Diversity through semisynthesis: The chemistry and biological activity of semisynthetic epothilone derivatives

Molecular Diversity

Volumn 15, Issue 2, 2011, Pages 383-399

  Altmann, Karl Heinz ^a   Gaugaz, Fabienne Z ^a   Schiess, Raphael ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Cancer; Drug discovery; Epothilones; Microtubules; Natural products; Review; SAR; Semisynthesis

Indexed keywords

ABJ 879; CAPECITABINE; EPOTHILONE A; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; IXABEPILONE; PACLITAXEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; TUBULIN MODULATOR;

BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; IC 50; NONHUMAN; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL PROLIFERATION; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CELL PROLIFERATION; DRUG DISCOVERY; EPOTHILONES; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 80051569814     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-010-9291-0     Document Type: Review

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