Epothilone A induces apoptosis in neuroblastoma cells with multiple mechanisms of drug resistance

International Journal of Oncology

Volumn 11, Issue 1, 1997, Pages 123-126

  Wolff, Armin ^b   Technau, Antje ^a   Brandner, Gerhard ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b NONE

Author keywords

Apoptosis; Epothilone A; Multiple drug resistance; Neuroblastoma cells; P glycoprotein; p53

Indexed keywords

CISPLATIN; EPOTHILONE A; GLYCOPROTEIN P; MACROLIDE; PACLITAXEL; PROTEIN P53; VERAPAMIL;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

EID: 0030836812     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.11.1.123     Document Type: Article

References (12)

1. Fritsche M, Haessler C, Brandner G: Nuclear accumulation of p53: an indicator of chromatin injury? J Cancer Res Clin Oncol 117: 53, 1991.
2. Fritsche M, Haessler C, Brandner G: Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8: 307-318, 1993.
3. Cote RJ: p53 and treatment of bladder cancer. Nature 385: 123-124, 1997.
4. Lowe SW, Jacks T: p53 and treatment of bladder cancer. Nature 385: 124-125, 1997.
5. Bollag DM, McQueney PA, Zhu J, Hensens O, Koupal L, Liesch J, Goetz M, Lazarides E, Woods CM: Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 55: 2325-2333, 1995.
6. Gerth K, Bedorf N, Höfle G, Irschik H, Reichenbach H: Epothilones A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria); production, physicochemical and biological properties. J Antibiot 49: 560-563, 1996.
7. Höfle G, Bedorf N, Steinmetz H, Schomburg D, Gerth K, Reichenbach H: Epothilone A and B - novel 16-membered macrolides with cytotoxic activity: isolation, crystal structure, and conformation in solution. Angew Chem Int Ed 35: 1567-1569, 1996.
8. Balog A, Meng D, Kamenecka T, Bertinato P, Su D-S, Sorensen EJ, Danishefsky SJ: Totalsynthese von (-)-Epothilone A. Angew Chem 108: 2976-2978, 1996.
9. Moll U, Ostermeyer AG, Haladay R, Winkfield B, Frazier M, Zambetti G: Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol 16: 1126-1137, 1995.
10. Mosman T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxity assay. J Immunol Meth 65: 55-63, 1983.
11. Nito S: Enhancement of cytogenetic and cytotoxic effects on multidrug-resistant (mdr) cells by a calcium antagonist (verapamil). Mut Res 227: 73-79, 1989.
12. Hamilton G, Theyer G, Baumgartner G: Calcium channel antagonists as modifiers of multidrug-resistant tumor cells. Wiener Med Woschr 19/20: 526-532, 1993.