Acamprosate: Recent findings and future research directions

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 7, 2008, Pages 1105-1110

  Mann, Karl ^a   Kiefer, Falk ^a   Spanagel, Rainer ^a   Littleton, John ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acamprosate; Alcoholism; Craving; Ethanol; Glutamate; Meta analysis; Pharmacodynamics

Indexed keywords

4 AMINOBUTYRIC ACID; ACAMPROSATE; GLUTAMIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NALTREXONE; PLACEBO; DRUG DERIVATIVE; DRUGS USED IN THE TREATMENT OF ADDICTION; GLUTAMIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT; TAURINE;

ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL BEHAVIOR; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CLINICAL TRIAL; DRUG EFFICACY; DRUG MECHANISM; ELECTROPHYSIOLOGY; HUMAN; MEDICAL RESEARCH; MUTANT; NEUROPHYSIOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PSYCHOMETRY; RECURRENT DISEASE; WILD TYPE; WITHDRAWAL SYNDROME; ANIMAL; DRINKING BEHAVIOR; METABOLISM; PATIENT SELECTION; REVIEW;

MUS; RATTUS;

ALCOHOL DETERRENTS; ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATES; HUMANS; NEUROPROTECTIVE AGENTS; PATIENT SELECTION; RECURRENCE; TAURINE;

EID: 54749111088     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00690.x     Document Type: Article

References (53)

1. Al Qatari M, Bouchenafa O, Littleton J (1998) Mechanism of action of acam-prosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 22:810-814.
2. Al Qatari M, Khan S, Harris B, Littleton J (2001) Acamprosate is neuropro-tective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res 25:1276-1283.
3. Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 295:2003-2017.
4. Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R (2005) The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology 30:1104-1110.
5. Cano-Cebrián MJ, Zornoza-Sabina T, Guerri C, Polache A, Granero L (2003) Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study. Naunyn Schmiedebergs Arch Pharmacol 367:119-125.
6. Cowen MS, Adams C, Kraehenbuehl T, Vengeliene V, Lawrence AJ (2005) The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system. Addict Biol 10:233-242.
7. Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF. (2006) Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol 11:195-269.
8. Dahchour A, De Witte P (1999) Effect of repeated ethanol withdrawal on glu-tamate microdialysate in the hippocampus. Alcohol Clin Exp Res 23:1698-1703.
9. Dahchour A, De Witte P (2003) Effects of acamprosate on excitatory amino acidsd uring multiple ethanol withdrawal periods. Alcohol Clin Exp Res 27:465-470.
10. Dahchour A, De Witte P, Bolo N, Nedelec JF, Muzet M, Durbin P, Macher JP (1998) Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res 82:107-114.
11. Dahchour A, Lallemand F, Ward RJ, De Witte P (2005) Production of reactive oxygen species following acute ethanol or acetaldehyde and its reduction by acamprosate in chronically alcoholized rats. Eur J Pharmacol 520:51-58.
12. De Witte P, Littleton J, Parot P, Koob G (2005) Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanisms of action. CNS Drugs 19:517-537.
13. Feeney GF, Connor JP, Young RM, Tucker J, McPherson A (2006) Combined acamprosate and naltrexone, with cognitive behavioral therapy is superior to either medication alone for alcohol abstinence: a single centres' experience with pharmacotherapy. Alcohol Alcohol 41:321-327.
14. Gallinat J, Kunz D, Lang UE, Neu P, Kassim N, Kienast T, Seifert F, Schubert F, Bajbouj M (2007) Association between cerebral glutamate and human behavior: the sensation seeking personality trait. Neuroimage 34:671-678.
15. Harris BR, Gibson DA, Prendergast MA, Blanchard JA, Holley RC, Hart SR, Scotland RL, Foster TC, Pedigo NW, Littleton JM (2003) The neurotoxicity induced by ethanol withdrawal in mature oranotypic hippo-campal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-d-aspartate receptors. Alcohol Clin Exp Res 27:1724-1735.
16. Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, Fu MC, Hart SR, Pedigo NW, Littleton JM (2002) Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcohol Clin Exp Res 26:1779-1793.
17. Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC (2007) Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 64:193-200.
18. Kauer JA, Malenka RC (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8:844-858.
19. Kiefer F, Jahn H, Otte C, Demiralay C, Wolf K, Wiedemann K (2005) Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism. J Psychiatr Res 39:545-551.
20. Kiefer F, Jahn H, Otte C, Nakovics H, Wiedemann K (2006) Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference. Neurosci Lett 404:103-106.
21. Kiefer F, Jahn H, Tarnaske T, Helwig H, Briken P, Holzbach R, Kampf P, Stracke R, Baehr M, Naber D, Wiedemann K (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry 60:92-99.
22. Kiefer F, Mann K (2006): Pharmacotherapy and behavioral intervention for alcohol dependence? JAMA 296:1727-1728.
23. Kotlinska J, Bochenski M, Danysz W (2006) N-methyl-d-aspartate and group I metabotropic glutamate receptors are involved in the expression of etha-nol-induced sensitization in mice. Behav Pharmacol 17:1-8.
24. Lemberger T, Parlato R, Dassesse D, Westphal M, Casanova E, Turiault M, Tronche F, Schiffmann SN, Schütz G (2007) Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci 8:4.
25. Littleton J (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90:1179-1188.
26. Mann K, Ende G, Spanagel R (2007) Neurometabolic plasticity and treatment response in alcoholism: a translastional glutamate spectroscopy study, in Learning, Memory, and Brain Plasticity: Implications for Psychopathology (Flor H, ed.), pp. 685-714. Heidelberg University Press, Heidelberg, Germany.
27. Mann K, Lehert P, Morgan MY (2004) The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res 28:51-63.
28. Mann K, Loeber S, Croissant B, Kiefer F (2006) Qualified Alcohol Detoxification of Alcohol Dependent Patients - Psychotherapeutic and Pharmacological Strategies - A Manual. Deutscher Ärzteverlag, Cologne.
29. Mayer S, Harris B, Gibson DA, Blanchard J, Prendergast MA, Holley RC, Littleton J (2002a) Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat. Alcohol Clin Exp Res 26:655-662.
30. Mayer S, Harris BR, Gibson DA, Blanchard J, Prendergast MA, Holley RC, Littleton JM (2002b) Acamprosate, MK801, and ifenprodil inhibit neuro-toxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcohol Clin Exp Res 26:1468-1478.
31. Melendez RI, Hicks MP, Cagle SS, Kalivas PW (2005) Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res 29:326-333.
32. Naassila K, Hammoumi S, Legrand E, Durbin P, Daoust M (1998) Mechanism of action of acamprosate. Part I. Characterization of spermidine sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 22:802-809.
33. O'Brien CP (2005) Adolescent opioid abuse. Arch Gen Psychiatry 62:1165.
34. Ooteman W, Koeter MW, Verheul R, Schippers GM, van den Brink W (2007) The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholics. Eur Neuropsychopharmacol 17:558-566.
35. Parlato R, Rieker C, Turiault M, Tronche F, Schutz G (2006) Survival of DA neurons is independent of CREM upregulation in absence of CREB. Genesis 44:454-464.
36. Pierrefiche O, Daoust M, Naassila M (2004) Biphasic effect of acamprosate on NMDA but not on GABAA receptors in spontaneous rhythmic activity from the isolated neonatal rat respiratory network. Neuropharmacology 47:35-45.
37. Popp RL, Lovinger D (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur J Pharmacol 394:221-231.
38. Rammes G, Mahal B, Putzke J, Parsons CG, Spielmanns P, Pestel E, Spanagel R, Zieglgansberger W, Schadrack J (2001) The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40:749-760.
39. Reilly MT, Lobo IA, McCracken LM, Borghese CM, Gong D, Horishita T, Harris RA (2008) Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcohol Clin Exp Res 32:188-196.
40. Rossetti ZL, Carboni S (1995) Ethanol withdrawal is associated with increased extracellular glutamate in the rat stria tum. Eur J Pharmacol 283:177-183.
41. Sanchis-Segura C, Spanagel R (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11:2-38.
42. Schubert F, Gallinat J, Seifert F, Rinneberg H (2004) Glutamate concentrations in human brain using single voxel proton magnetic resonance spectros-copy at 3 Tesla. Neuroimage 21:1762-1771.
43. Schulz B, Fendt M, Gasparini F, Limgenhohl K, Kuhn R, Koch M (2001) The metabotropic glutamate receptor antagonist MPEP blocks fear conditioning in rats. Neuropharmacology 41:1-7.
44. Spanagel R, Kiefer F (2008) Drugs for relapse prevention of alcoholism -10 years of progress. Trends Pharmacol Sci 29:109-115.
45. Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U (2005) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11:35-42.
46. Spanagel R, Zieglgansberger W (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18:54-59.
47. Tzschentke TM (2007) Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict Biol 12:227-462.
48. Verheul R, van den Brink W, Geerlings P (1999) A three-pathway psychobio- logical model of craving for alcohol. Alcohol Alcohol 34:197-222.
49. Walker DL, Davis M (2002) The role of amygdala glutamate receptors in fear learning, fear potentiated startle and extinction. Pharmacol Biochem Behav 71:379-392.
50. Yucel M, Lubman DI, Harrison BJ, Fornito A, Allen NB, Wellard RM, Roffel K, Clarke K, Wood SJ, Forman SD, Pantelis C (2007) A combined spectroscopic and functional MRI investigation of the dorsal anterior cingu-late region in opiate addiction. Mol Psychiatry 12:611,691-702.
51. Zalewska-Kaszubska J, Cwiek W, Dyr W, Czarnecka E (2005) Changes in the beta-endorphin plasma level after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference. Neurosci Lett 388:45-48.
52. Zeise ML, Kasparov S, Capogna M, Ziegelgansberger W (1993) Acamprosate (calcium acetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: Possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231:47-52.
53. Zhu W, Bie B, Pan ZZ (2007) Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol- induced reward behavior. J Neurosci 27:289-298.