FG, Chokshi RV, Rosen VC, (2000). Effects of moderate and high doses of alcohol on attention, impulsivity, discriminability, and response bias in immediate and delayed memory task performance. Alcohol Clin Exp Res 24: 1702-1711.
60. Duka T, Townshend JM, Collier K, Stephens DN, (2002). Kindling of withdrawal: a study of craving and anxiety after multiple detoxifications in alcoholic inpatients. Alcohol Clin Exp Res 26: 785-795. (Pubitemid 34666137)
61. Duka T, Gentry J, Malcolm R, Ripley TL, Borlikova G, Stephens DN, et al,. (2004). Consequences of multiple withdrawals from alcohol. Alcohol Clin Exp Res 28: 233-246. (Pubitemid 38233601)
62. Duka T, Crombag HS, Stephens DN, (2010). Experimental medicine in drug addiction: towards behavioural, cognitive and neurobiological biomarkers. J Psychopharmacology DOI: 10.1177/0269881110388324 [Epub ahead of print].
63. Duka T, Trick L, Nikolaou K, Gray MA, Kempton MJ, Williams H, et al,. (2011). Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics. Biol Psychiatry DOI: 10.1016/j.biopsych.2011.04. 006 [Epub ahead of print].
64. Earleywine M, (1994a). Anticipated biphasic effects of alcohol vary with risk for alcoholism: a preliminary report. Alcohol Clin Exp Res 18: 711-714. (Pubitemid 24189303)
65. Earleywine M, (1994b). Confirming the factor structure of the anticipated biphasic alcohol effects scale. Alcohol Clin Exp Res 18: 861-866. (Pubitemid 24264105)
66. Egli M, (2005). Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? Addict Biol 10: 309-319. (Pubitemid 41759264)
67. Engel SR, Lyons CR, Allan AM, (1998). 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Psychopharmacology (Berl) 140: 243-248. (Pubitemid 28538485)
68. Erblich J, Earleywine M, Erblich B, Bovbjerg DH, (2003). Biphasic stimulant and sedative effects of ethanol: are children of alcoholics really different? Addict Behav 28: 1129-1139. (Pubitemid 36808520)
69. Evans SM, Levin FR, Brooks DJ, Garawi F, (2007). A pilot double-blind treatment trial of memantine for alcohol dependence. Alcohol Clin Exp Res 31: 775-782. (Pubitemid 46587657)
70. Evenden JL, Ryan CN, (1999). The pharmacology of impulsive behaviour in rats VI: the effects of ethanol and selective serotonergic drugs on response choice with varying delays of reinforcement. Psychopharmacology (Berl) 146: 413-421. (Pubitemid 29513281)
71. Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW, (2008). Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci 363: 3125-3135.
72. Freedland CS, Sharpe AL, Samson HH, Porrino LJ, (2001). Effects of SR141716A on ethanol and sucrose self-administration. Alcohol Clin Exp Res 25: 277-282. (Pubitemid 32167445)
73. Froehlich JC, Harts J, Lumeng L, Li TK, (1990). Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav 35: 385-390. (Pubitemid 20075583)
74. Fuller RK, Gordis E, (2004). Does disulfiram have a role in alcoholism treatment today? Addiction 99: 21-24. (Pubitemid 38142216)
75. Gallagher M, Graham PW, Holland PC, (1990). The amygdala central nucleus and appetitive Pavlovian conditioning: lesions impair one class of conditioned behavior. J Neurosci 10: 1906-1911.
76. Gardell LR, Whalen CA, Chattophadyay S, Cavallaro CA, Hubbell CL, Reid LD, (1997). Combination of naltrexone and fluoxetine on rats' propensity to take alcoholic beverage. Alcohol Clin Exp Res 21: 1435-1439. (Pubitemid 27517927)
77. Gehlert DR, Cippitelli A, Thorsell A, Le AD, Hipskind PA, Hamdouchi C, et al,. (2007). 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6- dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. J Neurosci 27: 2718-2726. (Pubitemid 46393604)
78. George DT, Herion DW, Jones CL, Phillips MJ, Hersh J, Hill D, et al,. (2010). Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology (Berl) 208: 37-44.
79. Gewiss M, Heidbreder C, Opsomer L, Durbin P, De Witte P, (1991). Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour. Alcohol Alcohol 26: 129-137.
80. Gilman JM, Hommer DW, (2008). Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addict Biol 13: 423-434.
81. Glasner SV, Overmier JB, Balleine BW, (2005). The role of Pavlovian cues in alcohol seeking in dependent and nondependent rats. J Stud Alcohol 66: 53-61. (Pubitemid 40381601)
82. Goldsmith AA, Tran GQ, Smith JP, Howe SR, (2009). Alcohol expectancies and drinking motives in college drinkers: mediating effects on the relationship between generalized anxiety and heavy drinking in negative-affect situations. Addict Behav 34: 505-513.
83. Gonzalez LP, Veatch LM, Ticku MK, Becker HC, (2001). Alcohol withdrawal kindling: mechanisms and implications for treatment. Alcohol Clin Exp Res 25 (5 Suppl ISBRA): 197S-201S.
84. Goodwin FL, Campisi M, Babinska I, Amit Z, (2001). Effects of naltrexone on the intake of ethanol and flavored solutions in rats. Alcohol 25: 9-19. (Pubitemid 32982858)
85. Grahame NJ, Grose AM, (2003). Blood alcohol concentrations after scheduled access in high-alcohol-preferring mice. Alcohol 31: 99-104. (Pubitemid 37393315)
86. Grant KA, Samson HH, (1985). Induction and maintenance of ethanol self-administration without food deprivation in the rat. Psychopharmacology (Berl) 86: 475-479. (Pubitemid 15042315)
87. Gupta T, Syed YM, Revis AA, Miller SA, Martinez M, Cohn KA, et al,. (2008). Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice. Alcohol Clin Exp Res 32: 1992-1998.
88. Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, et al,. (2002). Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcohol Clin Exp Res 26: 1779-1793. (Pubitemid 36008614)
89. He XX, Nebert DW, Vasiliou V, Zhu H, Shertzer HG, (1997). Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics 7: 223-233. (Pubitemid 27290636)
90. Heidbreder CA, Hagan JJ, (2005). Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. Curr Opin Pharmacol 5: 107-118. (Pubitemid 40124543)
91. Heilig M, Egli M, (2006). Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111: 855-876. (Pubitemid 44118437)
92. Heilig M, Koob GF, (2007). A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406. (Pubitemid 47090230)
93. Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, et al,. (2010). Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev 35: 334-344.
94. Heyser CJ, Schulteis G, Durbin P, Koob GF, (1998). Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18: 125-133. (Pubitemid 28026682)
95. Heyser CJ, Moc K, Koob GF, (2003). Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology 28: 1463-1471. (Pubitemid 41070881)
96. Hogarth L, Dickinson A, Wright A, Kouvaraki M, Duka T, (2007). The role of drug expectancy in the control of human drug seeking. J Exp Psychol Anim Behav Process 33: 484-496. (Pubitemid 350100770)
97. Holter SM, Spanagel R, (1999). Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology (Berl) 145: 360-369. (Pubitemid 29424530)
98. Holter SM, Danysz W, Spanagel R, (2000a). Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 292: 545-552. (Pubitemid 30067417)
99. Holter SM, Henniger MS, Lipkowski AW, Spanagel R, (2000b). Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology (Berl) 153: 93-102. (Pubitemid 32127907)
100. Houchi H, Babovic D, Pierrefiche O, Ledent C, Daoust M, Naassila M, (2005). CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors. Neuropsychopharmacology 30: 339-349. (Pubitemid 40129485)
101. Howlett AC, (2002). The cannabinoid receptors. Prostaglandins Other Lipid Mediat 68-69: 619-631. (Pubitemid 35247425)
102. Hungund BL, Basavarajappa BS, (2000). Distinct differences in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption. J Neurosci Res 60: 122-128. (Pubitemid 30176756)
103. Hungund BL, Basavarajappa BS, Vadasz C, Kunos G, Rodriguez de Fonseca F, Colombo G, et al,. (2002). Ethanol, endocannabinoids, and the cannabinoidergic signaling system. Alcohol Clin Exp Res 26: 565-574. (Pubitemid 34408723)
104. Hyytia P, Sinclair JD, (1993). Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats. Alcohol Clin Exp Res 17: 631-636. (Pubitemid 23178449)
105. Johnson BA, (2008). Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol 75: 34-56. (Pubitemid 350235398)
106. Johnson BA, (2010). Medication treatment of different types of alcoholism. Am J Psychiatry 167: 630-639.
107. Johnson BA, Jasinski DR, Galloway GP, Kranzler H, Weinreib R, Anton RF, et al,. (1996). Ritanserin in the treatment of alcohol dependence-a multi-center clinical trial. Ritanserin Study Group. Psychopharmacology (Berl) 128: 206-215. (Pubitemid 26383308)
108. Kamdar NK, Miller SA, Syed YM, Bhayana R, Gupta T, Rhodes JS, (2007). Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice. Psychopharmacology (Berl) 192: 207-217. (Pubitemid 46669212)
109. Katner SN, Magalong JG, Weiss F, (1999). Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology 20: 471-479. (Pubitemid 29123874)
110. Kenna GA, (2010). Medications acting on the serotonergic system for the treatment of alcohol dependent patients. Curr Pharm Des 16: 2126-2135.
111. Kenna GA, Lomastro TL, Schiesl A, Leggio L, Swift RM, (2009). Review of topiramate: an antiepileptic for the treatment of alcohol dependence. Curr Drug Abuse Rev 2: 135-142.
112. Khisti RT, Wolstenholme J, Shelton KL, Miles MF, (2006). Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice. Alcohol 40: 119-126. (Pubitemid 46329323)
113. Kim AK, Souza-Formigoni ML, (2010). Disulfiram impairs the development of behavioural sensitization to the stimulant effect of ethanol. Behav Brain Res 207: 441-446.
114. Koob GF, (1992). Neural mechanisms of drug reinforcement. Ann N Y Acad Sci 654: 171-191.
115. Koob GF, Le Moal M, (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97-129.
116. Koob GF, Le Moal M, (2008). Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philos Trans R Soc Lond B Biol Sci 363: 3113-3123.
117. Kosten TR, O'Connor PG, (2003). Management of drug and alcohol withdrawal. N Engl J Med 348: 1786-1795. (Pubitemid 36514710)
118. Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC, (1998). Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav 59: 627-635. (Pubitemid 28144202)
119. Krishnan-Sarin S, Krystal JH, Shi J, Pittman B, O'Malley SS, (2007). Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking. Biol Psychiatry 62: 694-697. (Pubitemid 47314376)
120. Lallemand F, Soubrie PH, De Witte PH, (2001). Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration. Alcohol Clin Exp Res 25: 1317-1323. (Pubitemid 32868340)
121. Lange JE, Voas RB, (2000). Youth escaping limits on drinking: binging in Mexico. Addiction 95: 521-528. (Pubitemid 30220247)
122. Le A, Shaham Y, (2002). Neurobiology of relapse to alcohol in rats. Pharmacol Ther 94: 137-156. (Pubitemid 34615963)
123. Le AD, Poulos CX, Harding S, Watchus J, Juzytsch W, Shaham Y, (1999a). Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 21: 435-444. (Pubitemid 29333082)
124. Le W, Conneely OM, Zou L, He Y, Saucedo-Cardenas O, Jankovic J, et al,. (1999b). Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol 159: 451-458. (Pubitemid 29485231)
125. Le AD, Funk D, Harding S, Juzytsch W, Fletcher PJ, Shaham Y, (2006). Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) 186: 82-92. (Pubitemid 43668313)
126. Le Magnen J, Tran G, Durlach J, Martin C, (1987). Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4: 97-102. (Pubitemid 17073486)
127. Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS, (2010). Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addict Biol 15: 109-124.
128. Li XW, Li TK, Froehlich JC, (1998). Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference. Brain Res 794: 35-47. (Pubitemid 28298863)
129. Lin N, Hubbard JI, (1994). The increased ethanol preference in rats induced by choice, darkness, or drugs is reduced by ritanserin. Brain Res Bull 33: 633-638. (Pubitemid 24089792)
130. Litten RZ, Allen JP, (1998). Advances in development of medications for alcoholism treatment. Psychopharmacology (Berl) 139: 20-33. (Pubitemid 28416879)
131. Littleton J, (1995). Acamprosate in alcohol dependence: how does it work? Addiction 90: 1179-1188.
132. Littleton J, Zieglgansberger W, (2003). Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict 12 (Suppl. 1): S3-11. (Pubitemid 36583412)
133. Logrip ML, Janak PH, Ron D, (2009). Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol 43: 359-365.
134. Lovinger DM, Zhou Q, (1994). Alcohols potentiate ion current mediated by recombinant 5-HT3RA receptors expressed in a mammalian cell line. Neuropharmacology 33: 1567-1572.
135. Ludwig AM, Stark LH, (1974). Alcohol craving. Subjective and situational aspects. Q J Stud Alcohol 35: 899-905.
136. Mann K, Lehert P, Morgan MY, (2004). The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res 28: 51-63. (Pubitemid 38114023)
137. Mann K, Ackermann K, Diehl A, Ebert D, Mundle G, Nakovics H, et al,. (2006). Galantamine: a cholinergic patch in the treatment of alcoholism: a randomized, placebo-controlled trial. Psychopharmacology (Berl) 184: 115-121. (Pubitemid 43005764)
138. Mann K, Kiefer F, Spanagel R, Littleton J, (2008). Acamprosate: recent findings and future research directions. Alcohol Clin Exp Res 32: 1105-1110.
139. Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL, (2006). Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A 103: 2938-2942.
140. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM, (1993). Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17: 140-146. (Pubitemid 23080981)
141. Mason BJ, (2001). Treatment of alcohol-dependent outpatients with acamprosate: a clinical review. J Clin Psychiatry 62 (Suppl. 20): 42-48. (Pubitemid 32917098)
142. Mason BJ, Salvato FR, Williams LD, Ritvo EC, Cutler RB, (1999). A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch Gen Psychiatry 56: 719-724. (Pubitemid 29357733)
143. Maurel S, De Vry J, Schreiber R, (1999a). 5-HT receptor ligands differentially affect operant oral self-administration of ethanol in the rat. Eur J Pharmacol 370: 217-223. (Pubitemid 29192865)
144. Maurel S, De Vry J, Schreiber R, (1999b). Comparison of the effects of the selective serotonin-reuptake inhibitors fluoxetine, paroxetine, citalopram and fluvoxamine in alcohol-preferring cAA rats. Alcohol 17: 195-201. (Pubitemid 29187709)
145. McBride WJ, Li TK, (1998). Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12: 339-369. (Pubitemid 29073864)
146. McCusker CG, Brown K, (1990). Alcohol-predictive cues enhance tolerance to and precipitate 'craving' for alcohol in social drinkers. J Stud Alcohol 51: 494-499.
147. McCusker CG, Brown K, (1991). The cue-responsivity phenomenon in dependent drinkers: 'personality' vulnerability and anxiety as intervening variables. Br J Addict 86: 905-912.
148. McGeehan AJ, Olive MF, (2003). The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine. Br J Pharmacol 138: 9-12. (Pubitemid 36194197)
149. McNair DM, Lorr M, Droppelman LF, (1971). Profile of Mood States. Educational and Industrial Testing Service: San Diego, CA.
150. Mead AN, Brown G, Le Merrer J, Stephens DN, (2005). Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice. Psychopharmacology (Berl) 179: 164-171. (Pubitemid 40576703)
151. Meert TF, Awouters F, Niemegeers CJ, Schellekens KH, Janssen PA, (1991). Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats. Pharmacopsychiatry 24: 159-163.
152. Middaugh LD, Lee AM, Bandy AL, (2000). Ethanol reinforcement in nondeprived mice: effects of abstinence and naltrexone. Alcohol Clin Exp Res 24: 1172-1179. (Pubitemid 30650935)
153. Mikolajczak P, Okulicz-Kozaryn I, Kaminska E, Niedopad L, Polanska A, Gebka J, (2002). Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. Eur J Pharmacol 444: 83-96. (Pubitemid 34621337)
154. Mitchell JM, Tavares VC, Fields HL, D'Esposito M, Boettiger CA, (2007). Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls. Neuropsychopharmacology 32: 439-449. (Pubitemid 46106950)
155. Monti PM, Rohsenow DJ, Rubonis AV, Niaura RS, Sirota AD, Colby SM, et
156. Monti PM, Rohsenow DJ, Hutchison KE, Swift RM, Mueller TI, Colby SM, et al,. (1999). Naltrexone's effect on cue-elicited craving among alcoholics in treatment. Alcohol Clin Exp Res 23: 1386-1394. (Pubitemid 29409353)
157. Morse RM, Flavin DK, (1992). The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism. JAMA 268: 1012-1014.
158. Mulvihill LE, Skilling TA, Vogel-Sprott M, (1997). Alcohol and the ability to inhibit behavior in men and women. J Stud Alcohol 58: 600-605. (Pubitemid 27498055)
159. Murphy JM, Waller MB, Gatto GJ, McBride WJ, Lumeng L, Li TK, (1985). Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats. Alcohol 2: 349-352. (Pubitemid 15086686)
160. Mutschler J, Grosshans M, Koopmann A, Hermann D, Diehl A, Mann K, et al,. (2010). Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder-a case series. Alcohol Alcohol 45: 146-150.
161. Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M, (1998). Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 22: 802-809. (Pubitemid 28292462)
162. Naassila M, Pierrefiche O, Ledent C, Daoust M, (2004). Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. Neuropharmacology 46: 243-253. (Pubitemid 37532832)
163. Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N, (1994). Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 347: 249-274. (Pubitemid 24273427)
164. Ng GY, George SR, (1994). Dopamine receptor agonist reduces ethanol self-administration in the ethanol-preferring C57BL/6J inbred mouse. Eur J Pharmacol 269: 365-374. (Pubitemid 24348052)
165. Ng GY, O'Dowd BF, George SR, (1994). Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains. Eur J Pharmacol 269: 349-364. (Pubitemid 24348051)
166. NIAAA (2004). Binge drinking defined. NIAAA Newsletters 3: 3.
167. Nisbet RE, Wilson TD, (1977). Telling more than we can know-verbal reports on mental processes. Psychol Rev 84: 231-259.
168. Oberlin BG, Bristow RE, Heighton ME, Grahame NJ, (2010). Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring mice. Alcohol Clin Exp Res 34: 1363-1375.
169. O'Brien CP, Volpicelli LA, Volpicelli JR, (1996). Naltrexone in the treatment of alcoholism: a clinical review. Alcohol 13: 35-39. (Pubitemid 26061201)
170. O'Connor EC, Stephens DN, Crombag HS, (2010). Modelling appetitive povlovian instrumental interactions in mice. Curr Protoc Neurosci 53: 8.25.1-8.25.27.
171. Okulicz-Kozaryn I, Midolajczak P, Szczawinska K, Kaminska E, Kus K, (2001). Effects of acamprosate and scopolamine on the working memory of rats in a three-panel runway task. J Basic Clin Physiol Pharmacol 12: 197-216. (Pubitemid 33143990)
172. Olive MF, Nannini MA, Ou CJ, Koenig HN, Hodge CW, (2002). Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release. Eur J Pharmacol 437: 55-61. (Pubitemid 34178386)
173. Oliver YP, Ripley TL, Stephens DN, (2009). Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine. Psychopharmacology (Berl) 204: 679-692.
174. Olmstead MC, Hellemans KG, Paine TA, (2006). Alcohol-induced impulsivity in rats: an effect of cue salience? Psychopharmacology (Berl) 184: 221-228. (Pubitemid 43083659)
175. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B, (1992). Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry 49: 881-887.
176. O'Malley SS, Krishnan-Sarin S, Farren C, Sinha R, Kreek MJ, (2002). Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary- adrenocortical axis. Psychopharmacology (Berl) 160: 19-29. (Pubitemid 34169822)
177. Ooteman W, Koeter MW, Verheul R, Schippers GM, van den Brink W, (2007). The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholics. Eur Neuropsychopharmacol 17: 558-566. (Pubitemid 46778886)
178. Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, et al,. (2003). A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28: 1546-1552. (Pubitemid 41070891)
179. Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Braun C, Bartus RT, Crews FT, (1999). Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding. Alcohol Clin Exp Res 23: 1761-1771.
180. Panocka I, Massi M, (1992). Long-lasting suppression of alcohol preference in rats following serotonin receptor blockade by ritanserin. Brain Res Bull 28: 493-496.
181. Papp M, Willner P, Muscat R, (1991). An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology (Berl) 104: 255-259.
182. Paredes-Olay C, Abad MJ, Gamez M, Rosas JM, (2002). Transfer of control between causal predictive judgments and instrumental responding. Anim Learn Behav 30: 239-248.
183. Parkinson JA, Robbins TW, Everitt BJ, (2000). Dissociable roles of the central and basolateral amygdala in appetitive emotional learning. Eur J Neurosci 12: 405-413. (Pubitemid 30068449)
184. Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, (2005). Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 57: 1128-1137. (Pubitemid 40615774)
185. Phillips G, Willner P, Muscat R, (1991). Reward-dependent suppression or facilitation of consummatory behaviour by raclopride. Psychopharmacology (Berl) 105: 355-360.
186. Poulos CX, Parker JL, Le DA, (1998). Increased impulsivity after injected alcohol predicts later alcohol consumption in rats: evidence for 'loss-of-control drinking' and marked individual differences. Behav Neurosci 112: 1247-1257. (Pubitemid 28519007)
187. Racz I, Bilkei-Gorzo A, Toth ZE, Michel K, Palkovits M, Zimmer A, (2003). A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. J Neurosci 23: 2453-2458. (Pubitemid 36368934)
188. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, et al,. (2010). A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry DOI: 10.1038/mp.2010.56 [Epub ahead of print].
189. Ray LA, MacKillop J, Leventhal A, Hutchison KE, (2009). Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. Alcohol Clin Exp Res 33: 2154-2161.
190. Ray LA, Mackillop J, Monti PM, (2010). Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Substance Use & Misuse 45: 1742-1765.
191. Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, et al,. (1994). Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol 45: 330-334.
192. Rezvani AH, Overstreet DH, Mason GA, Janowsky DS, Hamedi M, Clark E, et al,. (2000). Combination pharmacotherapy: a mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats. Alcohol Alcohol 35: 76-83. (Pubitemid 30088739)
193. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC, (2005). Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 84: 53-63. (Pubitemid 40092065)
194. Rhodes JS, Ford MM, Yu CH, Brown LL, Finn DA, Garland T, et al,. (2007). Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav 6: 1-18. (Pubitemid 46090329)
195. Richards JB, Mitchell SH, de Wit H, Seiden LS, (1997). Determination of discount functions in rats with an adjusting-amount procedure. J Exp Anal Behav 67: 353-366. (Pubitemid 127460402)
196. Rimondini R, Arlinde C, Sommer W, Heilig M, (2002). Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 16: 27-35. (Pubitemid 34027947)
197. Ripley TL, Borlikova G, Lyons S, Stephens DN, (2004). Selective deficits in appetitive conditioning as a consequence of ethanol withdrawal. Eur J Neurosci 19: 415-425. (Pubitemid 38177880)
198. Risinger FO, (1997). Fluoxetine's effects on ethanol's rewarding, aversive and stimulus properties. Life Sci 61: 235-242.
199. Robbins TW, (1978). The acquisition of responding with conditioned reinforcement: effects of pipradrol, methylphenidate, d-amphetamine, and nomifensine. Psychopharmacology (Berl) 58: 79-87. (Pubitemid 8356986)
200. Robbins TW, (2002). The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163: 362-380.
201. Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HW, Koob GF, et al,. (2000). mu-Opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Ther 293: 1002-1008. (Pubitemid 30417870)
202. Robinson TE, Berridge KC, (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18: 247-291. (Pubitemid 23219500)
203. Robinson TE, Berridge KC, (2000). The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction 95 (Suppl. 2): S91-117. (Pubitemid 30650375)
204. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ, (2009). Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol 14: 152-164.
205. Rodd-Henricks ZA, McKinzie DL, Edmundson VE, Dagon CL, Murphy JM, McBride WJ, et al,. (2000). Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol 21: 73-85. (Pubitemid 30628650)
206. Roehrs TA, Samson HH, (1981). Ethanol reinforced behavior assessed with a concurrent schedule. Pharmacol Biochem Behav 15: 539-544. (Pubitemid 11015551)
207. Roehrs TA, Samson HH, (1982). Relative responding on concurrent schedules: indexing ethanol's reinforcing efficacy. Pharmacol Biochem Behav 16: 393-396. (Pubitemid 12147007)
208. Samson HH, (1986). Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10: 436-442. (Pubitemid 16034366)
209. Samson HH, Files FJ, Denning C, Marvin S, (1998). Comparison of alcohol-preferring and nonpreferring selectively bred rat lines. I. Ethanol initiation and limited access operant self-administration. Alcohol Clin Exp Res 22: 2133-2146. (Pubitemid 29031036)
210. Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, et al,. (2006). Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J Neurosci 26: 1231-1238. (Pubitemid 43239573)
211. Schmidt LG, Samochowiec J, Finckh U, Fiszer-Piosik E, Horodnicki J, Wendel B, et al,. (2002). Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Drug Alcohol Depend 65: 221-224. (Pubitemid 34159069)
212. Schroeder JP, Overstreet DH, Hodge CW, (2005). The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) 179: 262-270. (Pubitemid 40576714)
213. Schroeder JP, Cooper DA, Schank JR, Lyle MA, Gaval-Cruz M, Ogbonmwan YE, et al,. (2010). Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine beta-hydroxylase. Neuropsychopharmacology 35: 2440-2449.
214. Schuckit MA, (1984). Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41: 879-884. (Pubitemid 14026548)
215. Schuckit MA, (1994). Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151: 184-189. (Pubitemid 24053096)
216. Schulteis G, Markou A, Cole M, Koob GF, (1995). Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci U S A 92: 5880-5884.
217. Schwarz N, (2007). Retrospective and concurrent self-reports: the rationale for real-time data capture. In:, Stone A, Shiffman SS, Atienza A, Nebeling L, (eds). The Science of Real-Time Data Capture: Self Reports in Health Research. Oxford University Press: New York, pp. 11-26.
218. Sellers EM, Toneatto T, Romach MK, Somer GR, Sobell LC, Sobell MB, (1994). Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exp Res 18: 879-885. (Pubitemid 24264108)
219. Serra S, Carai MA, Brunetti G, Gomez R, Melis S, Vacca G, et al,. (2001). The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats. Eur J Pharmacol 430: 369-371. (Pubitemid 33050063)
220. Serra S, Brunetti G, Pani M, Vacca G, Carai MA, Gessa GL, et al,. (2002). Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats. Eur J Pharmacol 443: 95-97. (Pubitemid 34603602)
221. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J, (2003). The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) 168: 3-20. (Pubitemid 36851158)
222. Sharpe AL, Samson HH, (2001). Effect of naloxone on appetitive and consummatory phases of ethanol self-administration. Alcohol Clin Exp Res 25: 1006-1011. (Pubitemid 32656116)
223. Sinclair JD, (2001). Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol Alcohol 36: 2-10. (Pubitemid 32099659)
224. Skinner MD, Aubin HJ, (2010). Craving's place in addiction theory: contributions of the major models. Neurosci Biobehav Rev 34: 606-623.
225. Soini SL, Honkanen A, Hyytia P, Korpi ER, (1999). [3H] ethylketocyclazocine binding to brain opioid receptor subtypes in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol 18: 27-34. (Pubitemid 29269896)
226. Solomon RL, Corbit JD, (1974). An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol Rev 81: 119-145.
227. Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, et al,. (2008). Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry 63: 139-145. (Pubitemid 350299311)
228. de Sousa A, (2005). An open randomized study comparing disulfiram and acamprosate in the treatment of alcohol dependence. Alcohol Alcohol 40: 545-548. (Pubitemid 41600008)
229. Soyka M, Koller G, Schmidt P, Lesch OM, Leweke M, Fehr C, et al,. (2008). Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial. J Clin Psychopharmacol 28: 317-324.
230. Spanagel R, Holter SM, (2000). Pharmacological validation of a new animal model of alcoholism. J Neural Transm 107: 669-680. (Pubitemid 30364707)
231. Spanagel R, Kiefer F, (2008). Drugs for relapse prevention of alcoholism: ten years of progress. Trends Pharmacol Sci 29: 109-115.
232. Spanagel R, Zieglgansberger W, (1997). Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18: 54-59. (Pubitemid 27115855)
233. Spanagel R, Herz A, Shippenberg TS, (1992). Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci U S A 89: 2046-2050.
234. Spanagel R, Holter SM, Allingham K, Landgraf R, Zieglgansberger W, (1996a). Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305: 39-44. (Pubitemid 26195983)
235. Spanagel R, Putzke J, Stefferl A, Schobitz B, Zieglgansberger W, (1996b). Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat. Eur J Pharmacol 305: 45-50. (Pubitemid 26195984)
236. Sperling RE, Gomes SM, Sypek EI, Carey AN, McLaughlin JP, (2010). Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration. Psychopharmacology (Berl) 210: 199-209.
237. Staiger PK, White JM, (1991). Cue reactivity in alcohol abusers: stimulus specificity and extinction of the responses. Addict Behav 16: 211-221.
238. Stephens DN, Duka T, (2008). Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex. Philos Trans R Soc Lond B Biol Sci 363: 3169-3179.
239. Stephens DN, Brown G, Duka T, Ripley TL, (2001). Impaired fear conditioning but enhanced seizure sensitivity in rats given repeated experience of withdrawal from alcohol. Eur J Neurosci 14: 2023-2031. (Pubitemid 35463689)
240. Stephens DN, Pistovcakova J, Worthing L, Atack JR, Dawson GR, (2005). Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist. Eur J Pharmacol 526: 240-250. (Pubitemid 41744121)
241. Stephens DN, Duka T, Crombag HS, Cunningham CL, Heilig M, Crabbe JC, (2010). Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes. Addict Biol 15: 145-168.
242. Stewart J, de Wit H, Eikelboom R, (1984a). Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91: 251-268.
243. Stewart J, de Wit H, Eikelboom R, (1984b). Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91: 251-268.
244. Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O'Brien CP, (1998a). A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol 15: 281-289. (Pubitemid 28205097)
245. Stromberg MF, Volpicelli JR, O'Brien CP, (1998b). Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat. Alcohol Clin Exp Res 22: 2186-2191. (Pubitemid 29031041)
246. Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP, (2001). Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 23: 109-116. (Pubitemid 32377750)
247. Stromberg MF, Rukstalis MR, Mackler SA, Volpicelli JR, O'Brien CP, (2002). A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats. Pharmacol Biochem Behav 72: 483-490. (Pubitemid 34251362)
248. Svensson L, Fahlke C, Hard E, Engel JA, (1993). Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10: 219-224. (Pubitemid 23145458)
249. Swift RM, Whelihan W, Kuznetsov O, Buongiorno G, Hsuing H, (1994). Naltrexone-induced alterations in human ethanol intoxication. Am J Psychiatry 151: 1463-1467. (Pubitemid 24301690)
250. Tabakoff B, Hoffman PL, (2000). Animal models in alcohol research. Alcohol Res Health 24: 77-84.
251. Thanos PK, Dimitrakakis ES, Rice O, Gifford A, Volkow ND, (2005). Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors. Behav Brain Res 164: 206-213. (Pubitemid 41337875)
252. Tiffany ST, (1990). A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97: 147-168.
253. Tolliver GA, Sadeghi KG, Samson HH, (1988). Ethanol preference following the sucrose-fading initiation procedure. Alcohol 5: 9-13.
254. Tomie A, Aguado AS, Pohorecky LA, Benjamin D, (1998). Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping. Psychopharmacology (Berl) 139: 376-382. (Pubitemid 28435034)
255. Tzschentke TM, (1998). Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56: 613-672. (Pubitemid 29012461)
256. Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, et al,. (2002). Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res 26: 1494-1501. (Pubitemid 35192310)
257. Viken RJ, Rose RJ, Morzorati SL, Christian JC, Li TK, (2003). Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcohol Clin Exp Res 27: 795-803. (Pubitemid 36583362)
258. Vinod KY, Yalamanchili R, Thanos PK, Vadasz C, Cooper TB, Volkow ND, et al,. (2008). Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice. Synapse 62: 574-581. (Pubitemid 351951295)
259. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Gifford A, et al,. (1999). Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 156: 1440-1443. (Pubitemid 29416545)
260. Volkow ND, Fowler JS, Wang GJ, (2003). The addicted human brain: insights from imaging studies. J Clin Invest 111: 1444-1451. (Pubitemid 38063274)
261. Volpicelli JR, Watson NT, King AC, Sherman CE, O'Brien CP, (1995). Effect of naltrexone on alcohol 'high' in alcoholics. Am J Psychiatry 152: 613-615.
262. de Waele JP, Gianoulakis C, (1993). Effects of single and repeated exposures to ethanol on hypothalamic beta-endorphin and CRH release by the C57BL/6 and DBA/2 strains of mice. Neuroendocrinology 57: 700-709. (Pubitemid 23223637)
263. de Waele JP, Gianoulakis C, (1997). Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption. Alcohol Clin Exp Res 21: 754-762. (Pubitemid 27272809)
264. de Waele JP, Kiianmaa K, Gianoulakis C, (1995). Distribution of the mu and delta opioid binding sites in the brain of the alcohol-preferring AA and alcohol-avoiding ANA lines of rats. J Pharmacol Exp Ther 275: 518-527.
265. Wahlsten D, Bachmanov A, Finn DA, Crabbe JC, (2006). Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103: 16364-16369. (Pubitemid 44715202)
266. Walker BM, Koob GF, (2008). Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology 33: 643-652.
267. Wang L, Liu J, Harvey-White J, Zimmer A, Kunos G, (2003). Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Natl Acad Sci U S A 100: 1393-1398. (Pubitemid 36184012)
268. Weiss F, Mitchiner M, Bloom FE, Koob GF, (1990). Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology (Berl) 101: 178-186. (Pubitemid 20140215)
269. WHO (1973). The ICD-10 Classification of Mental and Behavioural Disorders. World Health Organization: Geneva.
270. Willner P, James D, Morgan M, (2005). Excessive alcohol consumption and dependence on amphetamine are associated with parallel increases in subjective ratings of both 'wanting' and 'liking'. Addiction 100: 1487-1495. (Pubitemid 41442318)
271. Wilson RI, Nicoll RA, (2002). Endocannabinoid signaling in the brain. Science 296: 678-682.
272. Woods JE, 2nd, McKay PF, Masters J, Seyoum R, Chen A, La Duff L, et al,. (2003). Differential responding for brain stimulation reward and sucrose in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcohol Clin Exp Res 27: 926-936. (Pubitemid 36759381)
273. Zeise ML, Kasparov S, Capogna M, Zieglgansberger W, (1993). Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231: 47-52. (Pubitemid 23039543)
274. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W, (2005). Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280: 32618-32624. (Pubitemid 41368304)
275. Zhao Y, Dayas CV, Aujla H, Baptista MA, Martin-Fardon R, Weiss F, (2006). Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala. J Neurosci 26: 9967-9974. (Pubitemid 44477158)
276. Zorrilla EP, Valdez GR, Weiss F, (2001). Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats. Psychopharmacology (Berl) 158: 374-381. (Pubitemid 33141313)