The Syrian hamster embryo (SHE) cell transformation assay: Review of the methods and results

Toxicologic Pathology

Volumn 29, Issue SUPPL., 2001, Pages 138-146

  Mauthe, R J ^a   Gibson, D P ^a   Bunch, R T ^a   Custer, L ^a  

^a PFIZER INC   (United States)

Author keywords

Epigenetic carcinogens; Genotoxic carcinogen; In vitro assay; Rodent carcinogenicity

Indexed keywords

AMPICILLIN; CARCINOGEN; CHLORPROMAZINE; CLOFIBRATE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DIELDRIN; DIETHYLSTILBESTROL; ESTRADIOL; HALOPERIDOL; MANNITOL; MELPHALAN; METHAPYRILENE; PHENACETIN; PHENOBARBITAL; PIRINIXIC ACID; RESERPINE; SULFAFURAZOLE; SULFAMETHOXAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; CARCINOGEN TESTING; CARCINOGENICITY; CELL TRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; GENOTOXICITY; HAMSTER; HUMAN; IN VITRO STUDY; MODEL; NONHUMAN; PRIORITY JOURNAL;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; MESOCRICETUS; MICE; MUTAGENS; PREDICTIVE VALUE OF TESTS; RATS; REPRODUCIBILITY OF RESULTS;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS; RODENTIA;

EID: 0034752076     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301753178546     Document Type: Conference Paper

References (11)

1. Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals
2. In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons
3. The induction of transformed-like morphology and enhanced growth in Syrian hamster embryo cells grown at acidic pH
4. The in vitro induction of an increase in cell multiplication and cellular life span by the water soluble carcinogen dimethylnitrosamine
5. Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals
6. A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70
7. Morphological transformation of early passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens
8. Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH
9. Enhanced morphological and neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70
10. A refined protocol for conducting the low pH 6.7 Syrian hamster embryo (SHE) cell transformation assay