Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity

Stem Cells

Volumn 27, Issue 5, 2009, Pages 1142-1151

  Delorme, Bruno ^a,b   Ringe, Jochen ^c   Pontikoglou, Charalampos ^a   Gaillard, Julien ^a,d   Langonné, Alain ^a,d   Sensebé, Luc ^a,d   Noël, Danièle ^e   Jorgensen, Christian ^e   Häupl, Thomas ^c   Charbord, Pierre ^a,f  

^a UNIVERSITÉ DE TOURS   (France)

^b MacoPharma   (France)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d ETABLISSEMENT FRANÇAIS DU SANG   (France)

^e LAPEYRONIE HOSPITAL   (France)

^f HÔPITAL PAUL BROUSSE   (France)

Author keywords

Adipocyte; Chondrocyte; Differentiation; Endothelium; Hepatocyte; Muscle; Neuron; Osteoblast

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SPECIFICITY; CONTROLLED STUDY; HEART MUSCLE; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LINEAGE PRIMING; LIVER CELL; MESENCHYMAL STEM CELL; MOLECULAR MODEL; NERVE CELL; NONHUMAN; OSTEOBLAST; PLASTICITY; PROTEIN BLOOD LEVEL; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; DOWN-REGULATION; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; HUMANS; MESENCHYMAL STEM CELLS; MICE; MUSCLE, SMOOTH, VASCULAR; RNA, MESSENGER; TRANS-ACTIVATORS;

PUFFINUS AURICULARIS;

EID: 66149168688     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.34     Document Type: Article

References (44)

1. Zipori D. The nature of stem cells: State rather than entity. Nat Rev Genet 2004;5:873-878. (Pubitemid 39457503)
2. Hu M, Krause D, Greaves M et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev 1997;11:774-785. (Pubitemid 27157165)
3. Peterkin T, Gibson A, Loose M et al. The roles of GATA-4, -5 and -6 in vertebrate heart development. Semin Cell Dev Biol 2005;16:83-94.
4. Loose M, Patient R. Global genetic regulatory networks controlling hematopoietic cell fates. Curr Opin Hematol 2006;13:229-236. (Pubitemid 44288898)
5. Vilquin JT, Rosset P. Mesenchymal stem cells in bone and cartilage repair: Current status. Regen Med 2006;1:589-604.
6. Horwitz EM, Gordon PL, Koo WK et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 2002;99:8932-8937. (Pubitemid 34693661)
7. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147. (Pubitemid 29282067)
8. Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-49. (Pubitemid 34742565)
9. Even-Ram S, Artym V, Yamada KM. Matrix control of stem cell fate. Cell 2006;126:645-647. (Pubitemid 44233640)
10. Dezawa M, Ishikawa H, Itokazu Y et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 2005;309:314-317.
11. Dezawa M, Kanno H, Hoshino M et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 2004;113:1701-1710. (Pubitemid 39071662)
12. Anjos-Afonso F, Bonnet D. Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood 2007;109:1298-1306. (Pubitemid 46220683)
13. Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982;30:215-224. (Pubitemid 13237099)
14. Park SR, Oreffo RO, Triffitt JT. Interconversion potential of cloned human marrow adipocytes in vitro. Bone 1999;24:549-554. (Pubitemid 29234067)
15. Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 2004;18:980-982. (Pubitemid 39561498)
16. Song L, Webb NE, Song Y et al. Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells 2006;24:1707-1718. (Pubitemid 44474184)
17. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74. (Pubitemid 27161245)
18. Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317.
19. Delorme B, Charbord P. Culture and characterization of human bone marrow mesenchymal stem cells. Methods Mol Med 2007;140:67-81.
20. Delorme B, Ringe J, Gallay N et al. Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood 2008;111:2631-2635.
21. Chateauvieux S, Ichante JL, Delorme B et al. Molecular profile of mouse stromal mesenchymal stem cells. Physiol Genomics 2007;29:128-138. (Pubitemid 46701994)
22. Sturn A, Quackenbush J, Trajanoski Z. Genesis: Cluster analysis of microarray data. Bioinformatics 2002;18:207-208. (Pubitemid 34145055)
23. Solchaga LA, Penick K, Porter JD et al. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 2005;203:398-409. (Pubitemid 40471774)
24. Pri-Chen S, Pitaru S, Lokiec F et al. Basic fibroblast growth factor enhances the growth and expression of the osteogenic phenotype of dexamethasone-treated human bone marrow-derived bone-like cells in culture. Bone 1998;23:111-117. (Pubitemid 28379871)
25. Tremain N, Korkko J, Ibberson D et al. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 2001;19:408-418. (Pubitemid 32900083)
26. Woodbury D, Reynolds K, Black IB. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 2002;69:908-917.
27. Minguell JJ, Fierro FA, Epunan MJ et al. Nonstimulated human uncommitted mesenchymal stem cells express cell markers of mesenchymal and neural lineages. Stem Cells Dev 2005;14:408-414. (Pubitemid 41243704)
28. Seshi B, Kumar S, King D. Multilineage gene expression in human bone marrow stromal cells as evidenced by single-cell microarray analysis. Blood Cells Mol Dis 2003;31:268-285. (Pubitemid 37075963)
29. Satomura K, Krebsbach P, Bianco P et al. Osteogenic imprinting upstream of marrow stromal cell differentiation. J Cell Biochem 2000;78:391-403. (Pubitemid 30491068)
30. Galmiche MC, Koteliansky VE, Briere J et al. Stromal cells from human long-term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway. Blood 1993;82:66-76. (Pubitemid 23188748)
31. Sacchetti B, Funari A, Michienzi S et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007;131:324-336. (Pubitemid 47592917)
32. Pontikoglou C, Delorme B, Charbord P. Human bone marrow native mesenchymal stem cells. Regen Med 2008;3:731-741.
33. da Silva Meirelles L, Caplan AI, Nardi NB. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008;26:2287-2299.
34. Oswald J, Boxberger S, Jorgensen B et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004;22:377-384. (Pubitemid 38736621)
35. Ball SG, Shuttleworth CA, Kielty CM. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol 2007;177:489-500. (Pubitemid 46718277)
36. Muguruma Y, Yahata T, Miyatake H et al. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 2006;107:1878-1887. (Pubitemid 43289366)
37. Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
38. Phinney DG, Prockop DJ. Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007;25:2896-2902. (Pubitemid 350127874)
39. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98:1076-1084. (Pubitemid 44128350)
40. Graf T. Differentiation plasticity of hematopoietic cells. Blood 2002;99:3089-3101. (Pubitemid 34525285)
41. Makino S, Fukuda K, Miyoshi S et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705. (Pubitemid 29122423)
42. Kaltz N, Funari A, Hippauf S et al. In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. Stem Cells 2008;26:2419-2424.
43. Peiffer I, Eid P, Barbet R et al. A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon alpha/beta. Leukemia 2007;21:714-724. (Pubitemid 46444555)
44. Breitbach M, Bostani T, Roell W et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007;110:1362-1369. (Pubitemid 47281438)