An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation

Alternatives to Laboratory Animals

Volumn 36, Issue 1, 2008, Pages 93-101

  Grindon, Christina ^a   Combes, Robert ^a   Cronin, Mark T D ^b   Roberts, David W ^b   Garrod, John F ^c  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c DEFRA   (United Kingdom)

Author keywords

Animal testing; Chronic toxicity; Decision trees; Defra; In silico models; In vitro testing; Integrated testing strategies; Long term toxicity; REACH; Repeat dose; Risk assessment; Three Rs

Indexed keywords

ANALYTIC METHOD; ANIMAL TESTING ALTERNATIVE; ANIMAL USE; CELL CULTURE; CHRONIC TOXICITY; COMPUTER MODEL; CULTURE MEDIUM; DECISION MAKING; IN VITRO STUDY; IN VIVO STUDY; LAW; NONHUMAN; NOTE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SAFETY; SUBCHRONIC TOXICITY; TOXICITY; CYTOTOXICITY; LONG TERM EXPOSURE; MEDICAL RESEARCH; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANIMALIA;

EID: 41149121608     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290803600110     Document Type: Note

References (51)

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