The molecular effects of acrolein

Toxicological Sciences

Volumn 57, Issue 1, 2000, Pages 6-15

  Kehrer, J P ^a   Biswal, S S ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Acrolein; Activator protein 1 (AP 1); Electrophile response element (ERE); Gene array; Glutathione GSH); Nuclear factor kappa B (NF B); Transcription factors

Indexed keywords

ACROLEIN; ALDEHYDE DERIVATIVE; CYCLOPHOSPHAMIDE; DRUG METABOLITE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

AIR POLLUTION; APOPTOSIS; CELL PROLIFERATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENETIC ANALYSIS; MOLECULAR DYNAMICS; OXIDATION REDUCTION STATE; REVIEW; SMOKE;

EID: 0033864802     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/57.1.6     Document Type: Review

References (99)

1. Acrolein-induced oxygen radical formation
2. Oxidative stress and gene regulation
3. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycoaldehyde, 2-hydroxypropanal, and acrolein: A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation
4. Gene expression and the thiol redox state
5. Modifications of cellular thiols during growth and squamous differentiation of cultured human bronchial epithelial cells
6. A critical review of the literature on acrolein toxicity
7. A decrease in inrracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes
8. An essential role for NF-κB in preventing TNF-α-induced cell death
9. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes
10. Effect of acrolein on AP-1 and gene expression in A549 cells
11. Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells
12. Bcl-x(L) overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal
13. Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: Relationship to caspase activity and the loss of glutathione
14. Allylamine cardiotoxicity: Metabolism and mechanism
15. 2-mercaptoethanol restores the ability of nuclear factor κB (NFκB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NFκB by PDTC
16. Distribution of the monochlorobimane-glutathione conjugate between nucleus and cytosol in isolated hepatocytes
17. Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
18. Extracellular glutathione suppresses human lung fibroblast proliferation
19. Air pollution
20. Bcl-x(L) is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis
21. Functions of glutathione and glutathione disulfide in immunology and immunopathology
22. DNA binding activity of the glucocorticoid receptor is sensitive to redox changes in intact cells
23. Apoptosis or necrosis: Intracellular levels of glutathione influence mode of cell death
24. Redox regulation of NF-kappa B activation
25. Cyclophosphamide toxicity. Characterising and avoiding the problem
26. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element
27. Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia
28. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor - κB: Studies with isolated mitochondria and rat hepatocytes
29. Optimal NFκB mediated trascriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals
30. Intracellular oxidation/reduction status in the regulation of transcription factors NF-kB and AP-1
31. Pathobiological effects of acrolein in cultured human bronchial epithelial cells
32. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
33. Acrolein causes IκB-independent decreases in NF-κB activation in human lung adenocarcinoma (A549) cells
34. Relationships between cell density, glutathione, and proliferation of A549 human lung adenocarcinoma cells treated with acrolein
35. No requirement of reactive oxygen intermediates in Fas-mediated apoptosis
36. Influence of the cellular redox state on NF-κB-regulated gene expression
37. Redox state changes in density-dependent regulation of proliferation
38. Cyclophosphamide-induced lung toxicity: Mechanism of endothelial cell injury
39. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
40. Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine
41. Buthionine sulfoximine enhances glutathione, but attenuates glutamate-stimulated cell proliferation
42. Glutathione content and growth in A549 human lung carcinoma cells
43. Function of the c-Myc oncoprotein
44. Acrolein enhances mechlorethamine-induced apoptosis
45. Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts
46. The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
47. Differential regulation of the c-myc oncogene promoter by the NF-κB rel family of transcription factors
48. Acrolein-induced cell death in human alveolar macrophages
49. Effect of acrolein on human alveolar macrophage NF-κB activity
50. NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
51. Antioxidant action via p53-mediated apoptosis
52. Interference with c-myc expression and RB phosphorylation during TNF-mediated growth arrest in human endothelial cells
53. Modulation of human microvascular endothelial cell bioenergetic status and glutathione levels during proliferative and differentiated growth
54. Rel/NF-κB and IκB proteins: An overview
55. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
56. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
57. Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-(jun), cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse
58. Differential processing of osteopontin characterizes the proliferative vascular smooth muscle cell phenotype induced by allylamine
59. Acrolein-induced injury to cultured pulmonary artery endothelial cells
60. Glutathione influences the proliferation as well as the extent of mitochondrial activation in rat splenocytes
61. Role of oxidants and antioxidants in the induction of AP-1, NF-κB, and glutathione S-transferase gene expression
62. Redox regulation of c-Ha-ras and osteopontin signaling in vascular smooth muscle cells: Implications in chemical atherogenesis
63. Altered protein secretion and extracellular matrix deposition is associated with the proliferative phenotype induced by allylamine in aortic smooth muscle cells
64. Studies on the basis for the toxicity of acrolein mercapturates
65. Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation
66. Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid-sensitive and -resistant human tumor cells
67. The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB
68. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants
69. Biochemical and molecular mechanisms regulating apoptosis
70. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1
71. Redox signaling and the emerging therapeutic potential of thiol antioxidants
72. Antioxidant and redox regulation of gene transcription
73. Acrolein genotoxicity in Drosphila melanogaster: I. Somatic and germinal mutagenesis under proficient repair conditions
74. Oxidative stress: Introduction
75. Therapeutic efficacy of cyclophosphamide as a function of its metabolism
76. Intracellular redox changes during apoptosis
77. Rel/NF-κB transcription factors and the control of apoptosis
78. Deoxyribonucleoside triphosphate pools and growth of glutathione-depleted 3T6 mouse fibroblasts
79. Carbonyl stress in the pathogenesis of diabetic nephropathy
80. N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-κB p50 and p65
81. Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro
82. Comparative toxicity of allylamine and acrolein in cultured myocytes and fibroblasts from neonatal rat heart
83. Current status of acrolein as a lipid peroxidation product
84. Suppression of TNF-α-induced apoptosis by NF-κB
85. Inhibition of TNF-induced apoptosis by NF-κB
86. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody
87. Bcl-2 expression causes redistribution of glutathione to the nucleus
88. Glutathione depletion in human T lymphocytes: Analysis of activation-associated gene expression and the stress response
89. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
90. Thiol-mediated redox regulation of neutrophil apoptosis
91. Biological interactions of alpha, beta-unsaturated aldehydes
92. Activation of NF-κB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway
93. NF-κB activation of p53. A potential mechanism for suppressing cell growth in response to stress
94. Inhibition of NF-κB/Rel induces apoptosis of murine B cells
95. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors
96. N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent, but transcription-dependent
97. Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols
98. Transforming growth factor beta induces myoblast differentiation in the presence of mitogens
99. Glutathione depletion in fibroblasts is the basis for apoptosis-induction by endogenous reactive oxygen species