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Volumn 455, Issue 7213, 2008, Pages 613-619

Challenges in the development of an HIV-1 vaccine

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DNA VACCINE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS VACCINE; VIRUS VECTOR;

EID: 53349160053     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07352     Document Type: Review
Times cited : (305)

References (93)
  • 1
    • 0020596551 scopus 로고
    • Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • Barre-Sinoussi, F. et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871 (1983).
    • (1983) Science , vol.220 , pp. 868-871
    • Barre-Sinoussi, F.1
  • 2
    • 0021261510 scopus 로고
    • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
    • Gallo, R. C. et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224, 500-503 (1984).
    • (1984) Science , vol.224 , pp. 500-503
    • Gallo, R.C.1
  • 3
    • 0021237243 scopus 로고
    • Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    • Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224, 497-500 (1984).
    • (1984) Science , vol.224 , pp. 497-500
    • Popovic, M.1    Sarngadharan, M.G.2    Read, E.3    Gallo, R.C.4
  • 4
    • 0021234845 scopus 로고
    • Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS
    • Sarngadharan, M. G., Popovic, M., Bruch, L., Schupbach, J. & Gallo, R. C. Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224, 506-508 (1984).
    • (1984) Science , vol.224 , pp. 506-508
    • Sarngadharan, M.G.1    Popovic, M.2    Bruch, L.3    Schupbach, J.4    Gallo, R.C.5
  • 5
    • 0021281132 scopus 로고
    • Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS
    • Schupbach, J. et al. Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS. Science 224, 503-505 (1984).
    • (1984) Science , vol.224 , pp. 503-505
    • Schupbach, J.1
  • 6
    • 43749123908 scopus 로고    scopus 로고
    • 25 years of HIV
    • Fauci, A. S. 25 years of HIV. Nature 453, 289-290 (2008).
    • (2008) Nature , vol.453 , pp. 289-290
    • Fauci, A.S.1
  • 7
    • 0034732201 scopus 로고    scopus 로고
    • Viral load and heterosexual transmission of human immunodeficiency virus type 1
    • Quinn, T. C. et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N. Engl. J. Med. 342, 921-929 (2000).
    • (2000) N. Engl. J. Med , vol.342 , pp. 921-929
    • Quinn, T.C.1
  • 8
    • 19144365910 scopus 로고    scopus 로고
    • Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group
    • Mascola, J. R. et al. Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group. J. Infect. Dis. 173, 340-348 (1996).
    • (1996) J. Infect. Dis , vol.173 , pp. 340-348
    • Mascola, J.R.1
  • 9
    • 0028917784 scopus 로고
    • Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120
    • Moore, J. P. et al. Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120. J. Virol. 69, 101-109 (1995).
    • (1995) J. Virol , vol.69 , pp. 101-109
    • Moore, J.P.1
  • 10
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn, N. M. et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J. Infect. Dis. 191, 654-665 (2005).
    • (2005) J. Infect. Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1
  • 11
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum, P. et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J. Infect. Dis. 194, 1661-1671 (2006).
    • (2006) J. Infect. Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1
  • 12
    • 43949099690 scopus 로고    scopus 로고
    • Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults
    • Priddy, F. H. et al. Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults. Clin. Infect. Dis. 46, 1769-1781 (2008).
    • (2008) Clin. Infect. Dis , vol.46 , pp. 1769-1781
    • Priddy, F.H.1
  • 13
    • 84945513769 scopus 로고    scopus 로고
    • Fauci, A. S. The release of new data from the HVTN 502 (STEP) HIV vaccine study. NIH News 〈http://www3.niaid.nih.gov/about/directors/news/ step_11707.htm〉 (2007). These data demonstrate that a homologous rAd5-Gag/Pol/Nef vaccine regimen did not protect against HIV-1 in humans and may have increased risk of HIV-1 acquisition in individuals with pre-existing Ad5-specific neutralizing antibodies.
    • Fauci, A. S. The release of new data from the HVTN 502 (STEP) HIV vaccine study. NIH News 〈http://www3.niaid.nih.gov/about/directors/news/ step_11707.htm〉 (2007). These data demonstrate that a homologous rAd5-Gag/Pol/Nef vaccine regimen did not protect against HIV-1 in humans and may have increased risk of HIV-1 acquisition in individuals with pre-existing Ad5-specific neutralizing antibodies.
  • 14
    • 0037189323 scopus 로고    scopus 로고
    • Diversity considerations in HIV-1 vaccine selection
    • Gaschen, B. et al. Diversity considerations in HIV-1 vaccine selection. Science 296, 2354-2360 (2002).
    • (2002) Science , vol.296 , pp. 2354-2360
    • Gaschen, B.1
  • 15
    • 0035377540 scopus 로고    scopus 로고
    • Immune control of HIV: The obstacles of HLA and viral diversity
    • Walker, B. D. & Korber, B. T. Immune control of HIV: the obstacles of HLA and viral diversity. Nature Immunol. 2, 473-475 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 473-475
    • Walker, B.D.1    Korber, B.T.2
  • 16
    • 38049094546 scopus 로고    scopus 로고
    • Antibody-based HIV-1 vaccines: Recent developments and future directions
    • Montefiori, D., Sattentau, Q., Flores, J., Esparza, J. & Mascola, J. Antibody-based HIV-1 vaccines: recent developments and future directions. PLoS Med. 4, e348 (2007).
    • (2007) PLoS Med , vol.4
    • Montefiori, D.1    Sattentau, Q.2    Flores, J.3    Esparza, J.4    Mascola, J.5
  • 17
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong, P. D. et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393, 648-659 (1998).
    • (1998) Nature , vol.393 , pp. 648-659
    • Kwong, P.D.1
  • 18
    • 0032543555 scopus 로고    scopus 로고
    • The antigenic structure of the HIV gp120 envelope glycoprotein
    • Wyatt, R. et al. The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393, 705-711 (1998).
    • (1998) Nature , vol.393 , pp. 705-711
    • Wyatt, R.1
  • 19
    • 13844302894 scopus 로고    scopus 로고
    • Structure of an unliganded simian immunodeficiency virus gp120 core
    • Chen, B. et al. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 433, 834-841 (2005).
    • (2005) Nature , vol.433 , pp. 834-841
    • Chen, B.1
  • 20
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei, X. et al. Antibody neutralization and escape by HIV-1. Nature 422, 307-312 (2003).
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1
  • 21
    • 0037389643 scopus 로고    scopus 로고
    • Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    • Richman, D. D., Wrin, T., Little, S. J. & Petropoulos, C. J. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc. Natl Acad. Sci. USA 100, 4144-4149 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4144-4149
    • Richman, D.D.1    Wrin, T.2    Little, S.J.3    Petropoulos, C.J.4
  • 22
    • 34948854718 scopus 로고    scopus 로고
    • Broad HIV-1 neutralization mediated by CD4-binding site antibodies
    • Li, Y. et al. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nature Med. 13, 1032-1034 (2007).
    • (2007) Nature Med , vol.13 , pp. 1032-1034
    • Li, Y.1
  • 23
    • 33847101745 scopus 로고    scopus 로고
    • Structural definition of a conserved neutralization epitope on HIV-1 gp120
    • Zhou, T. et al. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 445, 732-737 (2007).
    • (2007) Nature , vol.445 , pp. 732-737
    • Zhou, T.1
  • 24
    • 21344434534 scopus 로고    scopus 로고
    • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    • Haynes, B. F. et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 308, 1906-1908 (2005).
    • (2005) Science , vol.308 , pp. 1906-1908
    • Haynes, B.F.1
  • 25
    • 37849000389 scopus 로고    scopus 로고
    • HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
    • Sun, Z. Y. et al. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity 28, 52-63 (2008).
    • (2008) Immunity , vol.28 , pp. 52-63
    • Sun, Z.Y.1
  • 26
    • 41649090223 scopus 로고    scopus 로고
    • A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
    • Frey, G. et al. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc. Natl Acad. Sci. USA 105, 3739-3744 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 3739-3744
    • Frey, G.1
  • 27
    • 0033952103 scopus 로고    scopus 로고
    • Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    • Baba, T. W. et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nature Med. 6, 200-206 (2000).
    • (2000) Nature Med , vol.6 , pp. 200-206
    • Baba, T.W.1
  • 28
    • 0033951746 scopus 로고    scopus 로고
    • Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
    • Mascola, J. R. et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nature Med. 6, 207-210 (2000).
    • (2000) Nature Med , vol.6 , pp. 207-210
    • Mascola, J.R.1
  • 29
    • 0027979037 scopus 로고
    • + T cells with a predominant V beta usage during the primary immune response to HIV
    • + T cells with a predominant V beta usage during the primary immune response to HIV. Nature 370, 463-467 (1994).
    • (1994) Nature , vol.370 , pp. 463-467
    • Pantaleo, G.1
  • 30
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R. A. et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650-4655 (1994).
    • (1994) J. Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1
  • 31
    • 0028041344 scopus 로고
    • + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68, 6103-6110 (1994).
    • (1994) J. Virol , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.5
  • 32
    • 0030831656 scopus 로고    scopus 로고
    • Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection
    • Musey, L. et al. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N. Engl. J. Med. 337, 1267-1274 (1997).
    • (1997) N. Engl. J. Med , vol.337 , pp. 1267-1274
    • Musey, L.1
  • 33
    • 10644267588 scopus 로고    scopus 로고
    • Dominant influence of HLA-B in mediating the potential coevolution of HIV and HLA
    • Kiepiela, P. et al. Dominant influence of HLA-B in mediating the potential coevolution of HIV and HLA. Nature 432, 769-775 (2004).
    • (2004) Nature , vol.432 , pp. 769-775
    • Kiepiela, P.1
  • 34
    • 33846101731 scopus 로고    scopus 로고
    • + T-cell responses to different HIV proteins have discordant associations with viral load
    • + T-cell responses to different HIV proteins have discordant associations with viral load. Nature Med. 13, 46-53 (2007).
    • (2007) Nature Med , vol.13 , pp. 46-53
    • Kiepiela, P.1
  • 35
    • 0033524838 scopus 로고    scopus 로고
    • + lymphocytes
    • + lymphocytes. Science 283, 857-860 (1999).
    • (1999) Science , vol.283 , pp. 857-860
    • Schmitz, J.E.1
  • 36
    • 0033559648 scopus 로고    scopus 로고
    • + T cell depletion in simian immunodeficiency virus-infected macaques
    • + T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189, 991-998 (1999).
    • (1999) J. Exp. Med , vol.189 , pp. 991-998
    • Jin, X.1
  • 37
    • 0025827529 scopus 로고
    • Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
    • Phillips, R. E. et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354, 453-459 (1991).
    • (1991) Nature , vol.354 , pp. 453-459
    • Phillips, R.E.1
  • 38
    • 0034699512 scopus 로고    scopus 로고
    • Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
    • Allen, T. M. et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature 407, 386-390 (2000).
    • (2000) Nature , vol.407 , pp. 386-390
    • Allen, T.M.1
  • 39
    • 0037122796 scopus 로고    scopus 로고
    • Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    • Barouch, D. H. et al. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415, 335-339 (2002).
    • (2002) Nature , vol.415 , pp. 335-339
    • Barouch, D.H.1
  • 40
    • 33646686040 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Blood 107, 4781-4789 (2006).
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1
  • 41
    • 34250327922 scopus 로고    scopus 로고
    • + T cell responses
    • + T cell responses. J. Exp. Med. 204, 1405-1416 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1405-1416
    • Precopio, M.L.1
  • 42
    • 34250303350 scopus 로고    scopus 로고
    • Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
    • Darrah, P. A. et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nature Med. 13, 843-850 (2007).
    • (2007) Nature Med , vol.13 , pp. 843-850
    • Darrah, P.A.1
  • 43
    • 44949100369 scopus 로고    scopus 로고
    • Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
    • Watkins, D. I., Burton, D. R., Kallas, E. G., Moore, J. P. & Koff, W. C. Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nature Med. 14, 617-621 (2008).
    • (2008) Nature Med , vol.14 , pp. 617-621
    • Watkins, D.I.1    Burton, D.R.2    Kallas, E.G.3    Moore, J.P.4    Koff, W.C.5
  • 44
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: Implications for vaccine design
    • Seder, R. A., Darrah, P. A. & Roederer, M. T-cell quality in memory and protection: implications for vaccine design. Nature Rev. Immunol. 8, 247-258 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 45
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun, T. W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188 (1997).
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1
  • 46
    • 0032555117 scopus 로고    scopus 로고
    • + T cells during primary HIV-1 infection
    • + T cells during primary HIV-1 infection. Proc. Natl Acad. Sci. USA 95, 8869-8873 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 8869-8873
    • Chun, T.W.1
  • 47
    • 0037007670 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Nature 417, 95-98 (2002).
    • (2002) Nature , vol.417 , pp. 95-98
    • Douek, D.C.1
  • 48
    • 0032540418 scopus 로고    scopus 로고
    • + T cell depletion and viral replication in SIV infection
    • + T cell depletion and viral replication in SIV infection. Science 280, 427-431 (1998).
    • (1998) Science , vol.280 , pp. 427-431
    • Veazey, R.S.1
  • 49
    • 17844374605 scopus 로고    scopus 로고
    • + T cells in multiple tissues during acute SIV infection
    • + T cells in multiple tissues during acute SIV infection. Nature 434, 1093-1097 (2005).
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1
  • 50
    • 17844376742 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Nature 434, 1148-1152 (2005).
    • (2005) Nature , vol.434 , pp. 1148-1152
    • Li, Q.1
  • 51
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley, J. M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med. 12, 1365-1371 (2006).
    • (2006) Nature Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 52
    • 33745015013 scopus 로고    scopus 로고
    • Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge
    • Mattapallil, J. J. et al. Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge. J. Exp. Med. 203, 1533-1541 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1533-1541
    • Mattapallil, J.J.1
  • 53
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K. & Desrosiers, R. C. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941 (1992).
    • (1992) Science , vol.258 , pp. 1938-1941
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3    Sehgal, P.K.4    Desrosiers, R.C.5
  • 54
    • 0029951823 scopus 로고    scopus 로고
    • Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
    • Wyand, M. S., Manson, K. H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R. C. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70, 3724-3733 (1996).
    • (1996) J. Virol , vol.70 , pp. 3724-3733
    • Wyand, M.S.1    Manson, K.H.2    Garcia-Moll, M.3    Montefiori, D.4    Desrosiers, R.C.5
  • 55
    • 0033519616 scopus 로고    scopus 로고
    • Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort
    • Learmont, J. C. et al. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N. Engl. J. Med. 340, 1715-1722 (1999).
    • (1999) N. Engl. J. Med , vol.340 , pp. 1715-1722
    • Learmont, J.C.1
  • 56
    • 0028944667 scopus 로고
    • Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
    • Baba, T. W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1825 (1995).
    • (1995) Science , vol.267 , pp. 1820-1825
    • Baba, T.W.1
  • 57
    • 0032905068 scopus 로고    scopus 로고
    • Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
    • Baba, T. W. et al. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nature Med. 5, 194-203 (1999).
    • (1999) Nature Med , vol.5 , pp. 194-203
    • Baba, T.W.1
  • 58
    • 0024844908 scopus 로고
    • A formalin-inactivated whole SIV vaccine confers protection in macaques
    • Murphey-Corb, M. et al. A formalin-inactivated whole SIV vaccine confers protection in macaques. Science 246, 1293-1297 (1989).
    • (1989) Science , vol.246 , pp. 1293-1297
    • Murphey-Corb, M.1
  • 59
    • 27244443079 scopus 로고    scopus 로고
    • + T cell responses in nonhuman primates
    • + T cell responses in nonhuman primates. Proc. Natl Acad. Sci. USA 102, 15190-15194 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15190-15194
    • Wille-Reece, U.1
  • 60
    • 33646697743 scopus 로고    scopus 로고
    • Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    • Wille-Reece, U. et al. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J. Exp. Med. 203, 1249-1258 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1249-1258
    • Wille-Reece, U.1
  • 61
    • 0038664390 scopus 로고    scopus 로고
    • Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
    • Casimiro, D. R. et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J. Virol. 77, 6305-6313 (2003).
    • (2003) J. Virol , vol.77 , pp. 6305-6313
    • Casimiro, D.R.1
  • 62
    • 33845412550 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine
    • Graham, B. S. et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J. Infect. Dis. 194, 1650-1660 (2006).
    • (2006) J. Infect. Dis , vol.194 , pp. 1650-1660
    • Graham, B.S.1
  • 63
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch, D. H. et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486-492 (2000).
    • (2000) Science , vol.290 , pp. 486-492
    • Barouch, D.H.1
  • 64
    • 34249689699 scopus 로고    scopus 로고
    • Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques
    • Chong, S. Y. et al. Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine 25, 4967-4982 (2007).
    • (2007) Vaccine , vol.25 , pp. 4967-4982
    • Chong, S.Y.1
  • 65
    • 34248382494 scopus 로고    scopus 로고
    • Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
    • Luckay, A. et al. Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J. Virol. 81, 5257-5269 (2007).
    • (2007) J. Virol , vol.81 , pp. 5257-5269
    • Luckay, A.1
  • 66
    • 43949114521 scopus 로고    scopus 로고
    • Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
    • Liu, J., Kjeken, R., Mathiesen, I. & Barouch, D. H. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J. Virol. 82, 5643-5649 (2008).
    • (2008) J. Virol , vol.82 , pp. 5643-5649
    • Liu, J.1    Kjeken, R.2    Mathiesen, I.3    Barouch, D.H.4
  • 67
    • 0037122719 scopus 로고    scopus 로고
    • Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    • Shiver, J. W. et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415, 331-335 (2002).
    • (2002) Nature , vol.415 , pp. 331-335
    • Shiver, J.W.1
  • 68
    • 33845439080 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector
    • Catanzaro, A. T. et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J. Infect. Dis. 194, 1638-1649 (2006).
    • (2006) J. Infect. Dis , vol.194 , pp. 1638-1649
    • Catanzaro, A.T.1
  • 69
    • 0035815437 scopus 로고    scopus 로고
    • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    • Amara, R. R. et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292, 69-74 (2001).
    • (2001) Science , vol.292 , pp. 69-74
    • Amara, R.R.1
  • 70
    • 38749132973 scopus 로고    scopus 로고
    • An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
    • Harari, A. et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J. Exp. Med. 205, 63-77 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 63-77
    • Harari, A.1
  • 71
    • 1542299092 scopus 로고    scopus 로고
    • Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors
    • Shiver, J. W. & Emini, E. A. Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors. Annu. Rev. Med. 55, 355-372 (2004).
    • (2004) Annu. Rev. Med , vol.55 , pp. 355-372
    • Shiver, J.W.1    Emini, E.A.2
  • 72
    • 29244455769 scopus 로고    scopus 로고
    • MAC239 challenges in rhesus monkeys.
    • MAC239 challenges in rhesus monkeys.
  • 73
    • 0037321597 scopus 로고    scopus 로고
    • Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication
    • Mothe, B. R. et al. Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication. J. Virol. 77, 2736-2740 (2003).
    • (2003) J. Virol , vol.77 , pp. 2736-2740
    • Mothe, B.R.1
  • 74
    • 0036133208 scopus 로고    scopus 로고
    • ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency
    • Pal, R. et al. ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency. J. Virol. 76, 292-302 (2002).
    • (2002) J. Virol , vol.76 , pp. 292-302
    • Pal, R.1
  • 75
    • 0036882075 scopus 로고    scopus 로고
    • Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection
    • Zhang, Z. Q. et al. Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection. J. Virol. 76, 12845-12854 (2002).
    • (2002) J. Virol , vol.76 , pp. 12845-12854
    • Zhang, Z.Q.1
  • 76
    • 33744902339 scopus 로고    scopus 로고
    • Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
    • Wilson, N. A. et al. Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J. Virol. 80, 5875-5885 (2006).
    • (2006) J. Virol , vol.80 , pp. 5875-5885
    • Wilson, N.A.1
  • 77
    • 33744990609 scopus 로고    scopus 로고
    • + central memory T cells and survival in vaccinated SIV-challenged monkeys
    • + central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 312, 1530-1533 (2006).
    • (2006) Science , vol.312 , pp. 1530-1533
    • Letvin, N.L.1
  • 78
    • 0037771077 scopus 로고    scopus 로고
    • Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: Efficient human cell infection and bypass of preexisting adenovirus immunity
    • Vogels, R. et al. Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity. J. Virol. 77, 8263-8271 (2003).
    • (2003) J. Virol , vol.77 , pp. 8263-8271
    • Vogels, R.1
  • 79
    • 34247585475 scopus 로고    scopus 로고
    • Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D
    • Abbink, P. et al. Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D. J. Virol. 81, 4654-4663 (2007).
    • (2007) J. Virol , vol.81 , pp. 4654-4663
    • Abbink, P.1
  • 80
    • 34247623684 scopus 로고    scopus 로고
    • Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa
    • Thorner, A. R. et al. Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa. J. Clin. Microbiol. 44, 3781-3783 (2006).
    • (2006) J. Clin. Microbiol , vol.44 , pp. 3781-3783
    • Thorner, A.R.1
  • 81
    • 2942562284 scopus 로고    scopus 로고
    • Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vector
    • Kostense, S. et al. Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vector. AIDS 18, 1213-1216 (2004).
    • (2004) AIDS , vol.18 , pp. 1213-1216
    • Kostense, S.1
  • 82
    • 48249134364 scopus 로고    scopus 로고
    • Fauci, A. S. et al. HIV vaccine research: the way forward. Science 321, 530-532 (2008). This perspective describes revised NIH research priorities for HIV-1 vaccine research.
    • Fauci, A. S. et al. HIV vaccine research: the way forward. Science 321, 530-532 (2008). This perspective describes revised NIH research priorities for HIV-1 vaccine research.
  • 83
    • 34247201441 scopus 로고    scopus 로고
    • Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
    • Catanzaro, A. T. et al. Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25, 4085-4092 (2007).
    • (2007) Vaccine , vol.25 , pp. 4085-4092
    • Catanzaro, A.T.1
  • 84
    • 84945503484 scopus 로고    scopus 로고
    • NIAID will not move forward with the PAVE 100 HIV vaccine trial
    • Fauci, A. S. NIAID will not move forward with the PAVE 100 HIV vaccine trial. NIH News 〈http://www3.niaid.nih.gov/news/newsreleases/2008/ pave100.htm〉 (2008).
    • (2008) NIH News
    • Fauci, A.S.1
  • 85
    • 2442611810 scopus 로고    scopus 로고
    • Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity
    • Barouch, D. H. et al. Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity. J. Immunol. 172, 6290-6297 (2004).
    • (2004) J. Immunol , vol.172 , pp. 6290-6297
    • Barouch, D.H.1
  • 86
    • 33646586362 scopus 로고    scopus 로고
    • Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity
    • Roberts, D. M. et al. Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity. Nature 441, 239-243 (2006).
    • (2006) Nature , vol.441 , pp. 239-243
    • Roberts, D.M.1
  • 87
    • 0035164962 scopus 로고    scopus 로고
    • Replication-defective vector based on a chimpanzee adenovirus
    • Farina, S. F. et al. Replication-defective vector based on a chimpanzee adenovirus. J. Virol. 75, 11603-11613 (2001).
    • (2001) J. Virol , vol.75 , pp. 11603-11613
    • Farina, S.F.1
  • 88
    • 0037310512 scopus 로고    scopus 로고
    • A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag
    • Fitzgerald, J. C. et al. A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag. J. Immunol. 170, 1416-1422 (2003).
    • (2003) J. Immunol , vol.170 , pp. 1416-1422
    • Fitzgerald, J.C.1
  • 89
    • 43249127622 scopus 로고    scopus 로고
    • Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys
    • Liu, J. et al. Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys. J. Virol. 82, 4844-4852 (2008).
    • (2008) J. Virol , vol.82 , pp. 4844-4852
    • Liu, J.1
  • 90
    • 84945514478 scopus 로고    scopus 로고
    • Barouch, D. H. Novel adenovirus vector-based vaccines for HIV-1. Keystone Symposia on HIV Vaccines, Banff, Canada. Abstract X7 009, page 60 (Keystone Symposia, 27 March-1 April 2008).
    • Barouch, D. H. Novel adenovirus vector-based vaccines for HIV-1. Keystone Symposia on HIV Vaccines, Banff, Canada. Abstract X7 009, page 60 (Keystone Symposia, 27 March-1 April 2008).
  • 91
    • 33746689169 scopus 로고    scopus 로고
    • A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
    • Liao, H. X. et al. A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology 353, 268-282 (2006).
    • (2006) Virology , vol.353 , pp. 268-282
    • Liao, H.X.1
  • 92
    • 33745771090 scopus 로고    scopus 로고
    • Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen
    • Weaver, E. A. et al. Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen. J. Virol. 80, 6745-6756 (2006).
    • (2006) J. Virol , vol.80 , pp. 6745-6756
    • Weaver, E.A.1
  • 93
    • 33846111016 scopus 로고    scopus 로고
    • Fischer, W. et al. Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature Med. 13, 100-106 (2007). This manuscript proposes the use of polyvalent 'mosaic' antigens to improve immunologic coverage of global HIV-1 diversity.
    • Fischer, W. et al. Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature Med. 13, 100-106 (2007). This manuscript proposes the use of polyvalent 'mosaic' antigens to improve immunologic coverage of global HIV-1 diversity.


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