Promise of resveratrol for easing status epilepticus and epilepsy

Pharmacology and Therapeutics

Volumn 131, Issue 3, 2011, Pages 269-286

  Shetty, Ashok K ^a,b  

^a DURHAM VA MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acute seizures; Cognitive dysfunction; Dentate gyrus; Epilepsy; Epileptogenesis; GABA ergic interneurons; Hippocampal neurogenesis; Inflammation; Learning and memory; Neurodegeneration; Neuroinflammation; Neuroprotection; Oxidative stress; Polyphenol; Red wine; Resveratrol; Seizures; SIRT1; Status epilepticus; Temporal lobe epilepsy

Indexed keywords

4 AMINOBUTYRIC ACID; ADENYLATE KINASE; ANTICONVULSIVE AGENT; KAINIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; RESVERATROL; SIRTUIN 1;

ABSENCE OF SIDE EFFECTS; ANTICONVULSANT ACTIVITY; ARTICLE; BEHAVIOR; BRAIN FUNCTION; BRAIN INJURY; CELL FUNCTION; COGNITIVE DEFECT; DENTATE GYRUS; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG TOLERABILITY; ELECTRIC ACTIVITY; ELECTROENCEPHALOGRAPHY; ENTEROHEPATIC CIRCULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTIC STATE; EPILEPTOGENESIS; EXCITOTOXICITY; HIPPOCAMPUS; HUMAN; INFLAMMATION; LEARNING DISORDER; LIPID PEROXIDATION; MAXIMUM PLASMA CONCENTRATION; MEMORY DISORDER; MITOCHONDRION; NEPHROTOXICITY; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; OPTIMAL DRUG DOSE; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE DRUG DOSE; TEMPORAL LOBE EPILEPSY;

EID: 79960117900     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.04.008     Document Type: Review

References (210)

1. M. Abd El-Mohsen, H. Bayele, G. Kuhnle, G. Gibson, E. Debnam, and S. Kaila Srai Distribution of [3 H]trans-resveratrol in rat tissues following oral administration Br J Nutr 96 2006 62 70 (Pubitemid 44160897)
2. D.N. Abrous, M. Koehl, and M. Le Moal Adult neurogenesis: From precursors to network and physiology Physiol Rev 85 2005 523 569 (Pubitemid 40404636)
3. J.B. Aimone, J. Wiles, and F.H. Gage Potential role for adult neurogenesis in the encoding of time in new memories Nat Neurosci 9 2006 723 727
4. A. Alessio, B.P. Damasceno, C.H. Camargo, E. Kobayashi, C.A. Guerreiro, and F. Cendes Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy Epilepsy Behav 5 2004 22 27 (Pubitemid 38937059)
5. A. Alessio, E. Kobayashi, B.P. Damasceno, I. Lopes-Cendes, and F. Cendes Evidence of memory impairment in asymptomatic individuals with hippocampal atrophy Epilepsy Behav 5 2004 981 987 (Pubitemid 40003922)
6. V. Andre, A. Ferrandon, C. Marescaux, and A. Nehlig Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy Epilepsy Res 47 2001 99 117 (Pubitemid 32973652)
7. T.L. Babb, W.R. Kupfer, J.K. Pretorius, P.H. Crandall, and M.F. Levesque Synaptic reorganization by mossy fibers in human epileptic fascia dentata Neuroscience 42 1991 351 363
8. A. Balestrazzi, M. Bonadei, C. Calvio, F. Mattivi, and D. Carbonera Leaf-associated bacteria from transgenic white poplar producing resveratrol-like compounds: Isolation, molecular characterization, and evaluation of oxidative stress tolerance Can J Microbiol 55 2009 829 840
9. S. Bastianetto, W.H. Zheng, and R. Quirion Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons Br J Pharmacol Chemother 131 2000 711 720
10. J.A. Baur, and D.A. Sinclair Therapeutic potential of resveratrol: The in vivo evidence Nat Rev Drug Discov 5 2006 493 506 (Pubitemid 44136961)
11. J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, and A. Kalra Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342 (Pubitemid 44764104)
12. L. Belguendouz, L. Fremont, and A. Linard Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins Biochem Pharmacol 53 1997 1347 1355 (Pubitemid 27305634)
13. Y. Ben-Ari Seizures beget seizures: The quest for GABA as a key player Crit Rev Neurobiol 18 2006 135 144 (Pubitemid 350194067)
14. R.A. Bender, C. Dube, R. Gonzalez-Vega, E.W. Mina, and T.Z. Baram Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures Hippocampus 13 2003 399 412 (Pubitemid 36546772)
15. J. Bengzon, Z. Kokaia, E. Elmer, A. Nanobashvili, M. Kokaia, and O. Lindvall Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures Proc Natl Acad Sci U S A 94 1997 10432 10437
16. J. Bengzon, P. Mohapel, C.T. Ekdahl, and O. Lindvall Neuronal apoptosis after brief and prolonged seizures Prog Brain Res 135 2002 111 119 (Pubitemid 35461010)
17. C. Bernard, M. Esclapez, J.C. Hirsch, and Y. Ben-Ari Interneurones are not so dormant in temporal lobe epilepsy: A critical reappraisal of the dormant basket cell hypothesis Epilepsy Res 32 1998 93 103 (Pubitemid 28419481)
18. X.L. Bi, J.Y. Yang, Y.X. Dong, J.M. Wang, Y.H. Cui, and T. Ikeshima Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia Int Immunopharmacol 5 2005 185 193 (Pubitemid 39626704)
19. J.G. Boggs Mortality associated with status epilepticus Epilepsy Curr 4 2004 25 27
20. D.J. Boocock, G.E. Faust, K.R. Patel, A.M. Schinas, V.A. Brown, and M.P. Ducharme Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent Cancer Epidemiol Biomarkers Prev 16 2007 1246 1252 (Pubitemid 46984966)
21. D.J. Boocock, K.R. Patel, G.E. Faust, D.P. Normolle, T.H. Marczylo, and J.A. Crowell Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography J Chromatogr B Analyt Technol Biomed Life Sci 848 2007 182 187 (Pubitemid 46464044)
22. C. Brandt, H. Potschka, W. Loscher, and U. Ebert N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy Neuroscience 118 2003 727 740 (Pubitemid 36506960)
23. A.R. Brasier The NF-kappaB regulatory network Cardiovasc Toxicol 6 2006 111 130
24. L.M. Brown-Croyts, P.W. Caton, D.T. Radecki, and S.L. McPherson Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning Life Sci 67 2000 643 650 (Pubitemid 30451903)
25. A. Brunet, L.B. Sweeney, J.F. Sturgill, K.F. Chua, P.L. Greer, and Y. Lin Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 03 2004 2011 2015 (Pubitemid 38393275)
26. P.S. Buckmaster, G.F. Zhang, and R. Yamawaki Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit J Neurosci 22 2002 6650 6658 (Pubitemid 35386421)
27. M. Campagna, and C. Rivas Antiviral activity of resveratrol Biochem Soc Trans 38 2010 50 53
28. C.G. Castillo, S. Mendoza, W.J. Freed, and M. Giordano Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat Behav Brain Res 171 2006 109 115 (Pubitemid 43728391)
29. J.E. Cavazos, S.M. Jones, and D.J. Cross Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy Neuroscience 126 2004 677 688 (Pubitemid 38759261)
30. Y.S. Choi, M.Y. Lee, K.W. Sung, S.W. Jeong, J.S. Choi, and H.J. Park Regional differences in enhanced neurogenesis in the dentate gyrus of adult rats after transient forebrain ischemia Mol Cells 16 2003 232 238
31. S. Chung, H. Yao, S. Caito, J.W. Hwang, G. Arunachalam, and I. Rahman Regulation of SIRT1 in cellular functions: role of polyphenols Arch Biochem Biophys 501 2010 79 90
32. H.Y. Cohen, C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, and B. Kessler Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392 (Pubitemid 38938153)
33. S.M. Cornish, and H.V. Wheal Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat Neuroscience 28 1989 563 571 (Pubitemid 19081016)
34. C.H. Cottart, V. Nivet-Antoine, C. Laguillier-Morizot, and J.L. Beaudeux Resveratrol bioavailability and toxicity in humans Mol Nutr Food Res 54 2010 7 16
35. D.A. Coulter Chronic epileptogenic cellular alterations in the limbic system after status epilepticus Epilepsia 40 Suppl 1 1999 S23 S33
36. J.A. Crowell, P.J. Korytko, R.L. Morrissey, T.D. Booth, and B.S. Levine Resveratrol-associated renal toxicity Toxicol Sci 82 2004 614 619 (Pubitemid 39600090)
37. B. Dasgupta, and J. Milbrandt Resveratrol stimulates AMP kinase activity in neurons Proc Natl Acad Sci U S A 104 2007 7217 7222 (Pubitemid 47186035)
38. C.J. Davenport, W.J. Brown, and T.L. Babb GABAergic neurons are spared after intrahippocampal kainate in the rat Epilepsy Res 5 1990 28 42 (Pubitemid 20046590)
39. C.J. Davenport, W.J. Brown, and T.L. Babb Sprouting of GABAergic and mossy fiber axons in dentate gyrus following intrahippocampal kainate in the rat Exp Neurol 109 1990 180 190 (Pubitemid 20256212)
40. J. Detour, H. Schroeder, D. Desor, and A. Nehlig A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats Epilepsia 46 2005 499 508 (Pubitemid 40470671)
41. E. Drapeau, W. Mayo, C. Aurousseau, M. Le Moal, P.V. Piazza, and D.N. Abrous Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis Proc Natl Acad Sci U S A 100 2003 14385 14390 (Pubitemid 37499246)
42. C. Dube, M.J. da Silva Fernandes, and A. Nehlig Age-dependent consequences of seizures and the development of temporal lobe epilepsy in the rat Dev Neurosci 23 2001 219 223 (Pubitemid 34701676)
43. F.E. Dudek, and M. Spitz Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: Proposed role of synaptic reorganization J Clin Neurophysiol 14 1997 90 101 (Pubitemid 28246499)
44. F.E. Dudek, and T.P. Sutula Epileptogenesis in the dentate gyrus: A critical perspective Prog Brain Res 163 2007 755 773 (Pubitemid 47321462)
45. D. Dupret, J.M. Revest, M. Koehl, F. Ichas, F. De Giorgi, and P. Costet Spatial relational memory requires hippocampal adult neurogenesis PLoS One 3 2008 e1959
46. U. Ebert, C. Brandt, and W. Loscher Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat Epilepsia 43 Suppl 5 2002 86 95 (Pubitemid 34864213)
47. C.T. Ekdahl, P. Mohapel, E. Elmer, and O. Lindvall Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus Eur J Neurosci 14 2001 937 945 (Pubitemid 35463767)
48. P.S. Eriksson, E. Perfilieva, T. Bjork-Eriksson, A.M. Alborn, C. Nordborg, and D.A. Peterson Neurogenesis in the adult human hippocampus Nat Med 4 1998 1313 1317 (Pubitemid 28512114)
49. V. Eybl, D. Kotyzova, and J. Koutensky Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice Toxicology 225 2006 150 156 (Pubitemid 44108372)
50. R.J. Felling, and S.W. Levison Enhanced neurogenesis following stroke J Neurosci Res 73 2003 277 283 (Pubitemid 36918091)
51. J.E. Franck, D.D. Kunkel, D.G. Baskin, and P.A. Schwartzkroin Inhibition in kainate-lesioned hyperexcitable hippocampi: physiologic, autoradiographic, and immunocytochemical observations J Neurosci 8 1988 1991 2002
52. J.E. Franck, J. Pokorny, D.D. Kunkel, and P.A. Schwartzkroin Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus Epilepsia 36 1995 543 558
53. L. Fremont Biological effects of resveratrol Life Sci 66 2000 663 673
54. Z.B. Gao, and G.Y. Hu Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons Brain Res 1056 2005 68 75
55. Z.B. Gao, X.Q. Chen, and G.Y. Hu Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus Brain Res 1111 2006 41 47
56. J. Gao, W.Y. Wang, Y.W. Mao, J. Graff, J.S. Guan, and L. Pan A novel pathway regulates memory and plasticity via SIRT1 and miR-134 Nature 466 2010 1105 1109
57. S. Ge, D.A. Pradhan, G.L. Ming, and H. Song GABA sets the tempo for activity-dependent adult neurogenesis Trends Neurosci 30 2007 1 8 (Pubitemid 46001680)
58. M. Gernert, K.W. Thompson, W. Loscher, and A.J. Tobin Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats Exp Neurol 176 2002 183 192 (Pubitemid 34762118)
59. L. Golkar, X.Z. Ding, M.B. Ujiki, M.R. Salabat, D.L. Kelly, and D. Scholtens Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1 J Surg Res 138 2007 163 169 (Pubitemid 46365718)
60. C. Gong, T.W. Wang, H.S. Huang, and J.M. Parent Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus J Neurosci 27 2007 1803 1811
61. E. Gould, and C.G. Gross Neurogenesis in adult mammals: Some progress and problems J Neurosci 22 2002 619 623 (Pubitemid 34141740)
62. W.P. Gray, and L.E. Sundstrom Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat Brain Res 790 1998 52 59 (Pubitemid 28234487)
63. I. Groticke, K. Hoffmann, and W. Loscher Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice Exp Neurol 207 2007 329 349 (Pubitemid 47429663)
64. Y.K. Gupta, G. Chaudhary, K. Sinha, and A.K. Srivastava Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats Methods Find Exp Clin Pharmacol 23 2001 241 244 (Pubitemid 33009601)
65. Y.K. Gupta, S. Briyal, and G. Chaudhary Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats Pharmacol Biochem Behav 71 2002 245 249
66. B. Halliwell Oxidative stress and neurodegeneration: Where are we now? J Neurochem 97 2006 1634 1658 (Pubitemid 43873658)
67. Y.S. Han, W.H. Zheng, S. Bastianetto, J.G. Chabot, and R. Quirion Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: Involvement of protein kinase C Br J Pharmacol 141 2004 997 1005 (Pubitemid 38510083)
68. B. Hattiangady, and A.K. Shetty Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy Epilepsia 49 Suppl 5 2008 26 41 (Pubitemid 351782998)
69. B. Hattiangady, and A.K. Shetty Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy Hippocampus 20 2010 97 112
70. B. Hattiangady, M.S. Rao, and A.K. Shetty Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus Neurobiol Dis 17 2004 473 490 (Pubitemid 39574880)
71. B. Hattiangady, M.S. Rao, and A.K. Shetty Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy Exp Neurol 212 2008 468 481
72. B. Hattiangady, R. Kuruba, and A.K. Shetty Acute seizures in old age leads to a greater loss of CA1 pyramidal neurons, and increased propensity for developing chronic TLE and a severe cognitive dysfunction Aging Dis 2 2011 1 17
73. J.L. Hellier, P.R. Patrylo, P.S. Buckmaster, and F.E. Dudek Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: Assessment of a rat model of temporal lobe epilepsy Epilepsy Res 31 1998 73 84 (Pubitemid 28305406)
74. C.R. Houser Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy Brain Res 535 1990 195 204
75. C.R. Houser, and M. Esclapez Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures Epilepsy Res 26 1996 207 218 (Pubitemid 26420743)
76. C.R. Houser, J.E. Miyashiro, B.E. Swartz, G.O. Walsh, J.R. Rich, and A.V. Daelgado-Escuet Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy J Neurosci 10 1990 267 282 (Pubitemid 20059263)
77. K.T. Howitz, K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, and J.G. Wood Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 2003 191 196 (Pubitemid 37150899)
78. I. Imayoshi, M. Sakamoto, T. Ohtsuka, K. Takao, T. Miyakawa, and M. Yamaguchi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain Nat Neurosci 11 2008 1153 1161
79. K. Jakubs, A. Nanobashvili, S. Bonde, C.T. Ekdahl, Z. Kokaia, and M. Kokaia Environment matters: Synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability Neuron 52 2006 1047 1059 (Pubitemid 44909404)
80. J.H. Jang, and Y.J. Surh Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death Free Radic Biol Med 34 2003 1100 1110
81. D.S. Jang, B.S. Kang, S.Y. Ryu, I.M. Chang, and K.R. Min Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production Biochem Pharmacol 57 1999 705 712 (Pubitemid 29080762)
82. S. Jessberger, R.E. Clark, N.J. Broadbent, G.D. Clemenson Jr., A. Consiglio, and D.C. Lie Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats Learn Mem 16 2009 147 154
83. K.E. Jones, A.M. Puccio, K.J. Harshman, B. Falcione, N. Benedict, and B.T. Jankowitz Levetiracetam versus phenytoin for seizure prophylaxis in severe traumatic brain injury Neurosurg Focus 25 2008 E3
84. K.H. Jung, K. Chu, M. Kim, S.W. Jeong, Y.M. Song, and S.T. Lee Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus Eur J Neurosci 19 2004 3219 3226 (Pubitemid 38859539)
85. M. Kaeberlein, T. McDonagh, B. Heltweg, J. Hixon, E.A. Westman, and S.D. Caldwell Substrate-specific activation of sirtuins by resveratrol J Biol Chem 280 2005 17038 17045 (Pubitemid 41389166)
86. J. Kapur Role of neuronal loss in the pathogenesis of recurrent spontaneous seizures Epilepsy Curr 3 2003 166 167
87. S.S. Karuppagounder, J.T. Pinto, H. Xu, H.L. Chen, M.F. Beal, and G.E. Gibson Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease Neurochem Int 54 2009 111 118
88. N. Kee, C.M. Teixeira, A.H. Wang, and P.W. Frankland Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus Nat Neurosci 10 2007 355 362
89. H. Kim, J. Deshane, S. Barnes, and S. Meleth Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compounds Life Sci 78 2006 2060 2065
90. D. Kim, M.D. Nguyen, M.M. Dobbin, A. Fischer, F. Sananbenesi, and J.T. Rodgers SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J 26 2007 3169 3179 (Pubitemid 47057498)
91. S. Knake, H.M. Hamer, and F. Rosenow Status epilepticus: A critical review Epilepsy Behav 15 2009 10 14
92. M. Kobayashi, X. Wen, and P.S. Buckmaster Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy J Neurosci 23 2003 8471 8479 (Pubitemid 37158746)
93. R. Koyama, and Y. Ikegaya Mossy fiber sprouting as a potential therapeutic target for epilepsy Curr Neurovasc Res 1 2004 3 10
94. T.E. Kraft, D. Parisotto, C. Schempp, and T. Efferth Fighting cancer with red wine? Molecular mechanisms of resveratrol Crit Rev Food Sci Nutr 49 2009 782 799
95. R. Kuruba, and A.K. Shetty Could hippocampal neurogenesis be a future drug target for treating temporal lobe epilepsy? CNS Neurol Disord Drug Targets 6 2007 342 357 (Pubitemid 351486262)
96. R. Kuruba, B. Hattiangady, and A.K. Shetty Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy Epilepsy Behav 14 Suppl 1 2009 65 73
97. M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, and F. Daussin Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122 (Pubitemid 44894520)
98. I.H. Lee, L. Cao, R. Mostoslavsky, D.B. Lombard, J. Liu, and N.E. Bruns A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy Proc Natl Acad Sci U S A 105 2008 3374 3379 (Pubitemid 351723560)
99. P.P. Lenck-Santini, and G.L. Holmes Altered phase precession and compression of temporal sequences by place cells in epileptic rats J Neurosci 28 2008 5053 5062
100. S. Letty, M. Lerner-Natoli, and G. Rondouin Differential impairments of spatial memory and social behavior in two models of limbic epilepsy Epilepsia 36 1995 973 982
101. M. Li, Q.S. Wang, Y. Chen, Z.M. Wang, Z. Liu, and S.M. Guo Resveratrol inhibits neuronal discharges in rat hippocampal CA1 area Sheng Li Xue Bao 57 2005 355 360
102. X. Liu, R.U. Muller, L.T. Huang, J.L. Kubie, A. Rotenberg, and B. Rivard Seizure-induced changes in place cell physiology: Relationship to spatial memory J Neurosci 23 2003 11505 11515 (Pubitemid 38021279)
103. C. Liu, Z. Shi, L. Fan, C. Zhang, K. Wang, and B. Wang Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury Brain Res 1374 2010 100 109
104. W. Loscher, U. Ebert, H. Lehmann, C. Rosenthal, and G. Nikkhah Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra J Neurosci Res 51 1998 196 209 (Pubitemid 28073027)
105. D.H. Lowenstein, M.S. Seren, and F.M. Longo Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization Neuroscience 56 1993 597 604 (Pubitemid 23290574)
106. M. Lu, Y.J. Cai, J.G. Fang, Y.L. Zhou, Z.L. Liu, and L.M. Wu Efficiency and structure-activity relationship of the antioxidant action of resveratrol and its analogs Pharmazie 57 2002 474 478 (Pubitemid 34764306)
107. M. Lynch, and T. Sutula Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats J Neurophysiol 83 2000 693 704 (Pubitemid 30091281)
108. C.E. Maddox, L.M. Laur, and L. Tian Antibacterial activity of phenolic compounds against the phytopathogen Xylella fastidiosa Curr Microbiol 60 2010 53 58
109. P. Maher, R. Dargusch, L. Bodai, P.E. Gerard, J.M. Purcell, and J.L. Marsh ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease Hum Mol Genet 20 2010 261 270
110. S.K. Manna, A. Mukhopadhyay, and B.B. Aggarwal Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation J Immunol 164 2000 6509 6519 (Pubitemid 30408836)
111. F.Z. Marques, M.A. Markus, and B.J. Morris Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits Int J Biochem Cell Biol 41 2009 2125 2128
112. G.W. Mathern, F. Cifuentes, J.P. Leite, J.K. Pretorius, and T.L. Babb Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model Electroencephalogr Clin Neurophysiol 87 1993 326 339 (Pubitemid 23328867)
113. G.W. Mathern, T.L. Babb, J.P. Leite, K. Pretorius, K.M. Yeoman, and P.A. Kuhlman The pathogenic and progressive features of chronic human hippocampal epilepsy Epilepsy Res 26 1996 151 161 (Pubitemid 26420739)
114. D.P. McCloskey, T.M. Hintz, J.P. Pierce, and H.E. Scharfman Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat Eur J Neurosci 24 2006 2203 2210 (Pubitemid 44622341)
115. K. Mehlig, I. Skoog, X. Guo, M. Schütze, D. Gustafson, and M. Waern Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg Am J Epidemiol 167 2008 684 691 (Pubitemid 351430938)
116. S. Michan, Y. Li, M.M. Chou, E. Parrella, H. Ge, and J.M. Long SIRT1 is essential for normal cognitive function and synaptic plasticity J Neurosci 30 2010 9695 9707
117. M.A. Mikati, G.L. Holmes, S. Werner, N. Bakkar, L. Carmant, and Z. Liu Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats Epilepsy Behav 5 2004 168 174 (Pubitemid 38461206)
118. J.C. Milne, P.D. Lambert, S. Schenk, D.P. Carney, J.J. Smith, and D.J. Gagne Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716 (Pubitemid 350207685)
119. M. Mokni, S. Elkahoui, F. Limam, M. Amri, and E. Aouani Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat Neurochem Res 32 2007 981 987 (Pubitemid 46726017)
120. P. Molnar, and J.V. Nadler Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation J Neurophysiol 82 1999 1883 1894 (Pubitemid 29471276)
121. F. Morin, C. Beaulieu, and J.C. Lacaille Selective loss of GABA neurons in area CA1 of the rat hippocampus after intraventricular kainate Epilepsy Res 32 1998 363 369 (Pubitemid 28518242)
122. J.V. Nadler The recurrent mossy fiber pathway of the epileptic brain Neurochem Res 28 2003 1649 1658 (Pubitemid 37296207)
123. J.V. Nadler, B. Tu, O. Timofeeva, Y. Jiao, and H. Herzog Neuropeptide Y in the recurrent mossy fiber pathway Peptides 28 2007 357 364 (Pubitemid 46176247)
124. E. Nakagawa, Y. Aimi, O. Yasuhara, I. Tooyama, M. Shimada, and P.L. McGeer Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy Epilepsia 41 2000 10 18 (Pubitemid 30036848)
125. B.G. Neville, R.F. Chin, and R.C. Scott Childhood convulsive status epilepticus: Epidemiology, management and outcome Acta Neurol Scand 186 2007 21 24 (Pubitemid 46376167)
126. G. Nicolini, R. Rigolio, M. Miloso, A.A. Bertelli, and G. Tredici Anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line Neurosci Lett 302 2001 41 44 (Pubitemid 32244192)
127. J. Nissinen, K. Lukasiuk, and A. Pitkänen Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy? Hippocampus 11 2001 299 310 (Pubitemid 32655288)
128. A. Obenaus, M. Esclapez, and C.R. Houser Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures J Neurosci 13 1993 4470 4485 (Pubitemid 23299966)
129. S. Oddo, P. Solis, D. Consalvo, B. Giagante, W. Silva, and L. D'Alessio Mesial temporal lobe epilepsy and hippocampal sclerosis: Cognitive function assessment in Hispanic patients Epilepsy Behav 4 2003 717 722 (Pubitemid 38035695)
130. M. Okawara, H. Katsuki, E. Kurimoto, H. Shibata, T. Kume, and A. Akaike Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults Biochem Pharmacol 73 2007 550 560 (Pubitemid 46038859)
131. M.M. Okazaki, P. Molnar, and J.V. Nadler Recurrent mossy fiber pathway in rat dentate gyrus: Synaptic currents evoked in presence and absence of seizure-induced growth J Neurophysiol 81 1999 1645 1660 (Pubitemid 29262497)
132. F. Orallo Trans-resveratrol: A magical elixir of eternal youth? Curr Med Chem 15 2008 1887 1898
133. J.M. Parent Adult neurogenesis in the intact and epileptic dentate gyrus Prog Brain Res 163 2007 529 540
134. J.M. Parent, T.W. Yu, R.T. Leibowitz, D.H. Geschwind, R.S. Sloviter, and D.H. Lowenstein Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus J Neurosci 17 1997 3727 3738 (Pubitemid 27200597)
135. J.M. Parent, R.C. Elliott, S.J. Pleasure, N.M. Barbaro, and D.H. Lowenstein Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy Ann Neurol 59 2006 81 91 (Pubitemid 43042874)
136. P.R. Patrylo, J.S. Schweitzer, and F.E. Dudek Abnormal responses to perforant path stimulation in the dentate gyrus of slices from rats with kainate-induced epilepsy and mossy fiber reorganization Epilepsy Res 36 1999 31 42 (Pubitemid 29363013)
137. S. Paul, A.M. Rimando, H.J. Lee, Y. Ji, B.S. Reddy, and N. Suh Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells Cancer Prev Res 2 2009 650 657
138. N.D. Perkins Integrating cell-signalling pathways with NF-kappaB and IKK function Nat Rev Mol Cell Biol 8 2007 49 62 (Pubitemid 46012014)
139. J.P. Pierce, J. Melton, M. Punsoni, D.P. McCloskey, and H.E. Scharfman Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures Exp Neurol 196 2005 316 331 (Pubitemid 41607820)
140. S. Rajendrasozhan, S.R. Yang, V.L. Kinnula, and I. Rahman SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 177 2008 861 870 (Pubitemid 351600664)
141. M.S. Rao, B. Hattiangady, D.S. Reddy, and A.K. Shetty Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy J Neurosci Res 83 2006 1088 1105
142. M.S. Rao, B. Hattiangady, K.S. Rai, and A.K. Shetty Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy Neurobiol Dis 27 2007 117 132 (Pubitemid 47088974)
143. C.E. Ribak, P.H. Tran, I. Spigelman, M.M. Okazaki, and J.V. Nadler Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry J Comp Neurol 428 2000 240 253
144. R.M. Richardson, N.M. Barbaro, A. Alvarez-Buylla, and S.C. Baraban Developing cell transplantation for temporal lobe epilepsy Neurosurg Focus 24 2008 E17
145. M.A. Rigoulot, E. Koning, A. Ferrandon, and A. Nehlig Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy J Pharmacol Exp Ther 308 2004 787 795 (Pubitemid 38134245)
146. M.P. Robich, R.M. Osipov, R. Nezafat, J. Feng, R.T. Clements, and C. Bianchi Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia Circulation 122 2010 S142 S149
147. R. Rola, J. Raber, A. Rizk, S. Otsuka, S.R. VandenBerg, and D.R. Morhardt Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice Exp Neurol 188 2004 316 330 (Pubitemid 38891593)
148. L. Rossi, S. Mazzitelli, M. Arciello, C.R. Capo, and G. Rotilio Benefits from dietary polyphenols for brain aging and Alzheimer's disease Neurochem Res 33 2008 2390 2400
149. A. Rutten, M. van Albada, D.C. Silveira, B.H. Cha, X. Liu, and Y.N. Hu Memory impairment following status epilepticus in immature rats: Time-course and
150. Y. Sakata, H. Zhuang, H. Kwansa, R.C. Koehler, and S. Doré Resveratrol protects against experimental stroke: Putative neuroprotective role of heme oxygenase 1 Exp Neurol 224 2010 325 329
151. R. Sankar, D.H. Shin, H. Liu, A. Mazarati, A. Pereira de Vasconcelos, and C.G. Wasterlain Patterns of status epilepticus-induced neuronal injury during development and long-term consequences J Neurosci 18 1998 8382 8393 (Pubitemid 28465013)
152. V. Santhakumar, I. Aradi, and I. Soltesz Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: A network model of the dentate gyrus incorporating cell types and axonal topography J Neurophysiol 93 2005 437 453 (Pubitemid 40626852)
153. M. Sato, P.S. Ray, G. Maulik, N. Maulik, R.M. Engelman, and A.A. Bertelli Myocardial protection with red wine extract J Cardiovasc Pharmacol 35 2000 263 268 (Pubitemid 30073818)
154. U. Sayin, T.P. Sutula, and C.E. Stafstrom Seizures in the developing brain cause adverse long-term effects on spatial learning and anxiety Epilepsia 45 2004 1539 1548 (Pubitemid 39648279)
155. H.E. Scharfman, J.H. Goodman, and A.L. Sollas Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: Functional implications of seizure-induced neurogenesis J Neurosci 20 2000 6144 6158 (Pubitemid 30658408)
156. H.E. Scharfman, J.H. Goodman, A.L. Sollas, and S.D. Croll Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor Exp Neurol 174 2002 201 214 (Pubitemid 34293450)
157. H.E. Scharfman, A.L. Sollas, and J.H. Goodman Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus Neuroscience 111 2002 71 81 (Pubitemid 34310452)
158. H.E. Scharfman, A.E. Sollas, R.E. Berger, J.H. Goodman, and J.P. Pierce Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures Neuroscience 121 2003 1017 1029 (Pubitemid 37324601)
159. D.M. Shaner, S.A. McCurdy, M.O. Herring, and A.J. Gabor Treatment of status epilepticus: A prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin Neurology 38 1988 202 207 (Pubitemid 18036837)
160. L.R. Shao, and F.E. Dudek Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate Epilepsia 46 S5 2005 100 106 (Pubitemid 40962130)
161. L.A. Shapiro, and C.E. Ribak Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses Epilepsy Res 69 2006 53 66
162. A.K. Shetty, and B. Hattiangady Concise review: Prospects of stem cell therapy for temporal lobe epilepsy Stem Cells 25 2007 2396 2407 (Pubitemid 47582732)
163. A.K. Shetty, and D.A. Turner Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study Neuroscience 67 1995 561 582
164. A.K. Shetty, and D.A. Turner Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression J Comp Neurol 363 1995 581 599 (Pubitemid 26028723)
165. A.K. Shetty, and D.A. Turner Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation J Comp Neurol 414 1999 238 254 (Pubitemid 29489905)
166. A.K. Shetty, and D.A. Turner Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy J Neurosci 20 2000 8788 8801
167. A.K. Shetty, and D.A. Turner Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons Exp Neurol 169 2001 276 297 (Pubitemid 32524423)
168. A.K. Shetty, V. Zaman, and G.A. Shetty Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting J Neurochem 87 2003 147 159 (Pubitemid 37210649)
169. A.K. Shetty, M.S. Rao, B. Hattiangady, V. Zaman, and G.A. Shetty Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury J Neurosci Res 78 2004 520 532 (Pubitemid 39536496)
170. A.K. Shetty, V. Zaman, and B. Hattiangady Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy J Neurosci 25 2005 8391 8401 (Pubitemid 41324726)
171. A.K. Shetty, B. Hattiangady, and M.S. Rao Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age J Cell Mol Med 13 2009 2408 2423
172. K.S. Shindler, E. Ventura, M. Dutt, P. Elliott, D.C. Fitzgerald, and A. Rostami Oral resveratrol reduces neuronal damage in a model of multiple sclerosis J Neuroophthalmol 30 2010 328 339
173. U.P. Singh, N.P. Singh, B. Singh, L.J. Hofseth, R.L. Price, and M. Nagarkatti Resveratrol (trans-3,5,4′-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis J Pharmacol Exp Ther 332 2010 829 839
174. R.H. Singleton, H.Q. Yan, W. Fellows-Mayle, and C.E. Dixon Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury J Neurotrauma 27 2010 1091 1099
175. K. Sinha, G. Chaudhary, and Y.K. Gupta Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats Life Sci 71 2002 655 665 (Pubitemid 34628827)
176. J.I. Sirven, and E. Waterhouse Management of status epilepticus Am Fam Physician 68 2003 469 476 (Pubitemid 36962061)
177. C.T. Siwak-Tapp, E. Head, B.A. Muggenburg, N.W. Milgram, and C.W. Cotman Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function Neurobiol Learn Mem 88 2007 249 259 (Pubitemid 47223756)
178. R.S. Sloviter Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy Science 235 1987 73 76 (Pubitemid 17229272)
179. R.S. Sloviter Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy Hippocampus 1 1991 41 66
180. R.S. Sloviter Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats Neurosci Lett 137 1992 91 96
181. R.S. Sloviter, C.A. Zappone, B.D. Harvey, A.V. Bumanglag, R.A. Bender, and M. Frotscher "Dormant basket cell" hypothesis revisited: Relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat J Comp Neurol 459 2003 44 76 (Pubitemid 36348864)
182. H.J. Song, C.F. Stevens, and F.H. Gage Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons Nat Neurosci 5 2002 438 445 (Pubitemid 34454249)
183. G. Sperk, R. Wieser, R. Widmann, and E.A. Singer Kainic acid induced seizures: Changes in somatostatin, substance P and neurotensin Neuroscience 17 1986 1117 1126 (Pubitemid 16080100)
184. T.W. Strine, R. Kobau, D.P. Chapman, D.J. Thurman, P. Price, and L.S. Balluz Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: Results from the 2002 National Health Interview Survey Epilepsia 46 2005 1133 1139 (Pubitemid 40962160)
185. A.Y. Sun, Y.M. Chen, M. James-Kracke, P. Wixom, and Y. Cheng Ethanol-induced cell death by lipid peroxidation in PC12 cells Neurochem Res 22 1997 1187 1192 (Pubitemid 27440785)
186. A.Y. Sun, Q. Wang, A. Simonyi, and G.Y. Sun Resveratrol as a therapeutic agent for neurodegenerative diseases Mol Neurobiol 41 2010 375 383
187. T. Sutula Seizure-induced axonal sprouting: Assessing connections between injury, local circuits, and epileptogenesis Epilepsy Curr 2 2002 86 91
188. T. Sutula, H. Xiao-Xian, J. Cavazos, and G. Scott Synaptic reorganization in the hippocampus induced by abnormal functional activity Science 239 1988 1147 1150 (Pubitemid 18084325)
189. K.W. Thompson Genetically engineered cells with regulatable GABA production can affect afterdischarges and behavioral seizures after transplantation into the dentate gyrus Neuroscience 133 2005 1029 1037 (Pubitemid 40814610)
190. J.P. Tillement In vitro protection of cerebral mitochondrial function by E-resveratrol in anoxia followed by re-oxygenation Bull Acad Natl Med 185 2001 1429 1443
191. G. Tredici, M. Miloso, G. Nicolini, S. Galbiati, G. Cavaletti, and A. Bertelli Resveratrol, map kinases and neuronal cells: Might wine be a neuroprotectant? Drugs Exp Clin Res 25 1999 99 103 (Pubitemid 29257600)
192. D.M. Treiman GABAergic mechanisms in epilepsy Epilepsia 42 Suppl 3 2001 8 12 (Pubitemid 32781374)
193. H. van Praag, A.F. Schinder, B.R. Christie, N. Toni, T.D. Palmer, and F.H. Gage Functional neurogenesis in the adult hippocampus Nature 415 2002 1030 1034 (Pubitemid 34193451)
194. J. Vannest, J.P. Szaflarski, M.D. Privitera, B.K. Schefft, and S.K. Holland Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy Epilepsy Behav 12 2008 410 418
195. R. Vidavalur, H. Otani, P.K. Singal, and N. Maulik Significance of wine and resveratrol in cardiovascular disease: French paradox revisited Exp Clin Cardiol 11 2006 217 225 (Pubitemid 44540866)
196. M. Virgili, and A. Contestabile Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats Neurosci Lett 281 2000 123 126 (Pubitemid 30125880)
197. B. Waldau, B. Hattiangady, R. Kuruba, and A.K. Shetty Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy Stem Cells 28 2010 1153 1164
198. Q. Wang, J. Xu, G.E. Rottinghaus, A. Simonyi, D. Lubahn, and G.Y. Sun Resveratrol protects against global cerebral ischemic injury in gerbils Brain Res 958 2002 439 447 (Pubitemid 35441199)
199. Q. Wang, S. Yu, A. Simonyi, G. Rottinghaus, G.Y. Sun, and A.Y. Sun Resveratrol protects against neurotoxicity induced by kainic acid Neurochem Res 29 2004 2105 2112 (Pubitemid 39663888)
200. L.D. Williams, G.A. Burdock, J.A. Edwards, M. Beck, and J. Bausch Safety studies conducted on high-purity trans-resveratrol in experimental animals Food Chem Toxicol 47 2009 2170 2182
201. A. Williamson, P.R. Patrylo, and D.D. Spencer Decrease in inhibition in dentate granule cells from patients with medial temporal lobe epilepsy Ann Neurol 45 1999 92 99 (Pubitemid 29036437)
202. J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, and M. Tatar Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 2004 686 689 (Pubitemid 39061685)
203. Z. Wu, Q. Xu, L. Zhang, D. Kong, R. Ma, and L. Wang Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats Neurochem Res 34 2009 1393 1400
204. J.-P. Wuarin, and F.E. Dudek Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slice from kainate treated epileptic rats J Neurosci 16 1996 4438 4448 (Pubitemid 26243039)
205. F. Yeung, J.E. Hoberg, C.S. Ramsey, M.D. Keller, D.R. Jones, and R.A. Frye Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J 23 2004 2369 2380 (Pubitemid 38954844)
206. X. Zhang, S.S. Cui, A.E. Wallace, D.K. Hannesson, L.C. Schmued, and D.M. Saucier Relations between brain pathology and temporal lobe epilepsy J Neurosci 22 2002 6052 6061 (Pubitemid 35387648)
207. F. Zhang, J.S. Shi, H. Zhou, B. Wilson, J.S. Hong, and H.M. Gao Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions Mol Pharmacol 78 2010 466 477
208. H. Zhuang, Y.S. Kim, R.C. Koehler, and S. Dore Potential mechanism by which resveratrol, a red wine constituent, protects neurons Ann NY Acad Sci 993 2003 276 286 (Pubitemid 36808455)
209. R. Zini, C. Morin, A. Bertelli, A.A. Bertelli, and J.P. Tillement Effects of resveratrol on the rat brain respiratory chain Drugs Exp Clin Res 25 1999 87 97 (Pubitemid 29257599)
210. R. Zini, C. Morin, A. Bertelli, A.A. Bertelli, and J.P. Tillement Resveratrol-induced limitation of dysfunction of mitochondria isolated from rat brain in an anoxia-reoxygenation model Life Sci 71 2002 3091 3108 (Pubitemid 35284356)