From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family A G-protein-coupled receptors (GPCRs)

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 25859-25871

  Kleinau, Gunnar ^a,b   Hoyer, Inna ^a   Kreuchwig, Annika ^a   Haas, Ann Karin ^a   Rutz, Claudia ^a   Furkert, Jens ^a   Worth, Catherine L ^b   Krause, Gerd ^a   Schülein, Ralf ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE STATE; CELL SURFACE EXPRESSION; CORE SET; G PROTEIN COUPLED RECEPTORS; GENERAL ASPECTS; HELIX STRUCTURES; MOLECULAR INSIGHTS; NONPOLAR INTERACTIONS; POLAR INTERACTIONS; STRUCTURAL INFORMATION; THYROTROPIN RECEPTOR; TRANSMEMBRANE HELICES;

AMINO ACIDS; BACTERIOPHAGES; CELL MEMBRANES;

SIGNAL TRANSDUCTION;

ALANINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR FAMILY A; PROLINE; THYROTROPIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SECRETORY PATHWAY; SIGNAL TRANSDUCTION; TRANSMEMBRANE HELIX 5; TRANSMEMBRANE HELIX 6;

ANIMALS; CELL MEMBRANE; CONSERVED SEQUENCE; CYCLIC AMP; HEK293 CELLS; HUMANS; INOSITOL PHOSPHATES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION;

EID: 79960418114     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196980     Document Type: Article

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