A localizable, biological-based system for the delivery of bioactive IGF-1 utilizing microencapsulated genetically modified human fibroblasts

ASAIO Journal

Volumn 55, Issue 3, 2009, Pages 259-265

  Patel, Roshni S ^a   Temu, Tecla M ^b   Jeanbart, Laura ^c   Morgan, Jeffrey R ^a   Lysaght, Michael J ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c Yale University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CA-ALGINATE; FIRST ORDER KINETICS; GENETICALLY MODIFIED; GROWTH FACTOR; GROWTH FACTOR DELIVERY; HUMAN FIBROBLAST; INSULIN-LIKE GROWTH FACTOR; LOCALIZED SYNTHESIS AND DELIVERY; MICROCAPSULE; MITOGEN; NORMAL HUMAN FIBROBLAST; ORTHOPEDIC TISSUE ENGINEERING; PROLIFERATIVE EFFECTS; TISSUE GENERATION;

BIOACTIVITY; CALCIUM; CELL CULTURE; ENCAPSULATION; FIBROBLASTS; HYDROGELS; PEPTIDES;

TISSUE ENGINEERING;

CALCIUM ALGINATE; SOMATOMEDIN C; ALGINIC ACID; BIOMATERIAL; GLUCURONIC ACID; HEXURONIC ACID;

ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA MODIFICATION; DRUG ACTIVITY; GENE DELIVERY SYSTEM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; MICROCAPSULE; MICROENCAPSULATION; SKIN FIBROBLAST; CELL SURVIVAL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; SECRETION;

ALGINATES; BIOCOMPATIBLE MATERIALS; CELL PROLIFERATION; CELL SURVIVAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FIBROBLASTS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; TRANSFECTION;

EID: 67650458473     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e31819b0365     Document Type: Article

References (40)

1. Chen RR, Mooney DJ: Polymeric growth factor delivery strategies for tissue engineering. Pharm Res 20: 1103-1112, 2003.
2. Tessmar JK, Gopferich AM: Matrices and scaffolds for protein delivery in tissue engineering. Adv Drug Deliv Rev 59: 274-291, 2007.
3. Nerem RM: Cell-based therapies: From basic biology to replacement, repair, and regeneration. Biomaterials 28: 5074-5077, 2007.
4. Lanza RP, Hayes JL, Chick WL: Encapsulated cell technology. Nat Biotechnol 14: 1107-1111, 1996.
5. Whittemore AD, Chick WL, Galletti PM, et al: Effects of the hybrid artificial pancreas in diabetic rats. ASAIO Trans 23: 336-341, 1977.
6. Aebischer P, Ip TK, Miracoli L, Galletti PM: Renal epithelial cells grown on semipermeable hollow fibers as a potential ultrafiltrate processor. ASAIO Trans 33: 96-102, 1987.
7. Granicka LH, Kawiak JW, Glowacka E, Werynski A: Encapsulation of okt3 cells in hollow fibers. ASAIO J 42: M863-M866, 1996.
8. Buchser E, Goddard M, Heyd B, et al: Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience. Anesthesiology 85: 1005-1012, 1996; discussion 1029A-1030A.
9. Bloch J, Bachoud-Levi AC, Deglon N, et al: Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: Results of a phase I study. Hum Gene Ther 15: 968-975, 2004.
10. Sieving PA, Caruso RC, Tao W, et al: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A 103: 3896-3901, 2006.
11. Lim F, Sun AM: Microencapsulated islets as bioartificial endocrine pancreas. Science 210: 908-910, 1980.
12. Soon-Shiong P, Heintz R, Yao Z, et al: Glucose-insulin kinetics of the extravascular bioartificial pancreas. A study using microencapsulated rat islets. ASAIO J 38: 851-854, 1992.
13. Wikstrom J, Elomaa M, Syvajarvi H, et al: Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy. 29: 869-876, 2008.
14. Blandino A, Macias M, Cantero D: Formation of calcium alginate gel capsules: Influence of sodium alginate and cacl2 concentration on gelation kinetics. J Biosci Bioeng 88: 686-689, 1999.
15. Drury JL, Dennis RG, Mooney DJ: The tensile properties of alginate hydrogels. Biomaterials 25: 3187-3199, 2004.
16. Tanaka H, Matsumura M, Veliky IA: Diffusion characteristics of substrates in ca-alginate gel beads. Biotechnol Bioeng 26: 53-58, 1984.
17. Oosman SN, Lam AW, Harb G, et al: Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin. Mol Ther 16: 1138-1145, 2008.
18. Zhang H, Zhu SJ, Wang W, et al: Transplantation of microencapsulated genetically modified xenogeneic cells augments angiogenesis and improves heart function. Gene Ther 15: 40-48, 2008.
19. Mai G, Nguyen TH, Morel P, et al: Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Xenotransplantation 12: 457-464, 2005.
20. de Guzman RC, Ereifej ES, Broadrick KM, et al: Alginate-matrigel microencapsulated Schwann cells for inducible secretion of glial cell line derived neurotrophic factor. J Microencapsul 17: 1-12, 2008.
21. Cheng N, Wauthier E, Reid LM: Mature human hepatocytes from ex vivo differentiation of alginate-encapsulated hepatoblasts. Tissue Eng Part A 14: 1-7, 2008.
22. Eming SA, Snow RG, Yarmush ML, Morgan JR: Targeted expression of insulin-like growth factor to human keratinocytes: Modification of the autocrine control of keratinocyte proliferation. J Invest Dermatol 107: 113-120, 1996.
23. Cohick WS, Clemmons DR: The insulin-like growth factors. Annu Rev Physiol 55: 131-153, 1993.
24. Nesic D, Whiteside R, Brittberg M, et al: Cartilage tissue engineering for degenerative joint disease. Adv Drug Deliv Rev 58: 300-322, 2006.
25. Veilleux N, Spector M: Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthritis Cartilage 13: 278-286, 2005.
26. Pei M, Seidel J, Vunjak-Novakovic G, Freed LE: Growth factors for sequential cellular de- and re-differentiation in tissue engineering. Biochem Biophys Res Commun 294: 149-154, 2002.
27. van Osch GJ, van den Berg WB, Hunziker EB, Hauselmann HJ: Differential effects of IGF-1 and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. Osteoarthritis Cartilage 6: 187-195, 1998.
28. Cucchiarini M, Madry H: Gene therapy for cartilage defects. J Gene Med 7: 1495-1509, 2005.
29. Hunziker EB, Wagner J, Zapf J: Differential effects of insulin-like growth factor i and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. J Clin Invest 93: 1078-1086, 1994.
30. Langdahl BL, Kassem M, Moller MK, Eriksen EF: The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth hormone. Eur J Clin Invest 28: 176-183, 1998.
31. Lu HH, Vo JM, Chin HS, et al: Controlled delivery of platelet-rich plasma-derived growth factors for bone formation. J Biomed Mater Res 86: 1128-1136, 2008.
32. Campaner AB, Ferreira LM, Gragnani A, et al: Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring. J Invest Dermatol 126: 1168-1176, 2006.
33. Morgan JR, Barrandon Y, Green H, Mulligan RC: Expression of an exogenous growth hormone gene by transplantable human epidermal cells. Science 237: 1476-1479, 1987.
34. Karey KP, Sirbasku DA: Differential responsiveness of human breast cancer cell lines MCF-7 and T47d to growth factors and 17 beta-estradiol. Cancer Res 48: 4083-4092, 1988.
35. Youden WJ: Statistical Methods for Chemists. New York, John Wiley and Sons, Inc., 1951.
36. Paek HJ, Campaner AB, Kim JL, et al: In vitro characterization of TGF-beta1 release from genetically modified fibroblasts in ca(2+)-alginate microcapsules. ASAIO J 51: 379-384, 2005.
37. Edelstein ML, Abedi MR, Wixon J: Gene therapy clinical trials worldwide to 2007-an update. J Gene Med 9: 833-842, 2007.
38. Madry H, Kaul G, Cucchiarini M, et al: Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12: 1171-1179, 2005.
39. Goodrich LR, Hidaka C, Robbins PD, et al: Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 89: 672-685, 2007.
40. Brower-Toland BD, Saxer RA, Goodrich LR, et al: Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 12: 117-129, 2001.