The role of topiramate and other anticonvulsants in the treatment of alcohol dependence: A clinical review

CNS and Neurological Disorders - Drug Targets

Volumn 9, Issue 1, 2010, Pages 45-49

  De Sousa, Avinash ^a  

^a Carmel ^*  (India)

Author keywords

Alcohol dependence; Anticonvulsants; Topiramate

Indexed keywords

ACAMPROSATE; ANTICONVULSIVE AGENT; BUSPIRONE; CARBAMAZEPINE; DISULFIRAM; ETIRACETAM; GABAPENTIN; LORAZEPAM; NALTREXONE; OXCARBAZEPINE; PLACEBO; TOPIRAMATE; VALPROIC ACID;

ALCOHOL ABSTINENCE; ALCOHOL WITHDRAWAL; ALCOHOLISM; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; COGNITIVE DEFECT; COGNITIVE THERAPY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; HUMAN; KIDNEY TUBULE ACIDOSIS; MYOPIA; NEPHROLITHIASIS; PARESTHESIA; PATIENT COMPLIANCE; PSYCHOSOCIAL CARE; QUALITY OF LIFE; REVIEW; TIME TO MAXIMUM PLASMA CONCENTRATION; TITRIMETRY; WITHDRAWAL SEIZURE;

EID: 77949895295     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152710790966696     Document Type: Review

References (71)

1. Miller, N.S.; Gold, M.S. Comorbid cigarette and alcohol addiction: epidemiology and treatment. J. Addict. Dis., 1998, 17, 55-66.
2. Kenna, J.A.; McGeary, J.E.; Swift, R.M. Pharmacotherapy, pharmacogenomics and the future of alcohol dependence treatment, part 1. Am. J. Health. Syst. Pharm., 2004, 61, 2272-2279.
3. Finney, J.W.; Hahn, A.C.; Moos, R.H. The effectiveness of inpatient and outpatient treatment for alcohol abuse: the need to focus on mediators and moderators of setting effects. Addiction, 1996, 91, 1773-1796.
4. Wilkins, J.N. Traditional pharmacotherapy of alcohol dependence. J. Clin. Psychiatry, 2006, 67(Suppl 14), S14-S22.
5. Weiss, R.D.; Kueppenbender, K.D. Combining psychosocial treatment with pharmacotherapy for alcohol dependence. J. Clin. Psychopharmacol., 2006, 26(Suppl 1), S37-S42.
6. Johnson, B.A.; Ait-Daoud, N. Neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Psychopharmacology (Berl), 2000, 149, 327-344.
7. Hyman, S.E.; Malenka, R.C. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat. Rev. Neurosci., 2001, 2, 695-703.
8. Koob, G.F. Alcoholism : allostasis and beyond. Alcohol. Clin. Exp. Res., 2003, 27, 232-243.
9. Johnson, B.A. Progress in the development of Topiramate for treating alcohol dependence : from a hypothesis to a proof of concept study. Alcohol. Clin. Exp. Res., 2004, 28, 1137-1144.
10. Johnson, B.A. Topiramate induced neuromodulation of corticomesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence. Addict. Behav., 2004, 29, 1465-1479.
11. Shank, R.P.; Gardocki, J.F.; Streeter, A.J.; Maryanoff, B.E. An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics and mechanism of action. Epilepsia, 2000, 41(Suppl 1), S3-S9.
12. Bialer, M.; Johannessen, S.I.; Kupferberg, H.J.; Levy, R.H.; Loiseau, P.; Perucca, E. Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV). Epilepsy Res., 1999, 34, 1-41.
13. White, H.S. Mechanism of action of newer anticonvulsants. J. Clin. Psychiatry, 2003, 64(Suppl 8), 5-8.
14. Zupanc, M.L. Infantile spasms. Exp. Opin. Pharmacother., 2003, 4, 2039-2048.
15. Khan, S.H.; Wright, S.L.; Banigesh, A.; Miyashita, H.; Todd, K.; Hemmings, S.J.; Wishart, T.; Shuaib, A. Antiischemic effects of topiramate in a transient global ischemia model: a neurochemical, histological and behavioral evaluation. Neurochem. Res., 2003, 28, 1235-1239.
16. Qian, J.; Noebels, J.L. Topiramate alters excitatory synaptic transmission in muse hippocampus. Epilepsy Res., 2003, 55, 225-233.
17. White, H.S.; Brown, S.D.; Woodhead, J.H.; Skeen, G.A.; Wolf, H.H. Topiramate enhances GABA mediated chloride flux and GABA evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res., 1997, 28, 167-179.
18. White, H.S.; Brown, S.D.; Woodhead, J.H.; Skeen, G.A.; Wolf, H.H. Topiramate modulates GABA evoked currents in murine cortical neurons by a non benzodiazepine mechanism. Epilepsia, 2000, 41(Suppl 1), S17-S20.
19. Skradski, S.; White, H.S. Topiramate blocks kainite evoked cobalt influx into cultured neurons. Epilepsia, 2000, 41(Suppl 1), S45-S47.
20. Gryder, D.S.; Rogawski, M.A. Selective antagonism of GluR5 kainate receptor mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J. Neurosci., 2003, 23, 7069-7074.
21. Zhang, X.; Velumian, A.A.; Jones, O.T.; Carlen, P.L. Modulation of high voltage activated calcium channels in dentate granule cells by topiramate. Epilepsia, 2000, 41(Suppl 1), S52-S60.
22. + current fractions by the new anticonvulsant topiramate. J. Pharmacol. Exp. Ther., 1999, 288, 960-968.
23. Dodgson, S.J.; Shank, R.P.; Maryanoff, B.E. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia, 2000, 41(Suppl 1), S35-S39.
24. Garnett, W.R. Clinical pharmacology of topiramate: a review. Epilepsia, 2000, 41(Suppl 1), S61-S65.
25. Perruca, E.; Bialer, M. The clinical pharmacokinetics of newer antiepileptic drugs: focus on topiramate, zonisamide and tiagabine. Clin. Pharmacokin., 1996, 31, 29-46.
26. Biton, V.; Edwards, K.R.; Montouris, G.D.; Sackellares, J.C.; Harden, C.L.; Kamin, M.; Topiramate TPS-TR Study Group. Topiramate titration and tolerability. Ann. Pharmacother., 2001, 35, 173-179.
27. th ed.; Raritan NJ : Ortho-McNeil Pharmaceutical, Inc., 2003.
28. Kuo, R.L.; Moran, M.E.; Kim, D.H.; Abraham, H.M.; White, M.D.; Lingeman, J.E. Topiramate induced nephrolithiasis. J. Endourol., 2002, 16, 229-231.
29. Dodson, W.E.; Kamin, M.; Kraut, L.; Olson, W.H.; Wu, S.C. Topiramate titration to response : analysis of individualized therapy study (TRAITS). Ann. Pharmacother., 2003, 37, 615-620.
30. Johnson, B.A.; Ait-Daoud, N.; Bowden, C.L.; DiClemente, C.C.; Roache, J.D.; Lawson, K.; Javors, M.A.; Ma, J.Z. Oral topiramate for treatment of alcohol dependence: a randomized controlled trial. Lancet, 2003, 361, 1677-1685.
31. Schiffer, W.K.; Gerasimov, M.R.; Martseller, D.A.; Geiger, J.; Barnett, C.; Alexoff, D.L.; Dewey, S.L. Topiramate selectively attenuates nicotine induced increases in monoamine release. Synapse, 2001, 42, 196-198.
32. Nguyen, S.A.; DeLeon, C.P.; Middaugh, L.D. Topiramate effects on ethanol consumption by C57BL/6 mice. Alcohol. Clin. Exp. Res., 2004, 28(Suppl 5), 16A.
33. Knapp, C.M.; Markley, T.L.; Ciraulo, D.A.; Kornetsky, C. Topiramate and zonisamide reduce consumption of an ethanol sucrose solution in the rat. Alcohol. Clin. Exp. Res., 2004, 28(Suppl 5), 16A.
34. Carlezon, W.A.; Jr.; Nestler, E.J. Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse ? Trends Neurosci., 2002, 25, 610-5.
35. Erhardt, S.; Hajos, M.; Lindberg, A.; Engberg, G. Nicotine induced excitation of the locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid. Synapse, 2000, 37, 104-108.
36. Kawahara, Y.; Kawahara, H.; Westerink, B.H. Tonic regulation of the activity of noradrenergic neurons in the locus coeruleus of the conscious rat studied by dual probe microdialysis. Brain Res., 1999, 823, 42-48.
37. Cagetti, E.; Baicy, K.J.; Olsen, R.W. Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. Neuroreport, 2004, 15, 207-210.
38. 14C] guanidinium ion flux through GluR6 ion channels in transfected BHK cells using cytostar T scintillating microplates. Epilepsia, 2000, 41(Suppl 1), S48-S51.
39. Rustembegovic, A.; Sofic, E.; Kroyer, G. A pilot study of topiramate in the treatment of tonic clonic seizures of alcohol withdrawal syndromes. Med. Arh., 2002, 56, 211-212.
40. Krupitsky, E.M.; Rudenko, A.; Zvartau, E.; Slavina, T.; Grinenko, A. The pilot study of topiramate for alcohol withdrawal syndrome. Alcohol Alcohol., 2003, 38, 508-509.
41. Rubio, G.; Ponce, G.; Jimenez-Arriero, M.A.; Palomo, T.; Manzanares, J.; Ferre, F. Effects of topiramate in the treatment of alcohol dependence. Pharmacopsychiatry, 2004, 37, 37-40.
42. Johnson, B.A.; Ait-Daoud, N.; Akhtar, F.Z.; Ma, J.Z. Oral topiramate reduces the consequences of drinking and improves the quality of life in alcohol dependent individuals : a randomized controlled trial. Arch. Gen. Psychiatry, 2004, 61, 905-912.
43. Johnson, B.A.; Rosenthal, N.; Capece, J.A., Weigland, F.; Mao, L.; Beyers, K.; McKay, A.; Ait-Daoud, N.; Addoloroto, G.; Anton, R.F.; Ciraulo, D.A.; Kranzler, H.R.; Mann, K.; O'Malley, S.S.; Swift, R.M.; Topiramate for Alcoholism Advisory Board; Topiramate for Alcoholism Study Group. Topiramate improves the physical health and quality of life in of alcohol dependent individuals : a US multi-site randomized controlled trial. Arch. Intern. Med., 2008, 168, 1188-1199.
44. De Sousa, A.A.; De Sousa, J.; Kapoor, H. An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence. J. Subst. Abuse Treat., 2008, 34, 460-463.
45. Florez, G.; Garcia-Portilla, P.; Alvarez, S.; Saiz, P.A.; Nogueiras, L.; Bobes, J. Using topiramate or naltrexone for the treatment of alcohol dependent patients. Alcohol. Clin. Exp. Res., 2008, 32(7), 1251-1259.
46. Baltieri, D.A.; Daro, F.R.; Ribero, P.L.; de Andrade, A.G. Comparing topiramate with naltrexone in the treatment of alcohol dependence. Addiction, 2008, 103, 2035-2044.
47. Miranda, F.J.J.; Gonzalez, M.P.A.; Perez, M.M.; Gonzalez, D.T.; Cienfuegos, G.E.; Diaz, A.M.G.; Garcia, B.J. Topiramate as an add on therapy in non-respondent alcohol dependent patients : a 12 month follow up study. Actas Esp. Psiquatr., 2007, 35, 235-242.
48. Baltieri, D.A.; Daro, F.R.; Ribero, P.L.; Andrade, A.G. Effects of topiramate or naltrexone on tobacco use among alcohol dependent outpatients. Drug Alcohol Depend., 2009, (in press).
49. Rubio, G.; Martinez-Graz, I.; Manzanares, J. Modulation of impuslity by topiramate: implications for the treatment of alcohol dependence. J. Clin. Psychopharmacol., 2009, 29, 584-589.
50. Ragsdale, D.S.; Avoli, M. Sodium channels as molecular targets for antiepileptic drugs. Brain Res. Rev., 1998, 26, 16-24.
51. Malcolm, R.; Myrick, H.; Brady, K.T.; Ballenger, J.C. Update on anticonvulsants for the treatment of alcohol withdrawal. Am. J. Addict., 2001, 10(Suppl 1), 16-23.
52. Malcolm, R.; Myrick, H.; Roberts, J.; Wang, W.; Anton, R.F.; Ballenger, J.C. The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial. J. Gen. Intern. Med., 2002, 17, 349-355.
53. Mueller, T.I.; Stout, R.L.; Rudden, S.; Brown, R.A.; Gordon, A.; Solomon, D.A.; Recupero, P.R. A double blind placebo controlled pilot study of carbamezapine for the management of alcohol dependence. Alcohol. Clin. Exp. Res., 1997, 21, 86-92.
54. de Oliviera, I.R.; da Rocha, F.P.; Perriera, E.L.; Miranda Ade, A.; Ribeiro, M.G.; Melo, A. Combined carbamazepine buspirone treatment for alcohol dependence. J. Clin. Psychiatry, 1993, 54, 488.
55. Martinotti, G.; Romanelli, R.; Di Nicola, M.; Reina, D.; Mazza, M.; Janiri, L. Oxcarbazepine at high dosages for the treatment of alcohol dependence. Am. J. Addict., 2007, 16, 247-248.
56. Loscher, W. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Prog. Neurobiol., 1999, 58, 31-59.
57. Johannessen, C.U. Mechanisms of action of valproate: a commentary. Neurochem. Int., 2000, 37, 103-110.
58. Longo, L.P.; Campbell, T.; Hutbatch, S. Divalproex sodium for alcohol withdrawal and relapse prevention. J. Addict. Dis., 2002, 21, 55-64.
59. Reoux, J.P., Saxon, A.J.; Malte, C.A.; Baer, J.S.; Sloan, K.L. Divalproex sodium in alcohol withdrawal: a randomized double blind placebo controlled clinical trial. Alcohol. Clin. Exp. Res., 2001, 25, 1324-1329.
60. Brady, K.T.; Myrick, H.; Henderson, S.; Coffey, S.F. The use of divalproex in alcohol relapse prevention: a pilot study. Drug Alcohol Depend., 2002, 67, 323-330.
61. Meldrum, B.S. Update on the mechanism of action of anti-epileptic drugs. Epilepsia, 1996, 37(Suppl 6), S4-S11.
62. Roberto, M.; Gilpin, M.W.; O'Dell, L.E.; Cruz, M.T.; Morse, A.C.; Siggins, G.R.; Koob, G.F. Cellular and behavioral interactions of gabapentin with alcohol dependence. J. Neurosci., 2008, 28, 5762-5771.
63. Bonnet, U.; Banger, M.; Leweke, F.M. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry, 1999, 32, 107-109.
64. Chatterjee, C.R.; Ringold, A.L. A case report of reduction in alcohol craving and protection against alcohol withdrawal by gabapentin. J. Clin. Psychiatry, 1999, 60, 617.
65. Anton, R.F.; Myrick, M.; Baros, A.M.; Latham, P.K.; Randall, P.K.; Wright, T.M.; Stewart, S.H.; Waid, R.; Malcolm, R. Effect of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relation to alcohol withdrawal symptoms. J. Clin. Psychopharmacol., 2009, 29, 334-342.
66. Brower, M.J.; Myrakim, H.; Strobbe, S.; Karam-Hage, M.A.; Cosens, F.; Zucker, R.A. A randomized double blind placebo controlled trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol. Clin. Exp. Res., 2008, 32, 1429-1438.
67. Farooq, M.U.; Bhatt, A.; Majid, A.; Gupta, R.; Khasnis, A.; Kassab, M.Y. Levetiracetam for managing neurologic and psychiatric disorders. Am. J. Health Syst. Pharm., 2009, 66, 541-561.
68. Mariani, J.J.; Levin, R.R. Levetiracetam for the treatment of co-occurring alcohol dependence and anxiety disorders : case series and review. Am. J. Drug Alcohol Abuse, 2008, 34, 683-691.
69. Krebs, M.; Leopold, K.; Richter, C.; Kienast, T.; Hinzpeter, A.; Heinz, A.; Schaefer, M. Levetiracetam for the treatment of alcohol withdrawal syndrome: an open label pilot trial. J. Clin. Psychopharmacol., 2006, 26, 347-349.
70. Olmsted, C.L.; Kockler, D.R. Topiramate for alcohol dependence. Ann. Pharmacother., 2008, 42, 1475-1480.
71. Kenna, G.A.; Lomastro, T.L.; Schiesl, A.; Leggio, L.; Swift, R.M. Review of topiramate: an antiepileptic for the treatment of alcohol dependence. Curr. Drug Abuse Rev., 2009, 2, 135-142.