-
1
-
-
0030005099
-
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
-
Agata, Y.; Kawasaki, A.; Nishimura, H.; Ishida, Y.; Tsubata, T.; Yagita, H.; Honjo, T., Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 1996, 8 (5), 765-72. (Pubitemid 26148299)
-
(1996)
International Immunology
, vol.8
, Issue.5
, pp. 765-772
-
-
Agata, Y.1
Kawasaki, A.2
Nishimura, H.3
Ishida, Y.4
Tsubata, T.5
Yagita, H.6
Honjo, T.7
-
2
-
-
33645846313
-
Tissue expression of PD-L1 mediates peripheral T cell tolerance
-
Keir, M. E.; Liang, S. C.; Guleria, I.; Latchman, Y. E.; Qipo, A.; Albacker, L. A.; Koulmanda, M.; Freeman, G. J.; Sayegh, M. H.; Sharpe, A. H., Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006, 203 (4), 883-95.
-
(2006)
J Exp Med
, vol.203
, Issue.4
, pp. 883-895
-
-
Keir, M.E.1
Liang, S.C.2
Guleria, I.3
Latchman, Y.E.4
Qipo, A.5
Albacker, L.A.6
Koulmanda, M.7
Freeman, G.J.8
Sayegh, M.H.9
Sharpe, A.H.10
-
3
-
-
5644290600
-
Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: Role of hyporesponsiveness and anergy
-
DOI 10.1128/CMR.17.4.1012-1030.2004
-
Borkow, G.; Bentwich, Z., Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev 2004, 17 (4), 1012-30, table of contents (Pubitemid 39372528)
-
(2004)
Clinical Microbiology Reviews
, vol.17
, Issue.4
, pp. 1012-1030
-
-
Borkow, G.1
Bentwich, Z.2
-
4
-
-
10344226171
-
+ T cells
-
DOI 10.1016/j.cellimm.2004.09.004, PII S0008874904001698
-
Cai, G.; Karni, A.; Oliveira, E. M.; Weiner, H. L.; Hafler, D. A.; Freeman, G. J., PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol 2004, 230 (2), 89-98. (Pubitemid 39626650)
-
(2004)
Cellular Immunology
, vol.230
, Issue.2
, pp. 89-98
-
-
Cai, G.1
Karni, A.2
Oliveira, E.M.L.3
Weiner, H.L.4
Hafler, D.A.5
Freeman, G.J.6
-
5
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
DOI 10.1038/nature05115, PII NATURE05115
-
Day, C. L.; Kaufmann, D. E.; Kiepiela, P.; Brown, J. A.; Moodley, E. S.; Reddy, S.; Mackey, E. W.; Miller, J. D.; Leslie, A. J.; DePierres, C.; Mncube, Z.; Duraiswamy, J.; Zhu, B.; Eichbaum, Q.; Altfeld, M.; Wherry, E. J.; Coovadia, H. M.; Goulder, P. J.; Klenerman, P.; Ahmed, R.; Freeman, G. J.; Walker, B. D., PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443 (7109), 350-4 (Pubitemid 44435155)
-
(2006)
Nature
, vol.443
, Issue.7109
, pp. 350-354
-
-
Day, C.L.1
Kaufmann, D.E.2
Kiepiela, P.3
Brown, J.A.4
Moodley, E.S.5
Reddy, S.6
Mackey, E.W.7
Miller, J.D.8
Leslie, A.J.9
DePierres, C.10
Mncube, Z.11
Duraiswamy, J.12
Zhu, B.13
Eichbaum, Q.14
Altfeld, M.15
Wherry, E.J.16
Coovadia, H.M.17
Goulder, P.J.R.18
Klenerman, P.19
Ahmed, R.20
Freeman, G.J.21
Walker, B.D.22
more..
-
6
-
-
33749009709
-
+ T cells leads to reversible immune dysfunction
-
DOI 10.1038/nm1482, PII NM1482
-
Trautmann, L.; Janbazian, L.; Chomont, N.; Said, E. A.; Gimmig, S.; Bessette, B.; Boulassel, M. R.; Delwart, E.; Sepulveda, H.; Balderas, R. S.; Routy, J. P.; Haddad, E. K.; Sekaly, R. P., Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006, 12 (10), 1198-202. (Pubitemid 44527357)
-
(2006)
Nature Medicine
, vol.12
, Issue.10
, pp. 1198-1202
-
-
Trautmann, L.1
Janbazian, L.2
Chomont, N.3
Said, E.A.4
Gimmig, S.5
Bessette, B.6
Boulassel, M.-R.7
Delwart, E.8
Sepulveda, H.9
Balderas, R.S.10
Routy, J.-P.11
Haddad, E.K.12
Sekaly, R.-P.13
-
7
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
DOI 10.1038/85330
-
Latchman, Y.; Wood, C. R.; Chernova, T.; Chaudhary, D.; Borde, M.; Chernova, I.; Iwai, Y.; Long, A. J.; Brown, J. A.; Nunes, R.; Greenfield, E. A.; Bourque, K.; Boussiotis, V. A.; Carter, L. L.; Carreno, B. M.; Malenkovich, N.; Nishimura, H.; Okazaki, T.; Honjo, T.; Sharpe, A. H.; Freeman, G. J., PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001, 2 (3), 261-8. (Pubitemid 33706004)
-
(2001)
Nature Immunology
, vol.2
, Issue.3
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
Chaudhary, D.4
Borde, M.5
Chernova, I.6
Iwai, Y.7
Long, A.J.8
Brown, J.A.9
Nunes, R.10
Greenfield, E.A.11
Bourque, K.12
Boussiotis, V.A.13
Carter, L.L.14
Carreno, B.M.15
Malenkovich, N.16
Nishimura, H.17
Okazaki, T.18
Honjo, T.19
Sharpe, A.H.20
Freeman, G.J.21
more..
-
8
-
-
33749324118
-
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade
-
DOI 10.1084/jem.20061800
-
Freeman, G. J.; Wherry, E. J.; Ahmed, R.; Sharpe, A. H., Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med 2006, 203 (10), 2223-7. (Pubitemid 44498355)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.10
, pp. 2223-2227
-
-
Freeman, G.J.1
Wherry, E.J.2
Ahmed, R.3
Sharpe, A.H.4
-
9
-
-
0037815272
-
PD-1 inhibits antiviral immunity at the effector phase in the liver
-
DOI 10.1084/jem.20022235
-
Iwai, Y.; Terawaki, S.; Ikegawa, M.; Okazaki, T.; Honjo, T., PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med 2003, 198 (1), 39-50. (Pubitemid 36870184)
-
(2003)
Journal of Experimental Medicine
, vol.198
, Issue.1
, pp. 39-50
-
-
Iwai, Y.1
Terawaki, S.2
Ikegawa, M.3
Okazaki, T.4
Honjo, T.5
-
10
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
DOI 10.1038/nature04444, PII NATURE04444
-
Barber, D. L.; Wherry, E. J.; Masopust, D.; Zhu, B.; Allison, J. P.; Sharpe, A. H.; Freeman, G. J.; Ahmed, R., Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439 (7077), 682-7. (Pubitemid 43237609)
-
(2006)
Nature
, vol.439
, Issue.7077
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
Sharpe, A.H.6
Freeman, G.J.7
Ahmed, R.8
-
11
-
-
33749338938
-
+ T cell survival in HIV infection
-
DOI 10.1084/jem.20061496
-
Petrovas, C.; Casazza, J. P.; Brenchley, J. M.; Price, D. A.; Gostick, E.; Adams, W. C.; Precopio, M. L.; Schacker, T.; Roederer, M.; Douek, D. C.; Koup, R. A., PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 2006, 203 (10), 2281-92. (Pubitemid 44498363)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.10
, pp. 2281-2292
-
-
Petrovas, C.1
Casazza, J.P.2
Brenchley, J.M.3
Price, D.A.4
Gostick, E.5
Adams, W.C.6
Precopio, M.L.7
Schacker, T.8
Roederer, M.9
Douek, D.C.10
Koup, R.A.11
-
12
-
-
0037383592
-
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
-
DOI 10.1128/JVI.77.8.4911-4927.2003
-
Wherry, E. J.; Blattman, J. N.; Murali-Krishna, K.; van der Most, R.; Ahmed, R., Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003, 77 (8), 4911-27. (Pubitemid 36402840)
-
(2003)
Journal of Virology
, vol.77
, Issue.8
, pp. 4911-4927
-
-
Wherry, E.J.1
Blattman, J.N.2
Murali-Krishna, K.3
Van Der Most, R.4
Ahmed, R.5
-
13
-
-
0035282444
-
Skewed maturation of memory HIV-specific CD8 T lymphocytes
-
DOI 10.1038/35065118
-
Champagne, P.; Ogg, G. S.; King, A. S.; Knabenhans, C.; Ellefsen, K.; Nobile, M.; Appay, V.; Rizzardi, G. P.; Fleury, S.; Lipp, M.; Forster, R.; Rowland-Jones, S.; Sekaly, R. P.; McMichael, A. J.; Pantaleo, G., Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001, 410 (6824), 106-11. (Pubitemid 32225845)
-
(2001)
Nature
, vol.410
, Issue.6824
, pp. 106-111
-
-
Champagne, P.1
Ogg, G.S.2
King, A.S.3
Knabenhans, C.4
Ellefsen, K.5
Nobile, M.6
Appay, V.7
Rizzardi, G.P.8
Fleury, S.9
Lipp, M.10
Forster, R.11
Rowland-Jones, S.12
Sekaly, R.-P.13
McMichael, A.J.14
Pantaleo, G.15
-
14
-
-
68349139711
-
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
-
Chomont, N.; El-Far, M.; Ancuta, P.; Trautmann, L.; Procopio, F. A.; Yassine-Diab, B.; Boucher, G.; Boulassel, M. R.; Ghattas, G.; Brenchley, J. M.; Schacker, T. W.; Hill, B. J.; Douek, D. C.; Routy, J. P.; Haddad, E. K.; Sekaly, R. P., HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009, 15 (8), 893-900.
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 893-900
-
-
Chomont, N.1
El-Far, M.2
Ancuta, P.3
Trautmann, L.4
Procopio, F.A.5
Yassine-Diab, B.6
Boucher, G.7
Boulassel, M.R.8
Ghattas, G.9
Brenchley, J.M.10
Schacker, T.W.11
Hill, B.J.12
Douek, D.C.13
Routy, J.P.14
Haddad, E.K.15
Sekaly, R.P.16
-
15
-
-
33845236614
-
mac251-infected macaques
-
DOI 10.1182/blood-2006-04-010637
-
Hryniewicz, A.; Boasso, A.; Edghill-Smith, Y.; Vaccari, M.; Fuchs, D.; Venzon, D.; Nacsa, J.; Betts, M. R.; Tsai, W. P.; Heraud, J. M.; Beer, B.; Blanset, D.; Chougnet, C.; Lowy, I.; Shearer, G. M.; Franchini, G., CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood 2006, 108 (12), 3834-42. (Pubitemid 44864566)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3834-3842
-
-
Hryniewicz, A.1
Boasso, A.2
Edghill-Smith, Y.3
Vaccari, M.4
Fuchs, D.5
Venzon, D.6
Nacsa, J.7
Betts, M.R.8
Tsai, W.-P.9
Heraud, J.-M.10
Beer, B.11
Blanset, D.12
Chougnet, C.13
Lowy, I.14
Shearer, G.M.15
Franchini, G.16
-
16
-
-
33749491008
-
+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
-
DOI 10.1128/JVI.00249-06
-
Zaunders, J. J.; Ip, S.; Munier, M. L.; Kaufmann, D. E.; Suzuki, K.; Brereton, C.; Sasson, S. C.; Seddiki, N.; Koelsch, K.; Landay, A.; Grey, P.; Finlayson, R.; Kaldor, J.; Rosenberg, E. S.; Walker, B. D.; Fazekas de St Groth, B.; Cooper, D. A.; Kelleher, A. D., Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection. J Virol 2006, 80 (20), 10162-72. (Pubitemid 44522609)
-
(2006)
Journal of Virology
, vol.80
, Issue.20
, pp. 10162-10172
-
-
Zaunders, J.J.1
Ip, S.2
Munier, M.L.3
Kaufmann, D.E.4
Suzuki, K.5
Brereton, C.6
Sasson, S.C.7
Seddiki, N.8
Koelsch, K.9
Landay, A.10
Grey, P.11
Finlayson, R.12
Kaldor, J.13
Rosenberg, E.S.14
Walker, B.D.15
De St. Groth, B.F.16
Cooper, D.A.17
Kelleher, A.D.18
-
17
-
-
11144230063
-
The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation
-
DOI 10.1182/blood-2004-04-1596
-
Riley, J. L.; June, C. H., The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Blood 2005, 105 (1), 13-21. (Pubitemid 40053057)
-
(2005)
Blood
, vol.105
, Issue.1
, pp. 13-21
-
-
Riley, J.L.1
June, C.H.2
-
18
-
-
65349118810
-
PD-1 signaling in primary T cells
-
Riley, J. L., PD-1 signaling in primary T cells. Immunol Rev 2009, 229 (1), 114-25.
-
(2009)
Immunol Rev
, vol.229
, Issue.1
, pp. 114-125
-
-
Riley, J.L.1
-
19
-
-
34447646310
-
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
-
DOI 10.1016/j.immuni.2007.05.016, PII S1074761307003287
-
Butte, M. J.; Keir, M. E.; Phamduy, T. B.; Sharpe, A. H.; Freeman, G. J., Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007, 27 (1), 111-22. (Pubitemid 47089023)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
20
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
DOI 10.1016/S1074-7613(00)80346-5
-
Shiratori, T.; Miyatake, S.; Ohno, H.; Nakaseko, C.; Isono, K.; Bonifacino, J. S.; Saito, T., Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997, 6 (5), 583-9. (Pubitemid 27239349)
-
(1997)
Immunity
, vol.6
, Issue.5
, pp. 583-589
-
-
Shiratori, T.1
Miyatake, S.2
Ohno, H.3
Nakaseko, C.4
Isono, K.5
Bonifacino, J.S.6
Saito, T.7
-
21
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz, J. M.; Parry, R. V.; Nichols, K. E.; June, C. H.; Riley, J. L., SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 2004, 173 (2), 945-54. (Pubitemid 38924267)
-
(2004)
Journal of Immunology
, vol.173
, Issue.2
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
22
-
-
0346496097
-
CTLA-4 and Tolerance: The Biochemical Point of View
-
DOI 10.1385/IR:28:3:241
-
Chikuma, S.; Bluestone, J. A., CTLA-4 and tolerance: the biochemical point of view. Immunol Res 2003, 28 (3), 241-53. (Pubitemid 38091062)
-
(2003)
Immunologic Research
, vol.28
, Issue.3
, pp. 241-253
-
-
Chikuma, S.1
Bluestone, J.A.2
-
23
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
DOI 10.1128/MCB.25.21.9543-9553.2005
-
Parry, R. V.; Chemnitz, J. M.; Frauwirth, K. A.; Lanfranco, A. R.; Braunstein, I.; Kobayashi, S. V.; Linsley, P. S.; Thompson, C. B.; Riley, J. L., CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 2005, 25 (21), 9543-53. (Pubitemid 41507854)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.21
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
Kobayashi, S.V.6
Linsley, P.S.7
Thompson, C.B.8
Riley, J.L.9
-
24
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida, Y.; Agata, Y.; Shibahara, K.; Honjo, T., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992, 11 (11), 3887-95.
-
(1992)
EMBO J
, vol.11
, Issue.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
25
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
DOI 10.1016/S0968-0004(03)00091-4
-
Neel, B. G.; Gu, H.; Pao, L., The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 2003, 28 (6), 284-93. (Pubitemid 36776291)
-
(2003)
Trends in Biochemical Sciences
, vol.28
, Issue.6
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
26
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
Marengere, L. E.; Waterhouse, P.; Duncan, G. S.; Mittrucker, H. W.; Feng, G. S.; Mak, T. W., Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996, 272 (5265), 1170-3. (Pubitemid 26169471)
-
(1996)
Science
, vol.272
, Issue.5265
, pp. 1170-1173
-
-
Marengere, L.E.M.1
Waterhouse, P.2
Duncan, G.S.3
Mittrucker, H.-W.4
Feng, G.-S.5
Mak, T.W.6
-
27
-
-
33749609302
-
Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1
-
DOI 10.1385/IR:35:1:127, PII IR351127
-
Tsui, F. W.; Martin, A.; Wang, J.; Tsui, H. W., Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunol Res 2006, 35 (1-2), 127-36. (Pubitemid 44547508)
-
(2006)
Immunologic Research
, vol.35
, Issue.1-2
, pp. 127-136
-
-
Tsui, F.W.L.1
Martin, A.2
Wang, J.3
Tsui, H.W.4
-
28
-
-
0030037132
-
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C
-
DOI 10.1084/jem.184.1.295
-
Fry, A. M.; Lanier, L. L.; Weiss, A., Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J Exp Med 1996, 184 (1), 295-300 (Pubitemid 26247241)
-
(1996)
Journal of Experimental Medicine
, vol.184
, Issue.1
, pp. 295-300
-
-
Fry, A.M.1
Lanier, L.L.2
Weiss, A.3
-
29
-
-
21244437941
-
Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
-
DOI 10.1074/jbc.M502041200
-
Avril, T.; Freeman, S. D.; Attrill, H.; Clarke, R. G.; Crocker, P. R., Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem 2005, 280 (20), 19843-51. (Pubitemid 41379511)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.20
, pp. 19843-19851
-
-
Avril, T.1
Freeman, S.D.2
Attrill, H.3
Clarke, R.G.4
Crocker, P.R.5
-
30
-
-
0030932190
-
Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1
-
Ulyanova, T.; Blasioli, J.; Thomas, M. L., Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1. Immunol Res 1997, 16 (1), 101-13. (Pubitemid 27129632)
-
(1997)
Immunologic Research
, vol.16
, Issue.1
, pp. 101-113
-
-
Ulyanova, T.1
Blasioli, J.2
Thomas, M.L.3
-
31
-
-
0029904138
-
Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
-
Plas, D. R.; Johnson, R.; Pingel, J. T.; Matthews, R. J.; Dalton, M.; Roy, G.; Chan, A. C.; Thomas, M. L., Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 1996, 272 (5265), 1173-6 (Pubitemid 26169472)
-
(1996)
Science
, vol.272
, Issue.5265
, pp. 1173-1176
-
-
Plas, D.R.1
Johnson, R.2
Pingel, J.T.3
Matthews, R.J.4
Dalton, M.5
Roy, G.6
Chan, A.C.7
Thomas, M.L.8
-
32
-
-
0028989144
-
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
-
Pani, G.; Kozlowski, M.; Cambier, J. C.; Mills, G. B.; Siminovitch, K. A., Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 1995, 181 (6), 2077-84
-
(1995)
J Exp Med
, vol.181
, Issue.6
, pp. 2077-84
-
-
Pani, G.1
Kozlowski, M.2
Cambier, J.C.3
Mills, G.B.4
Siminovitch, K.A.5
-
33
-
-
0029844309
-
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
-
DOI 10.1073/pnas.93.18.9624
-
Lorenz, U.; Ravichandran, K. S.; Burakoff, S. J.; Neel, B. G., Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci U S A 1996, 93 (18), 9624-9. (Pubitemid 26296658)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.18
, pp. 9624-9629
-
-
Lorenz, U.1
Ravichandran, K.S.2
Burakoff, S.J.3
Neel, B.G.4
-
34
-
-
0033755417
-
Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GHpromoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B
-
Stofega, M. R.; Herrington, J.; Billestrup, N.; Carter-Su, C., Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GHpromoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. Mol Endocrinol 2000, 14 (9), 1338-50
-
(2000)
Mol Endocrinol
, vol.14
, Issue.9
, pp. 1338-50
-
-
Stofega, M.R.1
Herrington, J.2
Billestrup, N.3
Carter-Su, C.4
-
35
-
-
0037414817
-
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
-
DOI 10.1074/jbc.M210552200
-
Lehmann, U.; Schmitz, J.; Weissenbach, M.; Sobota, R. M.; Hortner, M.; Friederichs, K.; Behrmann, I.; Tsiaris, W.; Sasaki, A.; Schneider-Mergener, J.; Yoshimura, A.; Neel, B. G.; Heinrich, P. C.; Schaper, F., SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem 2003, 278 (1), 661-71 (Pubitemid 36043620)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.1
, pp. 661-671
-
-
Lehmann, U.1
Schmitz, J.2
Weissenbach, M.3
Sobota, R.M.4
Hortner, M.5
Friederichs, K.6
Behrmann, I.7
Tsiaris, W.8
Sasaki, A.9
Schneider-Mergener, J.10
Yoshimura, A.11
Neel, B.G.12
Heinrich, P.C.13
Schaper, F.14
-
36
-
-
0037094006
-
SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells
-
Yusa, S.; Catina, T. L.; Campbell, K. S., SHP-1-and phosphotyrosine- independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. J Immunol 2002, 168 (10), 5047-57. (Pubitemid 34495968)
-
(2002)
Journal of Immunology
, vol.168
, Issue.10
, pp. 5047-5057
-
-
Yusa, S.-I.1
Catina, T.L.2
Campbell, K.S.3
-
37
-
-
0346725003
-
Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome
-
DOI 10.1016/j.cellsig.2003.08.013
-
Staub, E.; Rosenthal, A.; Hinzmann, B., Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome. Cell Signal 2004, 16 (4), 435-56. (Pubitemid 38058627)
-
(2004)
Cellular Signalling
, vol.16
, Issue.4
, pp. 435-456
-
-
Staub, E.1
Rosenthal, A.2
Hinzmann, B.3
-
38
-
-
0036484220
-
The B7-CD28 superfamily
-
Sharpe, A. H.; Freeman, G. J., The B7-CD28 superfamily. Nat Rev Immunol 2002, 2 (2), 116-26. (Pubitemid 37323235)
-
(2002)
Nature Reviews Immunology
, vol.2
, Issue.2
, pp. 116-126
-
-
Sharpe, A.H.1
Freeman, G.J.2
-
39
-
-
0027429761
-
Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
-
Ward, S. G.; Westwick, J.; Hall, N. D.; Sansom, D. M., Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation. Eur J Immunol 1993, 23 (10), 2572-7. (Pubitemid 23295141)
-
(1993)
European Journal of Immunology
, vol.23
, Issue.10
, pp. 2572-2577
-
-
Ward, S.G.1
Westwick, J.2
Hall, N.D.3
Sansom, D.M.4
-
40
-
-
27744519400
-
Fuel feeds function: Energy metabolism and the T-cell response
-
DOI 10.1038/nri1710, PII N1710
-
Fox, C. J.; Hammerman, P. S.; Thompson, C. B., Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 2005, 5 (11), 844-52. (Pubitemid 41581666)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.11
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
41
-
-
0036207926
-
+ T cells and is overcome by IL-2
-
DOI 10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9
-
Carter, L.; Fouser, L. A.; Jussif, J.; Fitz, L.; Deng, B.; Wood, C. R.; Collins, M.; Honjo, T.; Freeman, G. J.; Carreno, B. M., PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol 2002, 32 (3), 634-43. (Pubitemid 34257540)
-
(2002)
European Journal of Immunology
, vol.32
, Issue.3
, pp. 634-643
-
-
Carter, L.L.1
Fouser, L.A.2
Jussif, J.3
Fitz, L.4
Deng, B.5
Wood, C.R.6
Collins, M.7
Honjo, T.8
Freeman, G.J.9
Carreno, B.M.10
-
42
-
-
2342553419
-
Fine-tuning lymphocyte regulation: What's new with tyrosine kinases and phosphatases?
-
DOI 10.1016/j.coi.2004.03.011, PII S0952791504000482
-
Cannons, J. L.; Schwartzberg, P. L., Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases? Curr Opin Immunol 2004, 16 (3), 296-303. (Pubitemid 38595368)
-
(2004)
Current Opinion in Immunology
, vol.16
, Issue.3
, pp. 296-303
-
-
Cannons, J.L.1
Schwartzberg, P.L.2
-
43
-
-
0034644505
-
Signaling takes shape in the immune system
-
Dustin, M. L.; Chan, A. C., Signaling takes shape in the immune system. Cell 2000, 103 (2), 283-94.
-
(2000)
Cell
, vol.103
, Issue.2
, pp. 283-294
-
-
Dustin, M.L.1
Chan, A.C.2
-
44
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-I negative feedback pathways
-
DOI 10.1038/ni895
-
Stefanova, I.; Hemmer, B.; Vergelli, M.; Martin, R.; Biddison, W. E.; Germain, R. N., TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 2003, 4 (3), 248-54. (Pubitemid 36322134)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 248-254
-
-
Stefanova, I.1
Hemmer, B.2
Vergelli, M.3
Martin, R.4
Biddison, W.E.5
Germain, R.N.6
-
45
-
-
0030566804
-
Identification and characterization of a substrate specific for the T cell protein tyrosine kinase ZAP-70
-
DOI 10.1016/S0014-5793(96)01241-0, PII S0014579396012410
-
Watts, J. D.; Brabb, T.; Bures, E. J.; Wange, R. L.; Samelson, L. E.; Aebersold, R., Identification and characterization of a substrate specific for the T cell protein tyrosine kinase ZAP-70. FEBS Lett 1996, 398 (2-3), 217-22. (Pubitemid 26414313)
-
(1996)
FEBS Letters
, vol.398
, Issue.2-3
, pp. 217-222
-
-
Watts, J.D.1
Brabb, T.2
Bures, E.J.3
Wange, R.L.4
Samelson, L.E.5
Aebersold, R.6
-
46
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
DOI 10.1038/ni1272, PII N1272
-
Yokosuka, T.; Sakata-Sogawa, K.; Kobayashi, W.; Hiroshima, M.; Hashimoto-Tane, A.; Tokunaga, M.; Dustin, M. L.; Saito, T., Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol 2005, 6 (12), 1253-62. (Pubitemid 43045637)
-
(2005)
Nature Immunology
, vol.6
, Issue.12
, pp. 1253-1262
-
-
Yokosuka, T.1
Sakata-Sogawa, K.2
Kobayashi, W.3
Hiroshima, M.4
Hashimoto-Tane, A.5
Tokunaga, M.6
Dustin, M.L.7
Saito, T.8
-
47
-
-
4444317516
-
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
-
DOI 10.1016/j.febslet.2004.07.083, PII S0014579304009779
-
Sheppard, K. A.; Fitz, L. J.; Lee, J. M.; Benander, C.; George, J. A.; Wooters, J.; Qiu, Y.; Jussif, J. M.; Carter, L. L.; Wood, C. R.; Chaudhary, D., PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 2004, 574 (1-3), 37-41. (Pubitemid 39200891)
-
(2004)
FEBS Letters
, vol.574
, Issue.1-3
, pp. 37-41
-
-
Sheppard, K.-A.1
Fitz, L.J.2
Lee, J.M.3
Benander, C.4
George, J.A.5
Wooters, J.6
Qiu, Y.7
Jussif, J.M.8
Carter, L.L.9
Wood, C.R.10
Chaudhary, D.11
-
48
-
-
0030886836
-
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
-
DOI 10.1073/pnas.94.18.9797
-
Cheng, A. M.; Negishi, I.; Anderson, S. J.; Chan, A. C.; Bolen, J.; Loh, D. Y.; Pawson, T., The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc Natl Acad Sci U S A 1997, 94 (18), 9797-801. (Pubitemid 27408144)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.18
, pp. 9797-9801
-
-
Cheng, A.M.1
Negishi, I.2
Anderson, S.J.3
Chan, A.C.4
Bolen, J.5
Loh, D.Y.6
Pawson, T.7
-
49
-
-
77949962019
-
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
-
Zikherman, J.; Jenne, C.; Watson, S.; Doan, K.; Raschke, W.; Goodnow, C. C.; Weiss, A., CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 2010, 32 (3), 342-54.
-
(2010)
Immunity
, vol.32
, Issue.3
, pp. 342-354
-
-
Zikherman, J.1
Jenne, C.2
Watson, S.3
Doan, K.4
Raschke, W.5
Goodnow, C.C.6
Weiss, A.7
-
50
-
-
0026968884
-
Regulation of protein tyrosine kinase activation by the T-cell antigen receptor ζ chain
-
Weiss, A.; Chan, A. C.; Iwashima, M.; Straus, D.; Irving, B. A., Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain. Cold Spring Harb Symp Quant Biol 1992, 57, 107-16. (Pubitemid 23174382)
-
(1992)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.57
, pp. 107-116
-
-
Weiss, A.1
Chan, A.C.2
Iwashima, M.3
Straus, D.4
Irving, B.A.5
-
51
-
-
0025881470
-
c-src
-
Nada, S.; Okada, M.; MacAuley, A.; Cooper, J. A.; Nakagawa, H., Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 1991, 351 (6321), 69-72. (Pubitemid 21896537)
-
(1991)
Nature
, vol.351
, Issue.6321
, pp. 69-72
-
-
Nada, S.1
Okada, M.2
MacAuley, A.3
Cooper, J.A.4
Nakagawa, H.5
-
52
-
-
1842763594
-
CD45 isoforms in T cell signalling and development
-
DOI 10.1016/j.imlet.2003.10.018, PII S0165247803003092
-
McNeill, L.; Cassady, R. L.; Sarkardei, S.; Cooper, J. C.; Morgan, G.; Alexander, D. R., CD45 isoforms in T cell signalling and development. Immunol Lett 2004, 92 (1-2), 125-34. (Pubitemid 38470059)
-
(2004)
Immunology Letters
, vol.92
, Issue.1-2
, pp. 125-134
-
-
McNeill, L.1
Cassady, R.L.2
Sarkardei, S.3
Cooper, J.C.4
Morgan, G.5
Alexander, D.R.6
-
53
-
-
33847208485
-
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
-
Davidson, D.; Schraven, B.; Veillette, A., PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol 2007, 27 (5), 1960-73.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.5
, pp. 1960-1973
-
-
Davidson, D.1
Schraven, B.2
Veillette, A.3
-
54
-
-
30944456522
-
Leukocyte-associated Ig-like receptor-1 SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase
-
DOI 10.1002/eji.200535226
-
Verbrugge, A.; Rijkers, E. S.; de Ruiter, T.; Meyaard, L., Leukocyteassociated Ig-like receptor-1 has SH2 domain-containing phosphataseindependent function and recruits C-terminal Src kinase. Eur J Immunol 2006, 36 (1), 190-8. (Pubitemid 43116405)
-
(2006)
European Journal of Immunology
, vol.36
, Issue.1
, pp. 190-198
-
-
Verbrugge, A.1
Rijkers, E.S.K.2
De Ruiter, T.3
Meyaard, L.4
-
55
-
-
0035933771
-
Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase
-
Chiang, G. G.; Sefton, B. M., Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase. J Biol Chem 2001, 276 (25), 23173-8.
-
(2001)
J Biol Chem
, vol.276
, Issue.25
, pp. 23173-23178
-
-
Chiang, G.G.1
Sefton, B.M.2
-
56
-
-
0038815306
-
CD45: A critical regulator of signaling thresholds in immune cells
-
DOI 10.1146/annurev.immunol.21.120601.140946
-
Hermiston, M. L.; Xu, Z.; Weiss, A., CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 2003, 21, 107-37. (Pubitemid 37174528)
-
(2003)
Annual Review of Immunology
, vol.21
, pp. 107-137
-
-
Hermiston, M.L.1
Xu, Z.2
Weiss, A.3
-
57
-
-
0032538443
-
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
-
DOI 10.1074/jbc.273.42.27518
-
Binstadt, B. A.; Billadeau, D. D.; Jevremovic, D.; Williams, B. L.; Fang, N.; Yi, T.; Koretzky, G. A.; Abraham, R. T.; Leibson, P. J., SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem 1998, 273 (42), 27518-23. (Pubitemid 28500472)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.42
, pp. 27518-27523
-
-
Binstadt, B.A.1
Billadeau, D.D.2
Jevremovic, D.3
Williams, B.L.4
Fang, N.5
Yi, T.6
Koretzky, G.A.7
Abraham, R.T.8
Leibson, P.J.9
-
58
-
-
56449128913
-
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism
-
Muthumani, K.; Choo, A. Y.; Shedlock, D. J.; Laddy, D. J.; Sundaram, S. G.; Hirao, L.; Wu, L.; Thieu, K. P.; Chung, C. W.; Lankaraman, K. M.; Tebas, P.; Silvestri, G.; Weiner, D. B., Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism. J Virol 2008, 82 (23), 11536-44.
-
(2008)
J Virol
, vol.82
, Issue.23
, pp. 11536-11544
-
-
Muthumani, K.1
Choo, A.Y.2
Shedlock, D.J.3
Laddy, D.J.4
Sundaram, S.G.5
Hirao, L.6
Wu, L.7
Thieu, K.P.8
Chung, C.W.9
Lankaraman, K.M.10
Tebas, P.11
Silvestri, G.12
Weiner, D.B.13
-
59
-
-
58149314579
-
NFATc1 regulates PD-1 expression upon T cell activation
-
Oestreich, K. J.; Yoon, H.; Ahmed, R.; Boss, J. M., NFATc1 regulates PD-1 expression upon T cell activation. J Immunol 2008, 181 (7), 4832-9.
-
(2008)
J Immunol
, vol.181
, Issue.7
, pp. 4832-4839
-
-
Oestreich, K.J.1
Yoon, H.2
Ahmed, R.3
Boss, J.M.4
-
60
-
-
34248399247
-
+ T cell functions during chronic viral infection
-
DOI 10.1073/pnas.0610335104
-
Agnellini, P.; Wolint, P.; Rehr, M.; Cahenzli, J.; Karrer, U.; Oxenius, A., Impaired NFAT nuclear translocation results in split exhaustion of virusspecific CD8+ T cell functions during chronic viral infection. Proc Natl Acad Sci U S A 2007, 104 (11), 4565-70. (Pubitemid 47186265)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.11
, pp. 4565-4570
-
-
Agnellini, P.1
Wolint, P.2
Rehr, M.3
Cahenzli, J.4
Karrer, U.5
Oxenius, A.6
-
61
-
-
37849054022
-
Molecular regulation of T-cell anergy
-
Zheng, Y.; Zha, Y.; Gajewski, T. F., Molecular regulation of T-cell anergy. EMBO Rep 2008, 9 (1), 50-5.
-
(2008)
EMBO Rep
, vol.9
, Issue.1
, pp. 50-55
-
-
Zheng, Y.1
Zha, Y.2
Gajewski, T.F.3
-
62
-
-
38849157031
-
Cbl-b regulates antigeninduced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity
-
Shamim, M.; Nanjappa, S. G.; Singh, A.; Plisch, E. H.; LeBlanc, S. E.; Walent, J.; Svaren, J.; Seroogy, C.; Suresh, M., Cbl-b regulates antigeninduced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity. J Immunol 2007, 179 (11), 7233-43
-
(2007)
J Immunol
, vol.179
, Issue.11
, pp. 7233-43
-
-
Shamim, M.1
Nanjappa, S.G.2
Singh, A.3
Plisch, E.H.4
Leblanc, S.E.5
Walent, J.6
Svaren, J.7
Seroogy, C.8
Suresh, M.9
-
63
-
-
41149123861
-
+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection
-
DOI 10.1128/JVI.01350-07
-
Ou, R.; Zhang, M.; Huang, L.; Moskophidis, D., Control of virusspecific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol 2008, 82 (7), 3353-68. (Pubitemid 351429913)
-
(2008)
Journal of Virology
, vol.82
, Issue.7
, pp. 3353-3368
-
-
Ou, R.1
Zhang, M.2
Huang, L.3
Moskophidis, D.4
-
64
-
-
0037396674
-
+ T cells
-
DOI 10.1016/S1074-7613(03)00084-0
-
Anandasabapathy, N.; Ford, G. S.; Bloom, D.; Holness, C.; Paragas, V.; Seroogy, C.; Skrenta, H.; Hollenhorst, M.; Fathman, C. G.; Soares, L., GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity 2003, 18 (4), 535-47. (Pubitemid 36513635)
-
(2003)
Immunity
, vol.18
, Issue.4
, pp. 535-547
-
-
Anandasabapathy, N.1
Ford, G.S.2
Bloom, D.3
Holness, C.4
Paragas, V.5
Seroogy, C.6
Skrenta, H.7
Hollenhorst, M.8
Fathman, C.G.9
Soares, L.10
-
65
-
-
0037438490
-
Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
-
Bennett, F.; Luxenberg, D.; Ling, V.; Wang, I. M.; Marquette, K.; Lowe, D.; Khan, N.; Veldman, G.; Jacobs, K. A.; Valge-Archer, V. E.; Collins, M.; Carreno, B. M., Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J Immunol 2003, 170 (2), 711-8. (Pubitemid 36070520)
-
(2003)
Journal of Immunology
, vol.170
, Issue.2
, pp. 711-718
-
-
Bennett, F.1
Luxenberg, D.2
Ling, V.3
Wang, I.-M.4
Marquette, K.5
Lowe, D.6
Khan, N.7
Veldman, G.8
Jacobs, K.A.9
Valge-Archer, V.E.10
Collins, M.11
Carreno, B.M.12
-
66
-
-
58149191881
-
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
-
Kinter, A. L.; Godbout, E. J.; McNally, J. P.; Sereti, I.; Roby, G. A.; O'Shea, M. A.; Fauci, A. S., The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 2008, 181 (10), 6738-46.
-
(2008)
J Immunol
, vol.181
, Issue.10
, pp. 6738-6746
-
-
Kinter, A.L.1
Godbout, E.J.2
McNally, J.P.3
Sereti, I.4
Roby, G.A.5
O'shea, M.A.6
Fauci, A.S.7
-
67
-
-
1942453326
-
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
-
DOI 10.1016/S0092-8674(04)00335-6, PII S0092867404003356
-
King, C.; Ilic, A.; Koelsch, K.; Sarvetnick, N., Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004, 117 (2), 265-77 (Pubitemid 38496245)
-
(2004)
Cell
, vol.117
, Issue.2
, pp. 265-277
-
-
King, C.1
Ilic, A.2
Koelsch, K.3
Sarvetnick, N.4
-
68
-
-
11144221749
-
The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
-
DOI 10.1016/j.it.2004.11.006, PII S1471490604003436
-
Baccala, R.; Theofilopoulos, A. N., The new paradigm of Tcell homeostatic proliferation-induced autoimmunity. Trends Immunol 2005, 26 (1), 5-8 (Pubitemid 40051984)
-
(2005)
Trends in Immunology
, vol.26
, Issue.1
, pp. 5-8
-
-
Baccala, R.1
Theofilopoulos, A.N.2
-
69
-
-
33746189876
-
Autoimmunity during lymphopenia: A two-hit model
-
DOI 10.1016/j.clim.2006.04.569, PII S1521661606006942
-
Krupica, T., Jr.; Fry, T. J.; Mackall, C. L., Autoimmunity during lymphopenia: a two-hit model. Clin Immunol 2006, 120 (2), 121-8. (Pubitemid 44088681)
-
(2006)
Clinical Immunology
, vol.120
, Issue.2
, pp. 121-128
-
-
Krupica Jr., T.1
Fry, T.J.2
Mackall, C.L.3
-
70
-
-
33750499311
-
Interleukin-10 determines viral clearance or persistence in vivo
-
DOI 10.1038/nm1492, PII NM1492
-
Brooks, D. G.; Trifilo, M. J.; Edelmann, K. H.; Teyton, L.; McGavern, D. B.; Oldstone, M. B., Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 2006, 12 (11), 1301-9. (Pubitemid 44706933)
-
(2006)
Nature Medicine
, vol.12
, Issue.11
, pp. 1301-1309
-
-
Brooks, D.G.1
Trifilo, M.J.2
Edelmann, K.H.3
Teyton, L.4
McGavern, D.B.5
Oldstone, M.B.A.6
-
71
-
-
33750530611
-
Resolution of a chronic viral infection after interleukin-10 receptor blockade
-
DOI 10.1084/jem.20061462
-
Ejrnaes, M.; Filippi, C. M.; Martinic, M. M.; Ling, E. M.; Togher, L. M.; Crotty, S.; von Herrath, M. G., Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med 2006, 203 (11), 2461-72. (Pubitemid 44664616)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.11
, pp. 2461-2472
-
-
Ejrnaes, M.1
Filippi, C.M.2
Martinic, M.M.3
Ling, E.M.4
Togher, L.M.5
Crotty, S.6
Von Herrath, M.G.7
-
72
-
-
42949160646
-
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
-
DOI 10.1073/pnas.0712278105
-
Lin, D. Y.; Tanaka, Y.; Iwasaki, M.; Gittis, A. G.; Su, H. P.; Mikami, B.; Okazaki, T.; Honjo, T.; Minato, N.; Garboczi, D. N., The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A 2008, 105 (8), 3011-6. (Pubitemid 351723659)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3011-3016
-
-
Lin, D.Y.-W.1
Tanaka, Y.2
Iwasaki, M.3
Gittis, A.G.4
Su, H.-P.5
Mikami, B.6
Okazaki, T.7
Honjo, T.8
Minato, N.9
Garboczi, D.N.10
-
73
-
-
0030031070
-
Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood
-
Hagiwara, E.; Sacks, T.; Leitman-Klinman, S. F.; Klinman, D. M., Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Hum Retroviruses 1996, 12 (2), 127-133. (Pubitemid 26039711)
-
(1996)
AIDS Research and Human Retroviruses
, vol.12
, Issue.2
, pp. 127-133
-
-
Hagiwara, E.1
Sacks, T.2
Leitman-Klinman, S.F.3
Klinman, D.M.4
-
74
-
-
33748448717
-
Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms
-
DOI 10.1016/j.immuni.2006.07.011, PII S1074761306003876
-
Li, M. O.; Sanjabi, S.; Flavell, R. A., Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006, 25 (3), 455-71 (Pubitemid 44354214)
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 455-471
-
-
Li, M.O.1
Sanjabi, S.2
Flavell, RichardA.3
-
75
-
-
68249152608
-
Cellintrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
-
Tinoco, R.; Alcalde, V.; Yang, Y.; Sauer, K.; Zuniga, E. I., Cellintrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 2009, 31 (1), 145-57.
-
(2009)
Immunity
, vol.31
, Issue.1
, pp. 145-157
-
-
Tinoco, R.1
Alcalde, V.2
Yang, Y.3
Sauer, K.4
Zuniga, E.I.5
-
76
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K.; Turner, A. P.; Shaffer, V. O.; Gangappa, S.; Keller, S. A.; Bachmann, M. F.; Larsen, C. P.; Ahmed, R., mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460 (7251), 108-12.
-
(2009)
Nature
, vol.460
, Issue.7251
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
Ahmed, R.8
-
77
-
-
53349160053
-
Challenges in the development of an HIV-1 vaccine
-
Barouch, D. H., Challenges in the development of an HIV-1 vaccine. Nature 2008, 455 (7213), 613-9
-
(2008)
Nature
, vol.455
, Issue.7213
, pp. 613-9
-
-
Barouch, D.H.1
-
78
-
-
0027043276
-
Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
-
Daniel, M. D.; Kirchhoff, F.; Czajak, S. C.; Sehgal, P. K.; Desrosiers, R. C., Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 1992, 258 (5090), 1938-41. (Pubitemid 23026733)
-
(1992)
Science
, vol.258
, Issue.5090
, pp. 1938-1941
-
-
Daniel, M.D.1
Kirchhoff, F.2
Czajak, S.C.3
Sehgal, P.K.4
Desrosiers, R.C.5
-
79
-
-
34548689151
-
Human Immunodeficiency Virus Controllers: Mechanisms of Durable Virus Control in the Absence of Antiretroviral Therapy
-
DOI 10.1016/j.immuni.2007.08.010, PII S1074761307004141
-
Deeks, S. G.; Walker, B. D., Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 2007, 27 (3), 406-16. (Pubitemid 47418678)
-
(2007)
Immunity
, vol.27
, Issue.3
, pp. 406-416
-
-
Deeks, S.G.1
Walker, B.D.2
-
80
-
-
34548637484
-
Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
-
D'Souza, M.; Fontenot, A. P.; Mack, D. G.; Lozupone, C.; Dillon, S.; Meditz, A.; Wilson, C. C.; Connick, E.; Palmer, B. E., Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol 2007, 179 (3), 1979-87.
-
(2007)
J Immunol
, vol.179
, Issue.3
, pp. 1979-1987
-
-
D'souza, M.1
Fontenot, A.P.2
MacK, D.G.3
Lozupone, C.4
Dillon, S.5
Meditz, A.6
Wilson, C.C.7
Connick, E.8
Palmer, B.E.9
-
81
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
DOI 10.1056/NEJMoa063842
-
Suntharalingam, G.; Perry, M. R.; Ward, S.; Brett, S. J.; Castello-Cortes, A.; Brunner, M. D.; Panoskaltsis, N., Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006, 355 (10), 1018-28. (Pubitemid 44343545)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.10
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
Brett, S.J.4
Castello-Cortes, A.5
Brunner, M.D.6
Panoskaltsis, N.7
-
82
-
-
0038784354
-
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
-
DOI 10.1182/blood-2002-10-3065
-
Trabattoni, D.; Saresella, M.; Biasin, M.; Boasso, A.; Piacentini, L.; Ferrante, P.; Dong, H.; Maserati, R.; Shearer, G. M.; Chen, L.; Clerici, M., B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003, 101 (7), 2514-20. (Pubitemid 36857606)
-
(2003)
Blood
, vol.101
, Issue.7
, pp. 2514-2520
-
-
Trabattoni, D.1
Saresella, M.2
Biasin, M.3
Boasso, A.4
Piacentini, L.5
Ferrante, P.6
Dong, H.7
Maserati, R.8
Shearer, G.M.9
Chen, L.10
Clerici, M.11
-
83
-
-
51249105975
-
PDL-1 upregulation on monocytes and T cells by HIV via type i interferon: Restricted expression of type i interferon receptor by CCR5-expressing leukocytes
-
Boasso, A.; Hardy, A. W.; Landay, A. L.; Martinson, J. L.; Anderson, S. A.; Dolan, M. J.; Clerici, M.; Shearer, G. M., PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes. Clin Immunol 2008, 129 (1), 132-44.
-
(2008)
Clin Immunol
, vol.129
, Issue.1
, pp. 132-144
-
-
Boasso, A.1
Hardy, A.W.2
Landay, A.L.3
Martinson, J.L.4
Anderson, S.A.5
Dolan, M.J.6
Clerici, M.7
Shearer, G.M.8
-
84
-
-
58549102319
-
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
-
Marzec, M.; Zhang, Q.; Goradia, A.; Raghunath, P. N.; Liu, X.; Paessler, M.; Wang, H. Y.; Wysocka, M.; Cheng, M.; Ruggeri, B. A.; Wasik, M. A., Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci U S A 2008, 105 (52), 20852-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.52
, pp. 20852-20857
-
-
Marzec, M.1
Zhang, Q.2
Goradia, A.3
Raghunath, P.N.4
Liu, X.5
Paessler, M.6
Wang, H.Y.7
Wysocka, M.8
Cheng, M.9
Ruggeri, B.A.10
Wasik, M.A.11
-
85
-
-
1342303482
-
Of Mice and Not Men: Differences between Mouse and Human Immunology
-
Mestas, J.; Hughes, C. C., Of mice and not men: differences between mouse and human immunology. J Immunol 2004, 172 (5), 2731-8. (Pubitemid 38263654)
-
(2004)
Journal of Immunology
, vol.172
, Issue.5
, pp. 2731-2738
-
-
Mestas, J.1
Hughes, C.C.W.2
-
86
-
-
85047690906
-
Turnover of lymphocytes and conceptual paradigms in HIV infection
-
DOI 10.1172/JCI200319799
-
Silvestri, G.; Feinberg, M. B., Turnover of lymphocytes and conceptual paradigms in HIV infection. J Clin Invest 2003, 112 (6), 821-4. (Pubitemid 38063737)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.6
, pp. 821-824
-
-
Silvestri, G.1
Feinberg, M.B.2
-
87
-
-
33645863160
-
The PD-1-PD-L pathway in immunological tolerance
-
Okazaki, T.; Honjo, T., The PD-1-PD-L pathway in immunological tolerance. Trends Immunol 2006, 27 (4), 195-201.
-
(2006)
Trends Immunol
, vol.27
, Issue.4
, pp. 195-201
-
-
Okazaki, T.1
Honjo, T.2
-
88
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger, R.; Rotem-Yehudar, R.; Slama, G.; Landes, S.; Kneller, A.; Leiba, M.; Koren-Michowitz, M.; Shimoni, A.; Nagler, A., Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008, 14 (10), 3044-51.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.10
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
Landes, S.4
Kneller, A.5
Leiba, M.6
Koren-Michowitz, M.7
Shimoni, A.8
Nagler, A.9
-
89
-
-
58149484842
-
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
-
Brooks, D. G.; Ha, S. J.; Elsaesser, H.; Sharpe, A. H.; Freeman, G. J.; Oldstone, M. B., IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A 2008, 105 (51), 20428-33.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.51
, pp. 20428-20433
-
-
Brooks, D.G.1
Ha, S.J.2
Elsaesser, H.3
Sharpe, A.H.4
Freeman, G.J.5
Oldstone, M.B.6
-
90
-
-
41149112957
-
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
-
DOI 10.1084/jem.20071949
-
Ha, S. J.; Mueller, S. N.; Wherry, E. J.; Barber, D. L.; Aubert, R. D.; Sharpe, A. H.; Freeman, G. J.; Ahmed, R., Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med 2008, 205 (3), 543-55 (Pubitemid 351439302)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.3
, pp. 543-555
-
-
Ha, S.-J.1
Mueller, S.N.2
Wherry, E.J.3
Barber, D.L.4
Aubert, R.D.5
Sharpe, A.H.6
Freeman, G.J.7
Ahmed, R.8
-
91
-
-
41149130734
-
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
-
DOI 10.1084/jem.20071948
-
Brooks, D. G.; Lee, A. M.; Elsaesser, H.; McGavern, D. B.; Oldstone, M. B., IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med 2008, 205 (3), 533-41. (Pubitemid 351439301)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.3
, pp. 533-541
-
-
Brooks, D.G.1
Lee, A.M.2
Elsaesser, H.3
McGavern, D.B.4
Oldstone, M.B.A.5
-
92
-
-
49549117077
-
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
-
Kumar, P.; Ban, H. S.; Kim, S. S.; Wu, H.; Pearson, T.; Greiner, D. L.; Laouar, A.; Yao, J.; Haridas, V.; Habiro, K.; Yang, Y. G.; Jeong, J. H.; Lee, K. Y.; Kim, Y. H.; Kim, S. W.; Peipp, M.; Fey, G. H.; Manjunath, N.; Shultz, L. D.; Lee, S. K.; Shankar, P., T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 2008, 134 (4), 577-86.
-
(2008)
Cell
, vol.134
, Issue.4
, pp. 577-586
-
-
Kumar, P.1
Ban, H.S.2
Kim, S.S.3
Wu, H.4
Pearson, T.5
Greiner, D.L.6
Laouar, A.7
Yao, J.8
Haridas, V.9
Habiro, K.10
Yang, Y.G.11
Jeong, J.H.12
Lee, K.Y.13
Kim, Y.H.14
Kim, S.W.15
Peipp, M.16
Fey, G.H.17
Manjunath, N.18
Shultz, L.D.19
Lee, S.K.20
Shankar, P.21
more..
-
93
-
-
0033811659
-
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
-
Shan, X.; Czar, M. J.; Bunnell, S. C.; Liu, P.; Liu, Y.; Schwartzberg, P. L.; Wange, R. L., Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol 2000, 20 (18), 6945-57.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.18
, pp. 6945-6957
-
-
Shan, X.1
Czar, M.J.2
Bunnell, S.C.3
Liu, P.4
Liu, Y.5
Schwartzberg, P.L.6
Wange, R.L.7
-
94
-
-
0037111475
-
Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors
-
Freeburn, R. W.; Wright, K. L.; Burgess, S. J.; Astoul, E.; Cantrell, D. A.; Ward, S. G., Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J Immunol 2002, 169 (10), 5441-50. (Pubitemid 35291641)
-
(2002)
Journal of Immunology
, vol.169
, Issue.10
, pp. 5441-5450
-
-
Freeburn, R.W.1
Wright, K.L.2
Burgess, S.J.3
Astoul, E.4
Cantrell, D.A.5
Ward, S.G.6
-
95
-
-
38149004467
-
STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation
-
Lockyer, H. M.; Tran, E.; Nelson, B. H., STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation. J Immunol 2007, 179 (8), 5301-8
-
(2007)
J Immunol
, vol.179
, Issue.8
, pp. 5301-8
-
-
Lockyer, H.M.1
Tran, E.2
Nelson, B.H.3
-
96
-
-
0037015055
-
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
-
DOI 10.1073/pnas.162359999
-
Riley, J. L.; Mao, M.; Kobayashi, S.; Biery, M.; Burchard, J.; Cavet, G.; Gregson, B. P.; June, C. H.; Linsley, P. S., Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A 2002, 99 (18), 11790-5. (Pubitemid 34994477)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.18
, pp. 11790-11795
-
-
Riley, J.L.1
Mao, M.2
Kobayashi, S.3
Biery, M.4
Burchard, J.5
Cavet, G.6
Gregson, B.P.7
June, C.H.8
Linsley, P.S.9
-
97
-
-
70350743827
-
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention
-
Kaufmann, D. E.; Walker, B. D., PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. J Immunol 2009, 182 (10), 5891-7.
-
(2009)
J Immunol
, vol.182
, Issue.10
, pp. 5891-5897
-
-
Kaufmann, D.E.1
Walker, B.D.2
|