TRPV1 signaling: Mechanistic understanding and therapeutic potential

Current Topics in Medicinal Chemistry

Volumn 11, Issue 17, 2011, Pages 2180-2191

  Xia, Rong ^a   Samad, Tarek A ^b   Btesh, Joan ^c   Jiang, Lin Hua ^d   Kays, Ibrahim ^e   Stjernborg, Louise ^a   Dekker, Niek ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b PFIZER INC   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Agonist; Antagonist; Hyperthemia; Ion channel; Therapy; Thermoregulation; TRP

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; 1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; 1 (5 ISOQUINOLINYL) 3 [4 (TRIFLUOROMETHYL)BENZYL]UREA; 4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; ABT 116; AZD 1386; BENZAMIDE DERIVATIVE; CALCINEURIN; CALCIUM ION; CALMODULIN; CAPSAICIN; CAPSAZEPINE; CIS CAPSAICIN; CIVAMIDE NASAL SOLUTION; GRC 6211; JNJ 39439335; JTS 653; LASSBIO 881; LEUKOTRIENE B4; M 68008; MK 2295; N (1,4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL)ACRYLAMIDE; N (4 TERT BUTYLPHENYL) 4 (3 CHLORO 2 PYRIDINYL) 1 PIPERAZINECARBOXAMIDE; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; N OLEOYLETHANOLAMINE; NGD 8243; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PIPERINE; QUINAZOLINE DERIVATIVE; RESINIFERATOXIN; RUTHENIUM RED; SAR 115740; SB 782443; SPERMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ARTICLE; CLINICAL TRIAL (TOPIC); CLUSTER HEADACHE; COUGHING; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; HUMAN; HYPERTHERMIA; NEUROPATHIC PAIN; NONHUMAN; OSTEOARTHRITIS; OVERACTIVE BLADDER; PAIN; POSTHERPETIC NEURALGIA; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; RHINITIS; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; THERMOREGULATION; TOOTH PAIN;

ANALGESICS; ANIMALS; HUMANS; PAIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 80052221211     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802611796904843     Document Type: Article

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