Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts

Journal of Nutritional Science and Vitaminology

Volumn 55, Issue 2, 2009, Pages 126-130

  Jia, Lihong ^a   Zhang, Zhiyu ^a   Zhai, Lingling ^a   Bai, Yinglong ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Acrolein; Cytotoxicity; Lipoic acid; Oxidative stress

Indexed keywords

ACROLEIN; ADENOSINE TRIPHOSPHATE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOCTIC ACID; ANTIOXIDANT; CYTOTOXIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL DEGENERATION; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; AIR POLLUTANT; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; EXPOSURE; FIBROBLAST; LUNG; METABOLISM; MITOCHONDRION; SMOKE;

ACROLEIN; ADENOSINE TRIPHOSPHATE; AIR POLLUTANTS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; CYTOTOXINS; FIBROBLASTS; GLUTATHIONE; HUMANS; INHALATION EXPOSURE; LUNG; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL DISEASES; REACTIVE OXYGEN SPECIES; SMOKE; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

EID: 67650739174     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.55.126     Document Type: Article

References (25)

1. Li L, Holian A. 1998. Acrolein: a respiratory toxin that suppresses pulmonary host defense. Rev Environ Health 13: 99-108. (Pubitemid 28388972)
2. Eiserich JP, van der Vliet A, Handelman GJ, Halliwell B, Cross CE. 1995. Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am J Clin Nutr 62: 1490S-1500S.
3. Feng Z, Hu W, Hu Y, Tang MS. 2006. Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc Natl Acad Sci USA 17: 15404-15409. (Pubitemid 44625604)
4. Nardini M, Finkelstein EI, Reddy S, Valacchi G, Traber M, Cross CE, Van der Viliet A. 2002. Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology 170: 173-185. (Pubitemid 34085057)
5. Biagini RE, Toraason MA, Lynch DW, Winston GW. 1990. Inhibition of rat heart mitochondrial electron transport in vitro: implications for the cardiotoxic action of allylamine or its primary metabolite, acrolein. Toxicology 62: 95-106.
6. Luo J, Shi R. 2005. Acrolein induces oxidative stress in brain mitochondria. Neurochem Int 46: 243-252.
7. Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. 2007. Acrolein, a toxin in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in retinal pigment epithelial cells: Protection by (R)-α-lipoic acid. Invest Ophthamol Vis Sci 48: 339-348. (Pubitemid 47251422)
8. Packer L, Roy S, Sen CK. 1997. Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 38: 79-101.
9. Biewenga GP, Haenen GR, Bast A. 1997. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29: 315-331.
10. Moini H, Packer L, Saris NE. 2002. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 182: 84-90. (Pubitemid 34775480)
11. Liu J, Ames BN. 2005. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci 8: 67-89. (Pubitemid 40959649)
12. Kamenova P. 2006. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens) 5: 251-258.
13. Evans JL, Goldfine ID. 2000. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2: 401-413.
14. Cho YS, Lee J, Lee TH, Lee EY, Lee KU, Psrl JY, Moon HB. 2004. Alpha-lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Allergy Clin Immunol 114: 429-435. (Pubitemid 39119048)
15. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW. 1991. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate- forming lipophilic cation JC-1. Proc Natl Acad Sci USA 88: 3671-3675. (Pubitemid 21916685)
16. Patane G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM. 2002. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 51: 2749-2756. (Pubitemid 34970928)
17. LeBel CP, Ischiropoulos H, Bondy SC. 1992. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5: 227-231.
18. Grafstrom RC, Dypbukt JM, Willey JC, Sundqvist K, Edman C, Atzori L, Harris CC. 1988. Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res 48: 1717-1721. (Pubitemid 18100141)
19. Esterbauer H, Schaur RJ, Zollner H. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11: 81-128. (Pubitemid 121003917)
20. Uchida K, Kanematsu M, Morimitsu Y, Osawa T, Noguchi N, Niki E. 1998. Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins. J Biol Chem 273: 16058-16066. (Pubitemid 28311374)
21. Luo J, Shi R. 2004. Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue. Neurochem Int 44: 475-486. (Pubitemid 38183298)
22. Adams JD Jr, Klaidman LK. 1993. Acrolein-induced oxygen radical formation. Free Radic Biol Med 15: 187-193.
23. Shigenaga MK, Hagen TM, Ames BN. 1994. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 91: 10771-10778.
24. Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM. 2004. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101: 3381-3386. (Pubitemid 38338203)
25. Suh JH, Wang H, Liu RM, Liu J, Hagen TM. 2004. (R)- alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys 423: 126-135. (Pubitemid 38198222)