Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects

Journal of Rheumatology

Volumn 29, Issue 9, 2002, Pages 1920-1930

  Adachi, Nobuo ^a   Sato, Kenji ^a   Usas, Arvydas ^a   Fu, Freddie H ^a   Ochi, Mitsuo ^a   Han, Chang Whan ^a   Niyibizi, Christopher ^a   Huard, Johnny ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cartilage; Gene therapy; Muscle derived cells; Retroviral vector; Tissue engineering

Indexed keywords

BETA GALACTOSIDASE; COLLAGEN TYPE 1; COLLAGEN TYPE 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL COUNT; CELL PROLIFERATION; CELL TRANSPLANTATION; CHONDROPATHY; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETROVIRUS; TISSUE REPAIR; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; CARTILAGE DISEASES; CARTILAGE, ARTICULAR; CELL TRANSPLANTATION; CHONDROCYTES; CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FEMALE; GELS; GENE THERAPY; GENE TRANSFER TECHNIQUES; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SKELETAL; PROBABILITY; RABBITS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 0036731957     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Chondrocyte transplantation
2. Articular cartilage repair
3. Role of abrasion arthroplasty and debridement in the management of arthritis of the knee
4. Arthroscopic abrasion arthroplasty historical and pathological perspective: Present status
5. Current concepts in the treatment of articular cartilage defects
6. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
7. Repair of articular cartilage defects with cultured chondrocytes in atelocollagen gel. Comparison with cultured chondrocytes in suspension
8. Rib perichondral grafts for the repair of full-thickness articular-cartilage defects
9. Reconstruction of the patellar articulation with periosteal grafts
10. Arthroscopic multiple osteochondral transplantation to the chondral defects in the knee associated with anterior cruciate ligament disruption
11. Chondrocytes embedded in collagen gels maintain cartilage phenotype during long term cultures
12. Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel
13. Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits
14. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
15. Transforming growth factor-β regulates the metabolism of proteoglycans in bovine cartilage organ cultures
16. Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes
17. Insulin-like growth factors I and II
18. Insulin-like growth factor-1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines
19. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage
20. Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1α effects on proteoglycan synthesis and content
21. Multilineage potential of adult human mesenchymal stem cells
22. Mesenchymal stem cells
23. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing
24. Dystrophin expression in the mdx mouse restored by stem cell transplantation
25. Muscle derived stem cells: Characterization and potential for cell-mediated therapy
26. Primary mouse myoblast purification, characterization, and transplantation for cell mediated gene therapy
27. Development of approaches to improve cell survival in myoblast transfer therapy
28. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year
29. Effects of basic fibroblast growth factor on proliferation and phenotype expression of chondrocytes embedded in collagen gel
30. Hyaluronic acid enhances proliferation and chondroitin sulfate synthesis in cultured chondrocytes embedded in collagen gels
31. The satellite cell and muscle regeneration
32. Human myoblast transplantation: Preliminary results of 4 cases
33. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study
34. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
35. Human chondrocyte proliferation and matrix synthesis cultured in Atelocollagen® gel
36. The fate of individual myoblasts after transplantation into muscles of DMD patients
37. Isolation of human myoblasts with the fluorescence-activated cell sorter