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Volumn 34, Issue 3, 2006, Pages 315-341

The assessment of repeated dose toxicity in vitro: A proposed approach

(21)  Prieto, Pilar a   Baird, Alan W b   Blaauboer, Bas J c   Ripoll, Jose Vicente Castell d   Corvi, Raffaella a   Dekant, Wolfgang e   Dietl, Paul f   Gennari, Alessandra a   Gribaldo, Laura a   Griffin, Julian L g   Hartung, Thomas a   Heindel, Jerry J h   Hoet, Peter i   Jennings, Paul j   Marocchio, Luciana k   Noraberg, Jens l   Pazos, Patricia a   Westmorland, Carl m   Wolf, Armin n   Wright, Jayne o   more..


Author keywords

[No Author keywords available]

Indexed keywords

BIOTRANSFORMATION; CHRONIC TOXICITY; CONFERENCE PAPER; IN VITRO STUDY; MATHEMATICAL MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT; TARGET ORGAN; TISSUE DISTRIBUTION; TOXICITY TESTING;

EID: 33746297145     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290603400307     Document Type: Conference Paper
Times cited : (44)

References (156)
  • 1
    • 0008511303 scopus 로고
    • ECVAM News and Views
    • Anon. (1994). ECVAM News and Views. ATLA 22, 7-11.
    • (1994) ATLA , vol.22 , pp. 7-11
  • 2
    • 5444230394 scopus 로고    scopus 로고
    • Establishing a European Chemicals Agency and Amending Directive 1999/45/EC and Regulation (EC) {Onpersistent Organic Pollutants} and Proposal for a Directive of the European Parliament and on the Council Amending Council Directive 67/548/EEC in Order to Adapt It to Regulation (EC) of the European Parliament and on the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals, COM(2003) 644 final, 158pp. Brussels, Belgium: European Commission. Website
    • European Commission (2003). Proposal for a Regulation of the European Parliament and of the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Establishing a European Chemicals Agency and Amending Directive 1999/45/EC and Regulation (EC) {onpersistent Organic Pollutants} and Proposal for a Directive of the European Parliament and on the Council Amending Council Directive 67/548/EEC in Order to Adapt it to Regulation (EC) of the European Parliament and on the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals, COM(2003) 644 final, 158pp. Brussels, Belgium: European Commission. Website http://europa.eu.int/eur-lex/en/com/pdf/2003/com2003_0644en.html (Accessed 2.02.06).
    • (2003) Proposal for a Regulation of the European Parliament and of the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
  • 3
    • 0142177156 scopus 로고    scopus 로고
    • Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (Text with EEA relevance)
    • Anon. (2003). Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (Text with EEA relevance). Official Journal of the European Union L66, 26-35.
    • (2003) Official Journal of the European Union , vol.L66 , pp. 26-35
  • 4
    • 0345873490 scopus 로고    scopus 로고
    • Use of NOAEL, benchmark dose, and other models for human risk assessment of hormonally active substances
    • Setzer, R.W. & Himmel, C.A. (2003). Use of NOAEL, benchmark dose, and other models for human risk assessment of hormonally active substances. Pure and Applied Chemistry 75, 2151-2158.
    • (2003) Pure and Applied Chemistry , vol.75 , pp. 2151-2158
    • Setzer, R.W.1    Himmel, C.A.2
  • 5
    • 0025363159 scopus 로고
    • Risk assessment of carcinogenic and non-carcinogenic chemicals
    • Johannsen, F.R. (1990). Risk assessment of carcinogenic and non-carcinogenic chemicals. Critical Reviews in Toxicology 20, 341-367.
    • (1990) Critical Reviews in Toxicology , vol.20 , pp. 341-367
    • Johannsen, F.R.1
  • 6
    • 0036284049 scopus 로고    scopus 로고
    • Critical issues in benchmark calculations from continuous data
    • Crump, K. (2002). Critical issues in benchmark calculations from continuous data. Critical Reviews in Toxicology 32, 133-153.
    • (2002) Critical Reviews in Toxicology , vol.32 , pp. 133-153
    • Crump, K.1
  • 7
    • 0001893556 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for chemicals testing: Current status and future prospects. A report prepared by ECVAM and the ECVAM working group on chemicals
    • Worth, A.P. & Balls, M., eds
    • Worth, A.P. & Balls, M., eds (2002). Alternative (non-animal) methods for chemicals testing: current status and future prospects. A report prepared by ECVAM and the ECVAM working group on chemicals. ALTA 30, Suppl. 1, 71.
    • (2002) ALTA , vol.30 , Issue.SUPPL. 1 , pp. 71
  • 8
    • 0002385233 scopus 로고    scopus 로고
    • An integrated approach to the prediction of systemic toxicity using biokinetic models and biological in vitro test methods
    • (eds. M. Balls, A.M. Van Zeller & M.E. Halder). Amsterdam, The Netherlands: Elsevier
    • Blaauboer, B.J., Forsby, A., Houston, J.B., Beckman, M., Combes, R.D. & DeJongh, J. (2000). An integrated approach to the prediction of systemic toxicity using biokinetic models and biological in vitro test methods. In Progress in the Reduction, Refinement and Replacement of Animal Experimentation (eds. M. Balls, A.M. Van Zeller & M.E. Halder), pp. 525-536. Amsterdam, The Netherlands: Elsevier.
    • (2000) Progress in the Reduction, Refinement and Replacement of Animal Experimentation , pp. 525-536
    • Blaauboer, B.J.1    Forsby, A.2    Houston, J.B.3    Beckman, M.4    Combes, R.D.5    DeJongh, J.6
  • 9
    • 1842678417 scopus 로고    scopus 로고
    • Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon
    • De Kanter, R., Monshouwer, M., Draaisma, A.L., De Jager, M.H., de Graaf, I.A., Proost, J.H., Meijer, D.K. & Groothuis, G.M. (2004). Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica 34, 229-241.
    • (2004) Xenobiotica , vol.34 , pp. 229-241
    • De Kanter, R.1    Monshouwer, M.2    Draaisma, A.L.3    De Jager, M.H.4    De Graaf, I.A.5    Proost, J.H.6    Meijer, D.K.7    Groothuis, G.M.8
  • 10
    • 3242701224 scopus 로고    scopus 로고
    • Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
    • Treijtel, N., Barendregt, A., Freidig, A.P., Blaauboer, B.J. & van Eijkeren, J.C.H. (2004). Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition 32, 884-891.
    • (2004) Drug Metabolism and Disposition , vol.32 , pp. 884-891
    • Treijtel, N.1    Barendregt, A.2    Freidig, A.P.3    Blaauboer, B.J.4    Van Eijkeren, J.C.H.5
  • 11
    • 23944490116 scopus 로고    scopus 로고
    • The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-Ethoxycoumarin and warfarin
    • Treijtel, N., van Helvoort, H., Barendregt, A, Blaauboer, B.J. & van Eijkeren, J.C. (2005). The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin. Drug Metabolism and Disposition 33, 1325-1332.
    • (2005) Drug Metabolism and Disposition , vol.33 , pp. 1325-1332
    • Treijtel, N.1    Van Helvoort, H.2    Barendregt, A.3    Blaauboer, B.J.4    Van Eijkeren, J.C.5
  • 16
    • 33746280723 scopus 로고    scopus 로고
    • Organ slices for the evaluation of human drug toxicity
    • Vickers, A.E. & Fisher, R.L. (2004). Organ slices for the evaluation of human drug toxicity. Chemico-Biological Interactions 32, 577-590.
    • (2004) Chemico-Biological Interactions , vol.32 , pp. 577-590
    • Vickers, A.E.1    Fisher, R.L.2
  • 17
    • 0026864194 scopus 로고
    • A stable long-term hepatocyte culture system for studies of physiologic processes: Cytokine stimulation of the acute phase in rat and human hepatocyte
    • Bader, A., Rinkes, I.H., Closs, E.I., Ryan, C.M., Toner, M., Cunningham, J.M., Tompkins, R.G. & Yarmush, M.L. (1992). A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase in rat and human hepatocyte. Biotechnology Progress 8, 219-225.
    • (1992) Biotechnology Progress , vol.8 , pp. 219-225
    • Bader, A.1    Rinkes, I.H.2    Closs, E.I.3    Ryan, C.M.4    Toner, M.5    Cunningham, J.M.6    Tompkins, R.G.7    Yarmush, M.L.8
  • 19
    • 0003874068 scopus 로고    scopus 로고
    • The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: The current status
    • Coecke, S., Rogiers, V., Bayliss, M., Castell, J., Doehmer, J., Fabre, G., Fry, J., Kern, A. & Westmoreland, C. (1999). The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: the current status. ATLA 27, 597-638.
    • (1999) ATLA , vol.27 , pp. 597-638
    • Coecke, S.1    Rogiers, V.2    Bayliss, M.3    Castell, J.4    Doehmer, J.5    Fabre, G.6    Fry, J.7    Kern, A.8    Westmoreland, C.9
  • 20
    • 0034839108 scopus 로고    scopus 로고
    • Summary: EU Standards measurements and testing projects PL95-3407. Development of a standardised in vitro methodology for hepatic and renal toxicity testing
    • Hartung, T. (2001). Summary: EU Standards measurements and testing projects PL95-3407. Development of a standardised in vitro methodology for hepatic and renal toxicity testing. ATLA 29, 493-495.
    • (2001) ATLA , vol.29 , pp. 493-495
    • Hartung, T.1
  • 22
    • 1542314570 scopus 로고    scopus 로고
    • Transepithelial resistance and inulin permeability as endpoints in in vitro nephrotoxicity testing
    • Duff, T., Carter, S., Feldman, G., McEwan, G., Pfaller, W., Rhodes, P., Ryan, M. & Hawksworth, G. (2002). Transepithelial resistance and inulin permeability as endpoints in in vitro nephrotoxicity testing. ATLA 30, 53-59.
    • (2002) ATLA , vol.30 , pp. 53-59
    • Duff, T.1    Carter, S.2    Feldman, G.3    McEwan, G.4    Pfaller, W.5    Rhodes, P.6    Ryan, M.7    Hawksworth, G.8
  • 24
    • 20044371666 scopus 로고    scopus 로고
    • The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics
    • Sambuy, Y., De Angelis, I., Ranaldi, G., Scarino, M.L., Stammati, A. & Zucco, F. (2005). The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biology and Toxicology 21, 1-26.
    • (2005) Cell Biology and Toxicology , vol.21 , pp. 1-26
    • Sambuy, Y.1    De Angelis, I.2    Ranaldi, G.3    Scarino, M.L.4    Stammati, A.5    Zucco, F.6
  • 25
    • 0033973754 scopus 로고    scopus 로고
    • Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: Permeabilities via diffusion, inside-and outside-directed carrier-mediated transport
    • Hilgendorf, C., Spahn-Langguth, H., Regardh, C.G., Lipka, E., Amidon, G.L. & Langguth, P. (2000). Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside-and outside-directed carrier-mediated transport. Journal of Pharmaceutical Sciences 89, 63-75.
    • (2000) Journal of Pharmaceutical Sciences , vol.89 , pp. 63-75
    • Hilgendorf, C.1    Spahn-Langguth, H.2    Regardh, C.G.3    Lipka, E.4    Amidon, G.L.5    Langguth, P.6
  • 26
    • 0020379671 scopus 로고
    • Enterocytic differentiation of cultured human colon cancer cells by replacement of glucose by galactose in the medium
    • Pinto, M., Appay, M.D., Simon-Assan, P., Chevalier, G., Dracopoli, N., Fogh, J. & Zweibaum, A. (1982). Enterocytic differentiation of cultured human colon cancer cells by replacement of glucose by galactose in the medium. Biology of the Cell 47, 193-196.
    • (1982) Biology of the Cell , vol.47 , pp. 193-196
    • Pinto, M.1    Appay, M.D.2    Simon-Assan, P.3    Chevalier, G.4    Dracopoli, N.5    Fogh, J.6    Zweibaum, A.7
  • 27
    • 0034807847 scopus 로고    scopus 로고
    • Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells
    • Behrens, I., Stenberg, P., Artursson, P. & Kissel, T. (2001). Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells. Pharmaceutical Research 18, 1138-1145.
    • (2001) Pharmaceutical Research , vol.18 , pp. 1138-1145
    • Behrens, I.1    Stenberg, P.2    Artursson, P.3    Kissel, T.4
  • 28
    • 0030827666 scopus 로고    scopus 로고
    • Maintenance of the differentiated type II cell phenotype by culture with an apical air surface
    • Dobbs, L.G., Pian, M.S., Maglio, M., Dumars, S. & Allen, L. (1997). Maintenance of the differentiated type II cell phenotype by culture with an apical air surface. American Journal of Physiology 273, L347-54.
    • (1997) American Journal of Physiology , vol.273
    • Dobbs, L.G.1    Pian, M.S.2    Maglio, M.3    Dumars, S.4    Allen, L.5
  • 29
    • 0035236614 scopus 로고    scopus 로고
    • Marker transport across biological barriers in vitro: Comparison of cell culture models for the gastrointestinal barrier, the blood-brain barrier and the alveolar epithelium of the lung
    • Gindorf, C., Steimerm A., Lehr, C.M., Bock, U., Schmitz, S. & Haltner, E. (2001). Marker transport across biological barriers in vitro: comparison of cell culture models for the gastrointestinal barrier, the blood-brain barrier and the alveolar epithelium of the lung. ALTEX 18, 155-164.
    • (2001) ALTEX , vol.18 , pp. 155-164
    • Gindorf, C.1    Steimerm, A.2    Lehr, C.M.3    Bock, U.4    Schmitz, S.5    Haltner, E.6
  • 30
    • 0035490411 scopus 로고    scopus 로고
    • Mechanisms of surfactant exocytosis in alveolar type II cells in vitro and in vivo
    • Dietl, P., Haller, T., Mair, N. & Frick, M. (2001). Mechanisms of surfactant exocytosis in alveolar type II cells in vitro and in vivo. News in Physiological Sciences 16, 239-243.
    • (2001) News in Physiological Sciences , vol.16 , pp. 239-243
    • Dietl, P.1    Haller, T.2    Mair, N.3    Frick, M.4
  • 34
    • 0033946184 scopus 로고    scopus 로고
    • Rat cortical neuron cultures: An in vitro model for differentiating mechanisms of chemically induced neurotoxicity
    • Schmuck, G., Ahr, H.J. & Schluter, G. (2000). Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity. In Vitro and Molecular Toxicology 13, 37-50.
    • (2000) In Vitro and Molecular Toxicology , vol.13 , pp. 37-50
    • Schmuck, G.1    Ahr, H.J.2    Schluter, G.3
  • 35
    • 0029185921 scopus 로고
    • Determination of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures
    • Forsby, A., Pilli, F., Bianchi, V. & Walum, E. (1995). Determination of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures. ATLA 23, 800-811.
    • (1995) ATLA , vol.23 , pp. 800-811
    • Forsby, A.1    Pilli, F.2    Bianchi, V.3    Walum, E.4
  • 36
    • 0030796951 scopus 로고    scopus 로고
    • Improved in vitro method for screening organophosphate-induced delayed polyneuropathy
    • Schmuck, G. & Ahr, H. (1997). Improved in vitro method for screening organophosphate-induced delayed polyneuropathy. Toxicology in Vitro 11, 263-270.
    • (1997) Toxicology in Vitro , vol.11 , pp. 263-270
    • Schmuck, G.1    Ahr, H.2
  • 37
    • 0003776785 scopus 로고    scopus 로고
    • Astrocytosis
    • (ed. M. Aschner & H.K. Kimelberg). Boca Raton, FL, USA: CRC Press
    • Norenberg, M.D. (1996). Astrocytosis. In The Role of Glia in Neurotoxicology (ed. M. Aschner & H.K. Kimelberg), pp. 93-110. Boca Raton, FL, USA: CRC Press.
    • (1996) The Role of Glia in Neurotoxicology , pp. 93-110
    • Norenberg, M.D.1
  • 39
    • 0037335027 scopus 로고    scopus 로고
    • Oligodendroglia in developmental neurotoxicity
    • Deng, W. & Poretz, R.D. (2003). Oligodendroglia in developmental neurotoxicity. Neurotoxicology 24, 161-178.
    • (2003) Neurotoxicology , vol.24 , pp. 161-178
    • Deng, W.1    Poretz, R.D.2
  • 40
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch, U.K. (2002). Microglia as a source and target of cytokines. Glia 40, 140-155.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 41
    • 0002424997 scopus 로고    scopus 로고
    • Aggregating neural cell cultures
    • (ed. S. Fedoroff & A. Richardson), 3rd edn, Totowa, NJ, USA: Humana Press
    • Honegger, P. & Monnet-Tschudi, F. (2001). Aggregating neural cell cultures. In Protocols for neural cell culture, (ed. S. Fedoroff & A. Richardson), 3rd edn, pp. 199-218, Totowa, NJ, USA: Humana Press.
    • (2001) Protocols for Neural Cell Culture , pp. 199-218
    • Honegger, P.1    Monnet-Tschudi, F.2
  • 42
    • 23644432411 scopus 로고    scopus 로고
    • Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin a in aggregating rat brain cell cultures
    • Zurich, M.G., Lengache, S., Braissant, O., Monnet-Tschudi, F., Pellerin, L. & Honegger, P. (2005). Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. Neuroscience 134, 771-782.
    • (2005) Neuroscience , vol.134 , pp. 771-782
    • Zurich, M.G.1    Lengache, S.2    Braissant, O.3    Monnet-Tschudi, F.4    Pellerin, L.5    Honegger, P.6
  • 44
    • 0031938377 scopus 로고    scopus 로고
    • Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures
    • Noraberg, J., Gramsbergen, J.B.P., Fonnum, F. & Zimmer, J. (1998). Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures. Brain Research 783, 305-315.
    • (1998) Brain Research , vol.783 , pp. 305-315
    • Noraberg, J.1    Gramsbergen, J.B.P.2    Fonnum, F.3    Zimmer, J.4
  • 46
    • 12344276497 scopus 로고    scopus 로고
    • Organotypic brain slice cultures: An efficient and reliable method for neurotoxicological screening and mechanistic studies
    • Noraberg, J. (2004). Organotypic brain slice cultures: An efficient and reliable method for neurotoxicological screening and mechanistic studies. ATLA 32, 329-337.
    • (2004) ATLA , vol.32 , pp. 329-337
    • Noraberg, J.1
  • 47
    • 0002588601 scopus 로고
    • The basic biology of haemopoiesis
    • (ed. D. Metcalf). Amsterdam, The Netherlands: Elsevier
    • Metcalf, D. (1984). The basic biology of haemopoiesis. In The Haemopoietic Colony Stimulating Factors (ed. D. Metcalf), pp. 1-26. Amsterdam, The Netherlands: Elsevier.
    • (1984) The Haemopoietic Colony Stimulating Factors , pp. 1-26
    • Metcalf, D.1
  • 48
    • 0023568307 scopus 로고
    • The molecular control of blood cell development
    • Sachs, L. (1987). The molecular control of blood cell development. Science, New York 238, 1374-1379.
    • (1987) Science, New York , vol.238 , pp. 1374-1379
    • Sachs, L.1
  • 50
    • 0027460675 scopus 로고
    • Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor
    • Neben, S., Marcus, K. & Mauch, P. (1993). Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81, 1960-1967.
    • (1993) Blood , vol.81 , pp. 1960-1967
    • Neben, S.1    Marcus, K.2    Mauch, P.3
  • 51
    • 0004265301 scopus 로고
    • Testa, N. & Molineux, G., eds. 317pp. New York, NY, USA: Oxford University Press
    • Testa, N. & Molineux, G., eds (1993). Haemopoiesis. A Practical Approach. 317pp. New York, NY, USA: Oxford University Press.
    • (1993) Haemopoiesis. A Practical Approach
  • 52
    • 0029151176 scopus 로고
    • Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures
    • Lemieux, M.E., Rebel, V.I., Lansdorp, P.M. & Eaves, C.J. (1995) Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures. Blood 86, 1339-1347.
    • (1995) Blood , vol.86 , pp. 1339-1347
    • Lemieux, M.E.1    Rebel, V.I.2    Lansdorp, P.M.3    Eaves, C.J.4
  • 53
    • 0024388891 scopus 로고
    • An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse
    • Ploemacher, R.E., van der Sluijs, J.P., Voerman, J.S. & Brons, N.H. (1989). An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74, 2755-2763.
    • (1989) Blood , vol.74 , pp. 2755-2763
    • Ploemacher, R.E.1    Van Der Sluijs, J.P.2    Voerman, J.S.3    Brons, N.H.4
  • 55
    • 21544448884 scopus 로고    scopus 로고
    • Improved early clinical development through human microdosing studies
    • Wilding, I.R. & Bell, J.A. (2005). Improved early clinical development through human microdosing studies. Drug Discovery Today 10, 890-894.
    • (2005) Drug Discovery Today , vol.10 , pp. 890-894
    • Wilding, I.R.1    Bell, J.A.2
  • 56
    • 0003139527 scopus 로고
    • Long-term cytotoxicity testing of the first twenty MEIC chemicals by the determination of the protein content in human embryonic lung cells
    • Dierickx, P.J. & Ekwall, B. (1992). Long-term cytotoxicity testing of the first twenty MEIC chemicals by the determination of the protein content in human embryonic lung cells. ATLA 20, 285-289.
    • (1992) ATLA , vol.20 , pp. 285-289
    • Dierickx, P.J.1    Ekwall, B.2
  • 57
    • 0001951416 scopus 로고
    • Long-term cytotoxicity testing of the MEIC chemicals 21-50 by determination of the protein content in human embryonic lung cells
    • Dierickx, P.J. & Ekwall, B. (1993). Long-term cytotoxicity testing of the MEIC chemicals 21-50 by determination of the protein content in human embryonic lung cells. ALTEX 2, 33-36.
    • (1993) ALTEX , vol.2 , pp. 33-36
    • Dierickx, P.J.1    Ekwall, B.2
  • 58
    • 0032978503 scopus 로고    scopus 로고
    • EDIT: A new international multicentre programme to develop and evaluate batteries of in vitro tests for acute and chronic systemic toxicity
    • Ekwall, B., Cledmenson, C., Ekwall, C., Ring, P. & Romert, L. (1999). EDIT: a new international multicentre programme to develop and evaluate batteries of in vitro tests for acute and chronic systemic toxicity. ATLA 27, 339-349.
    • (1999) ATLA , vol.27 , pp. 339-349
    • Ekwall, B.1    Cledmenson, C.2    Ekwall, C.3    Ring, P.4    Romert, L.5
  • 61
    • 0022455504 scopus 로고
    • Complete response to vasopressin requires epithelial organization in A6 cells in culture
    • Lang, M.A., Muller, J., Preston, A.S. & Handler, J.S. (1986). Complete response to vasopressin requires epithelial organization in A6 cells in culture. American Journal of Physiology 250, C138-145.
    • (1986) American Journal of Physiology , vol.250
    • Lang, M.A.1    Muller, J.2    Preston, A.S.3    Handler, J.S.4
  • 62
    • 0026580557 scopus 로고
    • A new method culturing renal cells under permanent superfusion and producing a luminal-basal medium gradient
    • Minuth, W.W., Dermietzel, R., Kloth, S. & Hennerkes, B. (1992). A new method culturing renal cells under permanent superfusion and producing a luminal-basal medium gradient. Kidney International 41, 215-219.
    • (1992) Kidney International , vol.41 , pp. 215-219
    • Minuth, W.W.1    Dermietzel, R.2    Kloth, S.3    Hennerkes, B.4
  • 63
    • 0035991228 scopus 로고    scopus 로고
    • LLC-PK1 cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism
    • Felder, E., Jennings, P., Seppi, T. & Pfaller, W. (2002). LLC-PK1 cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism. Cellular Physiology and Biochemistry 12, 153-162.
    • (2002) Cellular Physiology and Biochemistry , vol.12 , pp. 153-162
    • Felder, E.1    Jennings, P.2    Seppi, T.3    Pfaller, W.4
  • 64
    • 0037390828 scopus 로고    scopus 로고
    • Quantitative on-line monitoring of hippocampus glucose and lactate metabolism in organotypic cultures using biosensor technology
    • Gramsbergen, J.B., Leegsma-Vogt, G., Venema, K., Noraberg, J. & Korf, J. (2003). Quantitative on-line monitoring of hippocampus glucose and lactate metabolism in organotypic cultures using biosensor technology. Journal of Neurochemistry 85, 399-408.
    • (2003) Journal of Neurochemistry , vol.85 , pp. 399-408
    • Gramsbergen, J.B.1    Leegsma-Vogt, G.2    Venema, K.3    Noraberg, J.4    Korf, J.5
  • 65
    • 33746300735 scopus 로고    scopus 로고
    • A novel perfusion cell culture system for acute, repeat dose and long term toxicity testing
    • Pfaller, W., Jennings, P., Lechleitner, T. & Abberger, T. (2005). A novel perfusion cell culture system for acute, repeat dose and long term toxicity testing. ALTEX 22, Special Issue, 337.
    • (2005) ALTEX , vol.22 , pp. 337
    • Pfaller, W.1    Jennings, P.2    Lechleitner, T.3    Abberger, T.4
  • 66
    • 5044222331 scopus 로고    scopus 로고
    • Modelling of mammalian cells and cell culture processes
    • Sidoli, F.R., Mantalaris, A. & Asprey, S.P. (2004). Modelling of mammalian cells and cell culture processes. Cytotechnology 44, 27-46.
    • (2004) Cytotechnology , vol.44 , pp. 27-46
    • Sidoli, F.R.1    Mantalaris, A.2    Asprey, S.P.3
  • 67
    • 33746299393 scopus 로고    scopus 로고
    • Evaluation of perfusion culture for investigating the toxic effects of cadmium chloride to two renal epithelial cell lines
    • Abberger, T., Jennings, P. & Pfaller, W. (2005). Evaluation of perfusion culture for investigating the toxic effects of cadmium chloride to two renal epithelial cell lines. ALTEX 22, Special Issue, 324.
    • (2005) ALTEX , vol.22 , Issue.SPEC. ISSUE , pp. 324
    • Abberger, T.1    Jennings, P.2    Pfaller, W.3
  • 68
    • 0035900334 scopus 로고    scopus 로고
    • Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures
    • Jakobsen, B. & Zimmer, J. (2001). Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures. Neuroreport 12, 3593-3597,
    • (2001) Neuroreport , vol.12 , pp. 3593-3597
    • Jakobsen, B.1    Zimmer, J.2
  • 69
    • 0032487572 scopus 로고    scopus 로고
    • Ethanol induces MAP2 changes in organotypic hippocampal slice cultures
    • Noraberg, J. & Zimmer, J. (1998). Ethanol induces MAP2 changes in organotypic hippocampal slice cultures. Neuroreport 9, 3177-3182.
    • (1998) Neuroreport , vol.9 , pp. 3177-3182
    • Noraberg, J.1    Zimmer, J.2
  • 70
    • 0028136651 scopus 로고
    • Selective degeneration of CA1 pyramidal cells by chronic application of bismuth
    • Muller, M., Rietschin, L., Grogg, F., Streit, P. & Gähwiler, B.H. (1994). Selective degeneration of CA1 pyramidal cells by chronic application of bismuth. Hippocampus 4, 204-209.
    • (1994) Hippocampus , vol.4 , pp. 204-209
    • Muller, M.1    Rietschin, L.2    Grogg, F.3    Streit, P.4    Gähwiler, B.H.5
  • 72
    • 0036754015 scopus 로고    scopus 로고
    • Long term in vitro toxicity models: Comparisons between a flow cell bioreactor, a static cell bioreactor, and static cell cultures
    • Pazos, P., Fontaner, S. & Prieto, P. (2002). Long term in vitro toxicity models: comparisons between a flow cell bioreactor, a static cell bioreactor, and static cell cultures. ATLA 30, 515-523.
    • (2002) ATLA , vol.30 , pp. 515-523
    • Pazos, P.1    Fontaner, S.2    Prieto, P.3
  • 75
    • 0031896803 scopus 로고    scopus 로고
    • Gamma-glutamyltranspeptidase is a reliable marker for tubular effects of contras media
    • Donadio, C., Tramonti, G., Lucchesi, A., Giordani, R., Lucchetti, A. & Bianchi, C. (1998). Gamma-glutamyltranspeptidase is a reliable marker for tubular effects of contras media. Renal Failure 20, 319-324.
    • (1998) Renal Failure , vol.20 , pp. 319-324
    • Donadio, C.1    Tramonti, G.2    Lucchesi, A.3    Giordani, R.4    Lucchetti, A.5    Bianchi, C.6
  • 76
    • 18144448921 scopus 로고    scopus 로고
    • Glutathione S-transferases as biomarkers of organ damage: Applications of rodent and canine GST enzyme immunoassays
    • Kilty, C., Doyle, S., Hassett, B. & Manning, F. (1998). Glutathione S-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays. Chemico-Biological Interactions 111-112, 123-135.
    • (1998) Chemico-Biological Interactions , vol.111-112 , pp. 123-135
    • Kilty, C.1    Doyle, S.2    Hassett, B.3    Manning, F.4
  • 78
    • 25144460253 scopus 로고    scopus 로고
    • Cyclosporine a-induced renal fibrosis: A role for epithelial-mesenchymal transition
    • Slattery, C., Campbell, E., McMorrow, T. & Ryan, M.P. (2005). Cyclosporine a-induced renal fibrosis: a role for epithelial-mesenchymal transition. American Journal of Pathology 167, 395-407.
    • (2005) American Journal of Pathology , vol.167 , pp. 395-407
    • Slattery, C.1    Campbell, E.2    McMorrow, T.3    Ryan, M.P.4
  • 79
    • 13244258397 scopus 로고    scopus 로고
    • Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics
    • Karp, N.A., Griffin, J.L. & Lilley, K.S. (2005). Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics. Proteomics 5, 81-90.
    • (2005) Proteomics , vol.5 , pp. 81-90
    • Karp, N.A.1    Griffin, J.L.2    Lilley, K.S.3
  • 82
    • 0036975148 scopus 로고    scopus 로고
    • Pattern recognition techniques in microarray data analysis
    • Valafar, F. (2002). Pattern recognition techniques in microarray data analysis. Annals of the New York Academy of Science 980, 41-64.
    • (2002) Annals of the New York Academy of Science , vol.980 , pp. 41-64
    • Valafar, F.1
  • 84
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • Griffin, J.L. (2003). Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Current Opinion in Chemical Biology 7, 648-654.
    • (2003) Current Opinion in Chemical Biology , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 86
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • Robertson, D.G. (2005). Metabonomics in toxicology: a review. Toxicological Science 85, 809-822.
    • (2005) Toxicological Science , vol.85 , pp. 809-822
    • Robertson, D.G.1
  • 88
    • 0031752760 scopus 로고    scopus 로고
    • Apoptosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line
    • Healy, E., Dempsey, M., Lally, C. & Ryan, M.P. (1998). Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line. Kidney International 54, 1955-1966.
    • (1998) Kidney International , vol.54 , pp. 1955-1966
    • Healy, E.1    Dempsey, M.2    Lally, C.3    Ryan, M.P.4
  • 89
    • 0034830268 scopus 로고    scopus 로고
    • Use of flow cytometry and confocal microscopy techniques to investigate early CdCl(2)-induced nephrotoxicity in vitro
    • Alvarez-Barrientos, A., O'Connor, J.E., Nieto Castillo, R., Moreno Moreno, A.B. & Prieto, P. (2001). Use of flow cytometry and confocal microscopy techniques to investigate early CdCl(2)-induced nephrotoxicity in vitro. Toxicology in Vitro 15, 407-412.
    • (2001) Toxicology in Vitro , vol.15 , pp. 407-412
    • Alvarez-Barrientos, A.1    O'Connor, J.E.2    Nieto Castillo, R.3    Moreno Moreno, A.B.4    Prieto, P.5
  • 91
    • 33746303232 scopus 로고    scopus 로고
    • Telomics: Tissue-based screening for target validation and preclinical drug development
    • Striggow, F., Röhnert, P. & Reymann, K. (2002). Telomics: Tissue-based screening for target validation and preclinical drug development. New Drugs 1, 30-36.
    • (2002) New Drugs , vol.1 , pp. 30-36
    • Striggow, F.1    Röhnert, P.2    Reymann, K.3
  • 92
    • 22244446418 scopus 로고    scopus 로고
    • Application of emerging technologies in toxicology and safety assessment: Regulatory perspectives
    • Leighton, J.K. (2005). Application of emerging technologies in toxicology and safety assessment: regulatory perspectives. International Journal of Toxicology 24, 153-155.
    • (2005) International Journal of Toxicology , vol.24 , pp. 153-155
    • Leighton, J.K.1
  • 93
    • 22244456357 scopus 로고    scopus 로고
    • Understanding biology through bioinformatics
    • Rajpal, D.K. (2005). Understanding biology through bioinformatics. International Journal of Toxicology 24, 147-152.
    • (2005) International Journal of Toxicology , vol.24 , pp. 147-152
    • Rajpal, D.K.1
  • 94
    • 22144449591 scopus 로고    scopus 로고
    • Ushering in the new toxicology: Toxicogenomics and the public interest
    • Balbus, J.M. (2005). Ushering in the new toxicology: toxicogenomics and the public interest. Environmental Health Perspectives 113, 818-22.
    • (2005) Environmental Health Perspectives , vol.113 , pp. 818-822
    • Balbus, J.M.1
  • 96
  • 97
    • 27144452891 scopus 로고    scopus 로고
    • Systems toxicology: Applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
    • Heijne, W.H., Kienhuis, A.S., van Ommen, B., Stierum, R.H. & Groten, J.P. (2005). Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology. Expert Review of Proteomics 2, 767-780.
    • (2005) Expert Review of Proteomics , vol.2 , pp. 767-780
    • Heijne, W.H.1    Kienhuis, A.S.2    Van Ommen, B.3    Stierum, R.H.4    Groten, J.P.5
  • 98
    • 17944378642 scopus 로고    scopus 로고
    • Veterinary pharmacovigilance. Part 6. Predictability of adverse reactions in animals from laboratory toxicology studies
    • Woodward, K.N. (2005). Veterinary pharmacovigilance. Part 6. Predictability of adverse reactions in animals from laboratory toxicology studies. Journal of Veterinary Pharmacology and Therapeutics 28, 213-231.
    • (2005) Journal of Veterinary Pharmacology and Therapeutics , vol.28 , pp. 213-231
    • Woodward, K.N.1
  • 99
    • 3142719058 scopus 로고    scopus 로고
    • The evolution of safety assessments for veterinary medicinal products in the European Union
    • Woodward, K. (2004). The evolution of safety assessments for veterinary medicinal products in the European Union. Veterinary and Human Toxicology 46, 199-205.
    • (2004) Veterinary and Human Toxicology , vol.46 , pp. 199-205
    • Woodward, K.1
  • 101
    • 0037452436 scopus 로고    scopus 로고
    • Toxicokinetic modeling and its applications in chemical risk assessment
    • Andersen, M.E. (2003). Toxicokinetic modeling and its applications in chemical risk assessment. Toxicology Letters 138, 9-27.
    • (2003) Toxicology Letters , vol.138 , pp. 9-27
    • Andersen, M.E.1
  • 102
    • 0036298076 scopus 로고    scopus 로고
    • The applicability of in vitro-derived data in hazard identification and characterisation of chemicals
    • Blaauboer, B.J. (2002). The applicability of in vitro-derived data in hazard identification and characterisation of chemicals. Environmental Toxicology and Pharmacology 11, 213-225.
    • (2002) Environmental Toxicology and Pharmacology , vol.11 , pp. 213-225
    • Blaauboer, B.J.1
  • 103
    • 0036975586 scopus 로고    scopus 로고
    • The necessity of biokinetic information in the interpretation of in vitro toxicity data
    • Blaauboer, B.J. (2002). The necessity of biokinetic information in the interpretation of in vitro toxicity data. ATLA 30, 85-91.
    • (2002) ATLA , vol.30 , pp. 85-91
    • Blaauboer, B.J.1
  • 104
    • 0025974062 scopus 로고
    • Development and utilization of physiologically based models for toxicological applications
    • Leung, H.W. (1991). Development and utilization of physiologically based models for toxicological applications. Journal of Toxicology and Environmental Health 32, 247-267.
    • (1991) Journal of Toxicology and Environmental Health , vol.32 , pp. 247-267
    • Leung, H.W.1
  • 106
    • 0026170520 scopus 로고
    • Physiological modelling of organic compounds
    • Andersen, M.E. (1991). Physiological modelling of organic compounds. Annals of Occupational Hygiene 35, 309-321.
    • (1991) Annals of Occupational Hygiene , vol.35 , pp. 309-321
    • Andersen, M.E.1
  • 107
    • 0002715928 scopus 로고
    • A multiple dose-route physiological model for volatile chemicals using ACSL/PC
    • (ed. F.D. Cellier). San Diego, CA, USA: Society for Computer Simulation
    • Clewell, H.J. & Andersen, M.E. (1986). A multiple dose-route physiological model for volatile chemicals using ACSL/PC. In Languages for Continuous Simulation (ed. F.D. Cellier), pp. 95-110. San Diego, CA, USA: Society for Computer Simulation.
    • (1986) Languages for Continuous Simulation , pp. 95-110
    • Clewell, H.J.1    Andersen, M.E.2
  • 108
    • 0022410469 scopus 로고
    • Skin penetration and metabolism of topically applied chemicals in six mammalian species, including man: An in vitro study with benzo(a)pyrene and testosterone
    • Kao, J., Patterson, K. & Hall, J. (1985). Skin penetration and metabolism of topically applied chemicals in six mammalian species, including man: an in vitro study with benzo(a)pyrene and testosterone. Toxicology and Applied Pharmacology 81, 502-516.
    • (1985) Toxicology and Applied Pharmacology , vol.81 , pp. 502-516
    • Kao, J.1    Patterson, K.2    Hall, J.3
  • 109
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans an apparent drug permeability coefficients in human intestinal epithelial (CACO-2) cells
    • Artursson, P. & Karlsson, J. (1991). Correlation between oral drug absorption in humans an apparent drug permeability coefficients in human intestinal epithelial (CACO-2) cells. Biochemical and Biophysical Research Communications 175, 880-885.
    • (1991) Biochemical and Biophysical Research Communications , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 110
    • 0026504445 scopus 로고
    • In vitro skin permeation techniques
    • Friend, D.R. (1992). In vitro skin permeation techniques. Journal of Controlled Release 18, 235-248.
    • (1992) Journal of Controlled Release , vol.18 , pp. 235-248
    • Friend, D.R.1
  • 112
    • 0002544211 scopus 로고
    • Absorption, distribution and metabolism of drugs
    • (ed. J.G. Topliss). New York, NY, USA: Academic Press
    • Austel, V. & Kutter, E. (1983). Absorption, distribution and metabolism of drugs. In Quantitative-structure activity relationships of drugs (ed. J.G. Topliss), pp. 437-496. New York, NY, USA: Academic Press.
    • (1983) Quantitative-Structure Activity Relationships of Drugs , pp. 437-496
    • Austel, V.1    Kutter, E.2
  • 114
    • 0032795192 scopus 로고    scopus 로고
    • Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
    • Clark, D.E. (1999). Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption. Journal of Pharmaceutical Sciences 88, 807-814.
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , pp. 807-814
    • Clark, D.E.1
  • 116
    • 0026457029 scopus 로고
    • Methods of determining plasma and tissue binding of drugs
    • Pacifici, G.M. & Viani, A. (1992). Methods of determining plasma and tissue binding of drugs. Clinical Pharmacokinetics 23, 449-468.
    • (1992) Clinical Pharmacokinetics , vol.23 , pp. 449-468
    • Pacifici, G.M.1    Viani, A.2
  • 118
    • 0028925028 scopus 로고
    • A biologically-based algorithm for predicting human tissue: Blood partition coefficients of organic chemicals
    • Poulin, P. & Krishnan, K. (1995). A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals. Human and Experimental Toxicology 14, 273-280.
    • (1995) Human and Experimental Toxicology , vol.14 , pp. 273-280
    • Poulin, P.1    Krishnan, K.2
  • 119
    • 0029144723 scopus 로고
    • An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octanol:water partition coefficient data
    • Poulin, P. & Krishnan, K. (1995). An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octanol:water partition coefficient data. Journal of Toxicology and Environmental Health 46, 101-113.
    • (1995) Journal of Toxicology and Environmental Health , vol.46 , pp. 101-113
    • Poulin, P.1    Krishnan, K.2
  • 120
    • 0030052475 scopus 로고    scopus 로고
    • A tissue composition-based algorithm for predicting tissue:air partition coefficients or organic chemicals
    • Poulin, P. & Krishnan, K. (1996). A tissue composition-based algorithm for predicting tissue:air partition coefficients or organic chemicals. Toxicology and Applied Pharmacology 136, 126-130.
    • (1996) Toxicology and Applied Pharmacology , vol.136 , pp. 126-130
    • Poulin, P.1    Krishnan, K.2
  • 121
    • 0030048152 scopus 로고    scopus 로고
    • A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin
    • Poulin, P. & Krishnan, K. (1996). A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin. Toxicology and Applied Pharmacology 136, 131-137.
    • (1996) Toxicology and Applied Pharmacology , vol.136 , pp. 131-137
    • Poulin, P.1    Krishnan, K.2
  • 122
    • 0031413080 scopus 로고    scopus 로고
    • A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans
    • DeJongh, J., Verhaar, H.J. & Hermens, J.L. (1997). A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans. Archives of Toxicology 72, 17-25.
    • (1997) Archives of Toxicology , vol.72 , pp. 17-25
    • DeJongh, J.1    Verhaar, H.J.2    Hermens, J.L.3
  • 123
    • 0031722692 scopus 로고    scopus 로고
    • Role of kinetics in acute lethality of nonreactive volatile organic compounds (VOCs)
    • DeJongh, J., Verhaar, H.J. & Hermens, J.L. (1998). Role of kinetics in acute lethality of nonreactive volatile organic compounds (VOCs). Toxicological Sciences 45, 26-32.
    • (1998) Toxicological Sciences , vol.45 , pp. 26-32
    • DeJongh, J.1    Verhaar, H.J.2    Hermens, J.L.3
  • 126
    • 0025604621 scopus 로고
    • Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate
    • Gearhart, J.M., Jepson, G.W., Clewell, H., Andersen, M.E. & Conolly, R.B. (1990). Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Toxicology and Applied Pharmacology 106, 295-310.
    • (1990) Toxicology and Applied Pharmacology , vol.106 , pp. 295-310
    • Gearhart, J.M.1    Jepson, G.W.2    Clewell, H.3    Andersen, M.E.4    Conolly, R.B.5
  • 127
    • 0030850023 scopus 로고    scopus 로고
    • Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam
    • Carlile, D.J., Zomorodi, K. & Houston, J.B. (1997). Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam. Drug Metabolism and Disposition 25, 903-911.
    • (1997) Drug Metabolism and Disposition , vol.25 , pp. 903-911
    • Carlile, D.J.1    Zomorodi, K.2    Houston, J.B.3
  • 128
    • 0344333422 scopus 로고    scopus 로고
    • Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices
    • Houston, J.B. & Carlile, D.J. (1997). Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug Metabolism Reviews 29, 891-922.
    • (1997) Drug Metabolism Reviews , vol.29 , pp. 891-922
    • Houston, J.B.1    Carlile, D.J.2
  • 129
    • 0030856209 scopus 로고    scopus 로고
    • Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models
    • Houston, J.B. & Carlile, D.J. (1997). Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models. Toxicology in Vitro 11, 473-478.
    • (1997) Toxicology in Vitro , vol.11 , pp. 473-478
    • Houston, J.B.1    Carlile, D.J.2
  • 130
    • 0001815771 scopus 로고
    • In vitro toxicity testing: Purpose, validation and strategy
    • Flint, O.P. (1990). In vitro toxicity testing: purpose, validation and strategy. ATLA 18, 11-18.
    • (1990) ATLA , vol.18 , pp. 11-18
    • Flint, O.P.1
  • 131
    • 0000319985 scopus 로고
    • The use of liver cell cultures derived from different mammalian species in in vitro toxicological studies: Implementation in extrapolation models?
    • Blaauboer, B.J., Wortelboer, H.M. & Mennes, W.C (1990). The use of liver cell cultures derived from different mammalian species in in vitro toxicological studies: implementation in extrapolation models? ATLA 18, 251-258.
    • (1990) ATLA , vol.18 , pp. 251-258
    • Blaauboer, B.J.1    Wortelboer, H.M.2    Mennes, W.C.3
  • 133
    • 21844473983 scopus 로고    scopus 로고
    • Alternative (non animal) methods for cosmetic testing: Current status and future prospects. A report prepared in the context of the 7th Amendment of the Cosmetic Directive for establishing timetables for phasing out animal testing
    • Eskes, C. & Zuang, V., eds
    • Eskes, C. & Zuang, V., eds (2005). Alternative (non animal) methods for cosmetic testing: current status and future prospects. A report prepared in the context of the 7th Amendment of the Cosmetic Directive for establishing timetables for phasing out animal testing. ATLA 33, Suppl. 1, 1-228.
    • (2005) ATLA , vol.33 , Issue.SUPPL. 1 , pp. 1-228
  • 134
    • 0032916246 scopus 로고    scopus 로고
    • The integrated use of alternative methods in toxicological risk evaluation. ECVAM Integrated Testing Strategies Task Force Report 1
    • Blaauboer, B.J., Barratt, M.D. & Houston, J.B. (1999). The integrated use of alternative methods in toxicological risk evaluation. ECVAM Integrated Testing Strategies Task Force Report 1. ATLA 27, 229-237.
    • (1999) ATLA , vol.27 , pp. 229-237
    • Blaauboer, B.J.1    Barratt, M.D.2    Houston, J.B.3
  • 136
    • 0034997156 scopus 로고    scopus 로고
    • Factors influencing nominal effective concentrations of chemical compounds in vitro: Cell concentration
    • Gulden, M., Morchel, S. & Seibert, H. (2001). Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Toxicology in Vitro 15, 233-243.
    • (2001) Toxicology in Vitro , vol.15 , pp. 233-243
    • Gulden, M.1    Morchel, S.2    Seibert, H.3
  • 137
    • 0037076918 scopus 로고    scopus 로고
    • Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro
    • Gulden, M., Morchel, S., Tahan, S. & Seibert, H. (2002). Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology 175, 201-213.
    • (2002) Toxicology , vol.175 , pp. 201-213
    • Gulden, M.1    Morchel, S.2    Tahan, S.3    Seibert, H.4
  • 138
    • 0038798679 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation: Estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro
    • Gulden, M. & Seibert, H. (2003). In vitro-in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro. Toxicology 189, 211-222.
    • (2003) Toxicology , vol.189 , pp. 211-222
    • Gulden, M.1    Seibert, H.2
  • 139
    • 0037415394 scopus 로고    scopus 로고
    • Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay
    • Gulden, M., Morchel, S. & Seibert, H. (2003). Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicology Letters 137, 159-168.
    • (2003) Toxicology Letters , vol.137 , pp. 159-168
    • Gulden, M.1    Morchel, S.2    Seibert, H.3
  • 140
    • 0036616438 scopus 로고    scopus 로고
    • Factors influencing nominal effective concentrations of chemical compounds in vitro: Medium protein concentration
    • Seibert, H., Morchel, S. & Gulden, M. (2002). Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicology in Vitro 16, 289-297.
    • (2002) Toxicology in Vitro , vol.16 , pp. 289-297
    • Seibert, H.1    Morchel, S.2    Gulden, M.3
  • 142
    • 0003188910 scopus 로고
    • Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances
    • EEC (1967). Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances. Official Journal of the European Economic Community 196, 1-98.
    • (1967) Official Journal of the European Economic Community , vol.196 , pp. 1-98
  • 152
    • 8444237430 scopus 로고    scopus 로고
    • Metabolic and structural viability of precision-cut rat lung slices in culture
    • Umachandran, M., Howarth, J. & Ioannides, C. (2004). Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 34, 771-780.
    • (2004) Xenobiotica , vol.34 , pp. 771-780
    • Umachandran, M.1    Howarth, J.2    Ioannides, C.3
  • 153
    • 0033153096 scopus 로고    scopus 로고
    • The myeloid-lymphoid initiating cell (ML-IC) assay-assesses the fate of multipotent human progenitors in vitro
    • Punzel, M., Wissink, S.D., Miller, J.S., Moore, K.A., Lemischka, I.R. & Verfaillie, C.M. (1999). The myeloid-lymphoid initiating cell (ML-IC) assay-assesses the fate of multipotent human progenitors in vitro. Blood 93, 3750-3756.
    • (1999) Blood , vol.93 , pp. 3750-3756
    • Punzel, M.1    Wissink, S.D.2    Miller, J.S.3    Moore, K.A.4    Lemischka, I.R.5    Verfaillie, C.M.6
  • 154
    • 0025764473 scopus 로고
    • Blast colony-forming cells and precursors of colony-forming cells
    • Bernstein, I.D., Leary, A.G., Andrews, R.G. & Ogawa, M. (1991). Blast colony-forming cells and precursors of colony-forming cells detectable in long-term marrow culture express the same phenotype (CD33- CD34+). Experimental Hematology 19, 680-682.
    • (1991) Experimental Hematology , vol.19 , pp. 680-682
    • Bernstein, I.D.1    Leary, A.G.2    Andrews, R.G.3    Ogawa, M.4
  • 155
    • 0023620973 scopus 로고
    • Generation of murine hematopoietic precursor cells from macrophage high-proliferative-potential colony-forming cells
    • McNiece, I.K., Williams, N.T., Johnson, G.R., Kriegler, A.B., Bradley, T.R. & Hodgson, G.S. (1987). Generation of murine hematopoietic precursor cells from macrophage high-proliferative-potential colony-forming cells. Experimental Hematology 15, 972-977.
    • (1987) Experimental Hematology , vol.15 , pp. 972-977
    • McNiece, I.K.1    Williams, N.T.2    Johnson, G.R.3    Kriegler, A.B.4    Bradley, T.R.5    Hodgson, G.S.6


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