Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds

Reproductive Toxicology

Volumn 30, Issue 1, 2010, Pages 18-24

  van der Burg, Bart ^a   Winter, Roos ^a   Man, Hai yen ^a   Vangenechten, Clea ^c   Berckmans, Pascale ^c   Weimer, Marc ^b   Witters, Hilda ^c   van der Linden, Sander ^a  

^a BIODETECTION SYSTEMS B V   (Netherlands)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

Author keywords

Androgen reporter gene assay; Hershberger assay; In vitro; Prevalidation

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; ANDROGEN RECEPTOR; ANDROSTANOLONE; CORTICOSTERONE; FLUTAMIDE; LEVONORGESTREL; LINURON; LUCIFERASE; METHYLTESTOSTERONE; NORETYNODREL; PHTHALIC ACID DIBUTYL ESTER; PROCHLORAZ; PROGESTERONE; STEROID RECEPTOR; VINCLOZOLIN; ANDROGEN; ANDROGEN RECEPTOR ANTAGONIST; ANTIANDROGEN; ENDOCRINE DISRUPTOR;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; GENETIC TRANSFECTION; HORMONE RESISTANCE; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; OSTEOSARCOMA CELL; PROCESS OPTIMIZATION; REPORTER GENE; REPRODUCIBILITY; SCREENING TEST; SIGNAL TRANSDUCTION; TOXICITY TESTING; VALIDATION PROCESS; ANIMAL TESTING ALTERNATIVE; BIOASSAY; DOSE RESPONSE; GENETICS; PROCEDURES; STANDARDS; TUMOR CELL LINE;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMAL TESTING ALTERNATIVES; BIOLOGICAL ASSAY; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; GENES, REPORTER; HUMANS; RECEPTORS, ANDROGEN; REPRODUCIBILITY OF RESULTS; ANDROGEN RECEPTOR ANTAGONISTS;

EID: 77954084605     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.04.012     Document Type: Article

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