Compensated deleterious mutations in insect ganomes

Science

Volumn 306, Issue 5701, 2004, Pages 1553-1554

  Kulathinal, Rob J ^a   Bettencourt, Brian R ^a   Hartl, Daniel L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENES; PROTEINS;

DIPTERAN GENOMES; INSECT GANOMES; PHENOTYPIC EVOLUTION;

MUTAGENESIS;

AMINO ACID; PROTEIN;

MUTATION;

AMINO ACID SUBSTITUTION; ARTICLE; DROSOPHILA MELANOGASTER; GENE; GENOME; MUTATION; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; RNA STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANOPHELES GAMBIAE; CODON, NONSENSE; DROSOPHILA; DROSOPHILA MELANOGASTER; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENES, INSECT; GENOME; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; PHENOTYPE; PHYLOGENY; SELECTION (GENETICS); SEQUENCE ALIGNMENT;

AMINO ACIDS; GENES; MUTAGENS; PROTEINS;

DIPTERA; DROSOPHILA MELANOGASTER; INSECTA; MELANOGASTER;

EID: 9444269272     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1100522     Document Type: Article

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15. We thank members of the Hartl lab, especially D. Weinreich, for helpful discussions and the Computational Biology Group at the Bauer Center for Genomics Research for the use of their cluster. This work was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship (R.J.K.), a National Human Genome Research Institute (NHGRI) grant (P41-HG00739) to FlyBase (B.R.B.), and an NIH grant (GM068465) (D.L.H.).