Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats

Epilepsy and Behavior

Volumn 5, Issue 2, 2004, Pages 168-174

  Mikati, Mohamad A ^a,b   Holmes, Gregory L ^c   Werner, Suzanne ^b   Bakkar, Nadine ^a   Carmant, Lionel ^d   Liu, Zhao ^b   Stafstrom, Carl E ^e  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^d UNIVERSITY OF MONTREAL   (Canada)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Kainic acid; Nimodipine; Phenobarbital; Status epilepticus

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; KAINIC ACID DERIVATIVE; NIMODIPINE; PHENOBARBITAL;

ACUTE DISEASE; AGGRESSIVENESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; EPILEPTIC STATE; HYPERACTIVITY; LONG TERM CARE; MAZE TEST; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PERINATAL PERIOD; PREPUBERTY; RAT; RECURRENT DISEASE; SEIZURE; VIDEOTAPE;

EID: 1842687405     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yebeh.2003.12.002     Document Type: Article

References (53)

1. 0 during repetitive electrical stimulation and during pentetrazol induced seizure activity in the sensorimotor cortex of cats. Pflugers Arch 1983;398:310-7.
2. Pumain R, Kurcewicz I, Louvel J. Fast extracellular calcium transients: Involvement in epileptic processes. Science 1983;222:177-9.
3. Berg M, Bruhn T, Frandsen A, Schousboe A, Diemer NH. Kainic acid-induced seizures and brain damage in the rat: Role of calcium homeostasis. J Neurosci Res 1995;40:641-6.
4. 2+ channel antagonist nimodipine, in rat transient focal cerebral ischemia. Eur J Pharmacol 1999;364:99-105.
5. Harkany T, Dijkstra IM, Oosterink BJ, et al. Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine. Neuroscience 2000;101:101-14.
6. Korenkov AI, Pahnke J, Frei K, et al. Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev 2000;23:145-50.
7. Marinho MM, de Bruin VM, de Sousa FC, Aguiar LM, de Pinho RS, Viana GS. Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. Neurosci Lett 1997;235:13-6.
8. Chakrabarti A, Kaur Saini H, Garg SK. Dose-finding study with nimodipine: A selective central nervous system calcium channel blocker on aminophylline induced seizure model in rats. Brain Res Bull 1998;45:495-9.
9. Gasior M, Kaminski R, Brudniak T, Kleinrok Z, Czuczwar SJ. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J Neural Transm Gen Sect 1996;103:819-31.
10. Khosla P, Pandhi P. Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. Methods Find Exp Clin Pharmacol 2000;22:731-6.
11. Nadler JV. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 1981;29:2031-42.
12. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985;14:375-403.
13. Holmes GL, Thompson JL, Marchi T, Feldman DS. Behavioral effects of kainic acid administration on the immature brain. Epilepsia 1988;29:721-30.
14. Pollard H, Charriaut-Marlangue C, Cantagrel S, et al. Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 1994;63:7-18.
15. Stafstrom CE, Thompson JL, Holmes GL. Kainic acid seizures in the developing brain: Status epilepticus and spontaneous recurrent seizures. Brain Res Dev Brain Res 1992;65:227-36.
16. Stafstrom CE, Chronopoulos A, Thurber S, Thompson JL, Holmes GL. Age-dependent cognitive and behavioral deficits after kainic acid seizures. Epilepsia 1993;34:420-32.
17. Mikati MA, Holmes GL, Chronopoulos A, et al. Phenobarbital modifies seizure-related brain injury in the developing brain. Ann Neurol 1994;36:425-33.
18. Kinoshita K, Yamamura M, Matsuoka Y. Ameliorating effect of clentiazem (TA-3090), a new Ca antagonist, on the impaired learning ability of poststroke SHRSP. Pharmacol Biochem Behav 1995;50:509-15.
19. Zhu D, Li R, Liu G, Hua W. Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells. Life Sci 1999;65:PL221-31.
20. Holmes GL, Chronopoulos A, Stafstrom CE, et al. Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. Brain Res Dev Brain Res 1993;73:71-7.
21. Morris RG, Hagan JJ, Rawlins JN. Allocentric spatial learning by hippocamAectomisPd rats: A further test of the "spatial mapping" and "wOrking Temory" theories of hippocampal function. Q J Exp Psychol B 1986;38:365-95.
22. Mikati MA, Abi-Habib RJ, Sabban ME, et al. Hippocampal programmed cell death after status epilepticus: Evidence for NMDA receptor and ceramide mediated mechanisms. Epilepsia 2003;44:282-91.
23. Ben-Ari Y. Cell death and synaptic reorganizations produced by seizures. Epilepsia 2001;42(Suppl. 3):5-7.
24. Bolanos AR, Sarkisian M, Yang Y, et al. Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology 1998;51:41-8.
25. Mikati MA, Werner S, Gatt A, et al. Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Brain Res Dev Brain Res 1999;113:139-42.
26. Meyer FB, Anderson RE, Sundt Jr TM, Sharbrough FW. Selective central nervous system calcium channel blockers: A new class of anticonvulsant agents. Mayo Clin Proc 1986;61:239-47.
27. Popoli P, Pezzola A, Scotti de Carolis A. Effects of calcium antagonist nimodipine on pentylenetetrazole-induced seizures in rats and rabbits. Arch Int Pharmacodyn Ther 1988;292:58-67.
28. Kamal JA, Nadig RS, Joseph T, David J. Effect of calcium channel blockers on experimentally induced seizures in rats. Indian J Exp Biol 1990;28:605-8.
29. Zapater P, Javaloy J, Roman JF, Vidal MT, Horga JF. Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice. Brain Res 1998;796:311-4.
30. Wurpel JN, Iyer S. Calcium channel blockers verapamil and nimodipine inhibit kindling in adult and immature rats. Epilepsia 1994;35:443-9.
31. De Falco FA, Bartiromo U, Majello L, Di Geronimo G, Mundo P. Calcium antagonist nimodipine in intractable epilepsy. Epilepsia 1992;33:343-5.
32. Larkin JG, McKee PJ, Blacklaw J, Thompson GG, Morgan IC, Brodie MJ. Nimodipine in refractory epilepsy: A placebo-controlled, add-on study. Epilepsy Res 1991;9:71-7.
33. Treiman DM, Walton NY, Kendrick C. A progressive sequence of electroencephalographic changes during generalized convulsive status epilepticus. Epilepsy Res 1990;5:49-60.
34. Mikati MA, Werner S, Shehab L, et al. Stages of status epilepticus in the developing brain. Epilepsy Res 2003;55:9-19.
35. Clifford DB, Olney JW, Benz AM, Fuller TA, Zorumski CF. Ketamine, phencyclidine, and MK801 protect against kainic acid-induced seizure related brain damage. Epilepsia 1990;31:382-90.
36. De Sarro GB, De Sarro A, Trimarchi GR, Nistico' G. Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. Gen Pharmacol 1992;23:75-82.
37. Czuczwar SJ, Gasior M, Janusz W, Kleinrok Z. Influence of flunarizine, nicardipine and nimodipine on the anticonvulsant activity of different antiepileptic drugs in mice. Neuropharmacology 1992;31:1179-83.
38. Balakrishnan S, Pandhi P. Effect of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats. Methods Find Exp Clin Pharmacol 1997;19:693-7.
39. Balakrishnan S, Pandhi P, Bhargava VK. Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats. Indian J Exp Biol 1998;36:51-4.
40. Balakrishnan S, Bhargava VK, Pandhi P. Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. Indian J Exp Biol 1999;37:340-3.
41. Zapater P, Moreno J, Horga JF. Neuroprotection by the novel calcium antagonist PCA50938, nimodipine and flunarizine, in gerbil global brain ischemia. Brain Res 1997;772:57-62.
42. Stuiver BT, Douma BR, Bakker R, Nyakas C, Luiten PG. In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: Combined therapy and temporal course of protection. Neurodegeneration 1996;5:153-9.
43. Chua HC, Ng PY. Neuroprotection in acute stroke. Ann Acad Med Singapore 2001;30:134-42.
44. Mervis RF, Kuntz N, Burton D, et al. Structural-functional correlates of neuroprotection in the aging rabbit by a calcium channel blocker: Nimodipine reverses neocortical dendritic atrophy and improves memory retention. Ann NY Acad Sci 1995;765:312-3.
45. Toescu EC, Verkhratsky A. Parameters of calcium homeostasis in normal neuronal ageing. J Anat 2000;197(Pt 4):563-9.
46. Zipfel GJ, Babcock DJ, Lee JM, Choi DW. Neuronal apoptosis after CNS injury: The roles of glutamate and calcium. J Neurotrauma 2000;17:857-69.
47. Makarchuk NE, Bogach PG, Chaichenko GM. Effect of destruction of the basolateral portion and medial nuclei of the amygdaloid complex on defensive conditioned reflexes in rats. Zh Vyssh Nerv Deiat Im I P Pavlova 1981;31:78-85.
48. 3H]PY 108-068. J Neural Transm 1984;60:169-97.
49. Petrosini L, Leggio MG, Molinari M. The cerebellum in the spatial problem solving: A co-star or a guest star? Prog Neurobiol 1998;56:191-210.
50. Good M, Honey RC. Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behav Neurosci 1997;111 :487-93.
51. Kelly KM, Kume A, Albin RL, Macdonald RL. Autoradiography of L-type and N-type calcium channels in aged rat hippocampus, entorhinal cortex, and neocortex. Neurobiol Aging 2001;22: 17-23.
52. Taube JS, Kesslak JP, Cotman CW. Lesions of the rat postsubiculum impair performance on spatial tasks. Behav Neural Biol 1992;57:131-43.
53. Broersen LM, Uylings HB. Visual attention task performance in Wistar and Lister hooded rats: Response inhibition deficits after medial prefrontal cortex lesions. Neuroscience 1999;94: 47-57.