Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions

International Journal of Neuropsychopharmacology

Volumn 11, Issue 6, 2008, Pages 775-793

  Blednov, Yuri A ^a   Adron Harris, R ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Acamprosate; Ethanol; Intake; Knockout mice; mGluR5

Indexed keywords

ACAMPROSATE; ALCOHOL; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE DELETION; MALE; MOTOR ACTIVITY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; SEDATION; WITHDRAWAL SYNDROME;

ALCOHOL DETERRENTS; ALCOHOL DRINKING; ALCOHOLISM; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHOICE BEHAVIOR; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; REFLEX; SELF ADMINISTRATION; SEX FACTORS; TAURINE;

EID: 50849129629     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145708008584     Document Type: Article

References (51)

1. Alagarsamy S, Marino MJ, Rouse ST, Gereau IV, Heinemann SF, Conn PJ (1999). Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nature of Neuroscience 2, 234-240.
2. 3H]3-methoxy-5- (pyridin-2-ylethynyl)pyridine). European Journal of Pharmacology 473, 35-40.
3. Backstrom P, Bachteler D, Koch S, Hyytia P, Spanagel R (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29, 921-928.
4. Bäckström P, Hyytiä P (2006). Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31, 778-786.
5. Besheer J, Hodge CW (2005). Pharmacological and anatomical evidence for an interaction between mGluR5-and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol. Neuropsychopharmacology 30, 747-757.
6. Besheer J, Lepoutre V, Mole B, Hodge CW (2006a). GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon. Synapse 60, 411-419.
7. Besheer J, Stevenson RA, Hodge CW (2006b). mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats. European Journal of Pharmacology 551, 71-75.
8. Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005). Hybrid C57BL/6JxFVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29, 1949-1958.
9. Blednov YA, Stoffel M, Chang SR, Harris RA (2001). Potassium channels as targets for ethanol : studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. Journal of Pharmacology and Experimental Therapeutics 298, 521-530.
10. Blednov YA, Walker D, Osterndorf-Kahanek E, Harris RA (2004). Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanol. Alcohol 34, 251-259.
11. Brodkin J, Busse C, Sukoff SJ, Varney MA (2002). Anxiolytic-like activity of the mGluR5 antagonist MPEP a comparison with diazepam and buspirone. Pharmacology Biochemistry and Behavior 73, 359-366.
12. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S, Corsi M, Orzi F, Conquet F (2001). Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nature Neuroscience 4, 873-874.
13. Cohen C, Perrault G, Sanger DJ (1999). Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology 142, 102-110.
14. Cowen MS, Djouma E, Lawrence AJ (2005). The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. Journal of Pharmacology and Experimental Therapeutics 315, 590-600.
15. Crabbe JC, Keith LD, Kosobud A, Stack J (1983). Ethanol dependence and the pituitary-adrenal axis in mice. I. Genotypic differences in hormone levels. Life Sciences 33, 1877-1887.
16. Crabbe JC, Merrill C, Belknap JK (1991). Acute dependence on depressant drugs is determined by common genes in mice. Journal of Pharmacology and Experimental Therapeutics 257, 663-667.
17. Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF (2006). Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology 11, 195-269.
18. Daniell LC (1990). The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics. Pharmacology Biochemistry and Behavior 36, 111-115.
19. Dudek BC, Tritto T (1994). Biometrical genetic analysis of ethanol's psychomotor stimulant effect. Alcoholism : Clinical and Experimental Research 18, 956-963.
20. Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005). A procedure to produce high alcohol intake in mice. Psychopharmacology 178, 471-480.
21. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, et al. (1999). 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38, 1493-1503.
22. Goldstein DB, Kakihana R (1974). Alcohol withdrawal reactions and reserpine effects in inbred strains of mice. Life Sciences 15, 415-425.
23. Gustafsson L, Zhou Q, Nylander I (2007). Ethanol-induced effects on opioid peptides in adult male Wistar rats are dependent on early environmental factors. Neuroscience 146, 1137-1149.
24. Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, Fu MC, Hart SR, Pedigo NW, Littleton JM (2002). Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a site of action at metabotropic glutamate receptors. Alcohol Alcoholism: Clinical and Experimental Research 26, 1779-1793.
25. Heilig M, Egli M (2006). Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacology and Therapeutics 111, 855-876.
26. Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO (1999). Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. Nature Neuroscience 2, 997-1002.
27. Hodge CW, Miles MF, Sharko AC, Stevenson RA, Hillmann JR, Lepoutre V, Besheer J, Schroeder JP (2006). The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology 183, 429-438.
28. Jia Z, Lu Y, Henderson J, Taverna F, Romano C, Abramow-Newerly W, Wojtowicz JM, Roder J (1998). Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learning and Memory 5, 331-343.
29. Kachroo A, Orlando LR, Grandy DK, Chen JF, Young AB, Schwarzschild MA (2005). Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. Journal of Neuroscicnce 25, 10414-10419.
30. Lê AD, Tomkins D, Higgins G, Quan B, Sellers EM (1997). Effects of 5-HT3, D1 and D2 receptor antagonists on ethanol- and cocaine-induced locomotion. Pharmacology Biochemistry and Behavior 57, 325-332.
31. Lea 4th PM, Faden AI (2006). Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Reviews 12, 149-166.
32. O'Leary DM, Movsesyan V, Vicini S, Faden AI (2000). Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. British Journal of Pharmacology 131, 1429-1437.
33. Li X, Need AB, Baez M, Witkin JM (2006). Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice. Journal of Pharmacology and Experimental Therapeutics 319, 254-259.
34. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (2006). Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug and Alcohol Dependence 85, 142-156.
35. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC (1997). Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. Journal of Neuroscience 17, 5196-5205.
36. Lundquist F (1959). The determination of ethyl alcohol in blood and tissue. Methods of Biochemical Analysis 7, 217-251.
37. McMillen BA, Crawford MS, Kulers CM, Williams HL (2005). Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats. Alcohol and Alcoholism 40, 494-497.
38. Minami K, Gereau 4th RW, Minami M, Heinemann SF, Harris RA (1998). Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Molecular Pharmacology 53, 148-156.
39. Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PG, Knoblach SM, Faden AI (2001). mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. Journal of Pharmacology and Experimental Therapeutics 296, 41-47.
40. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO (2005). The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Molecular Pharmacology 67, 349-355.
41. Pastor R, Miquel M, Aragon CM (2005). Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice. Psychopharmacology 182, 436-446.
42. Paterson NE, Semenova S, Gasparini F, Markou A (2003). The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology 167, 257-264.
43. Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm 2nd SL, Homanics GE, Berman AE, et al. (2006). Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. Journal of Neuroscience 26, 5673-5683.
44. Popik P, Wrobel M (2002). Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 43, 1210-1217.
45. Reilly MT, Lobo IA, McCracken LM, Borghese CM, Gong D, Horishita T, Harris RA (2008). Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcoholism: Clinical and Experimental Research 32, 188-196.
46. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005). Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiology and Behavior 84, 53-63.
47. Schroeder JP, Overstreet DH, Hodge CW (2005). The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology 179, 262-270.
48. Sharko AC, Hodge CW (2007). Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice. Alcoholism : Clinical and Experimental Research 32, 67-76.
49. Spanagel R, Zieglgansberger W (1997). Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends in Pharmacological Sciences 18, 54-59.
50. Szumlinski KK, Lominac KD, Oleson EB, Walker JK, Mason A, Dehoff MH, Klugmann M, Cagle S, Welt K, During M, et al. (2005). Homer2 is necessary for EtOH-induced neuroplasticity. Journal of Neuroscience 25, 7054-7061.
51. Turyabahika-Thyen K, Wolffgramm J (2006). Loss of flexibility in alcohol-taking rats : promoting factors. European addiction Research 12, 210-221.