CTLA-4 and Tolerance: The Biochemical Point of View

Immunologic Research

Volumn 28, Issue 3, 2003, Pages 241-253

  Chikuma, Shunsuke ^a   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Costimulation; CTLA 4; Lipid rafts; Tolerance

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CHOLESTEROL; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOSPHINGOLIPID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN STRUCTURE; CALCIUM TRANSPORT; CATALYSIS; CELL ACTIVATION; CELL INTERACTION; CELL MEMBRANE; CELL MIGRATION; CELL POLARITY; CELL SURFACE; CHEMOTAXIS; COATED PIT; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; GENE EXPRESSION; GOLGI COMPLEX; HUMAN; IMMUNITY; IMMUNOLOGICAL TOLERANCE; INTERNALIZATION; LIGAND BINDING; LIPID BILAYER; LIPOGENESIS; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SYNAPTIC MEMBRANE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AUTOIMMUNITY; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0346496097     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:28:3:241     Document Type: Review

References (67)

1. Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP: CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992;356:607-609.
2. Noel PJ, Boise LH, Green JM, Thompson CB: CD28 costimulation prevents cell death during primary T cell activation. J Immunol 1996;157:636-642.
3. Ding L, Shevach EM: Activation of CD4+ T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation) . Eur J Immunol 1994;24:859-866.
4. Sytwu HK, Liblau RS, McDevitt HO: The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 1996;5:17-30.
5. Nishimura H, Honjo T: PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol 2001;22:265-268.
6. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, et al.: CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994:1:405-413.
7. Waterhouse P, Penninger JM, Timms E, et al.: Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985-988.
8. Tivol EA, Borriello F, Schweitzer An, et al.: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-547.
9. Karandikar NJ, Vanderlugt CL, Walunas TL, et al.: CTLA-4: a negative regulator of autoimmune disease. J Exp Med 1996;184:783-788.
10. Eagar TN, Karandikar NJ, Bluestone JA, Miller SD: The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur J Immunol 2002;32:972-981.
11. Leach DR, Krummel MF, Allison JP: Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-1736.
12. Bachmann MF, Waterhouse P, Speiser DE, McKall-Faienza K, Mak TW, Ohashi PS: Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J Immunol 1998;160:95-100.
13. Olsson C, Riesbeck K, Dohlsten M, et al.: CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts. J Biol Chem 1999;274:14400-14405
14. Fraser JH, Rincon M, McCoy KD, et al.: CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells. Eur J Immunol 1999;29:838-844.
15. Brunner MC, Chambers CA, Chan FK, Hanke J, Winoto A, Allison JP: CTLA-4-Mediated inhibition of early events of T cell proliferation. J Immunol 1999;162:5813-5820.
16. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA: CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol 2003;4:182-188.
17. Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994;1:793-801.
18. Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, et al.: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 2001;410:608-611.
19. Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature 2001;410:604-608.
20. Masteller EL, Chuang E, Mullen AC, Reiner SL, Thompson CB: Structural analysis of CTLA-4 function in vivo. J Immunol 2000;164:5319-5327.
21. Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, et al.: Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol 2001;167:5565-5573.
22. Alegre ML, Frauwirth KA, Thompson CB: T-cell regulation by CD28 and CTLA-4. Nature Rev Immunol 2001;1:220-228.
23. Calvo CR, Amsen D, Kruisbeek AM: Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J Exp Med 1997;186:1645-1653.
24. Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, et al.: Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152). J Immunol 2000;164:4433-4442.
25. Tacke M, Clark GJ, Dallman MJ, Hunig T: Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. J Immunol 1995;154:5121-5127.
26. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, et al.: Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol 1999:162:1270-1277.
27. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, et al.: Molecular basis of T cell inactivation by CTLA-4. Science 1998;282:2263-2266.
28. Egen JG, Allison JP: Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002;16:23-35.
29. Krummel MF, Davis MM: Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol 2002;14:66-74.
30. Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS: Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996;4:535-543.
31. Zhang Y, Allison JP: Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA 1997;94:9273-9278.
32. Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB: Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol 1997;159:144-151.
33. Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, et al.: Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol 1999;163:1868-1879.
34. Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T: Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152). Biochem Biophys Res Commun 1998;249:444-448.
35. Wang XB, Zheng CY, Giscombe R, Lefvert AK: Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells. Scand J Immunol 2001;54:453-458.
36. Chikuma S, Murakami M, Tanaka K, Uede T: Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule4. J Cell Biochem 2000;78:241-250.
37. Rigamonti L, Ariotti S, Losana G, Gradini R, Russo MA, Jouanguy E, et al.: Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes. J Immunol 2000;164:201-207.
38. Van Laethem F, Leo O: Membrane lipid rafts: new targets for immunoregulation. Curr Mol Med 2002;2:557-570.
39. Bi K, Tanaka Y, Coudronniere N, Sugie K, Hong S, van Stipdonk MJ, et al.: Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol 2001;2:556-563.
40. Viola A: The amplification of TCR signaling by dynamic membrane microdomains. Trends Immunol 2001;22:322-327.
41. Tuosto L, Parolini I, Schroder S, Sargiacomo M, Lanzavecchia A, Viola A: Organization of plasma membrane functional rafts upon T cell activation. Eur J Immunol 2001;31:345-349.
42. Gomez-Mouton C, Abad JL, Mira E, Lacalle RA, Gallardo E, Jimenez-Baranda S, et al.: Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc Natl Acad Sci USA 2001;98:9642-9647.
43. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A: T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999;283:680-682.
44. Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, et al.: Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J Exp Med 2002; 195:1337-1347.
45. Chikuma S, Imboden JB, Bluestone JA: Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2003;197:129-135.
46. Drake DR, 3rd, Braciale TJ: Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CDS+ T cells. J Immunol 2001;166:7009-7013.
47. Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS: T cell receptor signaling precedes immunological synapse formation. Science 2002;295:1539-1542.
48. Marengere LE, Waterhouse P, Duncan GS, Mittrucker HW, Feng GS, Mak TW: Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996;272:1170-1173.
49. Guntermann C, Alexander DR: CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J Immunol 2002;168:4420-4429.
50. Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, et al.: Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol 2002;168:5070-5078.
51. Chuang E, Fisher TS, Morgan RW, Robbins MD, Duerr JM, Vander Heiden MG, et al.: The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 2000;13:313-322.
52. Ugi S, Imamura T, Ricketts W, Olefsky JM: Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol 2002;22:2375-2387.
53. Shultz LD: Pleiotropic effects of deleterious alleles at the "motheaten" locus. Curr Top Microbiol Immunol 1988;137:216-222.
54. Kosugi A, Sakakura J, Yasuda K, Ogata M, Hamaoka T: Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 2001;14:669-680.
55. Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN: TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 2003;4:248-254.
56. Chambers CA, Allison JP: The role of tyrosine phosphorylation and PTP-IC in CTLA-4 signal transduction. Eur J Immunol 1996;26:3224-3229.
57. Frearson JA, Alexander DR: The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med 1998;187:1417-1426.
58. Lacalle RA, Mira E, Gomez-Mouton C, Jimenez-Baranda S, Martinez AC, Manes S: Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. J Cell Biol 2002;157:277-289.
59. Sharpe AH: Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice. Curr Opin Immunol 1995;7:389-395.
60. Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA: Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol 1999;162:5784-5791.
61. Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, et al.: CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol 1997;158:5091-5094.
62. Mandelbrot DA, McAdam AJ, Sharpe AH: B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med 1999;189:435-440.
63. Murakami M, Takahashi Y, Isashi Y, Kon S, Jia WY, Inobe M, et al.: Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells. Proc Natl Acad Sci USA 1996;93:7838-7842.
64. Aoki Y, Isselbacher KJ, Cherayil BJ, Pillai S: Tyrosine phosphory lation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. Proc Natl Acad Sci U S A 1994;91:4204-4208.
65. Irving BA, Alt FW, Killeen N: Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 1998;280:905-908.
66. Saint-Ruf C, Panigada M, Azogui O, Debey P, von Boehmer H, Grassi F: Different initiation of pre-TCR and gammadelta TCR signalling. Nature 2000;406:524-527.
67. Ueda H, Howson JM, Esposito L, et al.: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423:506-511.