Role of GABAA α5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist

European Journal of Pharmacology

Volumn 526, Issue 1-3, 2005, Pages 240-250

  Stephens, David N ^a   Pistovcakova, Jana ^a,c   Worthing, Lynn ^a   Atack, John R ^b   Dawson, Gerard R ^b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Ethanol abuse; Inverse agonist; Knockout; Reward

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; ALPHA5IA II; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; LIGAND; RECEPTOR SUBUNIT; SUCROSE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ALPHA5IA-II; BENZODIAZEPINE DERIVATIVE; GABRA5 PROTEIN, MOUSE; PROTEIN SUBUNIT; PYRIDINE DERIVATIVE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ATAXIA; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; DRUG ACTIVITY; DRUG RECEPTOR BINDING; FEMALE; GENE DELETION; HYPOTHESIS; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; REWARD; SEDATION; WILD TYPE; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG SELF ADMINISTRATION; GENETICS; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; BENZODIAZEPINES; DRUG ANTAGONISM; ETHANOL; FEMALE; GABA ANTAGONISTS; GENE DELETION; MALE; MICE; MICE, KNOCKOUT; PROTEIN SUBUNITS; PYRIDINES; RECEPTORS, GABA-A; REWARD; SELF ADMINISTRATION;

EID: 28544439628     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.09.031     Document Type: Conference Paper

References (33)

1. K. Bao, L.D. Middaugh, H.C. Becker, and C.L. Shepherd Effects of Ro 15-4513 and ethanol on operant behavior of male and female C57BL/6 mice Alcohol 9 1992 193
2. J.A. Benson, K. Low, R. Keist, H. Mohler, and U. Rudolph Pharmacology of recombinant gamma-aminobutyric acid A receptors rendered diazepam-insensitive by point-mutated alpha-subunits FEBS Lett. 431 1998 400
3. S.L. Boehm II, I. Ponomarev, A.W. Jennings, P.J. Whiting, T.W. Rosahl, E.M. Garrett, Y.A. Blednov, and R.A. Harris gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions Biochem. Pharmacol. 68 2004 1581
4. E.P. Bonetti, W.P. Burkard, M. Gabl, W. Hunkeler, H.P. Lorez, J.R. Martin, H. Moehler, W. Osterrieder, L. Pieri, and P. Polc Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol Pharmacol. Biochem. Behav. 31 1988 733
5. A alpha5 receptors with cognition enhancing properties J. Med. Chem. 47 2004 5829
6. A receptor alpha 1 and alpha 5 subunits in the ventral tegmental area and hippocampus J. Neurochem. 68 1997 121
7. A receptor J. Neurosci. 22 2002 5572
8. M.S. Dar Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice Pharmacol. Biochem. Behav. 42 1992 473
9. L.L. Devaud, F.D. Smith, D.R. Grayson, and A.L. Morrow Chronic ethanol consumption differentially alters the expression of gamma-aminobutyric acid A receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis Mol. Pharmacol. 48 1995 861
10. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits J. Comp. Neurol. 359 1995 154
11. J.R. Glowa, J. Crawley, P.D. Suzdak, and S.M. Paul Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513 Pharmacol. Biochem. Behav. 31 1988 767
12. K.L. Hadingham, P. Wingrove, B. Le Bourdelles, K.J. Palmer, C.I. Ragan, and P.J. Whiting Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acid A receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acid A receptors Mol. Pharmacol. 43 1993 970
13. A receptors containing gamma 3 subunits Eur. J. Pharmacol. 291 1995 301
14. H.L. June, R.W. Hughes, H.L. Spurlock, and M.J. Lewis Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil) Psychopharmacology (Berl) 115 1994 332
15. H.L. June, S.C. Harvey, K.L. Foster, P.F. McKay, R. Cummings, M. Garcia, D. Mason, C. Grey, S. McCane, L.S. Williams, T.B. Johnson, X. He, S. Rock, and J.M. Cook GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry J. Neurosci. 21 2001 2166
16. M.D. Kelly, A. Smith, G. Banks, P. Wingrove, P.W. Whiting, J. Atack, G.R. Seabrook, and K.A. Maubach Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands Br. J. Pharmacol. 135 2002 248
17. A. Lingford-Hughes, S.P. Hume, A. Feeney, E. Hirani, S. Osman, V.J. Cunningham, V.W. Pike, D.J. Brooks, and D.J. Nutt Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography J. Cereb. Blood Flow Metab. 22 2002 878
18. R.G. Lister, and D.J. Nutt Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants Br. J. Pharmacol. 93 1988 210
19. A/benzodiazepine receptor subtype Med. Chem. Res. 5 1995 700
20. A receptors J. Med. Chem. 39 1996 1928
21. A-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats Psychopharmacology (Berl) 172 2004 455
22. S. Pirker, C. Schwarzer, A. Wieselthaler, W. Sieghart, and G. Sperk GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain Neuroscience 101 2000 815
23. A receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys J. Pharmacol. Exp. Ther. 313 1993 658
24. S. Rassnick, E. D'Amico, E. Riley, and G.F. Koob GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol Alcohol., Clin. Exp. Res. 17 1993 124
25. H.H. Samson, G.A. Tolliver, A.O. Pfeffer, K.G. Sadeghi, and F.G. Mills Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513 Pharmacol. Biochem. Behav. 27 1987 517
26. H.H. Samson, M. Haraguchi, G.A. Tolliver, and K.G. Sadeghi Antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonists Ro15-4513 and FG 7142: relation to sucrose reinforcement Pharmacol. Biochem. Behav. 33 1989 601
27. A.J. Smith, L. Alder, J. Silk, C. Adkins, A.E. Fletcher, T. Scales, J. Kerby, G. Marshall, K.A. Wafford, R.M. McKernan, and J.R. Atack Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux Mol. Pharmacol. 59 2001 1108
28. L.J. Street, F. Sternfeld, R.A. Jelley, A.J. Reeve, R.W. Carling, K.W. Moore, R.M. McKernan, B. Sohal, S. Cook, A. Pike, G.R. Dawson, F.A. Bromidge, K.A. Wafford, G.R. Seabrook, S.A. Thompson, G. Marshall, G.V. Pillai, J.L. Castro, J.R. Atack, and A.M. MacLeod Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phth alazines and analogues as subtype-selective inverse agonists for the GABA(A) alpha5 benzodiazepine binding site J. Med. Chem. 47 2004 3642
29. P.D. Suzdak, J.R. Glowa, J.N. Crawley, R.D. Schwartz, P. Skolnick, and S.M. Paul A selective imidazobenzodiazepine antagonist of ethanol in the rat Science 234 1986 1243
30. K.A. Wafford, C.J. Bain, P.J. Whiting, and J.A. Kemp Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acid A/benzodiazepine receptors Mol. Pharmacol. 44 1993 437
31. A receptor subunit mRNAs in the rat brain: I. Telencephalon, diencephalon, mesencephalon J. Neurosci. 12 1992 1040
32. A.L. Wood, P.A. Healey, J.A. Menendez, S.L. Verne, and D.M. Atrens The intrinsic and interactive effects of RO 15-4513 and ethanol on locomotor activity, body temperature, and blood glucose concentration Life Sci. 45 1989 1467
33. L. Xue, L. Lin, J. Hsieh, and A. Matuszewski Determination of a selective GABA-A a5 receptor inverse agonist in human plasma by high-performance liquid chromatography with tandem mass spectrographic detection J. Liq. Chromatogr. Relat. Technol. 27 2004 689