-
1
-
-
77956176101
-
Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program
-
Aeby, P., Ashikaga, T., Bessou-Touya, S. et al. (2010). Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol. In Vitro 24, 1465-1473.
-
(2010)
Toxicol. In Vitro
, vol.24
, pp. 1465-1473
-
-
Aeby, P.1
Ashikaga, T.2
Bessou-Touya, S.3
-
2
-
-
0037265581
-
Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterization of formed peptide-hapten adducts
-
DOI 10.1159/000068288
-
Ahlfors, S. R., Sterner, O. and Hansson, C. (2003). Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterization of formed peptide-hapten adducts. Skin Pharmacol. Appl. Skin Physiol. 16, 59-68. (Pubitemid 36173471)
-
(2003)
Skin Pharmacology and Applied Skin Physiology
, vol.16
, Issue.1
, pp. 59-68
-
-
Ahlfors, S.R.1
Sterner, O.2
Hansson, C.3
-
3
-
-
0037452436
-
Toxicokinetic modeling and its applications in chemical risk assessment
-
Andersen, M. E. (2003). Toxicokinetic modeling and its applications in chemical risk assessment. Toxicol. Lett. 138, 9-27.
-
(2003)
Toxicol. Lett.
, vol.138
, pp. 9-27
-
-
Andersen, M.E.1
-
6
-
-
33748640373
-
Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: General principles and application to reactive toxicity
-
DOI 10.1021/tx0601004
-
Aptula, A. O. and Roberts, D. W. (2006). Mechanistic applicability domains for non animal-based prediction of toxicological end points: general principles and application to reactive toxicity. Chem. Res. Toxicol. 19, 1097-1105. (Pubitemid 44384841)
-
(2006)
Chemical Research in Toxicology
, vol.19
, Issue.8
, pp. 1097-1105
-
-
Aptula, A.O.1
Roberts, D.W.2
-
7
-
-
78349276123
-
A comparative evaluation of in vitro skin sensitisation tests: The human Cell-line Activation Test (h-CLAT) versus the Local Lymph Node Assay (LLNA)
-
Ashikaga, T., Sakaguchi, H., Sono, S. et al. (2010). A comparative evaluation of in vitro skin sensitisation tests: The human Cell-line Activation Test (h-CLAT) versus the Local Lymph Node Assay (LLNA). ATLA 38, 275-284.
-
(2010)
ATLA
, vol.38
, pp. 275-284
-
-
Ashikaga, T.1
Sakaguchi, H.2
Sono, S.3
-
8
-
-
80053501215
-
Alternative Testing Strategies Progress Report 2010
-
AXLR8 (2010). Alternative Testing Strategies Progress Report 2010. AXLR8 Consortium Report, http://www.AXLR8.eu
-
(2010)
AXLR8 Consortium Report
-
-
-
9
-
-
21344468371
-
The future of teratology research is in vitro
-
DOI 10.1163/1569391053722755
-
Bailey, J., Knight, A. and Balcombe, J. (2005). The future of teratology research is in vitro. Biogenic Amines 19, 97-145. (Pubitemid 40903996)
-
(2005)
Biogenic Amines
, vol.19
, Issue.2
, pp. 97-145
-
-
Bailey, J.1
Knight, A.2
Balcombe, J.3
-
10
-
-
70449565642
-
Comment: The SCHER report on non-human primate research - Biased and deeply flawed
-
Bailey, J. and Taylor, K. (2009). Comment: The SCHER report on non-human primate research - biased and deeply flawed. ATLA 37, 427-435.
-
(2009)
ATLA
, vol.37
, pp. 427-435
-
-
Bailey, J.1
Taylor, K.2
-
11
-
-
79251473744
-
A FRAME response to the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects-2010
-
Balls, M. and Clothier, R. (2010). A FRAME response to the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects-2010. ATLA 38, 345-353.
-
(2010)
ATLA
, vol.38
, pp. 345-353
-
-
Balls, M.1
Clothier, R.2
-
12
-
-
77953479723
-
In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances
-
Bercu, J. P., Morton, S. M., Deahl, J. T. et al. (2010). In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances. Regul. Toxicol. Pharmacol. 57, 300-306.
-
(2010)
Regul. Toxicol. Pharmacol.
, vol.57
, pp. 300-306
-
-
Bercu, J.P.1
Morton, S.M.2
Deahl, J.T.3
-
13
-
-
37049008719
-
Exposure-triggered reproductive toxicity testing under the REACH legislation: A proposal to define significant/relevant exposure
-
DOI 10.1016/j.toxlet.2007.10.008, PII S0378427407009940
-
Bernauer, U., Heinemeyer, G., Heinrich-Hirsch, B. et al. (2008). Exposure-triggered reproductive toxicity testing under the REACH legislation: A proposal to define significant/relevant exposure. Toxicol. Lett. 176, 68-76. (Pubitemid 50009765)
-
(2008)
Toxicology Letters
, vol.176
, Issue.1
, pp. 68-76
-
-
Bernauer, U.1
Heinemeyer, G.2
Heinrich-Hirsch, B.3
Ulbrich, B.4
Gundert-Remy, U.5
-
14
-
-
34247850820
-
The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative [2]
-
DOI 10.1007/s00204-006-0175-0
-
Blaauboer, B. J. and Andersen, M. E. (2007). The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative. Arch. Toxicol. 81, 385-387. (Pubitemid 46701597)
-
(2007)
Archives of Toxicology
, vol.81
, Issue.5
, pp. 385-387
-
-
Blaauboer, B.J.1
Andersen, M.E.2
-
15
-
-
77951605817
-
Toxicity testing in the 21st century: Using the new toxicity testing paradigm to create a taxonomy of adverse effects
-
Boekelheide, K. and Campion, S. N. (2010). Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol. Sci. 114, 20-24.
-
(2010)
Toxicol. Sci.
, vol.114
, pp. 20-24
-
-
Boekelheide, K.1
Campion, S.N.2
-
16
-
-
70649088692
-
A data-based assessment of alternative strategies for identification of potential human cancer hazards
-
Boobis, A. R., Cohen, S. M., Doerrer, N. G. et al. (2009). A data-based assessment of alternative strategies for identification of potential human cancer hazards. Toxicol. Pathol. 37, 714.
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 714
-
-
Boobis, A.R.1
Cohen, S.M.2
Doerrer, N.G.3
-
17
-
-
38649110420
-
Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63
-
Bouvier d'Yvoire, M., Prieto, P., Blaauboer, B. J, et al. (2007). Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63. ATLA 35, 661-671.
-
(2007)
ATLA
, vol.35
, pp. 661-671
-
-
Bouvier D'Yvoire, M.1
Prieto, P.2
Blaauboer, B.J.3
-
18
-
-
59849089046
-
The need for realism in reproductive toxicity testing
-
Bremer, S. (2008). The need for realism in reproductive toxicity testing. ATLA 36, 717.
-
(2008)
ATLA
, vol.36
, pp. 717
-
-
Bremer, S.1
-
19
-
-
0020031720
-
Methods for in vitro percutaneous absorption studies. I. Comparison with in vivo results
-
DOI 10.1016/0041-008X(82)90148-X
-
Bronaugh, R. L., Stewart, R. F., Congdon, E. R. et al. (1982). Methods for in vitro percutaneous absorption studies. I. Comparison with in vivo results. Toxicol. Appl. Pharmacol. 62, 474-80. (Pubitemid 12136694)
-
(1982)
Toxicology and Applied Pharmacology
, vol.62
, Issue.3
, pp. 474-480
-
-
Bronaugh, R.L.1
Stewart, R.F.2
Congdon, E.R.3
Giles Jr., A.L.4
-
20
-
-
33845347862
-
In vitro tests to evaluate immunotoxicity: A preliminary study
-
DOI 10.1016/j.tox.2006.09.003, PII S0300483X06005543
-
Carfi, M. A., Gennari, A., Malerba, I. et al. (2007). In vitro tests to evaluate immunotoxicity: A preliminary study. Toxicol. 229, 11-22. (Pubitemid 44881160)
-
(2007)
Toxicology
, vol.229
, Issue.1-2
, pp. 11-22
-
-
Carfi, M.1
Gennari, A.2
Malerba, I.3
Corsini, E.4
Pallardy, M.5
Pieters, R.6
Van Loveren, H.7
Vohr, H.W.8
Hartung, T.9
Gribaldo, L.10
-
22
-
-
77955342898
-
Global QSAR models of skin sensitisers for regulatory purposes
-
Chaundry, Q., Piclin, N., Cotterill, J. et al. (2010). Global QSAR models of skin sensitisers for regulatory purposes. Chem. Central J. 4, S5.
-
(2010)
Chem. Central J.
, vol.4
-
-
Chaundry, Q.1
Piclin, N.2
Cotterill, J.3
-
23
-
-
68249152290
-
Prediction of hepatic clearance in human from in vitro data for successful drug development
-
Chiba, M., Ishi, Y. and Sugiyama, Y. (2009). Prediction of hepatic clearance in human from in vitro data for successful drug development. AAPS J. 11, 262-276.
-
(2009)
AAPS J.
, vol.11
, pp. 262-276
-
-
Chiba, M.1
Ishi, Y.2
Sugiyama, Y.3
-
24
-
-
0032716592
-
Cell transformation assays as predictors of human carcinogenicity: The report and recommendations of ECVAM Workshop 39
-
Combes, R., Balls, M., Curren, R. et al. (1999). Cell transformation assays as predictors of human carcinogenicity. The report and recommendations of ECVAM Workshop 39. ATLA 27, 745-767. (Pubitemid 29503028)
-
(1999)
ATLA Alternatives to Laboratory Animals
, vol.27
, Issue.5
, pp. 745-767
-
-
Combes, R.1
Balls, M.2
Curren, R.3
Fischbach, M.4
Fusenig, N.5
Kirkland, D.6
Lasne, C.7
Landolph, J.8
LeBoeuf, R.9
Marquardt, H.10
McCormick, J.11
Muller, L.12
Rivedal, E.13
Sabbioni, E.14
Tanaka, N.15
Vasseur, P.16
Yamasaki, H.17
-
25
-
-
33846928060
-
Possibilities for a new approach to chemicals risk assessment - The report of a FRAME workshop
-
Combes, R., Balls, M., Illing, P. et al. (2006). Possibilities for a new approach to chemicals risk assessment. The report of a FRAME Workshop. ATLA 34, 621-649. (Pubitemid 46238601)
-
(2006)
ATLA Alternatives to Laboratory Animals
, vol.34
, Issue.6
, pp. 621-649
-
-
Combes, R.D.1
Balls, M.2
Illing, P.3
Bhogal, N.4
Dale, J.5
Duve, G.6
Feron, V.7
Grindon, C.8
Gulden, M.9
Loizou, G.10
Priston, R.11
Westmoreland, C.12
-
26
-
-
59449086706
-
The "uEST" in vitro test for embryotoxicity - Validated and endorsed or not?
-
Combes, R. (2009). The "uEST" in vitro test for embryotoxicity - Validated and endorsed or not? Toxicol. In Vitro 23, 360-336.
-
(2009)
Toxicol. In Vitro
, vol.23
, pp. 360-1336
-
-
Combes, R.1
-
27
-
-
36148935631
-
Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models
-
DOI 10.1016/j.yrtph.2007.07.001, PII S0273230007000864
-
Contrera, J. F., Kruhlak, N. L., Matthews, E. J. et al. (2007). Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models. Regul. Toxicol. Pharmacol. 49, 172-182. (Pubitemid 350103627)
-
(2007)
Regulatory Toxicology and Pharmacology
, vol.49
, Issue.3
, pp. 172-182
-
-
Contrera, J.F.1
Kruhlak, N.L.2
Matthews, E.J.3
Benz, R.D.4
-
28
-
-
46349085573
-
ECVAM retrospective validation of in vitro micronucleus test (MNT)
-
DOI 10.1093/mutage/gen010
-
Corvi, R., Albertini, S., Hartung, T. et al. (2008). ECVAM retrospective validation of in vitro micronucleus test (MNT). Mutagenesis 23, 271-283. (Pubitemid 351918959)
-
(2008)
Mutagenesis
, vol.23
, Issue.4
, pp. 271-283
-
-
Corvi, R.1
Albertini, S.2
Hartung, T.3
Hoffmann, S.4
Maurici, D.5
Pfuhler, S.6
Van Benthem, J.7
Vanparys, P.8
-
29
-
-
77954364273
-
Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes
-
Dartel, D. A. M., Pennings, J. L., De la Fonteyne, L. J. et al. (2010). Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes. Toxicol. Sci. 116, 130-139.
-
(2010)
Toxicol. Sci.
, vol.116
, pp. 130-139
-
-
Dartel, D.A.M.1
Pennings, J.L.2
De La Fonteyne, L.J.3
-
30
-
-
1542314570
-
Transepithelial resistance and inulin permeability as endpoints in in vitro nephrotoxicity testing
-
Duff, T., Carter, S., Feldman, G. et al. (2002). Transepithelial resistance and inulin permeability as endpoints in in vitro nephrotoxicity testing. ATLA 30, 53-59. (Pubitemid 36168713)
-
(2002)
ATLA Alternatives to Laboratory Animals
, vol.30
, Issue.SUPPL. 2
, pp. 53-59
-
-
Duff, T.1
Carter, S.2
Feldman, G.3
McEwan, G.4
Pfaller, W.5
Rhodes, P.6
Ryan, M.7
Hawksworth, G.8
-
33
-
-
0023144955
-
The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans
-
Ennever, F. K., Noonan, T. J. and Rosenkranz, H. S. (1987). The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans. Mutagenesis. 2, 73-78. (Pubitemid 17045278)
-
(1987)
Mutagenesis
, vol.2
, Issue.2
, pp. 73-78
-
-
Ennever, F.K.1
Noonan, T.J.2
Rosenkranz, H.S.3
-
34
-
-
0038159914
-
Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity
-
DOI 10.1016/S0273-2300(03)00068-0
-
Ennever, F. K. and Lave, L. B. (2003). Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity. Regul. Toxicol Pharmacol. 38, 52-57. (Pubitemid 36870870)
-
(2003)
Regulatory Toxicology and Pharmacology
, vol.38
, Issue.1
, pp. 52-57
-
-
Ennever, F.K.1
Lave, L.B.2
-
35
-
-
41649114183
-
Quantitative and mechanistic read across for predicting skin sensitisation potential of alkenes acting via Michael addition
-
Enoch, S. J., Cronin, M. T., Schultz, T. W. et al. (2008a). Quantitative and mechanistic read across for predicting skin sensitisation potential of alkenes acting via Michael addition. Chem. Res. Toxicol. 21, 513-520.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 513-520
-
-
Enoch, S.J.1
Cronin, M.T.2
Schultz, T.W.3
-
36
-
-
53849113018
-
Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach
-
Enoch, S. J., Madden, J. C. and Cronin, M. T. (2008b). Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach. SAR QSAR Environ. Res. 19, 555-578.
-
(2008)
SAR QSAR Environ. Res.
, vol.19
, pp. 555-578
-
-
Enoch, S.J.1
Madden, J.C.2
Cronin, M.T.3
-
37
-
-
77958099452
-
Mechanistic category formation for the prediction of respiratory sensitisation
-
Enoch, S. J., Roberts, D. W. and Cronin, M. T. (2010). Mechanistic category formation for the prediction of respiratory sensitisation. Chem. Res. Toxicol. 23, 1547-1555.
-
(2010)
Chem. Res. Toxicol.
, vol.23
, pp. 1547-1555
-
-
Enoch, S.J.1
Roberts, D.W.2
Cronin, M.T.3
-
40
-
-
2942512914
-
QSAR study of skin sensitization using local lymph node assay data
-
Fedorowicz, A., Lingyi, Z., Harshinder, S. et al. (2008). QSAR study of skin sensitisation using local lymph node assay data. Int. J. Mol. Sci. 5, 56-66. (Pubitemid 38760916)
-
(2004)
International Journal of Molecular Sciences
, vol.5
, Issue.2
, pp. 56-66
-
-
Fedorowicz, A.1
Zheng, L.2
Singh, H.3
Demchuk, E.4
-
41
-
-
77955393756
-
New public QSAR model for carcinogenicity
-
Fjodorova, N., Vračko, M., Novič, M. et al. (2010). New public QSAR model for carcinogenicity. Chemistry Central J. 4, S3.
-
(2010)
Chemistry Central J.
, vol.4
-
-
Fjodorova, N.1
Vračko, M.2
Novič, M.3
-
42
-
-
80053540931
-
Reduction of misleading (false) positive results in mammalian genotoxicity assays. I. Choice of cell type
-
in press.
-
Fowler, P., Smith, K., Jong, J. et al. (in press). Reduction of misleading (false) positive results in mammalian genotoxicity assays. I. Choice of cell type. Mutat Res.
-
Mutat Res.
-
-
Fowler, P.1
Smith, K.2
Jong, J.3
-
43
-
-
77954086059
-
Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor- Binding assay: Protocol optimization and intralaboratory assay performance as initial steps towards validation
-
Freyberger, A., Wilson, V., Weimer, M. et al. (2010a). Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor- binding assay: Protocol optimization and intralaboratory assay performance as initial steps towards validation. Reprod. Toxicol. 30, 50-59.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 50-59
-
-
Freyberger, A.1
Wilson, V.2
Weimer, M.3
-
44
-
-
77954083333
-
Short-term dynamic culture of rat testicular fragments as a model to assess effects on steroidogenesis-potential use and limitations
-
Freyberger, A., Weimer, M., Lofink, W. et al. (2010b). Short-term dynamic culture of rat testicular fragments as a model to assess effects on steroidogenesis-potential use and limitations. Reprod. Toxicol. 30, 36-43.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 36-43
-
-
Freyberger, A.1
Weimer, M.2
Lofink, W.3
-
45
-
-
0036098620
-
The ECVAM international validation study on in vitro embryotoxicity tests: Results of the definitive phase and evaluation of prediction models
-
Genschow, E., Spielmann, H., Scholz, G. et al. (2002). The EC-VAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. ATLA 30, 151-76. (Pubitemid 34534620)
-
(2002)
ATLA Alternatives to Laboratory Animals
, vol.30
, Issue.2
, pp. 151-176
-
-
Genschow, E.1
Spielmann, H.2
Scholz, G.3
Seiler, A.4
Brown, N.5
Piersma, A.6
Brady, M.7
Clemann, N.8
Huuskonen, H.9
Paillard, F.10
Bremer, S.11
Becker, K.12
-
46
-
-
34447547764
-
Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach
-
DOI 10.1093/toxsci/kfm064
-
Gerberick, G. F., Vassallo, J. D., Foertsch, L. M. et al. (2007). Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach. Toxicol. Sci. 97, 417-427. (Pubitemid 47073857)
-
(2007)
Toxicological Sciences
, vol.97
, Issue.2
, pp. 417-427
-
-
Gerberick, G.F.1
Vassallo, J.D.2
Foertsch, L.M.3
Price, B.B.4
Chaney, J.G.5
Lepoittevin, J.-P.6
-
47
-
-
59149093103
-
Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo
-
Goebel, C., Hewitt, N. J., Kunze, G. et al. (2009). Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo. Toxicol. Appl. Pharmacol. 235, 114-123.
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.235
, pp. 114-123
-
-
Goebel, C.1
Hewitt, N.J.2
Kunze, G.3
-
49
-
-
41149121608
-
An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation
-
Grindon, C., Combes, R., Cronin, M. T. et al. (2008). An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation. ATLA 36, 93-101. (Pubitemid 351439801)
-
(2008)
ATLA Alternatives to Laboratory Animals
, vol.36
, Issue.1
, pp. 93-101
-
-
Grindon, C.1
Combes, R.2
Cronin, M.T.D.3
Roberts, D.W.4
Garrod, J.F.5
-
50
-
-
77954087354
-
Metabolic activation capacity by primary hepatocytes expand the applicability of the embryonic stem cell test as an alternative to experimental animal testing
-
Hettwer, M., Reis-Fernandes, M. A., Iken, M. et al. (2010). Metabolic activation capacity by primary hepatocytes expand the applicability of the embryonic stem cell test as an alternative to experimental animal testing. Reprod. Toxicol. 30, 13-20.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 13-20
-
-
Hettwer, M.1
Reis-Fernandes, M.A.2
Iken, M.3
-
52
-
-
77953575185
-
In vitro hepatotoxicity testing in the early phase of drug discovery
-
Horii, I. and Yamada, H. (2007). In vitro hepatotoxicity testing in the early phase of drug discovery. AATEX 14, Spec. Issue, 437-441.
-
(2007)
AATEX
, vol.14
, Issue.SPEC. ISSUE
, pp. 437-441
-
-
Horii, I.1
Yamada, H.2
-
53
-
-
65449166750
-
Prediction of human pharmacokinetics from preclinical information: Comparative accuracy of quantitative prediction approaches
-
Hosea, N. A., Collard, W.T., Cole, S. et al. (2009). Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches. J. Clin. Pharmacol. 49, 513-533.
-
(2009)
J. Clin. Pharmacol.
, vol.49
, pp. 513-533
-
-
Hosea, N.A.1
Collard, W.T.2
Cole, S.3
-
54
-
-
77956342684
-
In vitro organ culture models of asthma
-
Huang, S., Wiszniewskia, L., Derouette, J. P. et al. (2009). In vitro organ culture models of asthma. Drug Discov. Today 6, 137-144.
-
(2009)
Drug Discov. Today
, vol.6
, pp. 137-144
-
-
Huang, S.1
Wiszniewskia, L.2
Derouette, J.P.3
-
55
-
-
0037401126
-
Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals
-
DOI 10.1016/S0278-6915(02)00326-5
-
Hurtt, M., Cappon, G. D., Browning, A. et al. (2003). Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food producing animals. Food Chem. Toxicol. 41, 611-619. (Pubitemid 36349541)
-
(2003)
Food and Chemical Toxicology
, vol.41
, Issue.5
, pp. 611-619
-
-
Hurtt, M.E.1
Cappon, G.D.2
Browning, A.3
-
56
-
-
0013151913
-
The murine local lymph node assay: A test method for assessing the allergic contact dermatitis potential of chemicals/compounds
-
National Toxicology Program
-
ICCVAM (1999). The murine local lymph node assay: A test method for assessing the allergic contact dermatitis potential of chemicals/compounds. National Toxicology Program, NIH Publication No. 99-4494; http://iccvam.niehs. nih.gov/
-
(1999)
NIH Publication No. 99-4494
-
-
-
57
-
-
80053527081
-
Predictive in vitro cardiotoxicity and hepatotoxicity screening system using neonatal rat heart cells and rat hepatocytes
-
Inoue, T., Tanaka, K., Mishima, M. et al. (2007). Predictive in vitro cardiotoxicity and hepatotoxicity screening system using neonatal rat heart cells and rat hepatocytes. AATEX 14, Spec. Issue, 457-462.
-
(2007)
AATEX
, vol.14
, Issue.SPEC. ISSUE
, pp. 457-462
-
-
Inoue, T.1
Tanaka, K.2
Mishima, M.3
-
58
-
-
79956341696
-
Enzyme activities for xenobiotic metabolism in human reconstructed skin models
-
Jäckh, C., Blatz, V., Guth, K. et al. (2010). Enzyme activities for xenobiotic metabolism in human reconstructed skin models. ALTEX 27, Spec. Issue, 60.
-
(2010)
ALTEX
, vol.27
, Issue.SPEC. ISSUE
, pp. 60
-
-
Jäckh, C.1
Blatz, V.2
Guth, K.3
-
59
-
-
79956351775
-
The role of the Nrf2 pathway in nephrotoxicity
-
Jennings, P. (2010). The role of the Nrf2 pathway in nephrotoxicity. ALTEX 27, Spec. Issue, 60.
-
(2010)
ALTEX
, vol.27
, Issue.SPEC. ISSUE
, pp. 60
-
-
Jennings, P.1
-
60
-
-
76149137205
-
Comparison of human human skin irritation patch test data with in vitro skin irritation assays and animal data
-
Jirova, D., Basketter, D., Liebsch, M. et al. (2010). Comparison of human human skin irritation patch test data with in vitro skin irritation assays and animal data. Contact Dermatitis 62, 109-116.
-
(2010)
Contact Dermatitis
, vol.62
, pp. 109-116
-
-
Jirova, D.1
Basketter, D.2
Liebsch, M.3
-
61
-
-
33646124969
-
A novel strategy for physiologically based predictions of human pharmacokinetics
-
Jones, H. M., Parrott, N., Jorga, K. et al. (2006). A novel strategy for physiologically based predictions of human pharmacokinetics. Clin. Pharmacokinet. 45, 511-542.
-
(2006)
Clin. Pharmacokinet.
, vol.45
, pp. 511-542
-
-
Jones, H.M.1
Parrott, N.2
Jorga, K.3
-
62
-
-
71449108383
-
Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data
-
Keller, D., Krauledat, M. and Scheel, J. (2009). Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data. Arch. Toxicol. 83, 1049-1060.
-
(2009)
Arch. Toxicol.
, vol.83
, pp. 1049-1060
-
-
Keller, D.1
Krauledat, M.2
Scheel, J.3
-
63
-
-
78149389641
-
Further analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern
-
Kirkland, D. and Fowler, P. (2010). Further analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern. Mutagenesis 25, 539-553.
-
(2010)
Mutagenesis
, vol.25
, pp. 539-553
-
-
Kirkland, D.1
Fowler, P.2
-
64
-
-
80053497189
-
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and noncarcinogens I. Sensitivity, specificity and relative predictivity
-
Kirkland, D. M., Aardema, M., Henderson, L. et al. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and noncarcinogens I. Sensitivity, specificity and relative predictivity. Mut. Res. 7, 70.
-
(2005)
Mut. Res.
, vol.7
, pp. 70
-
-
Kirkland, D.M.1
Aardema, M.2
Henderson, L.3
-
66
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. and Landis, J. (2004). Can the pharmaceutical industry reduce attrition rates? Nature Rev. 3, 711-715. (Pubitemid 39173511)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.8
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
67
-
-
35348984966
-
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients
-
DOI 10.1016/j.fct.2007.06.021, PII S0278691507002207
-
Kroes, R., Renwick, A. G., Feron, V. et al. (2007). Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem. Toxicol. 45, 2533-2562. (Pubitemid 47610800)
-
(2007)
Food and Chemical Toxicology
, vol.45
, Issue.12
, pp. 2533-2562
-
-
Kroes, R.1
Renwick, A.G.2
Feron, V.3
Galli, C.L.4
Gibney, M.5
Greim, H.6
Guy, R.H.7
Lhuguenot, J.C.8
Van De, S.J.J.M.9
-
68
-
-
77954917978
-
In silico classification of major clearance pathways of drugs based on physicochemical parameters
-
Kusama, M., Toshimoto, K., Maeda, K. et al. (2010). In silico classification of major clearance pathways of drugs based on physicochemical parameters. Drug Metab. Dispos. 38, 1362-1370.
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 1362-1370
-
-
Kusama, M.1
Toshimoto, K.2
Maeda, K.3
-
69
-
-
77950531643
-
Estrogenic in vitro assay on mouse embryonic Leydig cells
-
La Sala, G., Farini, D., and De Felici, M. (2010). Estrogenic in vitro assay on mouse embryonic Leydig cells. Int. J. Dev. Biol. 54, 717-722.
-
(2010)
Int. J. Dev. Biol.
, vol.54
, pp. 717-722
-
-
La Sala, G.1
Farini, D.2
De Felici, M.3
-
70
-
-
79956359954
-
The use of alternative methods for toxicity testing of nanomaterials
-
Landsiedel, R., Fabian, E., Gamer, A. et al. (2010). The use of alternative methods for toxicity testing of nanomaterials. ALTEX 27, Spec. Issue, 78.
-
(2010)
ALTEX
, vol.27
, Issue.SPEC. ISSUE
, pp. 78
-
-
Landsiedel, R.1
Fabian, E.2
Gamer, A.3
-
71
-
-
12244309482
-
Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release
-
Langezaal, I. S., Hoffmann, S., Hartung, T. et al. (2002). Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release. ATLA 30, 581-595. (Pubitemid 36168750)
-
(2002)
ATLA Alternatives to Laboratory Animals
, vol.30
, Issue.6
, pp. 581-595
-
-
Langezaal, I.1
Hoffmann, S.2
Hartung, T.3
Coecke, S.4
-
72
-
-
77449154369
-
In vitro testing for direct immunotoxicity: State of the art
-
Lankveld, D. P., van Loveren, H., Baken, K. A. et al. (2009). In vitro testing for direct immunotoxicity: State of the art. Meth. Mol. Biol. 598, 401-423.
-
(2009)
Meth. Mol. Biol.
, vol.598
, pp. 401-423
-
-
Lankveld, D.P.1
Van Loveren, H.2
Baken, K.A.3
-
73
-
-
56349160116
-
Developmental of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella
-
Lazzari, G., Tessaro, I., Crotti, G. et al. (2008). Developmental of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella. Toxicol. Appl. Pharmacol. 233, 360-370.
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.233
, pp. 360-370
-
-
Lazzari, G.1
Tessaro, I.2
Crotti, G.3
-
74
-
-
0030596897
-
The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals
-
DOI 10.1016/0027-5107(95)00199-9
-
LeBoeuf, R. A., Kerckaert, G. A., Aardema, M. J. et al. (1996). The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. Mut. Res. Fund. Mol. Mech. Mutagen. 356, 85-127. (Pubitemid 26308724)
-
(1996)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.356
, Issue.1
, pp. 85-127
-
-
LeBoeuf, R.A.1
Kerckaert, G.A.2
Aardema, M.J.3
Gibson, D.P.4
Brauninger, R.5
Isfort, R.J.6
-
75
-
-
78649317668
-
Predicting carcinogenicity in humans: The need to supplement animal-based toxicology
-
Long, M. E. (2007). Predicting carcinogenicity in humans: The need to supplement animal-based toxicology. AATEX 14, Spec. Issue, 553-559.
-
(2007)
AATEX
, vol.14
, Issue.SPEC. ISSUE
, pp. 553-559
-
-
Long, M.E.1
-
76
-
-
77954087353
-
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect
-
Luciano, A. M., Franciosi, F., Lodde, V. et al. (2010). Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect. Reprod. Toxicol. 30, 81-88.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 81-88
-
-
Luciano, A.M.1
Franciosi, F.2
Lodde, V.3
-
77
-
-
0037432753
-
Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates
-
DOI 10.1080/15287390306374
-
Malygin, V. V., Sokolov, V. B., Richardson, R. J. et al. (2003). Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of o-alkyl-o-methylchloroformimino phenylphosphonates. J. Toxicol. Environ. Health A 66, 611-25. (Pubitemid 36428448)
-
(2003)
Journal of Toxicology and Environmental Health - Part A
, vol.66
, Issue.7
, pp. 611-625
-
-
Malygin, V.V.1
Sokolov, V.B.2
Richardson, R.J.3
Makhaeva, G.F.4
-
78
-
-
0038407692
-
A hierarchical QSAR model for urinary excretion of drugs in humans as a predictive tool for biotransformation
-
Manga, N., Duffy, J. C., Rowe, P. H. et al. (2003). A hierarchical QSAR model for urinary excretion of drugs in humans as a predictive tool for biotransformation. QSAR Combinat. Sci. 22, 263-273. (Pubitemid 36723090)
-
(2003)
QSAR and Combinatorial Science
, vol.22
, Issue.2
, pp. 263-273
-
-
Manga, N.1
Duffy, J.C.2
Rowe, P.H.3
Cronin, M.T.D.4
-
80
-
-
53849084171
-
Prediction of chemical toxicity with local support vector regression and activity-specific kernels
-
Maunz, A. and Helma, C. (2008). Prediction of chemical toxicity with local support vector regression and activity-specific kernels. SAR QSAR Environ. Res. 19, 413-431.
-
(2008)
SAR QSAR Environ. Res.
, vol.19
, pp. 413-431
-
-
Maunz, A.1
Helma, C.2
-
81
-
-
0034752076
-
The Syrian hamster embryo (SHE) cell transformation assay: Review of the methods and results
-
Mauthe, R. J., Gibson, D. P., Bunch, R. T. et al. (2001). The Syrian hamster embryo (SHE) cell transformation assay: review of the methods and results. Toxicol. Pathol. 29, 138.
-
(2001)
Toxicol. Pathol.
, vol.29
, pp. 138
-
-
Mauthe, R.J.1
Gibson, D.P.2
Bunch, R.T.3
-
82
-
-
77949814178
-
Building a tiered approach to in vitro predictive toxicity screening: A focus on assays with in vivo relevance
-
McKim, J. M. Jr. (2010). Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance. Combinat. Chem. High Throughput Screen. 13, 188-206.
-
(2010)
Combinat. Chem. High Throughput Screen.
, vol.13
, pp. 188-206
-
-
McKim Jr., J.M.1
-
83
-
-
0343836809
-
Nephrotoxicity Testing In Vitro: The Current Situation - ECVAM Nephrotoxicity Task Force Report 1
-
Morin, J. P., De Broe, M. E., Pfaller, W. et al. (1997). Nephrotoxicity testing in vitro: the current situation. ECVAM Nephrotoxicity Task Force Report 1. ATLA 25, 497-503. (Pubitemid 127520772)
-
(1997)
ATLA Alternatives to Laboratory Animals
, vol.25
, Issue.5
, pp. 497-503
-
-
Morin, J.-P.1
De Broe, M.E.2
Pfaller, W.3
Schmuck, G.4
-
84
-
-
0029974283
-
Thresholds of toxicological concern based on structure-activity relationships
-
Munro, I. C., Ford, R. A., Kennepohl, E, et al. (1996). Thresholds of toxicological concern based on structure-activity relationships. Drug Metab. Rev. 28, 209-217. (Pubitemid 26178332)
-
(1996)
Drug Metabolism Reviews
, vol.28
, Issue.1-2
, pp. 209-217
-
-
Munro, I.C.1
Ford, R.A.2
Kennepohl, E.3
Sprenger, J.G.4
-
85
-
-
35649009496
-
Utility and limitations of a peptide reactivity assay to predict fragrance allergens in vitro
-
DOI 10.1016/j.tiv.2007.03.016, PII S0887233307001294, Fourteenth International Workshop on In Vitro Toxicology
-
Natsch, A., Gfeller, H., Rothaupt, M. et al. (2007). Utility and limitations of a peptide reactivity assay to predict fragrance allergens in vitro. Toxicol. In Vitro 21, 1220-1226. (Pubitemid 350030873)
-
(2007)
Toxicology in Vitro
, vol.21
, Issue.7
, pp. 1220-1226
-
-
Natsch, A.1
Gfeller, H.2
Rothaupt, M.3
Ellis, G.4
-
86
-
-
33747084103
-
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
-
DOI 10.1007/s00204-006-0091-3
-
O'Brien, P. J., Irwin, W., Diaz, D. et al. (2006). High concordance of drug induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch. Toxicol. 80, 580-604. (Pubitemid 44214526)
-
(2006)
Archives of Toxicology
, vol.80
, Issue.9
, pp. 580-604
-
-
O'Brien, P.J.1
Irwin, W.2
Diaz, D.3
Howard-Cofield, E.4
Krejsa, C.M.5
Slaughter, M.R.6
Gao, B.7
Kaludercic, N.8
Angeline, A.9
Bernardi, P.10
Brain, P.11
Hougham, C.12
-
91
-
-
0033771951
-
Concordance of the toxicity of pharmaceuticals in humans and animals
-
Olson, H., Betton, G., Robinson, D. et al. (2000). Concordance of the toxicity of pharmaceuticals in humans and animals. Reg. Toxicol. Pharmacol. 32, 56-67.
-
(2000)
Reg. Toxicol. Pharmacol.
, vol.32
, pp. 56-67
-
-
Olson, H.1
Betton, G.2
Robinson, D.3
-
92
-
-
43049085534
-
Assessment of the embryonic stem cell test and application and use in the pharmaceutical industry
-
DOI 10.1002/bdrb.20148
-
Paquette, J. A., Kumpf, S. W., Streck, R. D. et al. (2008). Assessment of the embryonic stem cell test and application and use in the pharmaceutical industry. Birth Defects Res. B Dev. Repro. Toxicol. 83, 104-111. (Pubitemid 351631344)
-
(2008)
Birth Defects Research Part B - Developmental and Reproductive Toxicology
, vol.83
, Issue.2
, pp. 104-111
-
-
Paquette, J.A.1
Kumpf, S.W.2
Streck, R.D.3
Thomson, J.J.4
Chapin, R.E.5
Stedman, D.B.6
-
93
-
-
78149396570
-
Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing
-
Parry, J. M., Parry, E., Phrakonkham, P. et al. (2010). Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing. Mutagenesis 25, 531-538.
-
(2010)
Mutagenesis
, vol.25
, pp. 531-538
-
-
Parry, J.M.1
Parry, E.2
Phrakonkham, P.3
-
94
-
-
60849110543
-
Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000-2006)
-
Pauwels, M., Dejaegher, B., Vander Heyden, Y. et al. (2009). Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000-2006). Food Chem. Toxicol. 47, 898-905.
-
(2009)
Food Chem. Toxicol.
, vol.47
, pp. 898-905
-
-
Pauwels, M.1
Dejaegher, B.2
Vander Heyden, Y.3
-
95
-
-
0034762255
-
Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay
-
DOI 10.1016/S0887-2333(01)00085-6, PII S0887233301000856
-
Pessina, A., Albella, B., Bueren, J. et al. (2001). Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay. Toxicol. In Vitro 15, 729-740. (Pubitemid 33043962)
-
(2001)
Toxicology in Vitro
, vol.15
, Issue.6
, pp. 729-740
-
-
Pessina, A.1
Albella, B.2
Bueren, J.3
Brantom, P.4
Casati, S.5
Gribaldo, L.6
Croera, C.7
Gagliardi, G.8
Foti, P.9
Parchment, R.10
Parent-Massin, D.11
Sibiril, Y.12
Van Den, H.R.13
-
96
-
-
51849160448
-
Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test
-
Peters, A. K., Steemans, M., Hansen, E. et al. (2008a). Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test. Toxicol. Sci. 105, 342-350.
-
(2008)
Toxicol. Sci.
, vol.105
, pp. 342-350
-
-
Peters, A.K.1
Steemans, M.2
Hansen, E.3
-
97
-
-
84954358518
-
Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity
-
Peters, A. K., Wouwer, G. V., Weyn, B. et al. (2008b). Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity. Toxicol. In Vitro 22, 1948-1956.
-
(2008)
Toxicol. In Vitro
, vol.22
, pp. 1948-1956
-
-
Peters, A.K.1
Wouwer, G.V.2
Weyn, B.3
-
98
-
-
0036144815
-
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution
-
DOI 10.1002/jps.10005
-
Poulin, P. and Theil, F. P. (2002). Predictions of pharmacokinetics prior to in vivo studies: I. Mechanism based prediction of volume if distribution. J. Pharm. Sci. 91, 129-156. (Pubitemid 34074473)
-
(2002)
Journal of Pharmaceutical Sciences
, vol.91
, Issue.1
, pp. 129-156
-
-
Poulin, P.1
Theil, F.-P.2
-
99
-
-
33746297145
-
The assessment of repeated dose toxicity in vitro: A proposed approach
-
Prieto, P., Baird, A. W., Blaauboer, B. J. et al. (2006). The assessment of repeated dose toxicity in vitro: a proposed approach. The Report and Recommendations of ECVAM Workshop 56. ATLA 34, 315-341. (Pubitemid 44105846)
-
(2006)
ATLA Alternatives to Laboratory Animals
, vol.34
, Issue.3
, pp. 315-341
-
-
Prieto, P.1
Baird, A.W.2
Blaauboer, B.J.3
Ripoll, J.V.C.4
Corvi, R.5
Dekant, W.6
Dietl, P.7
Gennari, A.8
Gribaldo, L.9
Griffin, J.L.10
Hartung, T.11
Heindel, J.J.12
Hoet, P.13
Jennings, P.14
Marocchio, L.15
Noraberg, J.16
Pazos, P.17
Westmorland, C.18
Wolf, A.19
Wright, J.20
Pfaller, W.21
more..
-
100
-
-
33947719856
-
Assessment of the U937 cell line for the detection of contact allergens
-
DOI 10.1016/j.taap.2006.12.026, PII S0041008X06005047
-
Python, F., Goebel, C. and Aeby, P. (2007). Assessment of the U937 cell line for the detection of contact allergens. Toxicol. Appl. Pharmacol. 220, 113-124. (Pubitemid 46507571)
-
(2007)
Toxicology and Applied Pharmacology
, vol.220
, Issue.2
, pp. 113-124
-
-
Python, F.1
Goebel, C.2
Aeby, P.3
-
101
-
-
42049110135
-
Determinants of skin sensitisation potential
-
DOI 10.1002/jat.1289
-
Roberts, D. W. and Aptula, A. O. (2008). Determinants of skin sensitisation potential. J. Appl. Toxicol. 28, 377-387. (Pubitemid 351518126)
-
(2008)
Journal of Applied Toxicology
, vol.28
, Issue.3
, pp. 377-387
-
-
Roberts, D.W.1
Aptula, A.O.2
-
102
-
-
77951576472
-
Updating the skin sensitization in vitro data assessment paradigm in 2009 - A chemistry and QSAR perspective
-
discussion 289
-
Roberts, D. W. and Patlewicz, G. Y. (2010). Updating the skin sensitization in vitro data assessment paradigm in 2009 - a chemistry and QSAR perspective. J. Appl. Toxicol. 30, 286-288; discussion 289.
-
(2010)
J. Appl. Toxicol.
, vol.30
, pp. 286-288
-
-
Roberts, D.W.1
Patlewicz, G.Y.2
-
103
-
-
60549103913
-
Safety assessment of cosmetics in Europe
-
Basel, Switzerland: S. Karger
-
Rogiers, W. and Pauwels, M. (2008). Safety assessment of cosmetics in Europe. Current Problems in Dermatology 36. Basel, Switzerland: S. Karger.
-
(2008)
Current Problems in Dermatology 36
-
-
Rogiers, W.1
Pauwels, M.2
-
105
-
-
63649113845
-
The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test - Human cell line activation test (h-CLAT)
-
Sakaguchi, H., Ashikaga, T., Miyazawa, M. et al. (2009). The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test - human cell line activation test (h-CLAT). Cell Biol. Toxicol. 25, 109-126.
-
(2009)
Cell Biol. Toxicol.
, vol.25
, pp. 109-126
-
-
Sakaguchi, H.1
Ashikaga, T.2
Miyazawa, M.3
-
107
-
-
0010446920
-
-
SCCNFP
-
th plenary meeting of 3 May 2000. http://ec.europa.eu/health/scientific-committees/consumer-safety/opinions/ sccnfp-opinions-97-04/sccp-out114-en.htm
-
(2000)
th Plenary Meeting of 3 May 2000
-
-
-
109
-
-
58749100443
-
REACH, non-testing approaches and the urgent need for a change in mind set
-
Schaafsma, G., Kroese, E. D., Tielemans, E. L. et al. (2009). REACH, non-testing approaches and the urgent need for a change in mind set. Regul. Toxicol. Pharmacol. 53, 70-80.
-
(2009)
Regul. Toxicol. Pharmacol.
, vol.53
, pp. 70-80
-
-
Schaafsma, G.1
Kroese, E.D.2
Tielemans, E.L.3
-
110
-
-
45549105564
-
The use of reconstructed human epidermis for skin absorption testing: Results of the validation study
-
Schäfer-Korting, M., Bock, U., Diembeck, W. et al. (2008). The use of reconstructed human epidermis for skin absorption testing: Results of the validation study. ATLA 36, 161-187. (Pubitemid 351861001)
-
(2008)
ATLA Alternatives to Laboratory Animals
, vol.36
, Issue.2
, pp. 161-187
-
-
Schafer-Korting, M.1
Bock, U.2
Diembeck, W.3
Dusing, H.-J.4
Gamer, A.5
Haltner-Ukomadu, E.6
Hoffmann, C.7
Kaca, M.8
Kamp, H.9
Kersen, S.10
Kietzmann, M.11
Korting, H.C.12
Krachter, H.-U.13
Lehr, C.-M.14
Liebsch, M.15
Mehling, A.16
Muller-Goymann, C.17
Netzlaff, F.18
Niedorf, F.19
Rubbelke, M.K.20
Schafer, U.21
Schmidt, E.22
Schreiber, S.23
Spielmann, H.24
Vuia, A.25
Weimer, M.26
more..
-
111
-
-
77954086651
-
The ReProTect feasibility study, a novel comprehensive in vitro approach to detect reproductive toxicants
-
Schenk, B., Weimer, M., Bremer, S. et al. (2010). The ReProTect feasibility study, a novel comprehensive in vitro approach to detect reproductive toxicants. Reprod. Toxicol. 30, 200-218.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 200-218
-
-
Schenk, B.1
Weimer, M.2
Bremer, S.3
-
112
-
-
67650165397
-
Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support
-
Schmelzer, E., Mutig, K., Schrade, P. et al. (2009). Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support. Biotechnol. Bioeng. 103, 817-827.
-
(2009)
Biotechnol. Bioeng.
, vol.103
, pp. 817-827
-
-
Schmelzer, E.1
Mutig, K.2
Schrade, P.3
-
115
-
-
70350049072
-
Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo
-
Selderslaghs, I. W., van Rompay, A. R., De, C. W. et al. (2009). Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Reprod. Toxicol. 28, 308-320.
-
(2009)
Reprod. Toxicol.
, vol.28
, pp. 308-320
-
-
Selderslaghs, I.W.1
Van Rompay, A.R.2
De, C.W.3
-
116
-
-
29544439001
-
Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities
-
DOI 10.1093/toxsci/kfj009
-
Sonneveld, E., Riteco, J. A., Jansen, H. J. et al. (2006). Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities. Toxicol. Sci. 89, 173-187. (Pubitemid 43013766)
-
(2006)
Toxicological Sciences
, vol.89
, Issue.1
, pp. 173-187
-
-
Sonneveld, E.1
Riteco, J.A.C.2
Jansen, H.J.3
Pieterse, B.4
Brouwer, A.5
Schoonen, W.G.6
Van Der Burg, B.7
-
117
-
-
79151477340
-
Validation of in vitro screening models for progestagenic activities: Inter-assay comparison and correlation with in vivo activity in rabbits
-
Sonneveld, E., Pieterse, B., Schoonen, W. G. et al. (2011). Validation of in vitro screening models for progestagenic activities: Inter-assay comparison and correlation with in vivo activity in rabbits. Toxicol. In Vitro 25, 545-554.
-
(2011)
Toxicol. In Vitro
, vol.25
, pp. 545-554
-
-
Sonneveld, E.1
Pieterse, B.2
Schoonen, W.G.3
-
118
-
-
11144304132
-
Ranking of hair dye substances according to predicted sensitization potency: Quantitative structure-activity relationships
-
DOI 10.1111/j.0105-1873.2004.00440.x
-
Søsted, H., Basketter, D. A., Estrada, E. et al. (2004). Ranking of hair dye substances according to predicted sensitization potency: quantitative structure-activity relationships. Contact Dermatitis 51, 241-254. (Pubitemid 40037048)
-
(2004)
Contact Dermatitis
, vol.51
, Issue.5-6
, pp. 241-254
-
-
Sosted, H.1
Basketter, D.A.2
Estrada, E.3
Johansen, J.D.4
Patlewicz, G.Y.5
-
119
-
-
70449570242
-
-
Cambridge, UK: accessed 24.08.09
-
Spanhaak, S., Cook, D., Barnes, J. et al. (2008). Species concordance for liver injury: from the safety intelligence program board (6pp.). Cambridge, UK: BioWisdom, Ltd. http://www.biowisdom.com/files/SIP-Board-Species-Concordance. pdf (accessed 24.08.09).
-
(2008)
Species Concordance for Liver Injury: From the Safety Intelligence Program Board
, pp. 6
-
-
Spanhaak, S.1
Cook, D.2
Barnes, J.3
-
120
-
-
69449083458
-
How to assess the mutagenic potential of cosmetic products without animal tests?
-
Speit, G. (2009). How to assess the mutagenic potential of cosmetic products without animal tests? Mutat. Res. 678, 108-112.
-
(2009)
Mutat. Res.
, vol.678
, pp. 108-112
-
-
Speit, G.1
-
121
-
-
8744315357
-
Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests
-
Spielmann, H., Genschow, E., Brown, N. A. et al. (2004). Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests. ATLA 32, 245-274. (Pubitemid 39517738)
-
(2004)
ATLA Alternatives to Laboratory Animals
, vol.32
, Issue.3
, pp. 245-274
-
-
Spielmann, H.1
Genschow, E.2
Brown, N.A.3
Piersma, A.H.4
Verhoef, A.5
Spanjersberg, M.Q.I.6
Huuskonen, H.7
Paillard, F.8
Seiler, A.9
-
122
-
-
77749252494
-
The way forward in reproductive/developmental toxicity testing
-
Spielmann, H. (2009). The way forward in reproductive/developmental toxicity testing. ATLA 37, 641-656.
-
(2009)
ATLA
, vol.37
, pp. 641-656
-
-
Spielmann, H.1
-
123
-
-
79251541186
-
Editorial: The EU Commission's Draft Report on alternative (nonanimal) methods for cosmetics testing: Current status and future prospects - 2010: A missed opportunity
-
Spielmann, H. (2010). Editorial: The EU Commission's Draft Report on alternative (nonanimal) methods for cosmetics testing: Current status and future prospects - 2010: A missed opportunity. ATLA 38, 339-343.
-
(2010)
ATLA
, vol.38
, pp. 339-343
-
-
Spielmann, H.1
-
124
-
-
50149120635
-
An improved protocol for primary culture of cardiomyocyte from neonatal mice
-
Sreejit, P., Kumar, S. and Verma, R. S. (2008). An improved protocol for primary culture of cardiomyocyte from neonatal mice. In Vitro Cell. Devel. Biol. - Anim. 44, 45-50.
-
(2008)
In Vitro Cell. Devel. Biol. - Anim.
, vol.44
, pp. 45-50
-
-
Sreejit, P.1
Kumar, S.2
Verma, R.S.3
-
125
-
-
33846799293
-
Integrated computational methods for prediction of the lowest observable adverse effect level of food-borne molecules
-
DOI 10.1002/qsar.200610060
-
Tilaoui, L., Schilter, B., Tran, L.-A. et al. (2007). Integrated computational methods for prediction of the lowest observable adverse effect level of food-borne molecules. QSAR Combinat. Sci. 26, 102-108. (Pubitemid 46202942)
-
(2007)
QSAR and Combinatorial Science
, vol.26
, Issue.1
, pp. 102-108
-
-
Tilaoui, L.1
Schilter, B.2
Tran, L.-A.3
Mazzatorta, P.4
Grigorov, M.5
-
126
-
-
77954084605
-
Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds
-
van der Burg B., Winter, R., Man, H. Y. et al. (2010). Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds. Reprod. Toxicol. 30, 18-24.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 18-24
-
-
Van Der Burg, B.1
Winter, R.2
Man, H.Y.3
-
127
-
-
31944435095
-
Weight of evidence: A review of concept and methods
-
Weed, D. (2005). Weight of evidence: a review of concept and methods. Risk Anal. 25, 1545-1557.
-
(2005)
Risk Anal.
, vol.25
, pp. 1545-1557
-
-
Weed, D.1
-
128
-
-
77954817641
-
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics
-
West, P. R., Weir, A. M., Smith, A. M. et al. (2010). Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics. Toxicol. Appl. Pharmacol. 247, 18-27.
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.247
, pp. 18-27
-
-
West, P.R.1
Weir, A.M.2
Smith, A.M.3
-
129
-
-
79952635364
-
Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety
-
Westmoreland, C., Carmichael, P., Dent, M. et al. (2010). Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety. ALTEX 27, 61-65.
-
(2010)
ALTEX
, vol.27
, pp. 61-65
-
-
Westmoreland, C.1
Carmichael, P.2
Dent, M.3
-
130
-
-
77954084613
-
The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability
-
Witters, H., Freyberger, A., Smits, K. et al. (2010). The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability. Reprod. Toxicol. 30, 60-72.
-
(2010)
Reprod. Toxicol.
, vol.30
, pp. 60-72
-
-
Witters, H.1
Freyberger, A.2
Smits, K.3
-
131
-
-
79951888374
-
Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: Physiologically based pharmacokinetic model versus traditional one compartment model
-
Yamazaki, S., Skaptason, J., Romero, D. et al. (2011). Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: physiologically based pharmacokinetic model versus traditional one compartment model. Drug Metab. Dispos. 39, 383-393.
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 383-393
-
-
Yamazaki, S.1
Skaptason, J.2
Romero, D.3
-
132
-
-
0032465960
-
Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: Premises, promises, and performance
-
Zeiger, E. (1998). Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance. Regul. Toxicol. Pharmacol. 28, 85-95.
-
(1998)
Regul. Toxicol. Pharmacol.
, vol.28
, pp. 85-95
-
-
Zeiger, E.1
-
133
-
-
79955441221
-
Scaling down of a clinical three- Dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies
-
Epub ahead of print, doi: 10.1089/ten.tec.2010.0580
-
Zeilinger, K., Schreiter, T., Darnell, M. et al. (2011). Scaling down of a clinical three- dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies. Tissue Eng. Part C Methods, Epub ahead of print, doi: 10.1089/ten.tec.2010.0580.
-
(2011)
Tissue Eng. Part C Methods
-
-
Zeilinger, K.1
Schreiter, T.2
Darnell, M.3
|