The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects

Biomaterials

Volumn 30, Issue 12, 2009, Pages 2385-2392

  Vogt, Stephan ^a   Wexel, Gabriele ^a   Tischer, Thomas ^a   Schillinger, Ulrike ^a   Ueblacker, Peter ^a,b   Wagner, Bettina ^a   Hensler, Daniel ^a   Wilisch, Jonas ^a   Geis, Christopher ^a   Wübbenhorst, Daniela ^a   Aigner, Joachim ^a   Gerg, Michael ^a   Krüger, Achim ^a   Salzmann, Gian M ^a   Martinek, Vladimir ^a   Anton, Martina ^a   Plank, Christian ^a   Imhoff, Andreas B ^a   Gansbacher, Bernd ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

BMP2; Cartilage; Fibrin clot; Hyaline; Osteochondral defect; Retroviral vector

Indexed keywords

BMP2; FIBRIN CLOT; HYALINE; OSTEOCHONDRAL DEFECT; RETROVIRAL VECTOR;

BACTERIOPHAGES; BIOACTIVITY; BIOLOGICAL RADIATION EFFECTS; CARTILAGE; COSMIC RAYS; GENE EXPRESSION; HISTOLOGY; LIGAMENTS; PROJECTILES; REPAIR;

DEFECTS;

AGGRECAN; AGGRECAN LINK PROTEIN; ALCIAN BLUE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; PROTEIN; PROTEOGLYCAN; RETROVIRUS VECTOR; TOLONIUM CHLORIDE; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE REGENERATION; BONE REMODELING; CARTILAGE CELL; CELL REGENERATION; CELL SIZE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRIN CLOT; GENE EXPRESSION; GENETIC TRANSDUCTION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMPLANTATION; IN VITRO STUDY; NONHUMAN; OSTEOCHONDRAL DEFECT; PRIORITY JOURNAL; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REPAIR;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CHONDROCYTES; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN; GENE EXPRESSION; GENE EXPRESSION REGULATION; PROSTHESES AND IMPLANTS; RABBITS; REGENERATION;

ORYCTOLAGUS CUNICULUS;

EID: 60549104556     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.01.016     Document Type: Article

References (31)

1. Hunziker E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10 (2002) 432-463
2. Bartlett W., Gooding C.R., Carrington R.W., Skinner J.A., Briggs T.W., and Bentley G. Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft: a preliminary report. J Bone Joint Surg Br 87 (2005) 330-332
3. Huard J., Li Y., Peng H., and Fu F.H. Gene therapy and tissue engineering for sports medicine. J Gene Med 5 (2003) 93-108
4. Ueblacker P., Wagner B., Vogt S., Salzmann G., Wexel G., Kruger A., et al. In vivo analysis of retroviral gene transfer to chondrocytes within collagen scaffolds for the treatment of osteochondral defects. Biomaterials 28 (2007) 4480-4487
5. Solchaga L.A., Temenoff J.S., Gao J., Mikos A.G., Caplan A.I., and Goldberg V.M. Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds. Osteoarthr Cartil 13 (2005) 297-309
6. Filova E., Jelinek F., Handl M., Lytvynets A., Rampichova M., Varga F., et al. Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee. J Biomed Mater Res B Appl Biomater 87 (2008) 415-424
7. Schillinger U., Wexel G., Hacker C., Kullmer M., Koch C., Gerg M., et al. A fibrin glue composition as carrier for nucleic acid vectors. Pharm Res 25 (2008) 2946-2962
8. Vogt S., Ueblacker P., Geis C., Wagner B., Wexel G., Tischer T., et al. Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector. Biomaterials 29 (2008) 1242-1249
9. Cucchiarini M., Madry H., Ma C., Thurn T., Zurakowski D., Menger M.D., et al. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12 (2005) 229-238
10. Goodrich L.R., Hidaka C., Robbins P.D., Evans C.H., and Nixon A.J. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 89 (2007) 672-685
11. Pagnotto M.R., Wang Z., Karpie J.C., Ferretti M., Xiao X., and Chu C.R. Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair. Gene Ther 14 (2007) 804-813
12. Baragi V.M., Renkiewicz R.R., Qiu L., Brammer D., Riley J.M., Sigler R.E., et al. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthr Cartil 5 (1997) 275-282
13. Ikeda T., Kubo T., Nakanishi T., Arai Y., Kobayashi K., Mazda O., et al. Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects. J Rheumatol 27 (2000) 990-996
14. Gouze E., Pawliuk R., Pilapil C., Gouze J.N., Fleet C., Palmer G.D., et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 5 (2002) 397-404
15. Majumdar M.K., Chockalingam P.S., Bhat R.A., Sheldon R., Keohan C., Blanchet T., et al. Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1. J Cell Physiol 215 (2008) 68-76
16. Carlberg A.L., Pucci B., Rallapalli R., Tuan R.S., and Hall D.J. Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2. Differentiation 67 (2001) 128-138
17. Musgrave D.S., Bosch P., Lee J.Y., Pelinkovic D., Ghivizzani S.C., Whalen J., et al. Ex vivo gene therapy to produce bone using different cell types. Clin Orthop Relat Res 378 (2000) 290-305
18. Sellers R.S., Zhang R., Glasson S.S., Kim H.D., Peluso D., D'Augusta D.A., et al. Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am 82 (2000) 151-160
19. Gelse K., von der Mark K., Aigner T., Park J., and Schneider H. Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 48 (2003) 430-441
20. Anton M., Wagner B., Haubner R., Bodenstein C., Essien B.E., Bonisch H., et al. Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells. J Gene Med 6 (2004) 119-126
21. Arlt M., Kopitz C., Pennington C., Watson K.L., Krell H.W., Bode W., et al. Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model. Cancer Res 62 (2002) 5543-5550
22. Mainil-Varlet P., Aigner T., Brittberg M., Bullough P., Hollander A., Hunziker E., et al. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 85 (2003) 45-57
23. Tischer T., Milz S., Maier M., Schieker M., and Benjamin M. An immunohistochemical study of the rabbit suprapatella, a sesamoid fibrocartilage in the quadriceps tendon containing aggrecan. J Histochem Cytochem 50 (2002) 955-960
24. De Luca F., Barnes K.M., Uyeda J.A., De-Levi S., Abad V., Palese T., et al. Regulation of growth plate chondrogenesis by bone morphogenetic protein-2. Endocrinology 142 (2001) 430-436
25. Wong G.A., Tang V., El-Sabeawy F., and Weiss R.H. BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Am J Physiol Endocrinol Metab 284 (2003) E972-E979
26. Tsuji K., Bandyopadhyay A., Harfe B.D., Cox K., Kakar S., Gerstenfeld L., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 38 (2006) 1424-1429
27. Fahlgren A., Chubinskaya S., Messner K., and Aspenberg P. A capsular incision leads to a fast osteoarthritic response, but also elevated levels of activated osteogenic protein-1 in rabbit knee joint cartilage. Scand J Med Sci Sports 16 (2006) 456-462
28. Hacein-Bey-Abina S., Von Kalle C., Schmidt M., McCormack M.P., Wulffraat N., Leboulch P., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302 (2003) 415-419
29. Logan A.C., Haas D.L., Kafri T., and Kohn D.B. Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration. J Virol 78 (2004) 8421-8436
30. Pluta K., Luce M.J., Bao L., Agha-Mohammadi S., and Reiser J. Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters. J Gene Med 7 (2005) 803-817
31. Ueblacker P., Wagner B., Kruger A., Vogt S., DeSantis G., Kennerknecht E., et al. Inducible nonviral gene expression in the treatment of osteochondral defects. Osteoarthr Cartil 12 (2004) 711-719