How to assess the mutagenic potential of cosmetic products without animal tests?

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 678, Issue 2, 2009, Pages 108-112

  Speit, Günter ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Genotoxicity testing; Hair dyes; In vitro tests; In vivo tests; New tests; Test strategy

Indexed keywords

HAIR DYE;

ADSORPTION; ASSAY; CELL LINE; CHEMISTRY; CLINICAL ASSESSMENT; CLINICAL RESEARCH; COMPREHENSION; CYTOTOXICITY; DECISION MAKING; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EUROPE; EVALUATION; FOLLOW UP; GENETIC ENGINEERING; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INFORMATION; MARKETING; METABOLIC ACTIVATION; MUTAGENICITY; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SKIN; SKIN CELL; TIME; VALIDATION STUDY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOTRANSFORMATION; CELL LINE; COSMETICS; MUTAGENICITY TESTS; MUTAGENS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ANIMALIA;

EID: 69449083458     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.04.006     Document Type: Review

References (17)

1. Kirkland D.J., Henderson L., Marzin D., Muller L., Parry J.M., Speit G., Tweats D.J., and Williams G.M. Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes. Mutat. Res. 588 (2005) 88-105
2. Pfuhler S., Albertini S., Fautz R., Herbold B., Madle S., Utesch D., and Poth A. Genetic toxicity assessment: employing the best science for human safety evaluation. Part IV. Recommendation of a working group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a simple and straightforward approach to genotoxicity testing. Toxicol. Sci. 97 (2007) 237-240
3. Bolt H.M., and Golka K. The debate on carcinogenicity of permanent hair dyes: new insights. Crit. Rev. Toxicol. 37 (2007) 521-536
4. Brendler-Schwaab S., Hartmann A., Pfuhler S., and Speit G. The in vivo comet assay: use and status in genotoxicity testing. Mutagenesis 20 (2005) 245-254
5. Aaron C.S., Bolcsfoldi G., Glatt H.R., Moore M., Nishi Y., Stankowski L., Theiss J., and Thompson E. Mammalian cell gene mutation assays working group report. Mutat. Res. 312 (1994) 235-239
6. Kirkland D., and Speit G. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. III. Appropriate follow-up testing in vivo. Mutat. Res. 654 (2008) 114-132
7. Kirkland D., Pfuhler S., Tweats D., Aardema M., Corvi R., Darroudi F., Elhajouji A., Glatt H., Hastwell P., Hayashi M., Kasper P., Kirchner S., Lynch A., Marzin D., Maurici D., Meunier J.R., Muller L., Nohynek G., Parry J., Parry E., Thybaud V., Tice R., van Benthem J., Vanparys P., and White P. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM workshop. Mutat. Res. 628 (2007) 31-55
8. Tweats D.J., Scott A.D., Westmoreland C., and Carmichael P.L. Determination of genetic toxicity and potential carcinogenicity in vitro-challenges post the Seventh Amendment to the European Cosmetics Directive. Mutagenesis 22 (2007) 5-13
9. Flamand N., Marrot L., Belaidi J.P., Bourouf L., Dourille E., Feltes M., and Meunier J.R. Development of genotoxicity test procedures with Episkin, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds?. Mutat. Res. 606 (2006) 39-51
10. Curren R.D., Mun G.C., Gibson D.P., and Aardema M.J. Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm). Mutat. Res. 607 (2006) 192-204
11. Hu T., Kaluzhny Y., Mun G.C., Barnett B., Karetsky V., Wilt N., Klausner M., Curren R.D., and Aardema M.J. Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay. Mutat. Res. 673 (2009) 100-108
12. Kirkland D., Kasper P., Muller L., Corvi R., and Speit G. Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop. Mutat. Res. 653 (2008) 99-108
13. Kirkland D.J., Aardema M., Banduhn N., Carmichael P., Fautz R., Meunier J.R., and Pfuhler S. In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results. Mutagenesis 22 (2007) 161-175
14. Doak S.H., Jenkins G.J., Johnson G.E., Quick E., Parry E.M., and Parry J.M. Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res. 67 (2007) 3904-3911
15. Speit G., Schutz P., Hogel J., and Schmid O. Characterization of the genotoxic potential of formaldehyde in V79 cells. Mutagenesis 22 (2007) 387-394
16. Kroes R., Renwick A.G., Feron V., Galli C.L., Gibney M., Greim H., Guy R.H., Lhuguenot J.C., and van de Sandt J.J. Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem. Toxicol. 45 (2007) 2533-2562
17. Maurici D., Aardema M., Corvi R., Kleber M., Krul C., Laurent C., Loprieno N., Pasanen M., Pfuhler S., Phillips B., Sabbioni E., Sanner T., and Vanparys P. Establishment of timetables for the phasing out of animal experiments for cosmetics. Altern. Lab. Anim. 33 (2005) 117-130