Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast

Science

Volumn 322, Issue 5900, 2008, Pages 405-410

  Roguev, Assen ^a,b   Bandyopadhyay, Sourav ^c   Zofall, Martin ^d   Zhang, Ke ^d   Fischer, Tamas ^d   Collins, Sean R ^a,b,e   Qu, Hongjing ^a,b   Shales, Michael ^a,b   Park, Han Oh ^f   Hayles, Jacqueline ^g   Hoe, Kwang Lae ^h   Kim, Dong Uk ^h   Ideker, Trey ^c   Grewal, Shiv I ^d   Weissman, Jonathan S ^a,b,e   Krogan, Nevan J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f Bioneer Corporation   (South Korea)

^g IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^h Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME; COMPARATIVE STUDY; CONSERVATION; DNA; EPISTASIS; MUTATION; PHENOTYPE; PROTEIN; YEAST;

ARTICLE; CHROMOSOME; EPISTASIS MAP; FUNGAL GENE; GENE FUNCTION; GENE INTERACTION; GENE MUTATION; GENETIC CONSERVATION; GENETIC EPISTASIS; MOLECULAR INTERACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; RSH1 GENE; SACCHAROMYCES CEREVISIAE;

DNA REPAIR; DNA REPLICATION; EPISTASIS, GENETIC; GENE EXPRESSION REGULATION, FUNGAL; GENE REGULATORY NETWORKS; GENES, FUNGAL; HISTONES; MUTATION; RNA INTERFERENCE; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 54249107599     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1162609     Document Type: Article

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42. We thank P. Beltrao and G. Cagney for critical reading of the manuscript; M. Wiren and S. Forsburg for discussion; P. Kemmeren for setting up the web database; S. Wang, C. Wen, and D. Avdic for technical help; and F. Stewart for sharing unpublished data. This work was supported by NIH [National Institute of General Medical Sciences grant GM084279 (T.I. and N. J.K.)], the Sandler Family Foundation (N.J.K), the Howard Hughes Medical Institute (J.S.W.), National Cancer Institute (S.I.G.), Center for Cancer Research (S.I.G.), and the California Institute of Quantitative Biology (N.J.K.).