Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait

Nature Genetics

Volumn 37, Issue 11, 2005, Pages 1253-1257

  Williams, Thomas N ^a,b   Mwangi, Tabitha W ^a,b   Wambua, Sammy ^a   Peto, Timothy E A ^b   Weatherall, David J ^b   Gupta, Sunetra ^c   Recker, Mario ^c   Penman, Bridget S ^c   Uyoga, Sophie ^a   MacHaria, Alex ^a   Mwacharo, Jedidah K ^a   Snow, Robert W ^a,b   Marsh, Kevin ^a,b  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN S;

AFRICA; ALPHA THALASSEMIA; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE MUTATION; GENETIC EPISTASIS; GENETIC TRAIT; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INCIDENCE; INHERITANCE; KENYA; MALARIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHOOL CHILD; SICKLE CELL;

AFRICA SOUTH OF THE SAHARA; ALPHA-THALASSEMIA; ANIMALS; CHILD; COHORT STUDIES; HEMOGLOBIN, SICKLE; HETEROZYGOTE; HUMANS; INCIDENCE; KENYA; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; SICKLE CELL TRAIT;

PLASMODIUM FALCIPARUM;

EID: 27644566200     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1660     Document Type: Article

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