Epigenetic regulation of mesenchymal stem cells: A focus on osteogenic and adipogenic differentiation

Stem Cells International

Volumn , Issue , 2011, Pages

  Teven, Chad M ^a   Liu, Xing ^a,b   Hu, Ning ^a,c   Tang, Ni ^a,c   Kim, Stephanie H ^a   Huang, Enyi ^a,d   Yang, Ke ^a,e   Li, Mi ^a,b   Gao, Jian Li ^a,f   Liu, Hong ^a,c   Natale, Ryan B ^a   Luther, Gaurav ^a   Luo, Qing ^a,b   Wang, Linyuan ^a   Rames, Richard ^a   Bi, Yang ^a,b   Luo, Jinyong ^a,c   Luu, Hue H ^a   Haydon, Rex C ^a   Reid, Russell R ^a   He, Tong Chuan ^a,b,c   more..

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d CHONGQING UNIVERSITY   (China)

^e THIRD MILITARY MEDICAL UNIVERSITY   (China)

^f ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE;

BONE DEFECT; BRAIN ISCHEMIA; CELL DIFFERENTIATION; CELL FATE; CELL ISOLATION; CELL RENEWAL; CELL TYPE; CHONDROPATHY; DNA METHYLATION; EMBRYONIC STEM CELL; EPIGENETICS; GENETIC REGULATION; HISTONE MODIFICATION; HUMAN; ISCHEMIC HEART DISEASE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLIC BONE DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE ENGINEERING; TISSUE REPAIR;

EID: 80052719188     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2011/201371     Document Type: Review

References (278)

1. Evans M. J., Kaufman M. H., Establishment in culture of pluripotential cells from mouse embryos Nature 1981 292 5819 154 156 (Pubitemid 11050741)
2. Martin G. R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proceedings of the National Academy of Sciences of the United States of America 1981 78 12 7634 7638 (Pubitemid 12186197)
3. Frankel M. S., In search of stem cell policy Science 2000 287 5457 1397 (Pubitemid 30127110)
4. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells Science 1999 284 5411 143 147 (Pubitemid 29282067)
5. Gage F. H., Mammalian neural stem cells Science 2000 287 5457 1433 1438 (Pubitemid 30127128)
6. Potten C. S., Stem cells in gastrointestinal epithelium: numbers, characteristics and death Philosophical Transactions of the Royal Society B 1998 353 1370 821 830 (Pubitemid 28314364)
7. Alison M., Sarraf C., Hepatic stem cells Journal of Hepatology 1998 29 4 676 682 (Pubitemid 28484959)
8. Margolis J., Spradling A., Identification and behavior of epithelial stem cells in the Drosophila ovary Development 1995 121 11 3797 3807
9. Conrad S., Renninger M., Hennenlotter J., Wiesner T., Just L., Bonin M., Aicher W., Bhring H. J., Mattheus U., Mack A., Wagner H. J., Minger S., Matzkies M., Reppel M., Hescheler J., Sievert K. D., Stenzl A., Skutella T., Generation of pluripotent stem cells from adult human testis Nature 2008 456 7220 344 349
10. Weissman I. L., Translating stem and progenitor cell biology to the clinic: barriers and opportunities Science 2000 287 5457 1442 1446 (Pubitemid 30127130)
11. Deng Z. L., Sharff K. A., Tang N., Song W. X., Luo J., Luo X., Chen J., Bennett E., Reid R., Manning D., Xue A., Montag A. G., Luu H. H., Haydon R. C., He T. C., Regulation of osteogenic differentiation during skeletal development Frontiers in Bioscience 2008 13 6 2001 2021 (Pubitemid 351589231)
12. Friedenstein A. J., Petrakova K. V., Kurolesova A. I., Frolova G. P., Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues Transplantation 1968 6 2 230 247
13. Luu H. H., Song W. X., Luo X., Manning D., Luo J., Deng Z. L., Sharff K. A., Montag A. G., Haydon R. C., He T. C., Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells Journal of Orthopaedic Research 2007 25 5 665 677 (Pubitemid 46730519)
14. Rastegar F., Shenaq D., Huang J., Mesenchymal stem cells: molecular characteristics and clinical applications World Journal of Stem Cells 2010 2 4 67 80
15. Russo V. E. A., Martienssen R. A., Riggs A. D., Epigenetic Mechanisms of Gene Regultation 1996 New York, NY, USA Cold Spring Harbor Laboratory Press
16. Vincent A., Van Seuningen I., Epigenetics, stem cells and epithelial cell fate Differentiation 2009 78 2-3 99 107
17. Robertson K. D., DNA methylation and human disease Nature Reviews Genetics 2005 6 8 597 610 (Pubitemid 41044297)
18. Wu H., Sun Y. E., Epigenetic regulation of stem cell differentiation Pediatric Research 2006 59 4, part 2 21R 25R (Pubitemid 43740031)
19. Egger G., Liang G., Aparicio A., Jones P. A., Epigenetics in human disease and prospects for epigenetic therapy Nature 2004 429 6990 457 463 (Pubitemid 38715140)
20. Nicholls R. D., Saitoh S., Horsthemke B., Imprinting in prader-willi and angelman syndromes Trends in Genetics 1998 14 5 194 200 (Pubitemid 28244244)
21. Goldstone A. P., Prader-willi syndrome: advances in genetics, pathophysiology and treatment Trends in Endocrinology and Metabolism 2004 15 1 12 20 (Pubitemid 38198094)
22. Kane M. F., Loda M., Gaida G. M., Lipman J., Mishra R., Goldman H., Jessup J. M., Kolodner R., Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines Cancer Research 1997 57 5 808 811 (Pubitemid 27097998)
23. Jones P. A., Baylin S. B., The fundamental role of epigenetic events in cancer Nature Reviews Genetics 2002 3 6 415 428 (Pubitemid 34587077)
24. Roberts C. W., Orkin S. H., The SWI/SNF complexchromatin and cancer Nature Reviews Cancer 2004 4 2 133 142
25. Feinberg A. P., Tycko B., The history of cancer epigenetics Nature Reviews Cancer 2004 4 2 143 153 (Pubitemid 38198742)
26. Soejima H., Nakagawachi T., Zhao W., Higashimoto K., Urano T., Matsukura S., Kitajima Y., Takeuchi M., Nakayama M., Oshimura M., Miyazaki K., Joh K., Mukai T., Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer Oncogene 2004 23 25 4380 4388 (Pubitemid 38850417)
27. Claus R., Lubbert M., Epigenetic targets in hematopoietic malignancies Oncogene 2003 22 42 6489 6496 (Pubitemid 37372329)
28. Siddiqi S., Mills J., Matushansky I., Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas Current Stem Cell Research Therapy 2010 5 1 63 73
29. Ganesan A., Nolan L., Crabb S. J., Packham G., Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery Current Cancer Drug Targets 2009 9 8 963 981
30. Collas P., Programming differentiation potential in mesenchymal stem cells Epigenetics 2010 5 6 476 482
31. Boquest A. C., Noer A., Collas P., Epigenetic programming of mesenchymal stem cells from human adipose tissue Stem Cell Reviews 2006 2 4 319 329 (Pubitemid 47504962)
32. Surani M. A., Hayashi K., Hajkova P., Genetic and epigenetic regulators of pluripotency Cell 2007 128 4 747 762 (Pubitemid 46273582)
33. Tachibana M., Sugimoto K., Nozaki M., Ueda J., Ohta T., Ohki M., Fukuda M., Takeda N., Niida H., Kato H., Shinkai Y., G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis Genes Development 2002 16 14 1779 1791 (Pubitemid 34803894)
34. Li E., Bestor T. H., Jaenisch R., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality Cell 1992 69 6 915 926
35. Kouzarides T., Chromatin modifications and their function Cell 2007 128 4 693 705 (Pubitemid 46273577)
36. Bird A., DNA methylation patterns and epigenetic memory Genes Development 2002 16 1-2 6 21 (Pubitemid 34049633)
37. Bird A. P., Taggart M. H., Nicholls R. D., Higgs D. R., Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene The EMBO Journal 1987 6 4 999 1004
38. Kass S. U., Landsberger N., Wolffe A. P., DNA methylation directs a time-dependent repression of transcription initiation Current Biology 1997 7 3 157 165 (Pubitemid 27164721)
39. Song F., Smith J. F., Kimura M. T., Morrow A. D., Matsuyama T., Nagase H., Held W. A., Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression Proceedings of the National Academy of Sciences of the United States of America 2005 102 9 3336 3341 (Pubitemid 40328046)
40. Weber M., Hellmann I., Stadler M. B., Ramos L., Pbo S., Rebhan M., Schbeler D., Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome Nature Genetics 2007 39 4 457 466 (Pubitemid 46514772)
41. Klose R. J., Bird A. P., Genomic DNA methylation: the mark and its mediators Trends in Biochemical Sciences 2006 31 2 89 97 (Pubitemid 43221841)
42. Turek-Plewa J., Jagodzinski P. P., The role of mammalian DNA methyltransferases in the regulation of gene expression Cellular and Molecular Biology Letters 2005 10 4 631 647 (Pubitemid 43161688)
43. Jaenisch R., Bird A., Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nature Genetics 2003 33 245 254 (Pubitemid 36278835)
44. Hoffman A. R., Hu J. F., Directing DNA methylation to inhibit gene expression Cellular and Molecular Neurobiology 2006 26 46 425 438
45. Morgan H. D., Santos F., Green K., Dean W., Reik W., Epigenetic reprogramming in mammals Human Molecular Genetics 2005 14 1 R47 R58
46. Young L. E., Beaujean N., DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep Animal Reproduction Science 2004 82-83 61 78 (Pubitemid 39027050)
47. Mann J. R., Imprinting in the germ line Stem Cells 2001 19 4 287 294 (Pubitemid 32721095)
48. Razin A., Shemer R., DNA methylation in early development Human Molecular Genetics 1995 4 1751 1755
49. Hellman A., Chess A., Gene body-specific methylation on the active X chromosome Science 2007 315 5815 1141 1143 (Pubitemid 46328027)
50. Tremblay K. D., Saam J. R., Ingram R. S., Tilghman S. M., Bartolomei M. S., A paternal-specific methylation imprint marks the alleles of the mouse H19 gene Nature Genetics 1995 9 4 407 413
51. Reik W., Howlett S. K., Surani M. A., Imprinting by DNA methylation: from transgenes to endogenous gene sequences Development 1990 99 106
52. Sapienza C., Peterson A. C., Rossant J., Balling R., Degree of methylation of transgenes is dependent on gamete of origin Nature 1987 328 6127 251 254 (Pubitemid 17108273)
53. Reik W., Collick A., Norris M. L., Barton S. C., Surani M. A., Genomic imprinting determines methylation of parental alleles in transgenic mice Nature 1987 328 6127 248 251 (Pubitemid 17108272)
54. Jaenisch R., Harbers K., Jahner D., Stewart C., Stuhlmann H., DNA methylation, retroviruses, and embryogenesis Journal of Cellular Biochemistry 1982 20 4 331 336 (Pubitemid 13059726)
55. Bibikova M., Chudin E., Wu B., Zhou L., Garcia E. W., Liu Y., Shin S., Plaia T. W., Auerbach J. M., Arking D. E., Gonzalez R., Crook J., Davidson B., Schulz T. C., Robins A., Khanna A., Sartipy P., Hyllner J., Vanguri P., Savant-Bhonsale S., Smith A. K., Chakravarti A., Maitra A., Rao M., Barker D. L., Loring J. F., Fan J. B., Human embryonic stem cells have a unique epigenetic signature Genome Research 2006 16 9 1075 1083 (Pubitemid 44320394)
56. Collas P., Noer A., Sorensen A. L., Epigenetic basis for the differentiation potential of mesenchymal and embryonic stem cells Transfusion Medicine and Hemotherapy 2008 35 3 205 215
57. Dahl J. A., Duggal S., Coulston N., Millar D., Melki J., Shahdadfar A., Brinchmann J. E., Collas P., Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous seum or fatal bovine serum International Journal of Developmental Biology 2008 52 8 1033 1042
58. Clark S. J., Statham A., Stirzaker C., Molloy P. L., Frommer M., DNA methylation: bisulphite modification and analysis Nature Protocols 2006 1 5 2353 2364
59. Hayatsu H., Shiraishi M., Negishi K., Bisulfite modification for analysis of DNA methylation Current Protocols in Nucleic Acid Chemistry 2008 chapter 6, unit 6.10
60. Bang O. Y., Lee J. S., Lee P. H., Lee G., Autologous mesenchymal stem cell transplantation in stroke patients Annals of Neurology 2005 57 6 874 882 (Pubitemid 40798626)
61. Dill T., Schachinger V., Rolf A., Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the reinfusion of enriched progenitor cells and infarct remodeling in acute myocardial infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy American Heart Journal 2009 157 3 541 547
62. Horwitz E. M., Gordon P. L., Koo W. K., Marx J. C., Neel M. D., McNall R. Y., Muul L., Hofmann T., Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone Proceedings of the National Academy of Sciences of the United States of America 2002 99 13 8932 8937 (Pubitemid 34693661)
63. Marcacci M., Kon E., Moukhachev V., Lavroukov A., Kutepov S., Quarto R., Mastrogiacomo M., Cancedda R., Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study Tissue Engineering 2007 13 5 947 955 (Pubitemid 46870419)
64. Wakitani S., Nawata M., Tensho K., Okabe T., Machida H., Ohgushi H., Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees Journal of Tissue Engineering and Regenerative Medicine 2007 1 1 74 79
65. Strahl B. D., Allis C. D., The language of covalent histone modifications Nature 2000 403 6765 41 45 (Pubitemid 30038513)
66. Jenuwein T., Allis C. D., Translating the histone code Science 2001 293 5532 1074 1080 (Pubitemid 32758077)
67. Lennartsson A., Ekwall K., Histone modification patterns and epigenetic codes Biochimica et Biophysica Acta 2009 1790 9 863 868
68. Turner B. M., Histone acetylation and an epigenetic code BioEssays 2000 22 9 836 845
69. Kouzarides T., Histone methylation in transcriptional control Current Opinion in Genetics Development 2002 12 2 198 209 (Pubitemid 34219493)
70. Schwartz Y. B., Pirrotta V., Polycomb silencing mechanisms and the management of genomic programmes Nature Reviews Genetics 2007 8 1 9 22 (Pubitemid 46006046)
71. Simon J. A., Kingston R. E., Mechanisms of polycomb gene silencing: knowns and unknowns Nature Reviews Molecular Cell Biology 2009 10 10 697 708
72. Agger K., Cloos P. A., Christensen J., Pasini D., Rose S., Rappsilber J., Issaeva I., Canaani E., Salcini A. E., Helin K., UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 2007 449 7163 731 734 (Pubitemid 47552088)
73. De Santa F., Totaro M. G., Prosperini E., Notarbartolo S., Testa G., Natoli G., The histone H3 lysine-27 demethylase JMJD3 links inflammation to inhibition of polycomb-mediated gene silencing Cell 2007 130 6 1083 1094 (Pubitemid 47410272)
74. Lan F., Bayliss P. E., Rinn J. L., Whetstine J. R., Wang J. K., Chen S., Iwase S., Alpatov R., Issaeva I., Canaani E., Roberts T. M., Chang H. Y., Shi Y., A histone H3 lysine 27 demethylase regulates animal posterior development Nature 2007 449 7163 689 694 (Pubitemid 47552096)
75. Nishioka K., Chuikov S., Sarma K., Erdjument-Bromage H., Allis C. D., Tempst P., Reinberg D., Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation Genes Development 2002 16 4 479 489 (Pubitemid 34165104)
76. Zardo G., Cimino G., Nervi C., Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming Leukemia 2008 22 8 1503 1518
77. Zhao X. D., Han X., Chew J. L., Liu J., Chiu K. P., Choo A., Orlov Y. L., Sung W. K., Shahab A., Kuznetsov V. A., Bourque G., Oh S., Ruan Y., Ng H. H., Wei C. L., Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells Cell Stem Cell 2007 1 3 286 298 (Pubitemid 47370914)
78. Bernstein B. E., Mikkelsen T. S., Xie X., Kamal M., Huebert D. J., Cuff J., Fry B., Meissner A., Wernig M., Plath K., Jaenisch R., Wagschal A., Feil R., Schreiber S. L., Lander E. S., A bivalent chromatin structure marks key developmental genes in embryonic stem cells Cell 2006 125 2 315 326
79. Schubeler D., MacAlpine D. M., Scalzo D., Wirbelauer C., Kooperberg C., Van Leeuwen F., Gottschling D. E., O'Neill L. P., Turner B. M., Delrow J., Bell S. P., Groudine M., The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote Genes Development 2004 18 11 1263 1271 (Pubitemid 38720594)
80. Santos-Rosa H., Schneider R., Bannister A. J., Sherriff J., Bernstein B. E., Emre N. C. T., Schreiber S. L., Mellor J., Kouzarides T., Active genes are tri-methylated at K4 of histone H3 Nature 2002 419 6905 407 411
81. Struhl K., Histone acetylation and transcriptional regulatory mechanisms Genes Development 1998 12 5 599 606 (Pubitemid 28134293)
82. Gilmour D. S., Lis J. T., Detecting protein-DNA interactions in vivo: distribution of RNA polymerase on specific bacterial genes Proceedings of the National Academy of Sciences of the United States of America 1984 81 14 4275 4279 (Pubitemid 14052426)
83. Gilmour D. S., Lis J. T., In vivo interactions of RNA polymerase II with genes of Drosophila melanogaster Molecular and Cellular Biology 1985 5 8 2009 2018 (Pubitemid 15049161)
84. Gilmour D. S., Lis J. T., RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells Molecular and Cellular Biology 1986 6 11 3984 3989
85. Carey M. F., Peterson C. L., Smale S. T., Chromatin immunoprecipitation (ChIP) Cold Spring Harbor Protocols 2009 2009
86. Collas P., Dahl J. A., Chop it, ChIP it, check it: the current status of chromatin immunoprecipitation Frontiers in Bioscience 2008 13 3 929 943 (Pubitemid 351594738)
87. Spivakov M., Fisher A. G., Epigenetic signatures of stem-cell identity Nature Reviews Genetics 2007 8 4 263 271 (Pubitemid 46439288)
88. Wiblin A. E., Cui W., Clark J. A., Bickmore W. A., Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells Journal of Cell Science 2005 118, part 17 3861 3868 (Pubitemid 41410270)
89. Williams R. R., Azuara V., Perry P., Sauer S., Dvorkina M., Jrgensen H., Roix J., McQueen P., Misteli T., Merkenschlager M., Fisher A. G., Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus Journal of Cell Science 2006 119, part 1 132 140 (Pubitemid 43169306)
90. Phair R. D., Gorski S. A., Misteli T., Measurement of dynamic protein binding to chromatin in Vivo, using photobleaching microscopy Methods in Enzymology 2004 375 393 414 (Pubitemid 38124881)
91. Meshorer E., Yellajoshula D., George E., Scambler P. J., Brown D. T., Misteli T., Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells Developmental Cell 2006 10 1 105 116 (Pubitemid 43025681)
92. Frye M., Fisher A. G., Watt F. M., Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation PLoS One 2007 2, article e763 1
93. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement Cytotherapy 2006 8 4 315 317 (Pubitemid 44269669)
94. da Silva Meirelles L., Caplan A. I., Nardi N. B., In search of the in Vivo identity of mesenchymal stem cells Stem Cells 2008 26 9 2287 2299
95. Peault B., Rudnicki M., Torrente Y., Cossu G., Tremblay J. P., Partridge T., Gussoni E., Kunkel L. M., Huard J., Stem and progenitor cells in skeletal muscle development, maintenance, and therapy Molecular Therapy 2007 15 5 867 877 (Pubitemid 46621645)
96. De Ugarte D. A., Morizono K., Elbarbary A., Alfonso Z., Zuk P. A., Zhu M., Dragoo J. L., Ashjian P., Thomas B., Benhaim P., Chen I., Fraser J., Hedrick M. H., Comparison of multi-lineage cells from human adipose tissue and bone marrow Cells Tissues Organs 2003 174 3 101 109 (Pubitemid 36819010)
97. Delorme B., Chateauvieux S., Charbord P., The concept of mesenchymal stem cells Regenerative Medicine 2006 1 4 497 509
98. Kern S., Eichler H., Stoeve J., Kluter H., Bieback K., Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Stem Cells 2006 24 5 1294 1301 (Pubitemid 44464698)
99. Shahdadfar A., Fronsdal K., Haug T., Reinholt F. P., Brinchmann J. E., In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability Stem Cells 2005 23 9 1357 1366 (Pubitemid 41504923)
100. Pedemonte E., Benvenuto F., Casazza S., Mancardi G., Oksenberg J. R., Uccelli A., Baranzini S. E., The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse BMC Genomics 2007 8, article 65
101. Boquest A. C., Shahdadfar A., Fronsdal K., Sigurjonsson O., Tunheim S. H., Collas P., Brinchmann J. E., Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture Molecular Biology of the Cell 2005 16 3 1131 1141 (Pubitemid 40349551)
102. De Ugarte D. A., Alfonso Z., Zuk P. A., Elbarbary A., Zhu M., Ashjian P., Benhaim P., Hedrick M. H., Fraser J. K., Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow Immunology Letters 2003 89 2-3 267 270 (Pubitemid 37222456)
103. Sorensen A. L., Timoskainen S., West F. D., Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell types Stem Cells and Development 2010 19 8 1257 1266
104. Kiel M. J., Morrison S. J., Maintaining hematopoietic stem cells in the vascular niche Immunity 2006 25 6 862 864 (Pubitemid 44894953)
105. Villagra A., Gutirrez J., Paredes R., Sierra J., Puchi M., Imschenetzky M., Van Wijnen A., Lian J., Stein G., Stein J., Montecino M., Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts Journal of Cellular Biochemistry 2002 85 1 112 122 (Pubitemid 34204074)
106. Arnsdorf E. J., Tummala P., Castillo A. B., Zhang F., Jacobs C. R., The epigenetic mechanism of mechanically induced osteogenic differentiation Journal of Biomechanics 2010 43 15 2881 2886
107. Dansranjavin T., Krehl S., Mueller T., Mueller L. P., Schmoll H. J., Dammann R. H., The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation Cell Cycle 2009 8 6 916 924
108. Hsiao S. H., Lee K. D., Hsu C. C., DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination Biochemical and Biophysical Research Communications 2010 400 3 305 312
109. Shen J., Hovhannisyan H., Lian J. B., Montecino M. A., Stein G. S., Stein J. L., Van Wijnen A. J., Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones H3 and H4 Molecular Endocrinology 2003 17 4 743 756 (Pubitemid 36403584)
110. Hassan M. Q., Tare R., Lee S. L., Mandeville M., Weiner B., Montecino M., Van Wijnen A. J., Stein J. L., Stein G. S., Lian J. B., HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes Molecular and Cellular Biology 2007 27 9 3337 3352 (Pubitemid 46685212)
111. Fan Z., Yamaza T., Lee J. S., Yu J., Wang S., Fan G., Shi S., Wang C. Y., BCOR regulates mesenchymal stem cell function by epigenetic mechanisms Nature Cell Biology 2009 11 8 1002 1009
112. Sorensen A. L., Jacobsen B. M., Reiner A. H., Andersen I. S., Collas P., Promoter DNA methylation patterns of differentiated cells are largely programmed at the progenitor stage Molecular Biology of the Cell 2010 21 12 2066 2077
113. Crisan M., Yap S., Casteilla L., Chen C. W., Corselli M., Park T. S., Andriolo G., Sun B., Zheng BO., Zhang LI., Norotte C., Teng P. N., Traas J., Schugar R., Deasy B. M., Badylak S., Buhring H. J., Giacobino J. P., Lazzari L., Huard J., Péault B., A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 2008 3 3 301 313
114. Dellavalle A., Sampaolesi M., Tonlorenzi R., Tagliafico E., Sacchetti B., Perani L., Innocenzi A., Galvez B. G., Messina G., Morosetti R., Li S., Belicchi M., Peretti G., Chamberlain J. S., Wright W. E., Torrente Y., Ferrari S., Bianco P., Cossu G., Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells Nature Cell Biology 2007 9 3 255 267 (Pubitemid 46349927)
115. Zannettino A. C., Paton S., Arthur A., Khor F., Itescu S., Gimble J. M., Gronthos S., Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo Journal of Cellular Physiology 2008 214 2 413 421 (Pubitemid 350308998)
116. Igura K., Zhang X., Takahashi K., Mitsuru A., Yamaguchi S., Takahashi T. A., Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta Cytotherapy 2004 6 6 543 553 (Pubitemid 40028913)
117. Baddoo M., Hill K., Wilkinson R., Gaupp D., Hughes C., Kopen G. C., Phinney D. G., Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection Journal of Cellular Biochemistry 2003 89 6 1235 1249 (Pubitemid 36959389)
118. Bosnakovski D., Mizuno M., Kim G., Takagi S., Okumura M., Fujinaga T., Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells Cell and Tissue Research 2005 319 2 243 253 (Pubitemid 40174518)
119. Devine S. M., Bartholomew A. M., Mahmud N., Nelson M., Patil S., Hardy W., Sturgeon C., Hewett T., Chung T., Stock W., Sher D., Weissman S., Ferrer K., Mosca J., Deans R., Moseley A., Hoffman R., Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion Experimental Hematology 2001 29 2 244 255 (Pubitemid 32112325)
120. Moscoso I., Centeno A., Lopez E., Rodriguez-Barbosa J. I., Santamarina I., Filgueira P., Snchez M. J., Domnguez-Perles R., Peuelas-Rivas G., Domenech N., Differentiation in vitro of primary and immortalized porcine mesenchymal stem cells into cardiomyocytes for cell transplantation Transplantation Proceedings 2005 37 1 481 482 (Pubitemid 40459824)
121. Santa Maria L., Rojas C. V., Minguell J. J., Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells Experimental Cell Research 2004 300 2 418 426 (Pubitemid 39314431)
122. Silva G. V., Litovsky S., Assad J. A., Sousa A. L. S., Martin B. J., Vela D., Coulter S. C., Lin J., Ober J., Vaughn W. K., Branco R. V. C., Oliveira E. M., He R., Geng Y. J., Willerson J. T., Perin E. C., Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model Circulation 2005 111 2 150 156 (Pubitemid 40139725)
123. Amoh Y., Li L., Campillo R., Kawahara K., Katsuoka K., Penman S., Hoffman R. M., Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves Proceedings of the National Academy of Sciences of the United States of America 2005 102 49 17734 17738 (Pubitemid 41803566)
124. Coles B. L., Angenieux B., Inoue T., Del Rio-Tsonis K., Spence J. R., McInnes R. R., Arsenijevic Y., Van Der Kooy D., Facile isolation and the characterization of human retinal stem cells Proceedings of the National Academy of Sciences of the United States of America 2004 101 44 15772 15777 (Pubitemid 39473563)
125. da Silva Meirelles L., Chagastelles P. C., Nardi N. B., Mesenchymal stem cells reside in virtually all post-natal organs and tissues Journal of Cell Science 2006 119 11 2204 2213 (Pubitemid 43960310)
126. Davis A. A., Temple S., A self-renewing multipotential stem cell in embryonic rat cerebral cortex Nature 1994 372 6503 263 266 (Pubitemid 24352447)
127. In't Anker P. S., Scherjon S. A., Kleijburg-van der Keur C., De Groot-Swings G. M. J. S., Claas F. H. J., Fibbe W. E., Kanhai H. H. H., Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta Stem Cells 2004 22 7 1338 1345 (Pubitemid 39636409)
128. Liu Z., Martin L. J., Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells Journal of Neurotrauma 2004 21 10 1479 1499 (Pubitemid 39435323)
129. Ringe J., Leinhase I., Stich S., Loch A., Neumann K., Haisch A., Hupl T., Manz R., Kaps C., Sittinger M., Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering Journal of Tissue Engineering and Regenerative Medicine 2008 2 2-3 136 146
130. Sinanan A. C., Hunt N. P., Lewis M. P., Human adult craniofacial muscle-derived cells: neural-cell-adhesion-molecule (NCAM; CD56)-expressing cells appear to contain multipotential stem cells Biotechnology and Applied Biochemistry 2004 40, part 1 25 34 (Pubitemid 39070905)
131. Zuk P. A., Zhu M., Mizuno H., Huang J., Futrell J. W., Katz A. J., Benhaim P., Lorenz H. P., Hedrick M. H., Multilineage cells from human adipose tissue: implications for cell-based therapies Tissue Engineering 2001 7 2 211 228 (Pubitemid 32295155)
132. Kollet O., Shivtiel S., Chen Y. Q., Suriawinata J., Thung S. N., Dabeva M. D., Kahn J., Spiegel A., Dar A., Samira S., Goichberg P., Kalinkovich A., Arenzana-Seisdedos F., Nagler A., Hardan I., Revel M., Shafritz D. A., Lapidot T., HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34 + stem cell recruitment to the liver Journal of Clinical Investigation 2003 112 2 160 169 (Pubitemid 38056352)
133. Airey J. A., Almeida-Porada G., Colletti E. J., Human mesenchymal stem cells form purkinje fibers in fetal sheep heart Circulation 2004 109 11 1401 1407 (Pubitemid 38387827)
134. Hare J. M., Traverse J. H., Henry T. D., A randomized, double-blind, placebo-controlled, dose-escalation study of Intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Journal of the American College of Cardiology 2009 54 24 2277 2286
135. Horwitz E. M., Prockop D. J., Fitzpatrick L. A., Koo W. K., Gordon P. L., Neel M., Sussman M., Orchard P., Marx J. C., Pyeritz R. E., Brenner M. K., Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Nature Medicine 1999 5 3 309 313 (Pubitemid 29124367)
136. Le Blanc K., Gotherstrom C., Ringden O., Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta Transplantation 2005 79 11 1607 1614 (Pubitemid 40847594)
137. Quarto R., Mastrogiacomo M., Cancedda R., Kutepov S. M., Mukhachev V., Lavroukov A., Kon E., Marcacci M., Repair of large bone defects with the use of autologous bone marrow stromal cells The New England Journal of Medicine 2001 344 5 385 386 (Pubitemid 32107654)
138. Kuroda R., Ishida K., Matsumoto T., Akisue T., Fujioka H., Mizuno K., Ohgushi H., Wakitani S., Kurosaka M., Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells Osteoarthritis and Cartilage 2007 15 2 226 231 (Pubitemid 46132105)
139. Wakitani S., Mitsuoka T., Nakamura N., Toritsuka Y., Nakamura Y., Horibe S., Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports Cell Transplantation 2004 13 5 595 600 (Pubitemid 39557438)
140. Wakitani S., Imoto K., Yamamoto T., Saito M., Murata N., Yoneda M., Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees Osteoarthritis and Cartilage 2002 10 3 199 206 (Pubitemid 34189569)
141. Digirolamo C. M., Stokes D., Colter D., Phinney D. G., Class R., Prockop D. J., Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to
142. Vacanti V., Kong E., Suzuki G., Sato K., Canty J. M., Lee T., Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture Journal of Cellular Physiology 2005 205 2 194 201 (Pubitemid 41428901)
143. Rosland G. V., Svendsen A., Torsvik A., Sobala E., McCormack E., Immervoll H., Mysliwietz J., Tonn J. C., Goldbrunner R., Lnning P. E., Bjerkvig R., Schichor C., Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation Cancer Research 2009 69 13 5331 5339
144. Miura M., Miura Y., Padilla-Nash H. M., Molinolo A. A., Fu B., Patel V., Seo B. M., Sonoyama W., Zheng J. J., Baker C. C., Chen W., Ried T., Shi S., Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation Stem Cells 2006 24 4 1095 1103 (Pubitemid 44464742)
145. Tolar J., Nauta A. J., Osborn M. J., Mortari A. P., McElmurry R. T., Bell S., Xia L., Zhou N., Riddle M., Schroeder T. M., Westendorf J. J., McIvor R. S., Hogendoorn P. C. W., Szuhai K., Oseth L., Hirsch B., Yant S. R., Kay M. A., Peister A., Prockop D. J., Fibbe W. E., Blazar B. R., Sarcoma derived from cultured mesenchymal stem cells Stem Cells 2007 25 2 371 379 (Pubitemid 46232791)
146. Rubio D., Garcia-Castro J., Martin M. C., De La Fuente R., Cigudosa J. C., Lloyd A. C., Bernad A., Spontaneous human adult stem cell transformation Cancer Research 2005 65 8 3035 3039 (Pubitemid 40524580)
147. Miura Y., Gao Z., Miura M., Seo B. M., Sonoyama W., Chen W., Gronthos S., Zhang LI., Shi S., Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource Stem Cells 2006 24 11 2428 2436 (Pubitemid 44674303)
148. Zhang Z. X., Guan L. X., Zhang K., Wang S., Cao P. C., Wang Y. H., Wang Z., Dai L. J., Cytogenetic analysis of human bone marrow-derived mesenchymal stem cells passaged in vitro Cell Biology International 2007 31 6 645 648 (Pubitemid 46660640)
149. Bernardo M. E., Zaffaroni N., Novara F., Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms Cancer Research 2007 67 19 9142 9149 (Pubitemid 47535900)
150. Noer A., Boquest A. C., Collas P., Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence BMC Cell Biology 2007 8, article 18
151. Fujiki K., Kano F., Shiota K., Murata M., Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes BMC Biology 2009 7, article 38
152. Yokomori N., Tawata M., Onaya T., DNA demethylation during the differentiation of 3T3-L1 cells affects the expression of the mouse GLUT4 gene Diabetes 1999 48 4 685 690 (Pubitemid 29153065)
153. Dolinoy D. C., Weidman J. R., Waterland R. A., Jirtle R. L., Maternal genistein alters coat color and protects avy mouse offspring from obesity by modifying the fetal epigenome Environmental Health Perspectives 2006 114 4 567 572
154. Musri M. M., Corominola H., Casamitjana R., Gomis R., Parrizas M., Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes Journal of Biological Chemistry 2006 281 25 17180 17188
155. Yoo E. J., Chung J. J., Choe S. S., Kim K. H, Kim J. B., Down-regulation of histone deacetylases stimulates adipocyte differentiation Journal of Biological Chemistry 2006 281 10 6608 6615
156. Fajas L., Egler V., Reiter R., Hansen J., Kristiansen K., Debril M. B., Mirard S., Auwerx J., The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation Developmental Cell 2002 3 6 903 910 (Pubitemid 35460789)
157. Humpherys D., Eggan K., Akutsu H., Hochedlinger K., Rideout W. M., Biniszkiewicz D., Yanagimachi R., Jaenisch R., Epigenetic instability in ES cells and cloned mice Science 2001 293 5527 95 97 (Pubitemid 32625502)
158. Schumacher A., Doerfler W., Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn -imprinting region in mouse embryonic stem cells Nucleic Acids Research 2004 32 4 1566 1576 (Pubitemid 38864684)
159. Meissner A., Mikkelsen T. S., Gu H., Wernig M., Hanna J., Sivachenko A., Zhang X., Bernstein B. E., Nusbaum C., Jaffe D. B., Gnirke A., Jaenisch R., Lander E. S., Genome-scale DNA methylation maps of pluripotent and differentiated cells Nature 2008 454 7205 766 770
160. Noer A., Serensen A. L., Boquest A. C., Collas P., Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue Molecular Biology of the Cell 2006 17 8 3543 3556 (Pubitemid 44156447)
161. Noer A., Lindeman L. C., Collas P., Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells Stem Cells and Development 2009 18 5 725 736
162. Delbarre E., Jacobsen B. M., Reiner A. H., Sorensen A. L., Kuntziger T., Collas P., Chromatin environment of histone variant H3.3 revealed by quantitative imaging and genome-scale chromatin and DNA immunoprecipitation Molecular Biology of the Cell 2010 21 11 1872 1884
163. Jaenisch R., Young R., Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming Cell 2008 132 4 567 582 (Pubitemid 351253686)
164. Young H. E., Ceballos E. M., Smith J. C., Mancini M. L., Wright R. P., Ragan B. L., Bushell I., Lucas P. A., Pluripotent mesenchymal stem cells reside within avian connective tissue matrices In Vitro Cellular Developmental Biology 1993 29A 9 723 736 (Pubitemid 23315945)
165. Young H. E., Duplaa C., Young T. M., Floyd J. A., Reeves M. L., Davis K. H., Mancini G. J., Eaton M. E., Hill J. D., Thomas K., Austin T., Edwards C., Cuzzourt J., Parikh A., Groom J., Hudson J., Black A. C., Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells Anatomical Record 2001 263 4 350 360 (Pubitemid 32730262)
166. D'Ippolito G., Diabira S., Howard G. A., Roos B. A., Schiller P. C., Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells Bone 2006 39 3 513 522 (Pubitemid 44149268)
167. Young H. E., Rogers J. J., Adkison L. R., Lucas P. A., Black A. C., Muscle morphogenetic protein induces myogenic gene expression in swiss-3T3 cells Wound Repair and Regeneration 1998 6 6 543 554 (Pubitemid 128659202)
168. Rogers J. J., Young H. E., Adkison L. R., Lucas P. A., Black A. C. Jr., Differentiation factors induce expression of muscle, fat, cartilage, and bone in a clone of mouse pluripotent mesenchymal stem cells The American Journal of Surgery 1995 61 3 231 236
169. Grigoriadis A. E., Heersche J. N., Aubin J. E., Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone Journal of Cell Biology 1988 106 6 2139 2151
170. Jiang Y., Jahagirdar B. N., Reinhardt R. L., Schwartz R. E., Keene C. D., Ortiz-Gonzalez X. R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S., Lisberg A., Low W. C., Lergaespada D. A., Verfaillie C. M., Pluripotency of mesenchymal stem cells derived from adult marrow Nature 2002 418 6893 41 49 (Pubitemid 34742565)
171. Schwartz R. E., Reyes M., Koodie L., Jiang Y., Blackstad M., Lund T., Lenvik T., Johnson S., Hu W. S., Verfaillie C. M., Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells Journal of Clinical Investigation 2002 109 10 1291 1302 (Pubitemid 34546893)
172. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C. M., Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells Blood 2001 98 9 2615 2625
173. Reyes M., Dudek A., Jahagirdar B., Koodie L., Marker P. H., Verfaillie C. M., Origin of endothelial progenitors in human postnatal bone marrow Journal of Clinical Investigation 2002 109 3 337 346 (Pubitemid 34141807)
174. D'Ippolito G., Diabira S., Howard G. A., Menei P., Roos B. A., Schiller P. C., Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential Journal of Cell Science 2004 117, part 14 2971 2981 (Pubitemid 39117672)
175. Boquest A. C., Noer A., Sorensen A. L., Vekterud K., Collas P., CpG methylation profiles of endothelial cell-specific gene promoter regions in adipose tissue stem cells suggest limited differentiation potential toward the endothelial cell lineage Stem Cells 2007 25 4 852 861 (Pubitemid 46572581)
176. Delorme B., Ringe J., Pontikoglou C., Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity Stem Cells 2009 27 5 1142 1151
177. Mohn F., Weber M., Rebhan M., Roloff T. C., Richter J., Stadler M. B., Bibel M., Schbeler D., Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors Molecular Cell 2008 30 6 755 766
178. Fouse S. D., Shen Y., Pellegrini M., Cole S., Meissner A., Van Neste L., Jaenisch R., Fan G., Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation Cell Stem Cell 2008 2 2 160 169 (Pubitemid 351168712)
179. Karsenty G., Role of Cbfa1 in osteoblast differentiation and function Seminars in Cell and Developmental Biology 2000 11 5 343 346 (Pubitemid 32096083)
180. Ducy P., Starbuck M., Priemel M., Shen J., Pinero G., Geoffroy V., Amling M., Karsenty G., A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development Genes Development 1999 13 8 1025 1036 (Pubitemid 29200985)
181. Komori T., Regulation of osteoblast differentiation by transcription factors Journal of Cellular Biochemistry 2006 99 5 1233 1239
182. Komori T., Runx2, a multifunctional transcription factor in skeletal development Journal of Cellular Biochemistry 2002 87 1 1 8 (Pubitemid 34969142)
183. Lian J. B., Stein J. L., Stein G. S., Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions Connective Tissue Research 2003 44 supplement 1 141 148 (Pubitemid 36395436)
184. Westendorf J. J., Transcriptional co-repressors of Runx2 Journal of Cellular Biochemistry 2006 98 1 54 64
185. Bird A. P., Wolffe A. P., Methylation-induced repressionbelts, braces, and chromatin Cell 1999 99 5 451 454
186. Stein G. S., Lian J. B., van Wijnen A. J., Stein J. L., Montecino M., Javed A., Zaidi S. K., Young D. W., Choi JE. Y., Pockwinse S. M., Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression Oncogene 2004 23 24 4315 4329 (Pubitemid 38758597)
187. Stein G. S., Lian J. B., van Wijnen A. J., Stein J. L., The osteocalcin gene: a model for multiple parameters of skeletal-specific transcriptional control Molecular Biology Reports 1997 24 3 185 196 (Pubitemid 27358372)
188. Montecino M., Pockwinse S., Lian J., Stein G., Stein J., DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene Biochemistry 1994 33 1 348 353 (Pubitemid 24046533)
189. Shur I., Benayahu D., Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein Journal of Molecular Biology 2005 352 3 646 655 (Pubitemid 41225475)
190. Shur I., Socher R., Benayahu D., In vivo association of CReMM/CHD9 with promoters in osteogenic cells Journal of Cellular Physiology 2006 207 2 374 378
191. Marom R., Shur I., Hager G. L., Benayahu D., Expression and regulation of CReMM, a chromodomain helicase-DNA-binding (CHD), in marrow stroma derived osteoprogenitors Journal of Cellular Physiology 2006 207 3 628 635 (Pubitemid 43668224)
192. Benayahu D., Shefer G., Shur I., Insights into the transcriptional and chromatin regulation of mesenchymal stem cells in musculo-skeletal tissues Annals of Anatomy 2009 191 1 2 12
193. Dehority W., Halloran B. P., Bikle D. D., Curren T., Kostenuik P. J., Wronski T. J., Shen Y., Rabkin B., Bouraoui A., Morey-Holton E., Bone and hormonal changes induced by skeletal unloading in the mature male rat American Journal of Physiology 1999 276 1, part 1 E62 E69
194. Lafage-Proust M. H., Collet P., Dubost J. M., Laroche N., Alexandre C., Vico L., Space-related bone mineral redistribution and lack of bone mass recovery after reambulation in young rats American Journal of Physiology 1998 274 2, part 2 R324 R334
195. Triplett J. W., O'Riley R., Tekulve K., Norvell S. M., Pavalko F. M., Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner Molecular and Cellular Biomechanics 2007 4 1 13 25 (Pubitemid 47342518)
196. Wronski T. J., Morey-Holton E. R., Doty S. B., Maese A. C., Walsh C. C., Histomorphometric analysis of rat skeleton following spaceflight American Journal of Physiology 1987 252 2, part 2 R252 R255
197. Friedl G., Schmidt H., Rehak I., Kostner G., Schauenstein K., Windhager R., Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro Osteoarthritis and Cartilage 2007 15 11 1293 1300 (Pubitemid 350029038)
198. Kreke M. R., Huckle W. R., Goldstein A. S., Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner Bone 2005 36 6 1047 1055 (Pubitemid 40798006)
199. Li Y. J., Batra N. N., You L., Meier S. C., Coe I. A., Yellowley C. E., Jacobs C. R., Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation Journal of Orthopaedic Research 2004 22 6 1283 1289 (Pubitemid 39317920)
200. Schulze B. R., Horn D., Kobelt A., Tariverdian G., Stellzig A., Rare dental abnormalities seen in oculo-facio-cardio-dental (OFCD) syndrome: three new cases and review of nine patients American Journal of Medical Genetics 1999 82 5 429 435 (Pubitemid 29096154)
201. Hedera P., Gorski J. L., Oculo-facio-cardio-dental syndrome: skewed X chromosome inactivation in mother and daughter suggest X-linked dominant inheritance American Journal of Medical Genetics 2003 123A 3 261 266 (Pubitemid 37464345)
202. Horn D., Chyrek M., Kleier S., Lttgen S., Bolz H., Hinkel G. K., Korenke G. C., Rie A., Schell-Apacik C., Tinschert S., Wieczorek D., Gillessen-Kaesbach G., Kutsche K., Novel mutations in BCOR in three patients with oculo-facio-cardio-dental syndrome, but none in Lenz microphthalmia syndrome European Journal of Human Genetics 2005 13 5 563 569 (Pubitemid 40691396)
203. Oberoi S., Winder A. E., Johnston J., Vargervik K., Slavotinek A. M., Case reports of oculofaciocardiodental syndrome with unusual dental findings American Journal of Medical Genetics 2005 136 3 275 277 (Pubitemid 40967095)
204. Ng D., Thakker N., Corcoran C. M., Donnai D., Perveen R., Schneider A., Hadley D. W., Tifft C., Zhang L., Wilkie A. O. M., Van Der Smagt J. J., Gorlin R. J., Burgess S. M., Bardwell V. J., Black G. C. M., Biesecker L. G., Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR Nature Genetics 2004 36 4 411 416 (Pubitemid 38437266)
205. Huynh K. D., Fischle W., Verdin E., Bardwell V. J., BCOR, a novel corepressor involved in BCL-6 repression Genes Development 2000 14 14 1810 1823 (Pubitemid 30602999)
206. Gearhart M. D., Corcoran C. M., Wamstad J. A., Bardwell V. J., Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets Molecular and Cellular Biology 2006 26 18 6880 6889 (Pubitemid 44387637)
207. Sanchez C., Sanches I., Demmers J. A., Rodriguez P., Strouboulis J., Vidal M., Proteomics analysis of Ring1B/Rnf2 interactions identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the BCL6 interacting corepressor Molecular Cellular Proteomics 2007 6 5 820 834 (Pubitemid 46831934)
208. Sonoyama W., Liu Y., Fang D., Yamaza T., Seo B. M., Zhang C., Liu HE., Gronthos S., Wang C. Y., Shi S., Wang S., Mesenchymal stem cell-mediated functional tooth regeneration in swine PLoS One 2006 1, article e79
209. Seo B. M., Miura M., Gronthos S., Bartold P. M., Batouli S., Brahim J., Young M., Robey P. G., Wang C. Y., Shi S., Investigation of multipotent postnatal stem cells from human periodontal ligament The Lancet 2004 364 9429 149 155 (Pubitemid 38891686)
210. Arthur A., Rychkov G., Shi S., Koblar S. A., Gronthose S., Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues Stem Cells 2008 26 7 1787 1795
211. Shi Y., Whetstine J. R., Dynamic regulation of histone lysine methylation by demethylases Molecular Cell 2007 25 1 1 14 (Pubitemid 46049067)
212. Klose R. J., Kallin E. M., Zhang Y., JmjC-domain-containing proteins and histone demethylation Nature Reviews Genetics 2006 7 9 715 727 (Pubitemid 44260007)
213. Frescas D., Guardavaccaro D., Bassermann F., Koyama-Nasu R., Pagano M., JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes Nature 2007 450 7167 309 313 (Pubitemid 350100537)
214. Tsukada Y. I., Fang J., Erdjument-Bromage H., Warren M. E., Borchers C. H., Tempst P., Zhang YI., Histone demethylation by a family of JmjC domain-containing proteins Nature 2006 439 7078 811 816 (Pubitemid 43255695)
215. Otto T. C., Lane M. D., Adipose development: from stem cell to adipocyte Critical Reviews in Biochemistry and Molecular Biology 2005 40 4 229 242 (Pubitemid 41140883)
216. Siersbaek R., Nielsen R., Mandrup S., PPARgamma in adipocyte differentiation and metabolismnovel insights from genome-wide studies FEBS Letters 2010 584 15 3242 3249
217. Farmer S. R., Transcriptional control of adipocyte formation Cell Metabolism 2006 4 4 263 273 (Pubitemid 44430910)
218. MacDougald O. A., Mandrup S., Adipogenesis: forces that tip the scales Trends in Endocrinology and Metabolism 2002 13 1 5 11 (Pubitemid 36734009)
219. Morrison R. F., Farmer S. R., Insights into the transcriptional control of adipocyte differentiation Journal of Cellular Biochemistry 1999 76 supplement 32-33 59 67 (Pubitemid 30041811)
220. Spiegelman B. M., PPAR-gamma: adipogenic regulator and thiazolidinedione receptor Diabetes 1998 47 4 507 514 (Pubitemid 28160438)
221. Guo W., Zhang K. M., Tu K., Li Y. X., Zhu LI., Xiao H. S., Yang Y., Wu J. R., Adipogenesis licensing and execution are disparately linked to cell proliferation Cell Research 2009 19 2 216 223
222. Martin C., Zhang Y., The diverse functions of histone lysine methylation Nature Reviews Molecular Cell Biology 2005 6 11 838 849 (Pubitemid 41568733)
223. Narlikar G. J., Fan H. Y., Kingston R. E., Cooperation between complexes that regulate chromatin structure and transcription Cell 2002 108 4 475 487 (Pubitemid 34260873)
224. Silva A. J., Ward K., White R., Mosaic methylation in clonal tissue Developmental Biology 1993 156 2 391 398 (Pubitemid 23122304)
225. Pfeifer G. P., Steigerwald S. D., Hansen R. S., Gartler S. M., Riggs A. D., Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability Proceedings of the National Academy of Sciences of the United States of America 1990 87 21 8252 8256
226. Hoffman L. M., Carpenter M. K., Human embryonic stem cell stability Stem Cell Reviews 2005 1 2 139 144 (Pubitemid 43074198)
227. Ushijima T., Okochi-Takada E., Aberrant methylations in cancer cells: where do they come from? Cancer Science 2005 96 4 206 211 (Pubitemid 40767056)
228. Esteller M., Aberrant DNA methylation as a cancer-inducing mechanism Annual Review of Pharmacology and Toxicology 2005 45 629 656 (Pubitemid 40261820)
229. Yatabe Y., Tavare S., Shibata D., Investigating stem cells in human colon by using methylation patterns Proceedings of the National Academy of Sciences of the United States of America 2001 98 19 10839 10844 (Pubitemid 32884117)
230. Horii T., Morita S., Kimura M., Hatada I., Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF PLoS One 2009 4, article e5809 6
231. Kang M. I., Kim H. S., Jung Y. C., Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation Journal of Cellular Biochemistry 2007 102 1 224 239
232. Musri M. M., Gomis R., Parrizas M., Chromatin and chromatin-modifying proteins in adipogenesis Biochemistry and Cell Biology 2007 85 4 397 410 (Pubitemid 47518035)
233. Yokomori N., Tawata M., Onaya T., DNA demethylation modulates mouse leptin promoter activity during the differentiation of 3T3-L1 cells Diabetologia 2002 45 1 140 148 (Pubitemid 34118553)
234. Melzner I., Scott V., Dorsch K., Fischer P., Wabitsch M., Brderlein S., Hasel C., Mller P., Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter Journal of Biological Chemistry 2002 277 47 45420 45427 (Pubitemid 36159150)
235. Feige J. N., Auwerx J., Transcriptional coregulators in the control of energy homeostasis Trends in Cell Biology 2007 17 6 292 301 (Pubitemid 46829846)
236. Liu L., Li Y., Tollefsbol T. O., Gene-environment interactions and epigenetic basis of human diseases Current Issues in Molecular Biology 2008 10 1 25 36 (Pubitemid 351756576)
237. Miltenberger R. J., Mynatt R. L., Wilkinson J. E., Woychik R. P., The role of the agouti gene in the yellow obese syndrome Journal of Nutrition 1997 127 9 1902S 1907S (Pubitemid 27386423)
238. Yamanaka S., Strategies and new developments in the generation of patient-specific pluripotent stem cells Cell Stem Cell 2007 1 1 39 49 (Pubitemid 46865811)
239. Hochedlinger K., Jaenisch R., Nuclear reprogramming and pluripotency Nature 2006 441 7097 1061 1067 (Pubitemid 43990717)
240. Wilmut I., Schnieke A. E., McWhir J., Kind A. J., Campbell K. H., Viable offspring derived from fetal and adult mammalian cells Nature 1997 385 6619 810 813 (Pubitemid 27106068)
241. Takahashi K., Yamanaka S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 2006 126 4 663 676 (Pubitemid 44233629)
242. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 2007 131 5 861 872 (Pubitemid 350138099)
243. Takahashi K., Okita K., Nakagawa M., Yamanaka S., Induction of pluripotent stem cells from fibroblast cultures Nature Protocols 2007 2 12 3081 3089
244. Niwa H., How is pluripotency determined and maintained? Development 2007 134 4 635 646 (Pubitemid 46437906)
245. Park I. H., Zhao R., West J. A., Yabuuchi A., Huo H., Ince T. A., Lerou P. H., Lensch M. W., Daley G. Q., Reprogramming of human somatic cells to pluripotency with defined factors Nature 2008 451 7175 141 146
246. Yu J., Vodyanik M. A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J. L., Tian S., Nie J., Jonsdottir G. A., Ruotti V., Stewart R., Slukvin I. I., Thomson J. A., Induced pluripotent stem cell lines derived from human somatic cells Science 2007 318 5858 1917 1920
247. Okita K., Ichisaka T., Yamanaka S., Generation of germline-competent induced pluripotent stem cells Nature 2007 448 7151 313 317 (Pubitemid 47080336)
248. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., Okita K., Mochiduki Y., Takizawa N., Yamanaka S., Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nature Biotechnology 2008 26 1 101 106
249. Wernig M., Meissner A., Cassady J. P., Jaenisch R., c-Myc is dispensable for direct reprogramming of mouse fibroblasts Cell Stem Cell 2008 2 1 10 12
250. Feldman N., Gerson A., Fang J., Li EN., Zhang YI., Shinkai Y., Cedar H., Bergman Y., G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis Nature Cell Biology 2006 8 2 188 194
251. Wernig M., Meissner A., Foreman R., Brambrink T., Ku M., Hochedlinger K., Bernstein B. E., Jaenisch R., In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 2007 448 7151 318 324 (Pubitemid 47080337)
252. Maherali N., Sridharan R., Xie W., Utikal J., Eminli S., Arnold K., Stadtfeld M., Yachechko R., Tchieu J., Jaenisch R., Plath K., Hochedlinger K., Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution Cell Stem Cell 2007 1 1 55 70
253. Yang X., Smith S. L., Tian X. C., Lewin H. A., Renard J. P., Wakayama T., Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning Nature Genetics 2007 39 3 295 302 (Pubitemid 46328492)
254. Hochedlinger K., Jaenisch R., Nuclear transplantation, embryonic stem cells, and the potential for cell therapy The New England Journal of Medicine 2003 349 3 275 286 (Pubitemid 36859480)
255. Faast R., Harrison S. J., Beebe L. F., McIlfatrick S. M., Ashman R. J., Nottle M. B., Use of adult mesenchymal stem cells isolated from bone marrow and blood for somatic cell nuclear transfer in pigs Cloning and Stem Cells 2006 8 3 166 173 (Pubitemid 44735171)
256. Jaenisch R., Eggan K., Humpherys D., Rideout W., Hochedlinger K., Nuclear cloning, stem cells, and genomic reprogramming Cloning and Stem Cells 2002 4 4 389 396 (Pubitemid 36105807)
257. Eggan K., Akutsu H., Loring J., Jackson-Grusby L., Klemm M., Rideout W. M., Yanagimachi R., Jaenisch R., Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation Proceedings of the National Academy of Sciences of the United States of America 2001 98 11 6209 6214 (Pubitemid 32488218)
258. Eggan K., Rode A., Jentsch I., Samuel C., Hennek T., Tintrup H., Zevnik B., Erwin J., Loring J., Jackson-Grusby L., Speicher M. R., Kuehn R., Jaenisch R., Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation Nature Biotechnology 2002 20 5 455 459 (Pubitemid 34495930)
259. Rideout W. M. III, Wakayama T., Wutz A., Eggan K., Jackson-Grusby L., Dausman J., Yanagimachi R., Jaenisch R., Generation of mice from wild-type and targeted ES cells by nuclear cloning Nature Genetics 2000 24 2 109 110 (Pubitemid 30094708)
260. Wakayama T., Rodriguez I., Perry A. C., Yanagimachi R., Mombaerts P., Mice cloned from embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America 1999 96 26 14984 14989 (Pubitemid 30019751)
261. Jin H. F., Kumar B. M., Kim J. G., Song H. J., Jeong Y. J., Cho S. K., Balasubramanian S., Choe S. Y., Rho G. J., Enhanced development of porcine embryos cloned from bone marrow mesenchymal stem cells International Journal of Developmental Biology 2007 51 1 85 90 (Pubitemid 46182044)
262. Bosch P., Pratt S. L., Stice S. L., Isolation, characterization, gene modification, and nuclear reprogramming of porcine mesenchymal stem cells Biology of Reproduction 2006 74 1 46 57 (Pubitemid 43068790)
263. Colleoni S., Donofrio G., Lagutina I., Duchi R., Galli C., Lazzari G., Establishment, differentiation, electroporation, viral transduction, and nuclear transfer of bovine and porcine mesenchymal stem cells Cloning and Stem Cells 2005 7 3 154 166 (Pubitemid 43150271)
264. Brero A., Hao R., Schieker M., Wierer M., Wolf E., Cremer T., Zakhartchenko V., Reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts Cloning and Stem Cells 2009 11 2 319 329
265. Kishigami S., Bui H. T., Wakayama S., Successful mouse cloning of an outbred strain by trichostatin a treatment after somatic nuclear transfer The Journal of Reproduction and Development 2007 53 1 165 170 (Pubitemid 46397253)
266. Kishigami S., Mizutani E., Ohta H., Significant improvement of mouse cloning technique by treatment with trichostatin a after somatic nuclear transfer Biochemical and Biophysical Research Communications 2006 340 1 183 189 (Pubitemid 41827663)
267. Li J., Svarcova O., Villemoes K., Kragh P. M., Schmidt M., Bgh I. B., Zhang Y., Du Y., Lin L., Purup S., Xue Q., Bolund L., Yang H., Maddox-Hyttel P., Vajta G., High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos Theriogenology 2008 70 5 800 808
268. Zhang Y., Li J., Villemoes K., Pedersen A. M., Purup S., Vajta G., An epigenetic modifier results in improved in vitro blastocyst production after somatic cell nuclear transfer Cloning and Stem Cells 2007 9 3 357 363
269. Iager A. E., Ragina N. P., Ross P. J., Beyhan Z., Cunniff K., Rodriguez R. M., Cibelli J. B., Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos Cloning and Stem Cells 2008 10 3 371 379
270. Ding X., Wang Y., Zhang D., Wang Y., Guo Z., Zhang Y., Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2′-deoxycytidine and trichostatin A Theriogenology 2008 70 4 622 630
271. Shi L. H., Miao Y. L., Ouyang Y. C., Huang J. C., Lei ZI. L., Yang JI. W., Han Z. M., Song X. F., Sun Q. Y., Chen DA. Y., Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos Developmental Dynamics 2008 237 3 640 648
272. Meng Q., Polgar Z., Liu J., Dinnyes A., Live birth of somatic cell-cloned rabbits following trichostatin A treatment and cotransfer of parthenogenetic embryos Cloning and Stem Cells 2009 11 1 203 208
273. Wu X., Li Y., Li G. P., Yang D., Yue Y., Wang L., Li K., Xin P., Bou S., Yu H., Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development Animal Biotechnology 2008 19 4 211 224
274. Marks P. A., Richon V. M., Rifkind R. A., Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells Journal of the National Cancer Institute 2000 92 15 1210 1216 (Pubitemid 30627729)
275. Maalouf W. E., Liu Z., Brochard V., Renard J. P., Debey P., Beaujean N., Zink D., Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term BMC Developmental Biology 2009 9, article 11
276. Li X., Kato Y., Tsuji Y., Tsunoda Y., The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts Cloning and Stem Cells 2008 10 1 133 142 (Pubitemid 351341549)
277. Wee G., Shim J. J., Koo D. B., Chae J. I., Lee K. K., Han Y. M., Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos Reproduction 2007 134 6 781 787
278. Martinez-Diaz M. A., Che L., Albornoz M., Seneda M. M., Collis D., Coutinho A. R., El-Beirouthi N., Laurin D., Zhao X., Bordignon V., Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases Cellular Reprogramming 2010 12 1 85 94