Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study

Osteoarthritis and Cartilage

Volumn 5, Issue 2, 1997, Pages 139-143

  Kang, R ^a   Marui, T ^a   Ghivizzani, S C ^a   Nita, I M ^a   Georgescu, H I ^a   Suh, J K ^a   Robbins, P D ^a   Evans, C H ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

cartilage injury; chondrocytes; gene therapy; transplantation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL TRANSPLANTATION; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; INJURY; PRIORITY JOURNAL; RABBIT;

EID: 0030893301     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1063-4584(97)80007-6     Document Type: Article

References (15)

1. Buckwalter JA Rosenberg L Coutts R Hunziker E Reddi AH Mow VC Articular cartilage: injury and repair Woo SL-Y Buckwaler JA Injury and Repair of the Musculoskeletal Soft Tissues 1988 American Academy of Orthopaedic Surgeons Park Ridge, IL 465 482
2. Brittberg M Lindahl A Nilsson A Ohlsson C Isakson O Peterson L Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation N Engl J Med 331 1994 889 895
3. Wakitani S Goto T Pineda SJ Young RG Mansour J Caplan AI Goldberg VM Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage J Bone Joint Surg 76A 1994 579 592
4. Wakitani S Kimura T Hirooka A Ochi T Yoneda M Owaki H Ono K Yasui N Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel J Bone Joint Surg 71B 1989 74 80
5. Grande DA Pitman MI Peterson L Mensche D Klein M The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation J Orthop Res 7 1989 208 218
6. Itay S Abramovici A Nevo Z Use of cultured embryonal chick ephiphyseal chondrocytes as grafts for defects in chick articular cartilage Clin Orthop Rel Res 220 1987 284 303
7. Aston JE Bentley G Repair of articular surfaces by allografts of articular and growth-plate cartilage J Bone Joint Surg 68B 1986 29 35
8. O'Driscoll SW Salter RB The repair of major osteochondral defects in joints surfaces by neochondrogenesis with autogenous osteoperiosteal grafts stimulated by continuous passive motion Clin Orthop Rel Res 208 1986 131 140
9. Amiel D Coutts RD Abel M Stewart W Hardwood F Akeson WH Rib perichondral grafts for the repair of full-thickness articular-cartilage defects J Bone Joint Surg 67A 1985 911 920
10. Green WT Articular cartilage repair: behavior of rabbit chondrocytes during tissue culture and subsequent allografting Clin Orthop Rel Res 124 1977 237 250
11. Bentley G Greer RB Homotransplantation of isolated epithyseal and articular cartilage chondrocytes into joint surfaces of rabbits Nature 230 1971 385 388
12. Bandara G Evans CH Intercellular regulation by synoviocytes Adolphe M Biological Regulation of the Chondrocytes 1992 CRC Press Boca Raton, FL 105 116
13. Evans CH Robbins PD Current concepts review: possible orthopaedic applications of gene therapy J Bone Joint Surg 77A 1995 1103 1114
14. Price J Turner D Cepko C Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer Proc Natl Acad Sci 84 1987 156 160
15. van Beuningen H van der Kraan PM Arntz OJ van den Berg W TGFβ1 stimulates articular cartilage proteoglycan synthesis and induces osteophyte formation in the murine knee joint Lab Invest 71 1994 279 290