The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative [2]

Archives of Toxicology

Volumn 81, Issue 5, 2007, Pages 385-387

  Blaauboer, Bas J ^a   Andersen, Melvin E ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAZARD ASSESSMENT; HEALTH HAZARD; LETTER; OCCUPATIONAL EXPOSURE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; TOXICITY TESTING; TOXICOKINETICS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; EUROPEAN UNION; HAZARDOUS SUBSTANCES; HUMANS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT; TOXICITY TESTS;

EID: 34247850820     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0175-0     Document Type: Letter

References (8)

1. Andersen ME (2003) Toxicokinetic modeling and its applications in chemical risk assessment. Toxicol Lett 138:9-27
2. Blaauboer BJ (2003) The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic modelling as a tool in hazard and risk assessment. A commentary Toxicol Lett 138:161-171
3. Eisenbrand G, Pool-Zobel B, Baker V, Balls M, Blaauboer BJ, Boobis A, Carere A, Kevekordes S, Lhuguenot J-C, Pieters R, Kleiner J (2002) Methods of in vitro toxicology. Food Chem Toxicol 40:193-236
4. DeJongh J, Nordin-Andersson M, Ploeger B, Forsby A (1999) Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations. Toxicol Appl Pharmacol 158:261-268
5. Greim H, Arand M, Autrup H, Bolt HM, Bridges J, Dybing E, Glomot R, Foa V, Schulte-Hermann R (2006) Toxicological comments to the discussion about REACH. Arch Toxicol 80:121-124
6. Goldberg AM, Hartung T (2005) Protecting more than animals. Reducing animal suffering often has the unexpected benefit of yielding more rigorous safety tests. Scientific American January 2005, pp 84-91
7. Gubbels-van Hal WM, Blaauboer BJ, Barentsen HM, Hoitink MA, Meerts IA, van der Hoeven JC (2005) An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing. Regul Toxicol Pharmacol 42:284-295
8. Verwei M, van Burgsteden JA, Krul CAM, van de Sandt JJM, Freidig AP (2006) Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Toxicol Letters 165:79-87