Validation of in vitro screening models for progestagenic activities: Inter-assay comparison and correlation with in vivo activity in rabbits

Toxicology in Vitro

Volumn 25, Issue 2, 2011, Pages 545-554

  Sonneveld, Edwin ^a,c   Pieterse, Bart ^a   Schoonen, Willem G ^b   van der Burg, Bart ^a  

^a BIODETECTION SYSTEMS B V   (Netherlands)

^b MSD   (Netherlands)

^c Dutch Childhood Oncology Group (SKION)   (Netherlands)

Author keywords

McPhail assay; Progesterone; Progesterone receptor; Reporter gene assay; Screening model; Validation

Indexed keywords

ANDROGEN; ESTROGEN; GESTAGEN; GLUCOCORTICOID; HORMONE RECEPTOR; PROGESTERONE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CANCER CELL; CELL LINE; CHO CELL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RABBIT; RECEPTOR BINDING; REPORTER GENE; SCREENING; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL ASSAY; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HUMANS; PROGESTERONE; RABBITS; RECEPTORS, PROGESTERONE;

CRICETULUS GRISEUS; ORYCTOLAGUS CUNICULUS;

EID: 79151477340     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.11.018     Document Type: Article

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