Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

Neuroscience Letters

Volumn 331, Issue 3, 2002, Pages 163-166

  Leoni, Valerio ^a,b   Masterman, Thomas ^b   Diczfalusy, Ulf ^b   De Luca, Giancarlo ^a   Hillert, Jan ^b   Björkhem, Ingemar ^b  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

24S Hydroxycholesterol; Cerebrospinal fluid; Magnetic resonance imaging; Multiple sclerosis; Oxysterols

Indexed keywords

24S HYDROXYCHOLESTEROL; GLATIRAMER; OXYSTEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL LOSS; CEREBROSPINAL FLUID LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISABILITY; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MULTIPLE SCLEROSIS; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RATING SCALE;

EID: 0037131563     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00887-X     Document Type: Article

References (12)

1. Babiker A., Diczfalusy U. Transport of side-chain oxidized oxysterols in the human circulation. Biochim. Biophys. Acta. 1392:1998;333-339.
2. Bjorkhem I., Lutjohann D., Diczfalusy U., Sthale L., Ahlborg G., Wahren J. Cholesterol homeostasis in the human brain: turnover of the 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res. 39:1998;1594-1600.
3. Bretillon L., Lutjohann D., Stahle L., Widhe T., Bindl L., Eggersten G., Diczfalusy U., Bjorkhem I. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J. Lipid Res. 41:2000;840-845.
4. Bretillon L., Siden A., Wahlund L.O., Lutjohann D., Minthon L., Crisby M., Hillert J., Groth C.G., Diczfalusy U., Bjorkhem I. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. Neurosci. Lett. 29:2000;387-390.
5. Dzeletovic S., Breuer O., Lund E., Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225:1995;73-80.
6. Keegan B.M., Noseworthy J.H. Multiple sclerosis. Annu. Rev. Med. 53:2000;285-302.
7. Lund E.G., Guileyardo J.M., Russell D.W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of the cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. USA. 96:1999;7238-7243.
8. Lutjohann D., Breuer O., Ahlborg G., Nennesmo I., Siden A., Diczfalusy U., Bjorkhem I. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA. 93:1996;9799-9804.
9. Lutjohann D., Papassotiropulos A., Bjorkhem I., Locatelli S., Bagli M., Oehring R.D., Schlegel U., Jessen F., Rao M.L., von Bergmann K., Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J. Lipid Res. 41:2000;195-198.
10. Noseworthy J.H., Lucchinetti C., Rodrigues M., Weishenker B.G. Multiple sclerosis. N. Engl. J. Med. 343:2000;938-952.
11. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebres G.C., Johnson K.P., Sibley W.A., Silberrberg D.H., Tourtellotte W.W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
12. Rudick R.A. Evolving concepts in the Pathogenesis of Multiple Sclerosis and their therapeutic implications. J. Neuropthalmol. 21:2001;279-283.