Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer

Arthritis and Rheumatism

Volumn 44, Issue 8, 2001, Pages 1943-1953

  Gelse, K ^a   Jiang, Q J ^b   Aigner, T ^a   Ritter, T ^a   Wagner, K ^a   Poschl E ^b   Von Der Mark, K ^a   Schneider, H ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COMPLEMENTARY DNA; GENE PRODUCT; GROWTH FACTOR; SOMATOMEDIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHONDROGENESIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KNEE; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOPHYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; DNA, COMPLEMENTARY; FEMALE; FIBROBLASTS; GENES, REPORTER; GENETIC VECTORS; HUMANS; INJECTIONS, INTRA-ARTICULAR; INSULIN-LIKE GROWTH FACTOR I; KNEE JOINT; MICE; MICE, INBRED C57BL; MIDDLE AGED; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034885826     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200108)44:8<1943::AID-ART332>3.0.CO;2-Z     Document Type: Article

References (46)

1. Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1
2. The role of the chondrocyte in osteoarthritis
3. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage
4. Type X collagen synthesis in human osteoarthritic cartilage: Indication of chondrocyte hypertrophy
5. Differentiation, modulation and dedifferentiation of chondrocytes
6. Articular cartilage repair and transplantation
7. Repair of partial thickness defects in articular cartilage: Cell recruitment from the synovial membrane
8. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
9. Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: A hypothesis
10. Differential effects of IGF-1 and TGFβ-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes
11. Differentiated cellular function in fetal chondrocytes with insulin-like growth factor-I and transforming growth factor-β
12. Effect of somatomedin-C/Insulin-like growth factor I and growth hormone on cultured growth plate and articular chondrocytes
13. Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplemented with exogenous insulin-like growth factor-I
14. Human fetal and adult chondrocytes: Effect of insulinlike growth factors I and II and growth hormone on clonal growth
15. Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2)
16. Enhanced repair of extensive articular cartilage defects by insulin-like growth factor-I-laden fibrin composites
17. Cartilage and bone regeneration using gene-enhanced tissue engineering
18. Insulinlike growth factor-1 gene therapy applications for cartilage repair
19. Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line
20. Novel regulators of bone formation: Molecular clones and activities
21. Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture
22. Phenotypic stability of articular chondrocytes in vitro: The effects of culture models, bone morphogenetic protein 2, and serum supplementation
23. A method for estimating macromolecular reflection by human synovium, using measurements of intra-articular half-lives
24. Possible orthopaedic applications of gene therapy
25. Gene therapy for rheumatic diseases
26. Vectors for gene therapy
27. Adenovirus mediated gene delivery to the joints of guinea pigs
28. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5
29. Widespread long-term gene transfer to mouse skeletal muscle and heart
30. A new technique for the assay of infectivity of human adenovirus 5 DNA
31. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
32. Successful expression of β-galactosidase and factor IX transgenes in fetal and neonatal sheep after ultrasound-guided percutaneous adenovirus vector administration into the umbilical vein
33. BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
34. Degradation and repair of articular cartilage
35. Regulation of cartilage and bone differentiation by bone morphogenetic proteins
36. Differential effects of local application of BMP-2 or TGF-β on both articular cartilage composition and osteophyte formation
37. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints
38. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
39. Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys
40. Insulin-like growth factor I as a cardiac hormone: Physiological and pathophysiological implications in heart disease
41. Resurfacing of articular cartilage explants with geneticallymodified human chondrocytes in vitro
42. Ex vivo gene delivery using an adenoviral vector in treatment for cartilage defects
43. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
44. Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells. I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures
45. Treatment of canine osteoarthritis with insulin-like growth factor-I (IGF-1) and sodium pentosan polysulfate
46. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model