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Volumn 55, Issue 9, 2011, Pages 1375-1390

Acrolein scavengers: Reactivity, mechanism and impact on health

Author keywords

Acrolein; Antioxidants; Lipid peroxidation; Scavengers

Indexed keywords


EID: 80052525395     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100149     Document Type: Review
Times cited : (70)

References (136)
  • 3
    • 57449115593 scopus 로고    scopus 로고
    • Acrolein environmental levels and potential for human exposure
    • Faroon, O., Roney, N., Taylor, J., Ashizawa, A. et al., Acrolein environmental levels and potential for human exposure. Toxicol. Ind. Health 2008, 24, 543-564.
    • (2008) Toxicol. Ind. Health , vol.24 , pp. 543-564
    • Faroon, O.1    Roney, N.2    Taylor, J.3    Ashizawa, A.4
  • 4
    • 0342309586 scopus 로고
    • Analysis of acrolein from heated cooking oils and beef fat
    • Umano, K., Shibamoto, T., Analysis of acrolein from heated cooking oils and beef fat. J. Agric. Food Chem. 1987, 35, 909-912.
    • (1987) J. Agric. Food Chem. , vol.35 , pp. 909-912
    • Umano, K.1    Shibamoto, T.2
  • 5
    • 28144464890 scopus 로고    scopus 로고
    • Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health
    • O'Brien, P. J., Siraki, A. G., Shangari, N., Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 2005, 35, 609-662.
    • (2005) Crit. Rev. Toxicol. , vol.35 , pp. 609-662
    • O'Brien, P.J.1    Siraki, A.G.2    Shangari, N.3
  • 6
    • 0025748742 scopus 로고
    • Cyclophosphamide-associated carcinoma of urothelium: modalities for prevention
    • Cannon, J., Linke, C. A., Cos, L. R., Cyclophosphamide-associated carcinoma of urothelium: modalities for prevention. Urology 1991, 38, 413-416.
    • (1991) Urology , vol.38 , pp. 413-416
    • Cannon, J.1    Linke, C.A.2    Cos, L.R.3
  • 7
    • 18244396095 scopus 로고    scopus 로고
    • Oxidation of all-cis-7,10,13,16,19-docosapentaenoic acid ethyl ester. Hydroperoxide distribution and volatile characterization
    • Pan, X. Q., Kaneko, H., Ushio, H., Ohshima, T., Oxidation of all-cis-7, 10, 13, 16, 19-docosapentaenoic acid ethyl ester. Hydroperoxide distribution and volatile characterization. Eur. J. Lipid Sci. Technol. 2005, 107, 228-238.
    • (2005) Eur. J. Lipid Sci. Technol. , vol.107 , pp. 228-238
    • Pan, X.Q.1    Kaneko, H.2    Ushio, H.3    Ohshima, T.4
  • 8
    • 0032568935 scopus 로고    scopus 로고
    • Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
    • Uchida, K., Kanematsu, M., Morimitsu, Y., Osawa, T. et al., Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins. J. Biol. Chem. 1998, 273, 16058-16066.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16058-16066
    • Uchida, K.1    Kanematsu, M.2    Morimitsu, Y.3    Osawa, T.4
  • 9
    • 13144266681 scopus 로고    scopus 로고
    • Protein-bound acrolein: potential markers for oxidative stress
    • Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T. et al., Protein-bound acrolein: potential markers for oxidative stress. Proc. Natl. Acad. Sci. USA 1998, 95, 4882-4887.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4882-4887
    • Uchida, K.1    Kanematsu, M.2    Sakai, K.3    Matsuda, T.4
  • 10
    • 0033452913 scopus 로고    scopus 로고
    • Current status of acrolein as a lipid peroxidation product
    • Uchida, K., Current status of acrolein as a lipid peroxidation product. Trends Cardiovasc. Med. 1999, 9, 109-113.
    • (1999) Trends Cardiovasc. Med. , vol.9 , pp. 109-113
    • Uchida, K.1
  • 11
    • 42949163044 scopus 로고    scopus 로고
    • Carbonyl-scavenging drugs and protection against carbonyl stress-associated cell injury
    • Burcham, P. C., Kaminskas, L. M., Tan, D., Pyke, S. M., Carbonyl-scavenging drugs and protection against carbonyl stress-associated cell injury. Mini Rev. Med. Chem. 2008, 8, 319-330.
    • (2008) Mini Rev. Med. Chem. , vol.8 , pp. 319-330
    • Burcham, P.C.1    Kaminskas, L.M.2    Tan, D.3    Pyke, S.M.4
  • 12
    • 38949113159 scopus 로고    scopus 로고
    • Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease
    • Stevens, J. F., Maier, C. S., Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol. Nutr. Food Res. 2008, 52, 7-25.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 7-25
    • Stevens, J.F.1    Maier, C.S.2
  • 13
    • 0024456697 scopus 로고
    • Biological interactions of alpha, beta-unsaturated aldehydes
    • Witz, G., Biological interactions of alpha, beta-unsaturated aldehydes. Free Radic. Biol. Med. 1989, 7, 333-349.
    • (1989) Free Radic. Biol. Med. , vol.7 , pp. 333-349
    • Witz, G.1
  • 14
    • 0032905632 scopus 로고    scopus 로고
    • Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease
    • Calingasan, N. Y., Uchida, K., Gibson, G. E., Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. J. Neurochem. 1999, 72, 751-756.
    • (1999) J. Neurochem. , vol.72 , pp. 751-756
    • Calingasan, N.Y.1    Uchida, K.2    Gibson, G.E.3
  • 15
    • 1342308332 scopus 로고    scopus 로고
    • Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity
    • Burcham, P. C., Fontaine, F. R., Kaminskas, L. M., Petersen, D. R., Pyke, S. M., Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity. Mol. Pharm. 2004, 65, 655-664.
    • (2004) Mol. Pharm. , vol.65 , pp. 655-664
    • Burcham, P.C.1    Fontaine, F.R.2    Kaminskas, L.M.3    Petersen, D.R.4    Pyke, S.M.5
  • 16
    • 0021319465 scopus 로고
    • 2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde
    • 2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde. Cancer Res. 1984, 44, 990-995.
    • (1984) Cancer Res. , vol.44 , pp. 990-995
    • Chung, F.L.1    Young, R.2    Hecht, S.S.3
  • 17
    • 49049091162 scopus 로고    scopus 로고
    • Interstrand DNA cross-links induced by alpha, beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources
    • Stone, M. P., Cho, Y. J., Huang, H., Kim, H. Y. et al., Interstrand DNA cross-links induced by alpha, beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources. Acc. Chem. Res. 2008, 41, 793-804.
    • (2008) Acc. Chem. Res. , vol.41 , pp. 793-804
    • Stone, M.P.1    Cho, Y.J.2    Huang, H.3    Kim, H.Y.4
  • 18
    • 0029824077 scopus 로고    scopus 로고
    • Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts
    • Chung, F. L., Chen, H. J. C., Nath, R. G., Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts. Carcinogenesis 1996, 17, 2105-2111.
    • (1996) Carcinogenesis , vol.17 , pp. 2105-2111
    • Chung, F.L.1    Chen, H.J.C.2    Nath, R.G.3
  • 20
    • 0036709597 scopus 로고    scopus 로고
    • Cellular glutathione and thiols metabolism
    • Dickinson, D. A., Forman, H. J., Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 2002, 64, 1019-1026.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1019-1026
    • Dickinson, D.A.1    Forman, H.J.2
  • 21
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer, H., Schaur, R. J., Zollner, H., Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 1991, 11, 81-128.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 22
    • 0033864802 scopus 로고    scopus 로고
    • The molecular effects of acrolein
    • Kehrer, J. P., Biswal, S. S., The molecular effects of acrolein. Toxicol. Sci. 2000, 57, 6-15.
    • (2000) Toxicol. Sci. , vol.57 , pp. 6-15
    • Kehrer, J.P.1    Biswal, S.S.2
  • 23
    • 0023894123 scopus 로고
    • Pathobiological effects of acrolein in cultured human bronchial epithelial cells
    • Grafstrom, R. C., Dypbukt, J. M., Willey, J. C., Sundqvist, K. et al., Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res. 1988, 48, 1717-1721.
    • (1988) Cancer Res. , vol.48 , pp. 1717-1721
    • Grafstrom, R.C.1    Dypbukt, J.M.2    Willey, J.C.3    Sundqvist, K.4
  • 24
    • 34250864375 scopus 로고    scopus 로고
    • Reactive carbonyls and oxidative stress: potential for therapeutic intervention
    • Ellis, E. M., Reactive carbonyls and oxidative stress: potential for therapeutic intervention. Pharmacol. Ther. 2007, 115, 13-24.
    • (2007) Pharmacol. Ther. , vol.115 , pp. 13-24
    • Ellis, E.M.1
  • 25
    • 0035112495 scopus 로고    scopus 로고
    • Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    • Lovell, M. A., Xie, C., Markesbery, W. R., Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiol. Aging 2001, 22, 187-194.
    • (2001) Neurobiol. Aging , vol.22 , pp. 187-194
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 26
    • 70450176923 scopus 로고    scopus 로고
    • Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury
    • Hamann, K., Shi, R., Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury. J. Neurochem. 2009, 111, 1348-1356.
    • (2009) J. Neurochem. , vol.111 , pp. 1348-1356
    • Hamann, K.1    Shi, R.2
  • 27
    • 78650781342 scopus 로고    scopus 로고
    • Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Muller glia dysfunction and death in diabetic retinopathy
    • Yong, P. H., Zong, H., Medina, R. J., Limb, G. A. et al., Evidence supporting a role for N-(3-formyl-3, 4-dehydropiperidino)lysine accumulation in Muller glia dysfunction and death in diabetic retinopathy. Mol. Vis. 2010, 16, 2524-2538.
    • (2010) Mol. Vis. , vol.16 , pp. 2524-2538
    • Yong, P.H.1    Zong, H.2    Medina, R.J.3    Limb, G.A.4
  • 28
    • 42149161725 scopus 로고    scopus 로고
    • Molecular mechanisms of the conjugated alpha, beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases
    • LoPachin, R. M., Barber, D. S., Gavin, T., Molecular mechanisms of the conjugated alpha, beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases. Toxicol. Sci. 2008, 104, 235-249.
    • (2008) Toxicol. Sci. , vol.104 , pp. 235-249
    • LoPachin, R.M.1    Barber, D.S.2    Gavin, T.3
  • 29
    • 33845780096 scopus 로고    scopus 로고
    • Protein and low molecular mass thiols as targets and inhihitors of glycation reactions
    • Zeng, J. M., Davies, M. J., Protein and low molecular mass thiols as targets and inhihitors of glycation reactions. Chem. Res. Toxicol. 2006, 19, 1668-1676.
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 1668-1676
    • Zeng, J.M.1    Davies, M.J.2
  • 30
    • 33846844719 scopus 로고    scopus 로고
    • Actin Cys374 as a nucleophilic target of alpha, beta-unsaturated aldehydes
    • Dalle-Donne, I., Carini, M., Vistoli, G., Gamberoni, L. et al., Actin Cys374 as a nucleophilic target of alpha, beta-unsaturated aldehydes. Free Radic. Biol. Med. 2007, 42, 583-598.
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 583-598
    • Dalle-Donne, I.1    Carini, M.2    Vistoli, G.3    Gamberoni, L.4
  • 31
    • 84870227385 scopus 로고
    • Reaction of glutathione with conjugated carbonyls
    • Esterbauer, H., Zollner, H., Scholz, N., Reaction of glutathione with conjugated carbonyls. Z. Naturforsch. C 1975, 30, 466-473.
    • (1975) Z. Naturforsch. C , vol.30 , pp. 466-473
    • Esterbauer, H.1    Zollner, H.2    Scholz, N.3
  • 32
    • 0000635578 scopus 로고
    • Reaction of cysteine with alpha, beta-unsaturated aldehydes
    • Esterbauer, H., Ertl, A., Scholz, N., Reaction of cysteine with alpha, beta-unsaturated aldehydes. Tetrahedron 1976, 32, 285-289.
    • (1976) Tetrahedron , vol.32 , pp. 285-289
    • Esterbauer, H.1    Ertl, A.2    Scholz, N.3
  • 33
    • 0024210285 scopus 로고
    • The reaction of sulfhydryl groups with carbonyl compounds
    • Wlodek, L., The reaction of sulfhydryl groups with carbonyl compounds. Acta Biochim. Pol. 1988, 35, 307-317.
    • (1988) Acta Biochim. Pol. , vol.35 , pp. 307-317
    • Wlodek, L.1
  • 34
    • 0038359545 scopus 로고    scopus 로고
    • Inactivation of acrolein by sodium 2-mercaptoethanesulfonate using headspace-solid-phase microextraction gas chromatography and mass spectrometry
    • Takamoto, S., Sakura, N., Yashiki, M., Kojima, T., Inactivation of acrolein by sodium 2-mercaptoethanesulfonate using headspace-solid-phase microextraction gas chromatography and mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 791, 365-369.
    • (2003) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.791 , pp. 365-369
    • Takamoto, S.1    Sakura, N.2    Yashiki, M.3    Kojima, T.4
  • 35
    • 4744352124 scopus 로고    scopus 로고
    • Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde
    • Kaminskas, L. M., Pyke, S. M., Burcham, P. C., Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Org. Biomol. Chem. 2004, 2, 2578-2584.
    • (2004) Org. Biomol. Chem. , vol.2 , pp. 2578-2584
    • Kaminskas, L.M.1    Pyke, S.M.2    Burcham, P.C.3
  • 36
    • 1342306400 scopus 로고    scopus 로고
    • Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease
    • Pocernich, C. B., Butterfield, D. A., Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotox. Res. 2003, 5, 515-520.
    • (2003) Neurotox. Res. , vol.5 , pp. 515-520
    • Pocernich, C.B.1    Butterfield, D.A.2
  • 37
    • 0029852202 scopus 로고    scopus 로고
    • Kinetics of the reaction of a potential chemopreventive agent, 2,6-dithiopurine, and its major metabolite, 2,6-dithiouric acid, with multiple classes of electrophilic toxicants
    • Qing, W. G., Powell, K. L., MacLeod, M. C., Kinetics of the reaction of a potential chemopreventive agent, 2, 6-dithiopurine, and its major metabolite, 2, 6-dithiouric acid, with multiple classes of electrophilic toxicants. Chem. Res. Toxicol. 1996, 9, 1298-1304.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 1298-1304
    • Qing, W.G.1    Powell, K.L.2    MacLeod, M.C.3
  • 38
    • 66049159838 scopus 로고    scopus 로고
    • Protein modification by acrolein: formation and stability of cysteine adducts
    • Cai, J., Bhatnagar, A., Pierce, W. M., Jr., Protein modification by acrolein: formation and stability of cysteine adducts. Chem. Res. Toxicol. 2009, 22, 708-716.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 708-716
    • Cai, J.1    Bhatnagar, A.2    Pierce Jr., W.M.3
  • 39
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D. et al., Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39, 44-84.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3    Cronin, M.T.D.4
  • 40
    • 0037505644 scopus 로고    scopus 로고
    • Analysis of glutathione: implication in redox and detoxification
    • Pastore, A., Federici, G., Bertini, E., Piemonte, F., Analysis of glutathione: implication in redox and detoxification. Clin. Chim. Acta 2003, 333, 19-39.
    • (2003) Clin. Chim. Acta , vol.333 , pp. 19-39
    • Pastore, A.1    Federici, G.2    Bertini, E.3    Piemonte, F.4
  • 41
    • 0024460929 scopus 로고
    • Metabolism of the glutathione-acrolein adduct, S-(2-aldehydo-ethyl)glutathione, by rat liver alcohol and aldehyde dehydrogenase
    • Mitchell, D. Y., Petersen, D. R., Metabolism of the glutathione-acrolein adduct, S-(2-aldehydo-ethyl)glutathione, by rat liver alcohol and aldehyde dehydrogenase. J. Pharmacol. Exp. Ther. 1989, 251, 193-198.
    • (1989) J. Pharmacol. Exp. Ther. , vol.251 , pp. 193-198
    • Mitchell, D.Y.1    Petersen, D.R.2
  • 42
    • 0031928728 scopus 로고    scopus 로고
    • 14C]acrolein in Sprague-Dawley rats: II. Identification of urinary and fecal metabolites
    • 14C]acrolein in Sprague-Dawley rats: II. Identification of urinary and fecal metabolites. Toxicol. Sci. 1998, 43, 110-120.
    • (1998) Toxicol. Sci. , vol.43 , pp. 110-120
    • Parent, R.A.1    Paust, D.E.2    Schrimpf, M.K.3    Talaat, R.E.4
  • 43
    • 34547638065 scopus 로고    scopus 로고
    • Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking
    • Carmella, S. G., Chen, M. L., Zhang, Y., Zhang, S. Y. et al., Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking. Chem. Res. Toxicol. 2007, 20, 986-990.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 986-990
    • Carmella, S.G.1    Chen, M.L.2    Zhang, Y.3    Zhang, S.Y.4
  • 44
    • 0021205298 scopus 로고
    • Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450
    • Marinello, A. J., Bansal, S. K., Paul, B., Koser, P. L. et al., Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450. Cancer Res. 1984, 44, 4615-4621.
    • (1984) Cancer Res. , vol.44 , pp. 4615-4621
    • Marinello, A.J.1    Bansal, S.K.2    Paul, B.3    Koser, P.L.4
  • 45
    • 0032974958 scopus 로고    scopus 로고
    • Role of glutathione on acrolein-induced cytotoxicity and mutagenicity in Escherichia coli
    • Nunoshiba, T., Yamamoto, K., Role of glutathione on acrolein-induced cytotoxicity and mutagenicity in Escherichia coli. Mutat. Res. 1999, 442, 1-8.
    • (1999) Mutat. Res. , vol.442 , pp. 1-8
    • Nunoshiba, T.1    Yamamoto, K.2
  • 46
    • 0007996162 scopus 로고    scopus 로고
    • The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall
    • He, N. G., Awasthi, S., Singhal, S. S., Trent, M. B., Boor, P. J., The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall. Toxicol. Appl. Pharm. 1998, 152, 83-89.
    • (1998) Toxicol. Appl. Pharm. , vol.152 , pp. 83-89
    • He, N.G.1    Awasthi, S.2    Singhal, S.S.3    Trent, M.B.4    Boor, P.J.5
  • 47
    • 1842636201 scopus 로고    scopus 로고
    • Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis
    • Yang, Y., Trent, M. B., He, N., Lick, S. D. et al., Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 2004, 173, 211-221.
    • (2004) Atherosclerosis , vol.173 , pp. 211-221
    • Yang, Y.1    Trent, M.B.2    He, N.3    Lick, S.D.4
  • 49
    • 0033967664 scopus 로고    scopus 로고
    • In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain
    • Pocernich, C. B., La Fontaine, M., Butterfield, D. A., In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain. Neurochem. Int. 2000, 36, 185-191.
    • (2000) Neurochem. Int. , vol.36 , pp. 185-191
    • Pocernich, C.B.1    La Fontaine, M.2    Butterfield, D.A.3
  • 50
    • 0030902329 scopus 로고    scopus 로고
    • Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro
    • Gillissen, A., Jaworska, M., Orth, M., Coffiner, M. et al., Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro. Resp. Med. 1997, 91, 159-168.
    • (1997) Resp. Med. , vol.91 , pp. 159-168
    • Gillissen, A.1    Jaworska, M.2    Orth, M.3    Coffiner, M.4
  • 51
    • 0027420576 scopus 로고
    • Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard
    • Gross, C. L., Innace, J. K., Hovatter, R. C., Meier, H. L., Smith, W. J., Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol. Toxicol. 1993, 9, 259-267.
    • (1993) Cell Biol. Toxicol. , vol.9 , pp. 259-267
    • Gross, C.L.1    Innace, J.K.2    Hovatter, R.C.3    Meier, H.L.4    Smith, W.J.5
  • 52
    • 0026343403 scopus 로고
    • Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy
    • Meister, A., Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol. Ther. 1991, 51, 155-194.
    • (1991) Pharmacol. Ther. , vol.51 , pp. 155-194
    • Meister, A.1
  • 53
    • 34547855128 scopus 로고    scopus 로고
    • Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients
    • Gugliucci, A., Lunceford, N., Kinugasa, E., Ogata, H. et al., Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients. Clin. Chim. Acta 2007, 384, 105-112.
    • (2007) Clin. Chim. Acta , vol.384 , pp. 105-112
    • Gugliucci, A.1    Lunceford, N.2    Kinugasa, E.3    Ogata, H.4
  • 54
    • 39149108124 scopus 로고    scopus 로고
    • Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: protection by cysteine
    • Gugliucci, A., Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: protection by cysteine. Life Sci. 2008, 82, 413-418.
    • (2008) Life Sci. , vol.82 , pp. 413-418
    • Gugliucci, A.1
  • 56
    • 33947412631 scopus 로고    scopus 로고
    • Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine
    • Tanel, A., Averill-Bates, D. A., Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine. J. Pharmacol. Exp. Ther. 2007, 321, 73-83.
    • (2007) J. Pharmacol. Exp. Ther. , vol.321 , pp. 73-83
    • Tanel, A.1    Averill-Bates, D.A.2
  • 57
    • 78650439462 scopus 로고    scopus 로고
    • Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease
    • Thanh Nam, D., Arseneault, M., Zarkovic, N., Waeg, G., Ramassamy, C., Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease. J. Alzheimers Dis. 2010.
    • (2010) J. Alzheimers Dis.
    • Thanh Nam, D.1    Arseneault, M.2    Zarkovic, N.3    Waeg, G.4    Ramassamy, C.5
  • 58
    • 0032870878 scopus 로고    scopus 로고
    • Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji
    • Yang, Q., Hergenhahn, M., Weninger, A., Bartsch, H., Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji. Carcinogenesis 1999, 20, 1769-1775.
    • (1999) Carcinogenesis , vol.20 , pp. 1769-1775
    • Yang, Q.1    Hergenhahn, M.2    Weninger, A.3    Bartsch, H.4
  • 59
    • 77956180402 scopus 로고    scopus 로고
    • SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    • Caito, S., Rajendrasozhan, S., Cook, S., Chung, S. et al., SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 2010, 24, 3145-3159.
    • (2010) FASEB J. , vol.24 , pp. 3145-3159
    • Caito, S.1    Rajendrasozhan, S.2    Cook, S.3    Chung, S.4
  • 60
    • 66149192420 scopus 로고    scopus 로고
    • alpha, beta-unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases
    • Moretto, N., Facchinetti, F., Southworth, T., Civelli, M. et al., alpha, beta-unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases. Am. J. Physiol. Lung Cell Mol. Physiol. 2009, 296, L839-L848.
    • (2009) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.296
    • Moretto, N.1    Facchinetti, F.2    Southworth, T.3    Civelli, M.4
  • 61
    • 62549138221 scopus 로고    scopus 로고
    • Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages
    • O'Toole, T. E., Zheng, Y. T., Hellmann, J., Conklin, D. J. et al., Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicol. Appl. Pharmacol. 2009, 236, 194-201.
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 194-201
    • O'Toole, T.E.1    Zheng, Y.T.2    Hellmann, J.3    Conklin, D.J.4
  • 62
    • 37049031908 scopus 로고    scopus 로고
    • Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells
    • Szadkowski, A., Myers, C. R., Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells. Toxicology 2008, 243, 164-176.
    • (2008) Toxicology , vol.243 , pp. 164-176
    • Szadkowski, A.1    Myers, C.R.2
  • 63
    • 0025040966 scopus 로고
    • Evaluation of N-acetylcysteine and methylprednisolone as therapies for oxygen and acrolein-induced lung damage
    • Critchley, J. A., Beeley, J. M., Clark, R. J., Summerfield, M. et al., Evaluation of N-acetylcysteine and methylprednisolone as therapies for oxygen and acrolein-induced lung damage. Environ. Health Perspect. 1990, 85, 89-94.
    • (1990) Environ. Health Perspect. , vol.85 , pp. 89-94
    • Critchley, J.A.1    Beeley, J.M.2    Clark, R.J.3    Summerfield, M.4
  • 65
    • 0025142630 scopus 로고
    • Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide
    • Kawabata, T. T., Chapman, M. Y., Kim, D. H., Stevens, W. D., Holsapple, M. P., Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide. Biochem. Pharmacol. 1990, 40, 927-935.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 927-935
    • Kawabata, T.T.1    Chapman, M.Y.2    Kim, D.H.3    Stevens, W.D.4    Holsapple, M.P.5
  • 66
    • 0038771122 scopus 로고    scopus 로고
    • Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells
    • Zaki, E. L., Springate, J. E., Taub, M., Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells. Toxicol. In Vitro 2003, 17, 397-402.
    • (2003) Toxicol. In Vitro , vol.17 , pp. 397-402
    • Zaki, E.L.1    Springate, J.E.2    Taub, M.3
  • 67
    • 0026599778 scopus 로고
    • Effects of cyclophosphamide and acrolein in organoid cultures of mouse limb bud cells grown in the presence of adult rat hepatocytes
    • Ghaida, J., Merker, H. J., Effects of cyclophosphamide and acrolein in organoid cultures of mouse limb bud cells grown in the presence of adult rat hepatocytes. Toxicol. In Vitro 1992, 6, 27-40.
    • (1992) Toxicol. In Vitro , vol.6 , pp. 27-40
    • Ghaida, J.1    Merker, H.J.2
  • 68
  • 69
    • 0031784171 scopus 로고    scopus 로고
    • Similar bioavailability of single-dose oral and intravenous mesna in the blood and urine of healthy human subjects
    • Goren, M. P., Houle, J. M., Bush, D. A., Li, J. T. et al., Similar bioavailability of single-dose oral and intravenous mesna in the blood and urine of healthy human subjects. Clin. Cancer Res. 1998, 4, 2313-2320.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2313-2320
    • Goren, M.P.1    Houle, J.M.2    Bush, D.A.3    Li, J.T.4
  • 70
    • 0028286112 scopus 로고
    • Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells
    • Mohrmann, M., Ansorge, S., Schonfeld, B., Brandis, M., Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells. Pediatr. Nephrol. 1994, 8, 458-465.
    • (1994) Pediatr. Nephrol. , vol.8 , pp. 458-465
    • Mohrmann, M.1    Ansorge, S.2    Schonfeld, B.3    Brandis, M.4
  • 71
    • 2342544918 scopus 로고    scopus 로고
    • Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress
    • Smith, A. R., Shenvi, S. V., Widlansky, M., Suh, J. H., Hagen, T. M., Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr. Med. Chem. 2004, 11, 1135-1146.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1135-1146
    • Smith, A.R.1    Shenvi, S.V.2    Widlansky, M.3    Suh, J.H.4    Hagen, T.M.5
  • 72
    • 78449282609 scopus 로고    scopus 로고
    • Metals, oxidative stress and neurodegenerative disorders
    • Jomova, K., Vondrakova, D., Lawson, M., Valko, M., Metals, oxidative stress and neurodegenerative disorders. Mol. Cell. Biochem. 2010, 345, 91-104.
    • (2010) Mol. Cell. Biochem. , vol.345 , pp. 91-104
    • Jomova, K.1    Vondrakova, D.2    Lawson, M.3    Valko, M.4
  • 73
    • 41049113671 scopus 로고    scopus 로고
    • Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity
    • Jia, Z., Hallur, S., Zhu, H., Li, Y., Misra, H. P., Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity. Neurochem. Res. 2008, 33, 790-800.
    • (2008) Neurochem. Res. , vol.33 , pp. 790-800
    • Jia, Z.1    Hallur, S.2    Zhu, H.3    Li, Y.4    Misra, H.P.5
  • 74
    • 67650739174 scopus 로고    scopus 로고
    • Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts
    • Jia, L., Zhang, Z., Zhai, L., Bai, Y., Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts. J. Nutr. Sci. Vitaminol. (Tokyo) 2009, 55, 126-130.
    • (2009) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.55 , pp. 126-130
    • Jia, L.1    Zhang, Z.2    Zhai, L.3    Bai, Y.4
  • 75
    • 1042290476 scopus 로고    scopus 로고
    • R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis
    • Suh, J. H., Wang, H., Liu, R. M., Liu, J., Hagen, T. M., (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch. Biochem. Biophys. 2004, 423, 126-135.
    • (2004) Arch. Biochem. Biophys. , vol.423 , pp. 126-135
    • Suh, J.H.1    Wang, H.2    Liu, R.M.3    Liu, J.4    Hagen, T.M.5
  • 76
    • 77953995280 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation
    • Nath, R. G., Wu, M. Y., Emami, A., Chung, F. L., Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation. Nutr. Cancer 2010, 62, 622-629.
    • (2010) Nutr. Cancer , vol.62 , pp. 622-629
    • Nath, R.G.1    Wu, M.Y.2    Emami, A.3    Chung, F.L.4
  • 77
    • 40949135748 scopus 로고    scopus 로고
    • Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction
    • Li, X., Liu, Z., Luo, C., Jia, H. et al., Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic. Biol. Med. 2008, 44, 1465-1474.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1465-1474
    • Li, X.1    Liu, Z.2    Luo, C.3    Jia, H.4
  • 78
    • 0032536166 scopus 로고    scopus 로고
    • Mixed effects of 2,6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice
    • Datta, K., Chin, A., Ahmed, T., Qing, W. G. et al., Mixed effects of 2, 6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice. Toxicology 1998, 125, 1-11.
    • (1998) Toxicology , vol.125 , pp. 1-11
    • Datta, K.1    Chin, A.2    Ahmed, T.3    Qing, W.G.4
  • 79
    • 0034522060 scopus 로고    scopus 로고
    • Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins
    • Kensler, T. W., Curphey, T. J., Maxiutenko, Y., Roebuck, B. D., Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabol. Drug Interact. 2000, 17, 3-22.
    • (2000) Drug Metabol. Drug Interact. , vol.17 , pp. 3-22
    • Kensler, T.W.1    Curphey, T.J.2    Maxiutenko, Y.3    Roebuck, B.D.4
  • 80
    • 0037298498 scopus 로고    scopus 로고
    • Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity
    • Cao, Z., Hardej, D., Trombetta, L. D., Trush, M. A., Li, Y., Induction of cellular glutathione and glutathione S-transferase by 3H-1, 2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity. Atherosclerosis 2003, 166, 291-301.
    • (2003) Atherosclerosis , vol.166 , pp. 291-301
    • Cao, Z.1    Hardej, D.2    Trombetta, L.D.3    Trush, M.A.4    Li, Y.5
  • 81
    • 58749115198 scopus 로고    scopus 로고
    • Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity
    • Jia, Z., Misra, B. R., Zhu, H., Li, Y., Misra, H. P., Upregulation of cellular glutathione by 3H-1, 2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity. Neurotoxicology 2009, 30, 1-9.
    • (2009) Neurotoxicology , vol.30 , pp. 1-9
    • Jia, Z.1    Misra, B.R.2    Zhu, H.3    Li, Y.4    Misra, H.P.5
  • 82
    • 55449130008 scopus 로고    scopus 로고
    • Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress
    • Zhu, H., Jia, Z., Strobl, J. S., Ehrich, M. et al., Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc. Toxicol. 2008, 8, 115-125.
    • (2008) Cardiovasc. Toxicol. , vol.8 , pp. 115-125
    • Zhu, H.1    Jia, Z.2    Strobl, J.S.3    Ehrich, M.4
  • 83
    • 70349978982 scopus 로고    scopus 로고
    • 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha, beta-unsaturated aldehyde acrolein
    • Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J. et al., 1-Cyano-2, 3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha, beta-unsaturated aldehyde acrolein. Carcinogenesis 2009, 30, 1754-1762.
    • (2009) Carcinogenesis , vol.30 , pp. 1754-1762
    • Kelleher, M.O.1    McMahon, M.2    Eggleston, I.M.3    Dixon, M.J.4
  • 84
    • 0034129716 scopus 로고    scopus 로고
    • The antihypertensive hydralazine is an efficient scavenger of acrolein
    • Burcham, P. C., Kerr, P. G., Fontaine, F., The antihypertensive hydralazine is an efficient scavenger of acrolein. Redox Rep. 2000, 5, 47-49.
    • (2000) Redox Rep. , vol.5 , pp. 47-49
    • Burcham, P.C.1    Kerr, P.G.2    Fontaine, F.3
  • 85
    • 0141457973 scopus 로고    scopus 로고
    • Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry
    • Carini, M., Aldini, G., Beretta, G., Arlandini, E., Facino, R. M., Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 2003, 38, 996-1006.
    • (2003) J. Mass Spectrom. , vol.38 , pp. 996-1006
    • Carini, M.1    Aldini, G.2    Beretta, G.3    Arlandini, E.4    Facino, R.M.5
  • 86
    • 4243088697 scopus 로고    scopus 로고
    • Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products
    • Burcham, P. C., Kaminskas, L. M., Fontaine, F. R., Petersen, D. R., Pyke, S. M., Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Toxicology 2002, 181, 229-236.
    • (2002) Toxicology , vol.181 , pp. 229-236
    • Burcham, P.C.1    Kaminskas, L.M.2    Fontaine, F.R.3    Petersen, D.R.4    Pyke, S.M.5
  • 87
    • 75149193424 scopus 로고    scopus 로고
    • Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms
    • Aldini, G., Vistoli, G., Regazzoni, L., Benfatto, M. C. et al., Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms. Antioxid. Redox Signal. 2010, 12, 381-392.
    • (2010) Antioxid. Redox Signal. , vol.12 , pp. 381-392
    • Aldini, G.1    Vistoli, G.2    Regazzoni, L.3    Benfatto, M.C.4
  • 88
    • 44249095307 scopus 로고    scopus 로고
    • Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations
    • Beretta, G., Arlandini, E., Artali, R., Anton, J. M. G., Facino, R. M., Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations. J. Pharm. Biomed. Anal. 2008, 47, 596-602.
    • (2008) J. Pharm. Biomed. Anal. , vol.47 , pp. 596-602
    • Beretta, G.1    Arlandini, E.2    Artali, R.3    Anton, J.M.G.4    Facino, R.M.5
  • 89
    • 0037280937 scopus 로고    scopus 로고
    • Hypertensive emergencies. Etiology and management
    • Tuncel, M., Ram, V. C., Hypertensive emergencies. Etiology and management. Am. J. Cardiovasc. Drugs 2003, 3, 21-31.
    • (2003) Am. J. Cardiovasc. Drugs , vol.3 , pp. 21-31
    • Tuncel, M.1    Ram, V.C.2
  • 90
    • 0020265835 scopus 로고
    • The reaction of amines with carbonyls: its significance in the nonenzymatic metabolism of xenobiotics
    • O'Donnell, J. P., The reaction of amines with carbonyls: its significance in the nonenzymatic metabolism of xenobiotics. Drug Metab. Rev. 1982, 13, 123-159.
    • (1982) Drug Metab. Rev. , vol.13 , pp. 123-159
    • O'Donnell, J.P.1
  • 91
    • 33644845649 scopus 로고    scopus 로고
    • Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection
    • Burcham, P. C., Pyke, S. M., Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection. Mol. Pharmacol. 2006, 69, 1056-1065.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 1056-1065
    • Burcham, P.C.1    Pyke, S.M.2
  • 92
    • 33745789386 scopus 로고    scopus 로고
    • Hydralazine rescues PC12 cells from acrolein-mediated death
    • Liu-Snyder, P., Borgens, R. B., Shi, R., Hydralazine rescues PC12 cells from acrolein-mediated death. J. Neurosci. Res. 2006, 84, 219-227.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 219-227
    • Liu-Snyder, P.1    Borgens, R.B.2    Shi, R.3
  • 93
    • 0020036935 scopus 로고
    • Allylamine cardiotoxicity - IV. Metabolism to acrolein by cardiovascular tissues
    • Nelson, T. J., Boor, P. J., Allylamine cardiotoxicity - IV. Metabolism to acrolein by cardiovascular tissues. Biochem. Pharmacol. 1982, 31, 509-514.
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 509-514
    • Nelson, T.J.1    Boor, P.J.2
  • 94
    • 53749101143 scopus 로고    scopus 로고
    • Critical role of acrolein in secondary injury following ex vivo spinal cord trauma
    • Hamann, K., Durkes, A., Ouyang, H., Uchida, K. et al., Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. J. Neurochem. 2008, 107, 712-721.
    • (2008) J. Neurochem. , vol.107 , pp. 712-721
    • Hamann, K.1    Durkes, A.2    Ouyang, H.3    Uchida, K.4
  • 95
    • 4243084363 scopus 로고    scopus 로고
    • Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice
    • Kaminskas, L. M., Pyke, S. M., Burcham, P. C., Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. J. Pharmacol. Exp. Ther. 2004, 310, 1003-1010.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 1003-1010
    • Kaminskas, L.M.1    Pyke, S.M.2    Burcham, P.C.3
  • 96
    • 78650678757 scopus 로고    scopus 로고
    • Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse
    • Leung, G., Sun, W., Zheng, L., Brookes, S. et al., Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse. Neuroscience 2011, 173, 150-155.
    • (2011) Neuroscience , vol.173 , pp. 150-155
    • Leung, G.1    Sun, W.2    Zheng, L.3    Brookes, S.4
  • 97
    • 54349107384 scopus 로고    scopus 로고
    • Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives
    • Galvani, S., Coatrieux, C., Elbaz, M., Grazide, M. H. et al., Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives. Free Radic. Biol. Med. 2008, 45, 1457-1467.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 1457-1467
    • Galvani, S.1    Coatrieux, C.2    Elbaz, M.3    Grazide, M.H.4
  • 99
    • 0028172783 scopus 로고
    • L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities
    • Babizhayev, M. A., Seguin, M. C., Gueyne, J., Evstigneeva, R. P. et al., L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Biochem. J. 1994, 304, 509-516.
    • (1994) Biochem. J. , vol.304 , pp. 509-516
    • Babizhayev, M.A.1    Seguin, M.C.2    Gueyne, J.3    Evstigneeva, R.P.4
  • 100
    • 0028185906 scopus 로고
    • Endogenous skeletal muscle antioxidants
    • Chan, K. M., Decker, E. A., Endogenous skeletal muscle antioxidants. Crit. Rev. Food Sci. Nutr. 1994, 34, 403-426.
    • (1994) Crit. Rev. Food Sci. Nutr. , vol.34 , pp. 403-426
    • Chan, K.M.1    Decker, E.A.2
  • 101
    • 0035966113 scopus 로고    scopus 로고
    • Chelating activity of advanced glycation end-product inhibitors
    • Price, D. L., Rhett, P. M., Thorpe, S. R., Baynes, J. W., Chelating activity of advanced glycation end-product inhibitors. J. Biol. Chem. 2001, 276, 48967-48972.
    • (2001) J. Biol. Chem. , vol.276 , pp. 48967-48972
    • Price, D.L.1    Rhett, P.M.2    Thorpe, S.R.3    Baynes, J.W.4
  • 102
    • 0027006712 scopus 로고
    • Carnosine: its properties, functions and potential therapeutic applications
    • Quinn, P. J., Boldyrev, A. A., Formazuyk, V. E., Carnosine: its properties, functions and potential therapeutic applications. Mol. Aspects Med. 1992, 13, 379-444.
    • (1992) Mol. Aspects Med. , vol.13 , pp. 379-444
    • Quinn, P.J.1    Boldyrev, A.A.2    Formazuyk, V.E.3
  • 103
    • 0028235687 scopus 로고
    • Retardation of the senescence of cultured human diploid fibroblasts by carnosine
    • Mcfarland, G. A., Holliday, R., Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp. Cell Res. 1994, 212, 167-175.
    • (1994) Exp. Cell Res. , vol.212 , pp. 167-175
    • Mcfarland, G.A.1    Holliday, R.2
  • 104
    • 0037325709 scopus 로고    scopus 로고
    • Methylglyoxal-induced glycation affects protein topography
    • Seidler, N. W., Kowalewski, C., Methylglyoxal-induced glycation affects protein topography. Arch. Biochem. Biophys. 2003, 410, 149-154.
    • (2003) Arch. Biochem. Biophys. , vol.410 , pp. 149-154
    • Seidler, N.W.1    Kowalewski, C.2
  • 105
    • 2642538378 scopus 로고    scopus 로고
    • Carnosine disaggregates glycated alpha-crystallin: an in vitro study
    • Seidler, N. W., Yeargans, G. S., Morgan, T. G., Carnosine disaggregates glycated alpha-crystallin: an in vitro study. Arch. Biochem. Biophys. 2004, 427, 110-115.
    • (2004) Arch. Biochem. Biophys. , vol.427 , pp. 110-115
    • Seidler, N.W.1    Yeargans, G.S.2    Morgan, T.G.3
  • 106
    • 0032408416 scopus 로고    scopus 로고
    • Pluripotent protective effects of carnosine, a naturally occurring dipeptide
    • Hipkiss, A. R., Preston, J. E., Himsworth, D. T., Worthington, V. C. et al., Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann. N Y Acad. Sci. 1998, 854, 37-53.
    • (1998) Ann. N Y Acad. Sci. , vol.854 , pp. 37-53
    • Hipkiss, A.R.1    Preston, J.E.2    Himsworth, D.T.3    Worthington, V.C.4
  • 107
    • 52749089692 scopus 로고    scopus 로고
    • Protection by histidine dipeptides against acrolein-induced neurofilament-L aggregation
    • Kang, J. H., Protection by histidine dipeptides against acrolein-induced neurofilament-L aggregation. Bull. Korean Chem. Soc. 2008, 29, 1732-1736.
    • (2008) Bull. Korean Chem. Soc. , vol.29 , pp. 1732-1736
    • Kang, J.H.1
  • 108
    • 0034107785 scopus 로고    scopus 로고
    • Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions
    • Thornalley, P. J., Yurek-George, A., Argirov, O. K., Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions. Biochem. Pharmacol. 2000, 60, 55-65.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 55-65
    • Thornalley, P.J.1    Yurek-George, A.2    Argirov, O.K.3
  • 109
    • 1942438654 scopus 로고    scopus 로고
    • Advanced glycation end-products and the progress of diabetic vascular complications
    • Jakus, V., Rietbrock, N., Advanced glycation end-products and the progress of diabetic vascular complications. Physiol. Res. 2004, 53, 131-142.
    • (2004) Physiol. Res. , vol.53 , pp. 131-142
    • Jakus, V.1    Rietbrock, N.2
  • 110
    • 43949083722 scopus 로고    scopus 로고
    • The pyridoxamine action on Amadori compounds: a reexamination of its scavenging capacity and chelating effect
    • Adrover, M., Vilanova, B., Frau, J., Munoz, F., Donoso, J., The pyridoxamine action on Amadori compounds: a reexamination of its scavenging capacity and chelating effect. Bioorg. Med. Chem. 2008, 16, 5557-5569.
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 5557-5569
    • Adrover, M.1    Vilanova, B.2    Frau, J.3    Munoz, F.4    Donoso, J.5
  • 111
    • 0036479252 scopus 로고    scopus 로고
    • A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation
    • Voziyan, P. A., Metz, T. O., Baynes, J. W., Hudson, B. G., A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J. Biol. Chem. 2002, 277, 3397-3403.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3397-3403
    • Voziyan, P.A.1    Metz, T.O.2    Baynes, J.W.3    Hudson, B.G.4
  • 112
    • 0142058743 scopus 로고    scopus 로고
    • Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications
    • Metz, T. O., Alderson, N. L., Thorpe, S. R., Baynes, J. W., Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications. Arch. Biochem. Biophys. 2003, 419, 41-49.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 41-49
    • Metz, T.O.1    Alderson, N.L.2    Thorpe, S.R.3    Baynes, J.W.4
  • 113
    • 0142211275 scopus 로고    scopus 로고
    • Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo. Evidence on the role of lipids in chemical modification of protein and development of diabetic complications
    • Metz, T. O., Alderson, N. L., Chachich, M. E., Thorpe, S. R., Baynes, J. W., Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo. Evidence on the role of lipids in chemical modification of protein and development of diabetic complications. J. Biol. Chem. 2003, 278, 42012-42019.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42012-42019
    • Metz, T.O.1    Alderson, N.L.2    Chachich, M.E.3    Thorpe, S.R.4    Baynes, J.W.5
  • 114
    • 35649008900 scopus 로고    scopus 로고
    • Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls
    • Aldini, G., Dalle-Donne, I., Facino, R. M., Milzani, A., Carini, M., Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med. Res. Rev. 2007, 27, 817-868.
    • (2007) Med. Res. Rev. , vol.27 , pp. 817-868
    • Aldini, G.1    Dalle-Donne, I.2    Facino, R.M.3    Milzani, A.4    Carini, M.5
  • 115
    • 55949128773 scopus 로고    scopus 로고
    • Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species
    • Shao, X., Bai, N., He, K., Ho, C. T. et al., Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species. Chem. Res. Toxicol. 2008, 21, 2042-2050.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 2042-2050
    • Shao, X.1    Bai, N.2    He, K.3    Ho, C.T.4
  • 116
    • 38149055114 scopus 로고    scopus 로고
    • Tea Polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species
    • Sang, S., Shao, X., Bai, N., Lo, C. Y. et al., Tea Polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species. Chem. Res. Toxicol. 2007, 20, 1862-1870.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1862-1870
    • Sang, S.1    Shao, X.2    Bai, N.3    Lo, C.Y.4
  • 117
    • 33845952217 scopus 로고    scopus 로고
    • Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions
    • Lo, C. Y., Li, S. M., Tan, D., Pan, M. H. et al., Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions. Mol. Nutr. Food Res. 2006, 50, 1118-1128.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 1118-1128
    • Lo, C.Y.1    Li, S.M.2    Tan, D.3    Pan, M.H.4
  • 118
    • 53049105773 scopus 로고    scopus 로고
    • Quenching of alpha, beta-unsaturated aldehydes by green tea polyphenols: HPLC-ESI-MS/MS studies
    • Beretta, G., Furlanetto, S., Regazzoni, L., Zarrella, M., Facino, R. M., Quenching of alpha, beta-unsaturated aldehydes by green tea polyphenols: HPLC-ESI-MS/MS studies. J. Pharm. Biomed. Anal. 2008, 48, 606-611.
    • (2008) J. Pharm. Biomed. Anal. , vol.48 , pp. 606-611
    • Beretta, G.1    Furlanetto, S.2    Regazzoni, L.3    Zarrella, M.4    Facino, R.M.5
  • 119
    • 61449259081 scopus 로고    scopus 로고
    • Trapping effects of green and black tea extracts on peroxidation-derived carbonyl substances of seal blubber oil
    • Zhu, Q., Liang, C. P., Cheng, K. W., Peng, X. et al., Trapping effects of green and black tea extracts on peroxidation-derived carbonyl substances of seal blubber oil. J. Agric. Food Chem. 2009, 57, 1065-1069.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 1065-1069
    • Zhu, Q.1    Liang, C.P.2    Cheng, K.W.3    Peng, X.4
  • 120
    • 70350248021 scopus 로고    scopus 로고
    • Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal
    • Zhu, Q., Zheng, Z. P., Cheng, K. W., Wu, J. J. et al., Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal. Chem. Res. Toxicol. 2009, 22, 1721-1727.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 1721-1727
    • Zhu, Q.1    Zheng, Z.P.2    Cheng, K.W.3    Wu, J.J.4
  • 121
    • 0031721802 scopus 로고    scopus 로고
    • Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance
    • Bravo, L., Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 1998, 56, 317-333.
    • (1998) Nutr. Rev. , vol.56 , pp. 317-333
    • Bravo, L.1
  • 122
    • 56049093212 scopus 로고    scopus 로고
    • Protective effect of pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity
    • Ansari, M. A., Keller, J. N., Scheff, S. W., Protective effect of pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. Free Radic. Biol. Med. 2008, 45, 1510-1519.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 1510-1519
    • Ansari, M.A.1    Keller, J.N.2    Scheff, S.W.3
  • 123
    • 77954982065 scopus 로고    scopus 로고
    • Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease
    • Singh, M., Murthy, V., Ramassamy, C., Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease. J. Alzheimers Dis. 2010, 21, 229-247.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 229-247
    • Singh, M.1    Murthy, V.2    Ramassamy, C.3
  • 124
    • 79951738359 scopus 로고    scopus 로고
    • Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells
    • Zhang, X. W., Li, W. F., Li, W. W., Ren, K. H. et al., Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm. Biol. 2011, 49, 256-261.
    • (2011) Pharm. Biol. , vol.49 , pp. 256-261
    • Zhang, X.W.1    Li, W.F.2    Li, W.W.3    Ren, K.H.4
  • 125
    • 70349382573 scopus 로고    scopus 로고
    • Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung
    • Yang, C. H., Lin, C. Y., Yang, J. H., Liou, S. Y. et al., Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung. Chin. J. Physiol. 2009, 52, 151-159.
    • (2009) Chin. J. Physiol. , vol.52 , pp. 151-159
    • Yang, C.H.1    Lin, C.Y.2    Yang, J.H.3    Liou, S.Y.4
  • 126
    • 77957358018 scopus 로고    scopus 로고
    • Robinetinidol-(4beta-->8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia Mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against acrolein-induced oxidative damage
    • Huang, W., Niu, H., Xue, X., Li, J., Li, C., Robinetinidol-(4beta-->8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia Mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against acrolein-induced oxidative damage. J. Alzheimers Dis. 2010, 21, 493-506.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 493-506
    • Huang, W.1    Niu, H.2    Xue, X.3    Li, J.4    Li, C.5
  • 127
    • 77954200118 scopus 로고    scopus 로고
    • Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage
    • Sheu, S. J., Liu, N. C., Chen, J. L., Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage. J. Ocul. Pharmacol. Ther. 2010, 26, 231-236.
    • (2010) J. Ocul. Pharmacol. Ther. , vol.26 , pp. 231-236
    • Sheu, S.J.1    Liu, N.C.2    Chen, J.L.3
  • 128
    • 40949095179 scopus 로고    scopus 로고
    • Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction
    • Liu, Z., Sun, L., Zhu, L., Jia, X. et al., Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J. Neurochem. 2007, 103, 2690-2700.
    • (2007) J. Neurochem. , vol.103 , pp. 2690-2700
    • Liu, Z.1    Sun, L.2    Zhu, L.3    Jia, X.4
  • 130
    • 0001635312 scopus 로고
    • A new role for L-ascorbic acid: Michael donor to alpha, beta-unsaturated carbonyl-compounds
    • Fodor, G., Arnold, R., Mohacsi, T., Karle, I., Flippenanderson, J., A new role for L-ascorbic acid: Michael donor to alpha, beta-unsaturated carbonyl-compounds. Tetrahedron 1983, 39, 2137-2145.
    • (1983) Tetrahedron , vol.39 , pp. 2137-2145
    • Fodor, G.1    Arnold, R.2    Mohacsi, T.3    Karle, I.4    Flippenanderson, J.5
  • 131
    • 77951215944 scopus 로고    scopus 로고
    • Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal
    • Kesinger, N. G., Langsdorf, B. L., Yokochi, A. F., Miranda, C. L., Stevens, J. F., Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5, 6, 7, 8-tetrahydroxy-4-oxooctanal. Chem. Res. Toxicol. 2010, 23, 836-844.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 836-844
    • Kesinger, N.G.1    Langsdorf, B.L.2    Yokochi, A.F.3    Miranda, C.L.4    Stevens, J.F.5
  • 132
    • 0025363915 scopus 로고
    • Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation
    • Bergsten, P., Amitai, G., Kehrl, J., Dhariwal, K. R. et al., Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation. J. Biol. Chem. 1990, 265, 2584-2587.
    • (1990) J. Biol. Chem. , vol.265 , pp. 2584-2587
    • Bergsten, P.1    Amitai, G.2    Kehrl, J.3    Dhariwal, K.R.4
  • 133
    • 25844513482 scopus 로고    scopus 로고
    • Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein E by hepatocytes
    • Arai, H., Uchida, K., Nakamura, K., Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein E by hepatocytes. Biosci. Biotechnol. Biochem. 2005, 69, 1760-1762.
    • (2005) Biosci. Biotechnol. Biochem. , vol.69 , pp. 1760-1762
    • Arai, H.1    Uchida, K.2    Nakamura, K.3
  • 134
    • 24044508943 scopus 로고    scopus 로고
    • Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure
    • Logan, M. P., Parker, S., Shi, R., Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure. Pathobiology 2005, 72, 171-178.
    • (2005) Pathobiology , vol.72 , pp. 171-178
    • Logan, M.P.1    Parker, S.2    Shi, R.3
  • 135
    • 0037168998 scopus 로고    scopus 로고
    • Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid
    • Nardini, M., Finkelstein, E. I., Reddy, S., Valacchi, G. et al., Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology 2002, 170, 173-185.
    • (2002) Toxicology , vol.170 , pp. 173-185
    • Nardini, M.1    Finkelstein, E.I.2    Reddy, S.3    Valacchi, G.4
  • 136
    • 77957256030 scopus 로고    scopus 로고
    • Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    • Singh, M., Nam, D. T., Arseneault, M., Ramassamy, C., Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein. J. Alzheimers Dis. 2010, 21, 741-756.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 741-756
    • Singh, M.1    Nam, D.T.2    Arseneault, M.3    Ramassamy, C.4


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