Nuclear transplantation, embryonic stem cells, and the potential for cell therapy

New England Journal of Medicine

Volumn 349, Issue 3, 2003, Pages 275-286

  Hochedlinger, Konrad ^a   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL CLONING; CELL DIFFERENTIATION; CELL NUCLEUS TRANSPLANTATION; CHROMOSOME ANALYSIS; CHROMOSOME STRUCTURE; EMBRYO TRANSFER; FERTILIZATION; GAMETOGENESIS; GENE EXPRESSION; GENETIC DISORDER; GENETICS; HEMATOPOIESIS; HUMAN; LABORATORY TEST; NONHUMAN; OMENN SYNDROME; PRIORITY JOURNAL; REPRODUCTION; REVIEW; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; TELOMERE; ZYGOTE; ADULT; ANIMAL; BIOMEDICAL AND BEHAVIORAL RESEARCH; CLONING; CYTOLOGY; EMBRYO; ETHICS; GENE THERAPY; GENETICS AND REPRODUCTION; METHODOLOGY; MOUSE; MOUSE MUTANT; STEM CELL;

BIOMEDICAL AND BEHAVIORAL RESEARCH; GENETICS AND REPRODUCTION;

ADULT; ANIMALS; CLONING, ORGANISM; EMBRYO; GENE EXPRESSION; GENE THERAPY; HUMANS; MICE; MICE, MUTANT STRAINS; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 0038678846     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMra035397     Document Type: Review

References (72)

1. Solter D. Mammalian cloning: advances and limitations. Nat Rev Genet 2000;1:199-207.
2. Rideout WM III, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293:1093-8.
3. Hochedlinger K, Jaenisch R. Nuclear transplantation: lessons from frogs and mice. Curr Opin Cell Biol 2002;14:741-8.
4. Wakayama T, Yanagimachi R. Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev 2001;58:376-83.
5. Hochedlinger K, Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature 2002;415:1035-8.
6. Wakayama T, Tabar V, Rodriguez I, Perry AC, Studer L, Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 2001;292:740-3.
7. Wakayama T, Yanagimachi R. Cloning of male mice from adult tail-tip cells. Nat Genet 1999;22:127-8.
8. Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 1998;394:369-74.
9. Munsie MJ, Michalska AE, O'Brien CM, Trounson AO, Pera MF, Mountford PS. Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei. Curr Biol 2000;10:989-92.
10. Eggan K, Akutsu H, Loring J, et al. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A 2001;98:6209-14.
11. Rideout WM III, Wakayama T, Wutz A, et al. Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet 2000;24:109-10.
12. Cheong HT, Takahashi Y, Kanagawa H. Birth of mice after transplantation of early cell-cycle-stage embryonic nuclei into enucleated oocytes. Biol Reprod 1993;48:958-63.
13. McGrath J, Solter D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 1984;37:179-83.
14. Tanaka S, Oda M, Toyoshima Y, et al. Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer. Biol Reprod 2001;65:1813-21.
15. Hill JR, Burghardt RC, Jones K, et al. Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol Reprod 2000;63:1787-94.
16. Young LE, Sinclair KD, Wilmut I. Large offspring syndrome in cattle and sheep. Rev Reprod 1998;3:155-63.
17. Humpherys D, Eggan K, Akutsu H, et al. Epigenetic instability in ES cells and cloned mice. Science 2001;293:95-7.
18. Cibelli JB, Campbell KH, Seidel GE, West MD, Lanza RP. The health profile of cloned animals. Nat Biotechnol 2002;20:13-4.
19. Tamashiro KL, Wakayama T, Akutsu H, et al. Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med 2002;8:262-7.
20. Ogonuki N, Inoue K, Yamamoto Y, et al. Early death of mice cloned from somatic cells. Nat Genet 2002;30:253-4.
21. Bortvin A, Eggan K, Skaletsky H, et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 2003;130:1673-80.
22. Boiani M, Eckardt S, Scholer HR, McLaughlin KJ. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev 2002;16:1209-19.
23. Kang YK, Koo DB, Park JS, et al. Aberrant methylation of donor genome in cloned bovine embryos. Nat Genet 2001;28:173-7.
24. Kang YK, Park JS, Koo DB, et al. Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos. EMBO J 2002;21:1092-100.
25. Dean W, Santos F, Stojkovic M, et al. Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci U S A 2001;98:13734-8.
26. Gao S, Chung YG, Williams JW, Riley J, Moley K, Latham KE. Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei. Biol Reprod (in press).
27. Jaenisch R, Eggan K, Humpherys D, Rideout W, Hochedlinger K. Nuclear cloning, stem cells, and genomic reprogramming. Cloning Stem Cells 2002;4:389-96.
28. Humpherys D, Eggan K, Akutsu H, et al. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A 2002;99:12889-94.
29. Eggan K, Akutsu H, Hochedlinger K, Rideout W III, Yanagimachi R, Jaenisch R. X-chromosome inactivation in cloned mouse embryos. Science 2000;290:1578-81.
30. Betts D, Bordignon V, Hill J, et al. Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci U S A 2001;98:1077-82.
31. Lanza RP, Cibelli JB, Blackwell C, et al. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 2000;288:665-9.
32. Tian XC, Xu J, Yang X. Normal telomere lengths found in cloned cattle. Nat Genet 2000;26:272-3.
33. Wakayama T, Shinkai Y, Tamashiro KL, et al. Cloning of mice to six generations. Nature 2000;407:318-9.
34. Wells DN, Misica PM, Tervit HR. Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells. Biol Reprod 1999;60:996-1005.
35. Gurdon JB, Laskey RA, Reeves OR. The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. J Embryol Exp Morphol 1975;34:93-112.
36. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-3. [Erratum, Nature 1997;386:200.]
37. Liu L. Cloning efficiency and differentiation. Nat Biotechnol 2001;19:406.
38. Oback B, Wells D. Donor cells for nuclear cloning: many are called, but few are chosen. Cloning Stem Cells 2002;4:147-68.
39. Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000;100:157-68.
40. Vogelstein B, Alberts B, Shine K. Genetics: please don't call it cloning! Science 2002;295:1237.
41. Colman A, Kind A. Therapeutic cloning: concepts and practicalities. Trends Biotechnol 2000;18:192-6.
42. Zwaka TP, Thomson JA. Homologous recombination in human embryonic stem cells. Nat Biotechnol 2003;21:319-21.
43. Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2000;97:11307-12.
44. Odorico JS, Kaufman DS, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells 2001;19:193-204.
45. Carpenter MK, Inokuma MS, Denham J, Mujtaba T, Chiu CP, Rao MS. Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neurol 2001;172:383-97.
46. Reubinoff BE, Itsykson P, Turetsky T, et al. Neural progenitors from human embryonic stem cells. Nat Biotechnol 2001;19:1134-40.
47. Schuldiner M, Eiges R, Eden A, et al. Induced neuronal differentiation of human embryonic stem cells. Brain Res 2001;913:201-5.
48. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2001;98:10716-21.
49. Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001;50:1691-7.
50. Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002;110:385-97.
51. Kim JH, Auerbach JM, Rodriguez-Gomez JA, et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002;418:50-6.
52. Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-62.
53. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 2002;109:29-37.
54. Klug MG, Soonpaa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 1996;98:216-24.
55. Li M, Pevny L, Lovell-Badge R, Smith A. Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 1998;8:971-4.
56. Rideout WM III, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 2002;109:17-27.
57. Buehr M, Nichols J, Stenhouse F, et al. Rapid loss of oct-4 and pluripotency in cultured rodent blastocysts and derivative cell lines. Biol Reprod 2003;68:222-9.
58. Reik W, Maher ER. Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome. Trends Genet 1997;13:330-4.
59. Moorehead RA, Sanchez OH, Baldwin RM, Khokha R. Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma. Oncogene 2003;22:853-7.
60. Byrne JA, Simonsson S, Gurdon JB. From intestine to muscle: nuclear reprogramming through defective cloned embryos. Proc Natl Acad Sci U S A 2002;99:6059-63.
61. Joshi CV, Enver T. Plasticity revisited. Curr Opin Cell Biol 2002;14:749-55.
62. Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature 2002;416:545-8.
63. Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416:542-5.
64. Vassilopoulos G, Wang P-R, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003;422:901-4.
65. Wang X, Willenbring H, Akkari Y, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
66. Morshead CM, Benveniste P, Iscove NN, van der Kooy D. Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med 2002;8:268-73.
67. Wagers AJ, Sherwood RJ, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297:2256-9.
68. Check E. Second cancer case halts gene-therapy trials. Nature 2003;421:305.
69. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-9.
70. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000;24:372-6.
71. Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-91.
72. Hübner K, Fuhrmann G, Christenson LK, et al. Derivation of oocytes from mouse embryonic stem cells. Science 2003;300:1251-6.