The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 8, 2008, Pages 3011-3016

  Lin, David Yin Wei ^a,d   Tanaka, Yoshimasa ^b,c   Iwasaki, Masashi ^b   Gittis, Apostolos G ^a   Su, Hua Poo ^a,e   Mikami, Bunzo ^b   Okazaki, Taku ^b   Honjo, Tasuku ^b   Minato, Nagahiro ^b   Garboczi, David N ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d PURDUE UNIVERSITY   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Coreceptor; Costimulation; Inhibitory receptor

Indexed keywords

PROGRAMMED DEATH 1; PROTEIN; T LYMPHOCYTE RECEPTOR; ANTIBODY; CD274 PROTEIN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PD 1 ANTIGEN, MOUSE; PD-1 ANTIGEN, MOUSE;

ANTIGEN BINDING; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; GENE MUTATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RESIDUE ANALYSIS; ANIMAL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; COMPUTATIONAL BIOLOGY; CRYSTALLIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, MOLECULAR; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 42949160646     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712278105     Document Type: Article

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