Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats

Journal of Neuroscience

Volumn 16, Issue 14, 1996, Pages 4438-4448

  Wuarin, Jean Pierre ^a   Dudek, F Edward ^a,b  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b Dept of Anatomy and Neurobiology ^*  (United States)

Author keywords

epilepsy; glutamate microstimulation; granule cell; hippocampus; kainic acid; mossy fibers; seizure like bursting; sprouting

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; HIPPOCAMPUS; MOSSY FIBER; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0029937283     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-14-04438.1996     Document Type: Article

References (37)

1. Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31:571-591.
2. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF (1991) Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42:351-363.
3. Ben-Ari Y (1985) Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14:375-403.
4. Christian EP, Dudek FE (1988a) Characteristics of local excitatory circuits studied with glutamate microapplication in the CA3 area of rat hippocampal slices. J Neurophysiol 59:90-109.
5. Christian EP, Dudek FE (1988b) Electrophysiological evidence from glutamate microapplications of local excitatory circuits in the CA1 area of rat hippocampal slices. J Neurophysiol 59:110-123.
6. Cronin J, Obenaus A, Houser CR, Dudek FE (1992) Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers. Brain Res 573:305-310.
7. de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD (1989) Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 495:387-395.
8. Dichter M, Spencer WA (1969a) Penicillin-induced interictal discharges from the cat hippocampus. I. Characteristics and topographical features. J Neurophysiol 32:649-662.
9. Dichter M, Spencer WA (1969b) Penicillin-induced interictal discharges from the cat hippocampus. II. Mechanisms underlying origin and restriction. J Neurophysiol 32:663-687.
10. Franck JE (1993) Cell death, plasticity, and epilepsy: insights provided by experimental models of hippocampal sclerosis. In: Epilepsy, models, mechanisms, and concepts (Schwartzkroin P, ed), pp 281-304. Cambridge: Cambridge UP.
11. Fricke RA, Prince DA (1984) Electrophysiology of dentate gyrus granule cells. J Neurophysiol 51:195-209.
12. Haas HL, Schaerer B, Vosmansky M (1979) A simple perfusion chamber for the study of nervous tissue slices in vitro. J Neurosci Methods 1:323-325.
13. Houser CR (1992) Morphological changes in the dentate gyrus in human lobe epilepsy. In: The dentate gyrus and its role in seizures (Ribak CE, Gall CM, Mody I, eds), pp 223-234. Amsterdam: Elsevier.
14. Knowles WD, Schwartzkroin PA (1981) Local circuit synaptic interactions in hippocampal brain slices. J Neurosci 1:318-322.
15. Korn SJ, Giacchino JL, Chamberlain NL, Dingledine R (1987) Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition. J Neurophysiol 57:325-340.
16. Larner AJ (1995) Axonal sprouting and synaptogenesis in temporal lobe epilepsy: possible pathogenetic and therapeutic roles in neurite growth inhibitory factors. Seizure 4:249-258.
17. Margerison JH, Corsellis JAN (1966) Epilepsy and the temporal lobes: a clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain 89:499-536.
18. Meier CL, Dudek FE (1993) Spontaneous and stimulation-induced synchronized afterdischarges in the isolated CA1 of kainate-treated rats. Soc Neurosci Abstr 33:1464.
19. Meier CL, Obenaus A, Dudek FE (1992) Persistent hyperexcitability in isolated hippocampal CA1 of kainate-lesioned rats. J Neurophysiol 68:2120-2127.
20. Miles R, Wong RKS (1983) Single neurones can initiate synchronized population discharge in the hippocampus. Nature 306:371-373.
21. Miles R, Wong RKS (1986) Excitatory synaptic interactions between CA3 neurones in the guinea-pig hippocampus. J Physiol (Lond) 373:397-418.
22. Miles R, Wong RKS (1987) Inhibitory control of local excitatory circuits in the guinea pig hippocampus. J Physiol (Lond) 388:611-629.
23. Miles R, Wong RKS, Traub RD (1984) Synchronized afterdischarges in the hippocampus: contribution of local synaptic interactions. Neuroscience 12:1179-1189.
24. Nadler JV (1981) Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 29:2031-2042.
25. Nakajima S, Frank JE, Bilkey D, Schwartzkroin PA (1991) Local circuit synaptic interactions between CA1 pyramidal cells and interneurons in the kainate-lesioned hyperexcitable hippocampus. Hippocampus 1:67-78.
26. Prince DA (1985) Physiological mechanisms of focal epileptogenesis. Epilepsia 26:S3-S14.
27. Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294.
28. Represa A, Niquet J, Pollard H, Ben-Ari Y (1994) Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J Neurobiol 26:413-425.
29. Sloviter RS (1992) Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci Lett 137:91-96.
30. Sperk G (1994) Kainic acid seizures in the rat. Prog Neurobiol 42:1-32.
31. Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 26:321-330.
32. Tauck DL, Nadler JV (1985) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci 5:1016-1022.
33. Traub RD, Wong RKS (1981) Penicillin-induced epileptiform activity in the hippocampal slice: a model of synchronization in epilepsy. Neuroscience 6:223-230.
34. Traub RD, Wong RKS (1982) Cellular mechanism of neuronal synchronization in epilepsy. Science 216:745-747.
35. Traynelis SF, Dingledine R (1988) Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J. Neurophysiol. 59:259-276.
36. Wenzel HJ, Wooley CS, Schwartzkroin PA (1995) Kainic acid-induced mossy fiber sprouting and synapse formation in the rat dentate gyrus. Soc Neurosci Abstr 21:1472.
37. Zhang N, Houser CR (1995) Dynorphin immunoreactivity in the dentate gyrus in human temporal lobe epilepsy: an electron microscopic study of reorganized mossy fiber synapses. Soc Neurosci Abstr 21:1962.