LASSBio-881: An N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation

British Journal of Pharmacology

Volumn 159, Issue 8, 2010, Pages 1716-1723

  Tributino, Jlm ^a,b   Santos, Mlh ^a   Mesquita, Cm ^a   Lima, Ckf ^a   Silva, Ll ^a   Maia, Rc ^a   Duarte, Cd ^a   Barreiro, Ej ^a   Fraga, Cam ^a   Castro, Ng ^a   Miranda, Alp ^a   Guimaraes, Mzp ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Capsaicin; Electrophysiology; N acylhydrazone; Neuropathic pain; Oocytes; TRPV1 antagonist

Indexed keywords

ANTINOCICEPTIVE AGENT; CAPSAICIN; CARRAGEENAN; LASSBIO 881; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; EVOKED RESPONSE; FEMALE; HYPERNOCICEPTION; HYPERSENSITIVITY; HYPERTHERMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NEUROPATHY; NOCICEPTION; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMAL STIMULATION; XENOPUS;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CAPSAICIN; FEMALE; HYDRAZINES; MICE; PAIN; RATS; RATS, WISTAR; SCIATIC NERVE; TRPV CATION CHANNELS; XENOPUS LAEVIS;

EID: 77950278560     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00672.x     Document Type: Article

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