Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Virology Journal

Volumn 8, Issue , 2011, Pages

  Revie, Dennis ^a   Salahuddin, Syed Zaki ^b  

^a CALIFORNIA LUTHERAN UNIVERSITY   (United States)

^b California Institute of Molecular Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD81 ANTIGEN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; VIRUS PROTEIN; VIRUS RNA;

5' UNTRANSLATED REGION; ADRENAL GLAND; ANTIGEN EXPRESSION; ATHEROSCLEROSIS; B LYMPHOCYTE; BINDING AFFINITY; BONE MARROW; BRAIN; CADAVER; CARDIOMYOLITIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL TYPE; CENTRAL NERVOUS SYSTEM; CHIMPANZEE; CHRONIC DISEASE; CRYOGLOBULINEMIA; DENDRITIC CELL; FLOW CYTOMETRY; HEART DISEASE; HEMOPHILIA; HEPATIC DUCT; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; LICHEN PLANUS; LIVER; LIVER CELL; LIVER CELL CARCINOMA; LIVER FAILURE; LYMPH NODE; LYMPHOPROLIFERATIVE DISEASE; MACROPHAGE; MIXED INFECTION; MONOCYTE; MOUTH CANCER; MUSCLE; NATURAL KILLER CELL; NERVE; NONHUMAN; OCCULT BLOOD; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SJOEGREN SYNDROME; SKIN; SPECIES IDENTIFICATION; SPLEEN; T LYMPHOCYTE; THYROID GLAND; TISSUE; VIRUS CULTURE; VIRUS DETECTION; VIRUS REPLICATION; CELL LINE; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; PATHOGENICITY; VIROLOGY;

HEPATITIS C VIRUS; RNA VIRUSES;

B-LYMPHOCYTES; CELL LINE; HEPACIVIRUS; HEPATOCYTES; HUMANS; LIVER; MACROPHAGES; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 79960044905     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-346     Document Type: Review

References (214)

1. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. QL Choo G Kuo AJ Weiner LR Overby DW Bradley M Houghton, Science 1989 244 359 362 10.1126/science.2523562 2523562 (Pubitemid 19117877)
2. Genetic organization and diversity of the hepatitis C virus. QL Choo KH Richman JH Han K Berger C Lee C Dong C Gallegos D Coit R Medina-Selby PJ Barr,, et al. Proc Natl Acad Sci USA 1991 88 2451 2455 10.1073/pnas.88.6.2451 1848704 (Pubitemid 21916435)
3. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. D Pavlovic DC Neville O Argaud B Blumberg RA Dwek WB Fischer N Zitzmann, Proc Natl Acad Sci USA 2003 100 6104 6108 10.1073/pnas.1031527100 12719519 (Pubitemid 36576938)
4. Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. JL Walewski TR Keller DD Stump AD Branch, Rna 2001 7 710 721 10.1017/S1355838201010111 11350035 (Pubitemid 32405868)
5. HCV 5' and 3'UTR: When Translation Meets Replication. ST Shi MMC Lai, 2006
6. A novel sequence found at the 3' terminus of hepatitis C virus genome. T Tanaka N Kato MJ Cho K Shimotohno, Biochem Biophys Res Commun 1995 215 744 749 10.1006/bbrc.1995.2526 7488017
7. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. R Misiani P Bellavita D Fenili G Borelli D Marchesi M Massazza G Vendramin B Comotti E Tanzi G Scudeller,, et al. Ann Intern Med 1992 117 573 577 1326246
8. Association between hepatitis C virus and mixed cryoglobulinemia [see comment]. C Ferri F Greco G Longombardo P Palla A Moretti E Marzo A Mazzoni G Pasero S Bombardieri P Highfield,, et al. Clin Exp Rheumatol 1991 9 621 624 1662567
9. Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma: evidence for a pathogenetic role. AL Zignego C Ferri C Giannini L La Civita G Careccia G Longombardo G Bellesi F Caracciolo V Thiers P Gentilini, Arch Virol 1997 142 545 555 10.1007/s007050050100 9349300 (Pubitemid 27161774)
10. A role for hepatitis C virus infection in type II cryoglobulinemia. V Agnello RT Chung LM Kaplan, N Engl J Med 1992 327 1490 1495 10.1056/ NEJM199211193272104 1383822
11. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. G Pozzato C Mazzaro M Crovatto ML Modolo S Ceselli G Mazzi S Sulfaro F Franzin P Tulissi M Moretti,, et al. Blood 1994 84 3047 3053 7949176 (Pubitemid 24328097)
12. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. C Ferri F Caracciolo AL Zignego L La Civita M Monti G Longombardo F Lombardini F Greco E Capochiani A Mazzoni,, et al. Br J Haematol 1994 88 392 394 10.1111/j.1365-2141.1994.tb05036.x 7803287 (Pubitemid 24318191)
13. Incidence and characteristics of non-Hodgkin lymphomas in a multicenter case file of patients with hepatitis C virus-related symptomatic mixed cryoglobulinemias. G Monti P Pioltelli F Saccardo M Campanini M Candela G Cavallero S De Vita C Ferri C Mazzaro S Migliaresi,, et al. Arch Intern Med 2005 165 101 105 10.1001/archinte.165.1.101 15642884 (Pubitemid 40096090)
14. Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study. A Mele A Pulsoni E Bianco P Musto A Szklo MG Sanpaolo E Iannitto A De Renzo B Martino V Liso,, et al. Blood 2003 102 996 999 10.1182/blood-2002-10-3230 12714514 (Pubitemid 36917795)
15. Hepatitis C virus-related lymphoproliferative disorders: an overview. AL Zignego C Giannini C Ferri, World J Gastroenterol 2007 13 2467 2478 17552031 (Pubitemid 46929503)
16. The physical state of the negative strand of hepatitis C virus RNA in serum of patients with chronic hepatitis C. M Shindo AM Di Bisceglie T Akatsuka TL Fong L Scaglione M Donets JH Hoofnagle SM Feinstone, Proc Natl Acad Sci USA 1994 91 8719 8723 10.1073/pnas.91.18.8719 8078948 (Pubitemid 24273736)
17. Hepatitis C Virus entry: the early steps in the viral replication cycle. A Sabahi, Virol J 2009 6 117 10.1186/1743-422X-6-117 19643019
18. The dynamics of hepatitis C virus binding to platelets and 2 mononuclear cell lines. S Hamaia C Li JP Allain, Blood 2001 98 2293 2300 10.1182/blood.V98.8.2293 11588022
19. Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets. E Yamada M Montoya CG Schuettler TP Hickling AW Tarr A Vitelli J Dubuisson AH Patel JK Ball P Borrow, J Gen Virol 2005 86 2507 2512 10.1099/vir.0.81169-0 16099909 (Pubitemid 41167599)
20. Flow cytometric detection of hepatitis C virus antigens in infected peripheral blood leukocytes: binding and entry. MK el-Awady AA Tabll RM Redwan el S Youssef MH Omran F Thakeb M el-Demellawy, World J Gastroenterol 2005 11 5203 5208 16127753 (Pubitemid 41410340)
21. Improved attachment of natural HCV isolate to Daudi cells upon elimination of immune complexes and close pH control. J Quer J Cos P Murillo JI Esteban R Esteban J Guardia, Intervirology 2005 48 285 291 10.1159/000085096 15956795 (Pubitemid 40868961)
22. Interaction of immune complexes isolated from hepatitis C virus-infected individuals with human cell lines. R Marino L Deibis JB De Sanctis NE Bianco F Toro, Med Microbiol Immunol 2005 194 73 80 10.1007/s00430-003-0216-8 14758545 (Pubitemid 40064630)
23. Transmission of human hepatitis C virus from patients in secondary cells for long term culture. D Revie RS Braich D Bayles N Chelyapov R Khan C Geer R Reisman AS Kelley JG Prichard SZ Salahuddin, Virol J 2005 2 37 10.1186/1743-422X-2-37 15840164
24. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. D Rosa S Campagnoli C Moretto E Guenzi L Cousens M Chin C Dong AJ Weiner JY Lau QL Choo,, et al. Proc Natl Acad Sci USA 1996 93 1759 1763 10.1073/pnas.93.5.1759 8700831 (Pubitemid 26079830)
25. Detection of replicative intermediates of hepatitis C viral RNA in liver and serum of patients with chronic hepatitis C. TL Fong M Shindo SM Feinstone JH Hoofnagle AM Di Bisceglie, J Clin Invest 1991 88 1058 1060 10.1172/JCI115368 1653272
26. Hepatitis C virus plus- and minus-strand RNA in hepatocellular carcinoma and adjoining nontumorous liver. N Horiike T Nonaka I Kumamoto K Kajino M Onji Y Ohta, J Med Virol 1993 41 312 315 10.1002/jmv.1890410410 8106865 (Pubitemid 24000228)
27. False detection of negative-strand hepatitis C virus RNA. PH McGuinness GA Bishop GW McCaughan R Trowbridge EJ Gowans, Lancet 1994 343 551 552 10.1016/S0140-6736(94)91509-1 7906802 (Pubitemid 24062315)
28. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR. RE Lanford C Sureau JR Jacob R White TR Fuerst, Virology 1994 202 606 614 10.1006/viro.1994.1381 8030225 (Pubitemid 24254873)
29. Search for hepatitis C virus extrahepatic replication sites in patients with acquired immunodeficiency syndrome: specific detection of negative-strand viral RNA in various tissues. T Laskus M Radkowski LF Wang H Vargas J Rakela, Hepatology 1998 28 1398 1401 10.1002/hep.510280531 9794927 (Pubitemid 28493852)
30. Vertical transmission of HCV is related to maternal peripheral blood mononuclear cell infection. C Azzari M Resti M Moriondo R Ferrari P Lionetti A Vierucci, Blood 2000 96 2045 2048 10979945
31. Injection drug use facilitates hepatitis C virus infection of peripheral blood mononuclear cells. M Resti C Azzari M Moriondo L Betti I Sforzi E Novembre A Vierucci, Clin Infect Dis 2002 35 236 239 10.1086/341302 12115087 (Pubitemid 34800269)
32. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. TN Pham SA MacParland PM Mulrooney H Cooksley NV Naoumov TI Michalak, J Virol 2004 78 5867 5874 10.1128/JVI.78.11.5867-5874.2004 15140984 (Pubitemid 38661674)
33. Ultracentrifugation of serum samples allows detection of hepatitis C virus RNA in patients with occult hepatitis C. J Bartolome JM Lopez-Alcorocho I Castillo E Rodriguez-Inigo JA Quiroga R Palacios V Carreno, J Virol 2007 81 7710 7715 10.1128/JVI.02750-06 17475654 (Pubitemid 47047856)
34. Detection of widespread hepatocyte infection in chronic hepatitis C. V Agnello G Abel GB Knight E Muchmore, Hepatology 1998 28 573 584 10.1002/hep.510280240 9696027 (Pubitemid 28363689)
35. Distribution of markers of hepatitis C virus infection throughout the body. EJ Gowans, Semin Liver Dis 2000 20 85 102 10.1055/s-2000-9503 10895434 (Pubitemid 30421411)
36. Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. I Castillo E Rodriguez-Inigo J Bartolome S de Lucas N Ortiz-Movilla JM Lopez-Alcorocho M Pardo V Carreno, Gut 2005 54 682 685 10.1136/gut.2004.057281 15831916 (Pubitemid 40559255)
37. Evidences of Hepatitis C Virus Replication in Hepatocytes and Peripheral Blood Monocuclear Cells from Patients Negative for Viral RNA in Serum. V Falcán N Acosta-Rivero M Shibayama J Luna-Munoz M Miranda-Sanchez M-C de la Rosa I Menéndez W García B Gra S Duẽas-Carrera,, et al. American Journal of Infectious Diseases 2005 1 34 42
38. Extrahepatic and intrahepatic replication and expression of hepatitis C virus. T Deying Y Daofeng W Weihua X Qin S Shuxian S Peihui L Theilmann, Journal of Huazhong University of Science and Technology - Medical Sciences - 1998 18 149 152
39. Fluorescent "in situ" hybridization of hepatitis C virus RNA in peripheral blood mononuclear cells from patients with chronic hepatitis C. E Rodriguez-Inigo M Casqueiro S Navas J Bartolome M Pardo V Carreno, J Med Virol 2000 60 269 274 10.1002/(SICI)1096-9071(200003)60:3<269::AID-JMV43.0.CO;2-1 10630958 (Pubitemid 30054280)
40. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization. J Moldvay P Deny S Pol C Brechot E Lamas, Blood 1994 83 269 273 8274741 (Pubitemid 24016541)
41. Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. S Pal DG Sullivan S Kim KK Lai J Kae SJ Cotler RL Carithers Jr BL Wood JD Perkins DR Gretch, Gastroenterology 2006 130 1107 1116 10.1053/j.gastro.2005.12.039 16618405
42. Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. S De Vita D Sansonno R Dolcetti G Ferraccioli A Carbone V Cornacchiulo G Santini M Crovatto A Gloghini F Dammacco M Boiocchi, Blood 1995 86 1887 1892 7655017
43. In situ detection of hepatitis C virus RNA in salivary glands. JJ Arrieta E Rodriguez-Inigo N Ortiz-Movilla J Bartolome M Pardo F Manzarbeitia H Oliva DM Macias V Carreno, Am J Pathol 2001 158 259 264 10.1016/S0002-9440(10)63964-8 11141499 (Pubitemid 32096491)
44. Detection of hepatitis C virus replication by In situ hybridization in epithelial cells of anti-hepatitis C virus-positive patients with and without oral lichen planus. JJ Arrieta E Rodriguez-Inigo M Casqueiro J Bartolome F Manzarbeitia M Herrero M Pardo V Carreno, Hepatology 2000 32 97 103 10869295 (Pubitemid 30432372)
45. Determination of hepatitis C virus-infected, monocyte lineage reservoirs in individuals with or without HIV coinfection. G Coquillard BK Patterson, J Infect Dis 2009 200 947 954 10.1086/605476 19678757
46. Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients. D Sansonno AR Iacobelli V Cornacchiulo G Iodice F Dammacco, Clin Exp Immunol 1996 103 414 421 8608640
47. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. S Letendre AD Paulino E Rockenstein A Adame L Crews M Cherner R Heaton R Ellis IP Everall I Grant E Masliah, J Infect Dis 2007 196 361 370 10.1086/519285 17597450 (Pubitemid 47093886)
48. Expression of hepatitis C virus proteins in epithelial intestinal cells in vivo. S Deforges A Evlashev M Perret M Sodoyer S Pouzol JY Scoazec B Bonnaud O Diaz G Paranhos-Baccala V Lotteau P Andre, J Gen Virol 2004 85 2515 2523 10.1099/vir.0.80071-0 15302945 (Pubitemid 39214347)
49. Hepatitis C virus-related proteins in kidney tissue from hepatitis C virus-infected patients with cryoglobulinemic membranoproliferative glomerulonephritis. D Sansonno L Gesualdo C Manno FP Schena F Dammacco, Hepatology 1997 25 1237 1244 10.1002/hep.510250529 9141444 (Pubitemid 27199954)
50. Quantification of hepatitis C virus-infected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction. L Muratori D Gibellini M Lenzi M Cataleta P Muratori MC Morelli FB Bianchi, Blood 1996 88 2768 2774 8839874 (Pubitemid 26327532)
51. Viral dynamics of hepatitis C early after orthotopic liver transplantation: evidence for rapid turnover of serum virions. T Fukumoto T Berg Y Ku WO Bechstein M Knoop HP Lemmens H Lobeck U Hopf P Neuhaus, Hepatology 1996 24 1351 1354 10.1002/hep.510240606 8938160 (Pubitemid 26399029)
52. Second hepatitis C replication compartment indicated by viral dynamics during liver transplantation. H Dahari A Feliu M Garcia-Retortillo X Forns AU Neumann, J Hepatol 2005 42 491 498 10.1016/j.jhep.2004.12.017 15763335 (Pubitemid 40342927)
53. Hepatitis C viral kinetics in plasma and peripheral blood mononuclear cells during pegylated interferon-alpha2a/ribavirin therapy. P Pugnale E Herrmann AU Neumann JM Pawlotsky SW Schalm C Ferrari Y Homburger S Zeuzem F Negro, J Hepatol 2008 48 932 938 10.1016/j.jhep.2008.02.018 18433918
54. Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization. KT Nouri Aria R Sallie D Sangar GJ Alexander H Smith J Byrne B Portmann AL Eddleston R Williams, J Clin Invest 1993 91 2226 2234 10.1172/JCI116449 8387544 (Pubitemid 23141499)
55. Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo. S Pal MC Shuhart L Thomassen SS Emerson T Su N Feuerborn J Kae DR Gretch, J Virol 2006 80 2280 2290 10.1128/JVI.80.5.2280- 2290.2006 16474135 (Pubitemid 43271534)
56. In situ distribution of hepatitis C virus replicative-intermediate RNA in hepatic tissue and its correlation with liver disease. M Chang AP Marquardt BL Wood O Williams SJ Cotler SL Taylor RL Carithers Jr DR Gretch, J Virol 2000 74 944 955 10.1128/JVI.74.2.944-955.2000 10623757 (Pubitemid 30036231)
57. Hepatitis C virus replicates in the liver of patients who have a sustained response to antiviral treatment. I Castillo E Rodriguez-Inigo JM Lopez-Alcorocho M Pardo J Bartolome V Carreno, Clin Infect Dis 2006 43 1277 1283 10.1086/508198 17051492 (Pubitemid 44706453)
58. Hepatitis C virus replicates in the same immune cell subsets in chronic hepatitis C and occult infection. TN Pham D King SA Macparland JS McGrath SB Reddy FR Bursey TI Michalak, Gastroenterology 2008 134 812 822 10.1053/j.gastro.2007.12.011 18243182 (Pubitemid 351312726)
59. Is single-strand conformation polymorphism analysis of the full 5' untranslated region an adequate approach to study hepatitis C virus quasispecies distribution? J Vera-Otarola MI Barria U Leon P Carvallo A Soza M Lopez-Lastra, J Virol 2009 83 9018 9021 10.1128/JVI.00971-09 19553315
60. Differences in hepatitis C virus quasispecies composition between liver, peripheral blood mononuclear cells and plasma. F Maggi C Fornai ML Vatteroni M Giorgi A Morrica M Pistello G Cammarota S Marchi P Ciccorossi A Bionda M Bendinelli, J Gen Virol 1997 78 Pt 7 1521 1525 9225024 (Pubitemid 27343088)
61. Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C. M Radkowski JF Gallegos-Orozco J Jablonska TV Colby B Walewska-Zielecka J Kubicka J Wilkinson D Adair J Rakela T Laskus, Hepatology 2005 41 106 114 10.1002/hep.20518 15619235 (Pubitemid 40066388)
62. Distribution of different hepatitis C virus genotypes in patients with hepatitis C virus infection. F Bokharaei Salim H Keyvani A Amiri F Jahanbakhsh Sefidi R Shakeri F Zamani, World J Gastroenterol 2010 16 2005 2009 10.3748/wjg.v16.i16.2005 20419838
63. Compartmentalization of hepatitis C virus genotypes between plasma and peripheral blood mononuclear cells. AM Roque-Afonso D Ducoulombier G Di Liberto R Kara M Gigou E Dussaix D Samuel C Feray, J Virol 2005 79 6349 6357 10.1128/JVI.79.10.6349-6357.2005 15858018 (Pubitemid 40617238)
64. Comparison of Envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC isolates. MW Welker C Welsch D Ochs WP Hofmann E Herrmann A Piiper RW Hartmann S Zeuzem C Sarrazin B Kronenberger, J Viral Hepat 2011 18 181 192 10.1111/j.1365-2893.2010.01296.x 20367804
65. Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome. G Zehender C De Maddalena F Bernini E Ebranati G Monti P Pioltelli M Galli, J Virol 2005 79 9145 9156 10.1128/JVI.79.14.9145-9156.2005 15994809 (Pubitemid 40934826)
66. Hepatitis C virus superinfection of liver grafts: a detailed analysis of early exclusion of non-dominant virus strains. S Ramirez S Perez-del-Pulgar JA Carrion M Coto-Llerena L Mensa J Dragun JC Garcia-Valdecasas M Navasa X Forns, J Gen Virol 2010 91 1183 1188 10.1099/vir.0.018929-0 20089799
67. Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients. J Vera-Otarola MI Barria U Leon D Marsac P Carvallo A Soza M Lopez-Lastra, J Viral Hepat 2009 16 633 643 10.1111/j.1365-2893.2009.01112.x 19254350
68. Hepatitis C virus RNA in the bone marrow of patients with mixed cryoglobulinemia and in subjects with noncryoglobulinemic chronic hepatitis type C. M Galli G Zehender G Monti M Ballare F Saccardo S Piconi C De Maddalena MC Bertoncelli G Rinaldi F Invernizzi,, et al. J Infect Dis 1995 171 672 675 10.1093/infdis/171.3.672 7876614
69. Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets. AM Roque Afonso J Jiang F Penin C Tareau D Samuel MA Petit H Bismuth E Dussaix C Feray, J Virol 1999 73 9213 9221 10516029 (Pubitemid 29487076)
70. Hepatitis C virus in lymphoid cells of patients coinfected with human immunodeficiency virus type 1: evidence of active replication in monocytes/macrophages and lymphocytes. T Laskus M Radkowski A Piasek M Nowicki A Horban J Cianciara J Rakela, J Infect Dis 2000 181 442 448 10.1086/315283 10669324 (Pubitemid 30131808)
71. Frequent compartmentalization of hepatitis C virus variants in circulating B cells and monocytes. D Ducoulombier AM Roque-Afonso G Di Liberto F Penin R Kara Y Richard E Dussaix C Feray, Hepatology 2004 39 817 825 10.1002/hep.20087 14999702 (Pubitemid 38337663)
72. Infection and dysfunction of circulating blood dendritic cells and their subsets in chronic hepatitis C virus infection. E Tsubouchi SM Akbar N Horiike M Onji, J Gastroenterol 2004 39 754 762 15338369 (Pubitemid 39264144)
73. Evidence of viral replication in circulating dendritic cells during hepatitis C virus infection. N Goutagny A Fatmi V De Ledinghen F Penin P Couzigou G Inchauspe C Bain, J Infect Dis 2003 187 1951 1958 10.1086/375350 12792872 (Pubitemid 36724494)
74. Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues. Y Nagao M Sata S Noguchi T Seno'o M Kinoshita T Kameyama T Ueno, J Oral Pathol Med 2000 29 259 266 10.1034/j.1600-0714.2000.290604.x 10890556 (Pubitemid 30411214)
75. Hepatitis C virus populations in the plasma, peripheral blood mononuclear cells and cerebrospinal fluid of HIV/hepatitis C virus-co-infected patients. S Bagaglio P Cinque S Racca R Pedale MA Grasso A Lazzarin G Morsica, Aids 2005 19 Suppl 3 151 165 10.1097/01.aids.0000192085.87302.39 16251813
76. Clinical and therapeutic implications of hepatitis C virus compartmentalization. G Di Liberto AM Roque-Afonso R Kara D Ducoulombier G Fallot D Samuel C Feray, Gastroenterology 2006 131 76 84 10.1053/j.gastro.2006. 04.016 16831592 (Pubitemid 44015750)
77. Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells. J Laporte C Bain P Maurel G Inchauspe H Agut A Cahour, Blood 2003 101 52 57 10.1182/blood-2002-03-0818 12393733 (Pubitemid 36025886)
78. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. C Bain A Fatmi F Zoulim JP Zarski C Trepo G Inchauspe, Gastroenterology 2001 120 512 524 10.1053/gast.2001.21212 11159892 (Pubitemid 32147649)
79. Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants. DM Forton P Karayiannis N Mahmud SD Taylor-Robinson HC Thomas, J Virol 2004 78 5170 5183 10.1128/JVI.78.10.5170- 5183.2004 15113899 (Pubitemid 38581469)
80. Clinicopathologic correlates of hepatitis C virus in brain: a pilot study. J Murray SL Fishman E Ryan FJ Eng JL Walewski AD Branch S Morgello, J Neurovirol 2008 14 17 27 10.1080/13550280701708427 18300072 (Pubitemid 351314970)
81. Molecular and bioinformatic evidence of hepatitis C virus evolution in brain. SL Fishman JM Murray FJ Eng JL Walewski S Morgello AD Branch, J Infect Dis 2008 197 597 607 10.1086/526519 18275278 (Pubitemid 351321539)
82. Detection and analysis of hepatitis C virus sequences in cerebrospinal fluid. T Laskus M Radkowski A Bednarska J Wilkinson D Adair M Nowicki GB Nikolopoulou H Vargas J Rakela, J Virol 2002 76 10064 10068 10.1128/JVI.76.19. 10064-10068.2002 12208987 (Pubitemid 35006549)
83. Detection and quasispecies analysis of hepatitis C virus in the cerebrospinal fluid of infected patients. F Maggi M Giorgi C Fornai A Morrica ML Vatteroni M Pistello G Siciliano A Nuccorini M Bendinelli, J Neurovirol 1999 5 319 323 10.3109/13550289909015819 10414523 (Pubitemid 29329107)
84. Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. M Radkowski J Wilkinson M Nowicki D Adair H Vargas C Ingui J Rakela T Laskus, J Virol 2002 76 600 608 10.1128/JVI.76.2.600-608.2002 11752151 (Pubitemid 34033359)
85. Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation. HE Vargas T Laskus M Radkowski J Wilkinson V Balan DD Douglas ME Harrison DC Mulligan K Olden D Adair J Rakela, Liver Transpl 2002 8 1014 1019 10.1053/jlts.2002.36393 12424714 (Pubitemid 35363627)
86. Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions. B Cabot JI Esteban M Martell J Genesca V Vargas R Esteban J Guardia J Gomez, J Virol 1997 71 1732 1734 8995709 (Pubitemid 27030358)
87. Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver. B Cabot M Martell JI Esteban S Sauleda T Otero R Esteban J Guardia J Gomez, J Virol 2000 74 805 811 10.1128/JVI.74.2.805-811.2000 10623742 (Pubitemid 30036216)
88. Longitudinal evaluation of the structure of replicating and circulating hepatitis C virus quasispecies in nonprogressive chronic hepatitis C patients. B Cabot M Martell JI Esteban M Piron T Otero R Esteban J Guardia J Gomez, J Virol 2001 75 12005 12013 10.1128/JVI.75.24.12005-12013.2001 11711591 (Pubitemid 33115873)
89. Differences between hepatitis C virus 5' untranslated region quasispecies in serum and liver. SJ Jang LF Wang M Radkowski J Rakela T Laskus, J Gen Virol 1999 80 Pt 3 711 716 10092011 (Pubitemid 29101226)
90. Presence of hepatitis C virus (HCV) RNA in the genital tracts of HCV/HIV-1-coinfected women. MJ Nowicki T Laskus G Nikolopoulou M Radkowski J Wilkinson WB Du J Rakela A Kovacs, J Infect Dis 2005 192 1557 1565 10.1086/491742 16206070 (Pubitemid 41504691)
91. Possible compartmentalization of hepatitis C viral replication in the genital tract of HIV-1-coinfected women. C Minosse S Calcaterra I Abbate M Selleri MS Zaniratti MR Capobianchi, J Infect Dis 2006 194 1529 1536 10.1086/508889 17083037 (Pubitemid 44851894)
92. Hepatitis C virus in the semen of men coinfected with HIV-1: prevalence and origin. A Briat E Dulioust J Galimand H Fontaine ML Chaix H Letur-Konirsch S Pol P Jouannet C Rouzioux M Leruez-Ville, Aids 2005 19 1827 1835 10.1097/01.aids.0000189847.98569.2d 16227790 (Pubitemid 41546601)
93. Temporal Variations in the Hepatitis C Virus Intrahost Population during Chronic Infection. S Ramachandran DS Campo ZE Dimitrova GL Xia MA Purdy YE Khudyakov, J Virol 85 6369 6380
94. Detection of intrahepatic hepatitis C virus replication by strand-specific semi-quantitative RT-PCR: preliminary application to the liver transplantation model. F Negro E Giostra K Krawczynski R Quadri L Rubbia-Brandt G Mentha G Colucci L Perrin A Hadengue, J Hepatol 1998 29 1 11 10.1016/S0168-8278(98)80172-4 9696486 (Pubitemid 28307977)
95. Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance. L Lin L Libbrecht J Verbeeck C Verslype T Roskams J van Pelt M Van Ranst J Fevery, J Med Virol 2009 81 1569 1575 10.1002/jmv.21510 19626615
96. Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells. H Lerat F Berby MA Trabaud O Vidalin M Major C Trepo G Inchauspe, J Clin Invest 1996 97 845 851 10.1172/JCI118485 8609243 (Pubitemid 26057104)
97. Hepatitis C virus in peripheral blood mononuclear cells from a chronically infected patient receiving liver graft from infected donor. M Radkowski LF Wang H Vargas J Rakela T Laskus, Transplantation 1999 67 627 629 10.1097/00007890-199902270-00023 10071038 (Pubitemid 29114229)
98. The origin of hepatitis C virus reinfecting transplanted livers: serum-derived versus peripheral blood mononuclear cell-derived virus. T Laskus M Radkowski J Wilkinson H Vargas J Rakela, J Infect Dis 2002 185 417 421 10.1086/338635 11865392 (Pubitemid 34142802)
99. Frequent compartmentalization of hepatitis C virus with leukocyte-related amino acids in the setting of liver transplantation. F Schramm E Soulier C Royer T Weitten S Fafi-Kremer N Brignon N Meyer B Ellero ML Woehl-Jaegle C Meyer,, et al. J Infect Dis 2008 198 1656 1666 10.1086/592986 18925843
100. Hepatitis C virus compartmentalization and infection recurrence after liver transplantation. S Ramirez S Perez-Del-Pulgar JA Carrion J Costa P Gonzalez A Massaguer C Fondevila JC Garcia-Valdecasas M Navasa X Forns, Am J Transplant 2009 9 1591 1601 10.1111/j.1600-6143.2009.02666.x 19459796
101. Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation. H Li DG Sullivan N Feuerborn S McArdle K Bekele S Pal M Yeh RL Carithers JD Perkins DR Gretch, Virology 2010 402 248 255 10.1016/j.virol.2010.03.040 20400171
102. Comparative analysis of translation efficiencies of hepatitis C virus 5' untranslated regions among intraindividual quasispecies present in chronic infection: opposite behaviors depending on cell type. J Laporte I Malet T Andrieu V Thibault JJ Toulme C Wychowski JM Pawlotsky JM Huraux H Agut A Cahour, J Virol 2000 74 10827 10833 10.1128/JVI.74.22.10827-10833.2000 11044132
103. Occult infection of peripheral B cells by hepatitis C variants which have low translational efficiency in cultured hepatocytes. T Durand G Di Liberto H Colman A Cammas S Boni P Marcellin A Cahour S Vagner C Feray, Gut 2010 59 934 942 10.1136/gut.2009.192088 20442199
104. Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons. JT Blackard L Smeaton Y Hiasa N Horiike M Onji DJ Jamieson I Rodriguez KH Mayer RT Chung, J Infect Dis 2005 192 258 265 10.1086/430949 15962220 (Pubitemid 40993395)
105. Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. JT Blackard Y Hiasa L Smeaton DJ Jamieson I Rodriguez KH Mayer RT Chung, J Infect Dis 2007 195 1765 1773 10.1086/518251 17492592 (Pubitemid 46870249)
106. Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus. H Toyoda Y Fukuda Y Koyama J Takamatsu H Saito T Hayakawa, J Hepatol 1997 26 975 982 10.1016/S0168-8278(97)80105-5 9186827 (Pubitemid 27242586)
107. Within-host dynamics of the hepatitis C virus quasispecies population in HIV-1/HCV coinfected patients. F Bernini E Ebranati C De Maddalena R Shkjezi L Milazzo A Lo Presti M Ciccozzi M Galli G Zehender, PLoS One 6 16551
108. Detection and distribution of hepatitis C-specific antigens in naturally infected liver. K Blight RR Lesniewski JT LaBrooy EJ Gowans, Hepatology 1994 20 553 557 7521312 (Pubitemid 24271260)
109. Leukocytes are the major target of hepatitis C virus infection: Possible mechanism of multiorgan involvement including the heart. A Matsumori M Shimada T Obata, CVD Prevention and Control 2010 5 51 58 10.1016/j.cvdpc.2010.04.005
110. In vitro infection of peripheral blood mononuclear cells by hepatitis C virus. B Cribier C Schmitt A Bingen A Kirn F Keller, J Gen Virol 1995 76 Pt 10 2485 2491 7595352
111. Divergent evolution of hepatitis C virus in liver and peripheral blood mononuclear cells of infected patients. F Maggi C Fornai A Morrica ML Vatteroni M Giorgi S Marchi P Ciccorossi M Bendinelli M Pistello, J Med Virol 1999 57 57 63 10.1002/(SICI)1096-9071(199901)57:1<57::AID-JMV83.0.CO;2-R 9890422 (Pubitemid 28553380)
112. Cell type-specific enhancement of hepatitis C virus internal ribosome entry site-directed translation due to 5' nontranslated region substitutions selected during passage of virus in lymphoblastoid cells. H Lerat Y Shimizu S Lemon, J Virol 2000 74 7024 7031 10.1128/JVI.74.15.7024-7031.2000 10888641 (Pubitemid 30470685)
113. Replication of hepatitis C virus in B lymphocytes (CD19+). G Morsica G Tambussi G Sitia R Novati A Lazzarin L Lopalco S Mukenge, Blood 1999 94 1138 1139 10454799 (Pubitemid 29361849)
114. HCV recovery from peripheral blood mononuclear cell culture supernatants derived from HCV-HIV co-infected haemophilic patients with undetectable HCV viraemia. P Bare I Massud L Belmonte M Corti M Villafane R Perez Bianco M de Tezanos-pinto MM de Bracco B Ruibal-Ares, Haemophilia 2003 9 598 604 10.1046/j.1365-2516.2003.00808.x 14511301 (Pubitemid 37236097)
115. Continuous release of hepatitis C virus (HCV) by peripheral blood mononuclear cells and B-lymphoblastoid cell-line cultures derived from HCV-infected patients. P Bare I Massud C Parodi L Belmonte G Garcia MC Nebel M Corti MT Pinto RP Bianco MM Bracco,, et al. J Gen Virol 2005 86 1717 1727 10.1099/vir.0.80882-0 15914850 (Pubitemid 40766884)
116. Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. YK Shimizu A Iwamoto M Hijikata RH Purcell H Yoshikura, Proc Natl Acad Sci USA 1992 89 5477 5481 10.1073/pnas.89.12.5477 1319062
117. Susceptibility of human T-lymphotropic virus type I infected cell line MT-2 to hepatitis C virus infection. N Kato T Nakazawa T Mizutani K Shimotohno, Biochem Biophys Res Commun 1995 206 863 869 10.1006/bbrc.1995.1123 7832798
118. Characterization of hepatitis C virus replication in cloned cells obtained from a human T-cell leukemia virus type 1-infected cell line, MT-2. T Mizutani N Kato S Saito M Ikeda K Sugiyama K Shimotohno, J Virol 1996 70 7219 7223 8794370 (Pubitemid 26307440)
119. Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes. M Ikeda N Kato T Mizutani K Sugiyama K Tanaka K Shimotohno, J Hepatol 1997 27 445 454 10.1016/S0168-8278(97)80347-9 9314120 (Pubitemid 27390890)
120. Infection of primary human macrophages with hepatitis C virus in vitro: induction of tumour necrosis factor-alpha and interleukin 8. M Radkowski A Bednarska A Horban J Stanczak J Wilkinson DM Adair M Nowicki J Rakela T Laskus, J Gen Virol 2004 85 47 59 10.1099/vir.0.19491-0 14718619 (Pubitemid 38128869)
121. Human immunodeficiency virus facilitates infection/replication of
122. Study of the infection of human blood derived monocyte/macrophages with hepatitis C virus in vitro. C Caussin-Schwemling C Schmitt F Stoll-Keller, J Med Virol 2001 65 14 22 10.1002/jmv.1095 11505438
123. A study of susceptibility of primary human Kupffer cells to hepatitis C virus. C Royer AM Steffan MC Navas A Fuchs D Jaeck F Stoll-Keller, J Hepatol 2003 38 250 256 12586289 (Pubitemid 36286536)
124. Ultrastructural observations in hepatitis C virus-infected lymphoid cells. A Steffan P Marianneau C Caussin-Schwemling C Royer C Schmitt D Jaeck P Wolf J Gendrault F Stoll-Keller, Microbes Infect 2001 3 193 202 10.1016/S1286-4579(01)01369-7 11358713 (Pubitemid 32453147)
125. Dendritic cell susceptibility to hepatitis C virus genotype 1 infection. MC Navas A Fuchs E Schvoerer A Bohbot AM Aubertin F Stoll-Keller, J Med Virol 2002 67 152 161 10.1002/jmv.2204 11992576 (Pubitemid 34493429)
126. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. V Lohmann F Korner J Koch U Herian L Theilmann R Bartenschlager, Science 1999 285 110 113 10.1126/science.285.5424.110 10390360 (Pubitemid 29307577)
127. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. T Wakita T Pietschmann T Kato T Date M Miyamoto Z Zhao K Murthy A Habermann H Krausslich M Mizokami,, et al. Nat Med 2005 11 791 796 10.1038/nm1268 15951748 (Pubitemid 41021213)
128. Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells. S Marukian CT Jones L Andrus MJ Evans KD Ritola ED Charles CM Rice LB Dustin, Hepatology 2008 48 1843 1850 10.1002/hep.22550 19003912
129. Huh-7: a human "hemochromatotic" cell line. C Vecchi G Montosi A Pietrangelo, Hepatology 51 654 659
130. Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. A Palagyi K Neveling U Plinninger A Ziesch BS Targosz GU Denk S Ochs A Rizzani D Meier WE Thasler,, et al. Mol Cancer 9 127
131. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. R Sumpter Jr YM Loo E Foy K Li M Yoneyama T Fujita SM Lemon M Gale Jr, J Virol 2005 79 2689 2699 10.1128/JVI.79.5.2689-2699.2005 15708988 (Pubitemid 40270547)
132. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. V Sung S Shimodaira A Doughty G Picchio H Can T Yen K Lindsay A Levine M Lai, J Virol 2003 77 2134 2146 10.1128/JVI.77.3.2134-2146.2003 12525648 (Pubitemid 36110026)
133. Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines. Y Kondo VM Sung K Machida M Liu MM Lai, Virology 2007 361 161 173 10.1016/j.virol.2006.11.009 17175001 (Pubitemid 46551226)
134. Lymphotropic HCV strain can infect human primary naive CD4(+) cells and affect their proliferation and IFN-gamma secretion activity. Y Kondo Y Ueno E Kakazu K Kobayashi M Shiina K Tamai K Machida J Inoue Y Wakui K Fukushima,, et al. J Gastroenterol 2011 46 232 241 10.1007/s00535-010-0297-2 20714907
135. Detection of a 5' UTR variation in the HCV genome after a long-term in vitro infection. MB Valli L Bertolini S Iacovacci A Ponzetto G Carloni, Res Virol 1995 146 285 288 10.1016/0923-2516(96)80573-5 8539491
136. Ultrastructural observations of viral particles within hepatitis C virus-infected human B lymphoblastoid cell line. A Serafino MB Valli A Alessandrini A Ponzetto G Carloni L Bertolini, Res Virol 1997 148 153 159 10.1016/S0923-2516(97)89902-5 9108618 (Pubitemid 27162810)
137. Transmission in vitro of hepatitis C virus from persistently infected human B-cells to hepatoma cells by cell-to-cell contact. MB Valli A Serafino A Crema L Bertolini A Manzin G Lanzilli C Bosman S Iacovacci S Giunta A Ponzetto,, et al. J Med Virol 2006 78 192 201 10.1002/jmv.20527 16372297 (Pubitemid 43132563)
138. Molecular and cellular determinants of cell-to-cell transmission of HCV in vitro. MB Valli A Crema G Lanzilli A Serafino L Bertolini G Ravagnan A Ponzetto S Menzo M Clementi G Carloni, J Med Virol 2007 79 1491 1499 10.1002/jmv.20947 17705190 (Pubitemid 47328738)
139. Suggested role of the Golgi apparatus and endoplasmic reticulum for crucial sites of hepatitis C virus replication in human lymphoblastoid cells infected in vitro. A Serafino MB Valli F Andreola A Crema G Ravagnan L Bertolini G Carloni, J Med Virol 2003 70 31 41 10.1002/jmv.10367 12629641 (Pubitemid 36368862)
140. De novo infection and propagation of wild-type Hepatitis C virus in human T lymphocytes in vitro. SA MacParland TN Pham SA Gujar TI Michalak, J Gen Virol 2006 87 3577 3586 10.1099/vir.0.81868-0 17098973 (Pubitemid 44816991)
141. Hepatitis C virus persisting after clinically apparent sustained virological response to antiviral therapy retains infectivity in vitro. SA MacParland TN Pham CS Guy TI Michalak, Hepatology 2009 49 1431 1441 10.1002/hep.22802 19177592
142. Establishment of long-term monocyte suspension cultures from normal human peripheral blood. SZ Salahuddin PD Markham RC Gallo, J Exp Med 1982 155 1842 1857 10.1084/jem.155.6.1842 6804592 (Pubitemid 12074219)
143. Analysis of in vitro replicated human hepatitis C virus (HCV) for the determination of genotypes and quasispecies. D Revie MO Alberti RS Braich N Chelyapov D Bayles JG Prichard SZ Salahuddin, Virol J 2006 3 81 10.1186/1743-422X-3-81 17010197
144. Discovery of significant variants containing large deletions in the 5'UTR of human hepatitis C virus (HCV). D Revie MO Alberti RS Braich D Bayles JG Prichard SZ Salahuddin, Virol J 2006 3 82 10.1186/1743-422X-3-82 17010198
145. Analysis of the 5'UTR of HCV genotype 3 grown in vitro in human B cells, T cells, and macrophages. D Revie MO Alberti JG Prichard AS Kelley SZ Salahuddin, Virol J 2010 7 155 10.1186/1743-422X-7-155 20626910
146. The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell. SZ Salahuddin KA Snyder A Godwin R Grewal JG Prichard AS Kelley D Revie, Virol J 2007 4 106 10.1186/1743-422X-4-106 17958914
147. Dynamics of hepatitis C virus replication in human liver. M Chang O Williams J Mittler A Quintanilla RL Carithers Jr J Perkins L Corey DR Gretch, Am J Pathol 2003 163 433 444 10.1016/S0002-9440(10)63673-5 12875965 (Pubitemid 36909407)
148. Hepatitis C virus-RNAs in plasma and in peripheral blood mononuclear cells of hemophiliacs with chronic hepatitis C: evidence for viral replication in peripheral blood mononuclear cells. M Willems K Peerlinck H Moshage I Deleu C Van Den Eynde J Vermylen SH Yap, J Med Virol 1994 42 272 278 10.1002/jmv.1890420314 7516421 (Pubitemid 24131397)
149. Peripheral mononuclear cells of haemophiliacs with chronic liver disease are infected with replicating hepatitis C virus. C Henin M Makris J Brown IR Peake EF Preston, Br J Haematol 1994 87 215 217 10.1111/j.1365-2141.1994. tb04898.x 7947252 (Pubitemid 24207027)
150. HCV in peripheral blood mononuclear cells are predominantly carried on the surface of cells in HIV/HCV co-infected individuals. V Natarajan S Kottilil A Hazen J Adelsberger AA Murphy MA Polis JA Kovacs, J Med Virol 2010 82 2032 2037 10.1002/jmv.21906 20981790
151. Hepatitis C virus RNA in plasma and blood mononuclear cells in patients with chronic hepatitis C treated with alpha-interferon. A Ounanian N Gueddah A Rolachon MA Thelu JP Zarski JM Seigneurin, J Med Virol 1995 45 141 145 10.1002/jmv.1890450205 7775931
152. Replication of hepatitis C virus in peripheral blood mononuclear cells. Effect of alpha-interferon therapy. C Qian J Camps MD Maluenda MP Civeira J Prieto, J Hepatol 1992 16 380 383 10.1016/S0168-8278(05)80674-9 1336787 (Pubitemid 23013235)
153. Active hepatitis C virus infection in bone marrow and peripheral blood mononuclear cells from patients with mixed cryoglobulinaemia. A Gabrielli A Manzin M Candela ML Caniglia S Paolucci MG Danieli M Clementi, Clin Exp Immunol 1994 97 87 93 8033425 (Pubitemid 24244060)
154. Detection of hepatitis C virus RNA sequences in B-cell non-Hodgkin lymphoma. SJ Karavattathayyil G Kalkeri HJ Liu P Gaglio RF Garry JR Krause S Dash, Am J Clin Pathol 2000 113 391 398 10.1309/REV9-FDTM-5NGC-HBWY 10705820 (Pubitemid 30217387)
155. Detection of plus and minus HCV RNA in normal liver of anti-HCV-positive patients. S Navas I Castillo V Carreno, Lancet 1993 341 904 905 8096611 (Pubitemid 23094557)
156. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. P Bouffard PH Hayashi R Acevedo N Levy JB Zeldis, J Infect Dis 1992 166 1276 1280 10.1093/infdis/166.6. 1276 1385547
157. HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-alpha. HF Lohr B Goergen KH Meyer zum Buschenfelde G Gerken, J Med Virol 1995 46 314 320 10.1002/jmv.1890460405 7595407
158. Presence of hepatitis C virus (HCV) genomic RNA and viral replicative intermediates in bone marrow and peripheral blood mononuclear cells from HCV-infected patients. A Manzin M Candela S Paolucci ML Caniglia A Gabrielli M Clementi, Clin Diagn Lab Immunol 1994 1 160 163 7496938 (Pubitemid 2057599)
159. B-lymphocytes are predominantly involved in viral propagation of hepatitis C virus (HCV). HM Muller B Kallinowski C Solbach L Theilmann T Goeser E Pfaff, Arch Virol Suppl 1994 9 307 316 8032262
160. Peripheral blood leukocytes serve as a possible extrahepatic site for hepatitis C virus replication. HM Muller E Pfaff T Goeser B Kallinowski C Solbach L Theilmann, J Gen Virol 1993 74 Pt 4 669 676 8385695 (Pubitemid 23113370)
161. Presence of viral replicative intermediates in the liver and serum of patients infected with hepatitis C virus. AH Sherker JS Twu GR Reyes WS Robinson, J Med Virol 1993 39 91 96 10.1002/jmv.1890390203 8387574 (Pubitemid 23062355)
162. Peripheral blood neutrophils from hepatitis C virus-infected patients are replication sites of the virus. M Crovatto G Pozzato F Zorat E Pussini F Nascimben S Baracetti MG Grando C Mazzaro M Reitano ML Modolo,, et al. Haematologica 2000 85 356 361 10756359 (Pubitemid 30318507)
163. Infection of peripheral mononuclear blood cells by hepatitis C virus. AL Zignego D Macchia M Monti V Thiers M Mazzetti M Foschi E Maggi S Romagnani P Gentilini C Brechot, J Hepatol 1992 15 382 386 1332999
164. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. TT Chang KC Young YJ Yang HY Lei HL Wu, Hepatology 1996 23 977 981 10.1002/hep.510230506 8621178
165. HCV replication in PBMC and its influence on interferon therapy. GZ Gong LY Lai YF Jiang Y He XS Su, World J Gastroenterol 2003 9 291 294 12532451 (Pubitemid 36215807)
166. In vivo tropism of hepatitis C virus genomic sequences in hematopoietic cells: influence of viral load, viral genotype, and cell phenotype. H Lerat S Rumin F Habersetzer F Berby MA Trabaud C Trepo G Inchauspe, Blood 1998 91 3841 3849 9573022 (Pubitemid 28225753)
167. Hepatitis C virus RNA in peripheral blood mononuclear cells: relation with response to interferon treatment. G Taliani C Badolato R Lecce G Poliandri A Bozza F Duca C Pasquazzi C Clementi C Furlan C De Bac, J Med Virol 1995 47 16 22 10.1002/jmv.1890470105 8551253
168. Hepatitis C virus replication in liver and peripheral blood mononuclear cells of interferon-alpha-treated and untreated patients with chronic hepatitis C. ZB Yun A Sonnerborg O Weiland, Scand J Gastroenterol 1994 29 82 86 10.3109/00365529409090442 8128182 (Pubitemid 24027427)
169. Testing for hepatitis C virus sequences in peripheral blood mononuclear cells of patients with chronic hepatitis C in the absence of serum hepatitis C virus RNA. L Muratori F Giostra M Cataleta R Francesconi G Ballardini F Cassani M Lenzi FB Bianchi, Liver 1994 14 124 128 8078391 (Pubitemid 24221767)
170. Detection of genomic viral RNA in nerve and muscle of patients with HCV neuropathy. FJ Authier G Bassez C Payan L Guillevin JM Pawlotsky JD Degos RK Gherardi L Belec, Neurology 2003 60 808 812 12629238 (Pubitemid 36297365)
171. Specific detection of positive and negative stranded hepatitis C viral RNA using chemical RNA modification. T Gunji N Kato M Hijikata K Hayashi S Saitoh K Shimotohno, Arch Virol 1994 134 293 302 10.1007/BF01310568 7510473 (Pubitemid 2053383)
172. Positive and negative strand of hepatitis C virus RNA sequences in peripheral blood mononuclear cells in patients with chronic hepatitis C: no correlation with viral genotypes 1b, 2a, and 2b. JH Kao PJ Chen MY Lai TH Wang DS Chen, J Med Virol 1997 52 270 274 10.1002/(SICI)1096-9071(199707)52:3<270: :AID-JMV63.0.CO;2-# 9210035 (Pubitemid 27305745)
173. Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells. JT Wang JC Sheu JT Lin TH Wang DS Chen, J Infect Dis 1992 166 1167 1169 10.1093/infdis/166.5.1167 1328405
174. Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes. M Artini R Nisini G Missale A Costanzo D Accapezzato C Balsano V Barnaba M Levrero, Viral Immunol 1995 8 63 73 10.1089/vim.1995.8.63 8825291 (Pubitemid 26025306)
175. A novel strand-specific RT-PCR for detection of hepatitis C virus negative-strand RNA (replicative intermediate): evidence of absence or very low level of HCV replication in peripheral blood mononuclear cells. L Lin J Fevery S Hiem Yap, J Virol Methods 2002 100 97 105 10.1016/S0166-0934(01)00399-8 11742656 (Pubitemid 34003628)
176. Low level or absent in vivo replication of hepatitis C virus and hepatitis G virus/GB virus C in peripheral blood mononuclear cells. J Mellor G Haydon C Blair W Livingstone P Simmonds, J Gen Virol 1998 79 Pt 4 705 714 9568964 (Pubitemid 28161943)
177. A reevaluation of the association of hepatitis C virus replicative intermediates with peripheral blood cells including granulocytes by a tagged reverse transcription/polymerase chain reaction technique. S Mihm H Hartmann G Ramadori, J Hepatol 1996 24 491 497 10.1016/S0168-8278(96)80171-1 8738737
178. Detection of negative-stranded hepatitis C virus RNA using a novel strand-specific reverse transcription-polymerase chain reaction. T Mizutani M Ikeda S Saito K Sugiyama K Shimotohno N Kato, Virus Res 1998 53 209 214 10.1016/S0168-1702(97)00150-0 9620212 (Pubitemid 28127857)
179. Positive and negative hepatitis C virus RNA strands in serum, liver and peripheral blood mononuclear cells in anti-HCV patients: relation with the liver lesion. S Navas I Castillo J Bartolome E Marriott M Herrero V Carreno, J Hepatol 1994 21 182 186 10.1016/S0168-8278(05)80392-7 7989707 (Pubitemid 24270542)
180. Characterization of the genome and structural proteins of hepatitis C virus resolved from infected human liver. SU Nielsen MF Bassendine AD Burt DJ Bevitt GL Toms, J Gen Virol 2004 85 1497 1507 10.1099/vir.0.79967-0 15166434 (Pubitemid 38807747)
181. Detection of the minus strand of hepatitis C virus RNA by reverse transcription and polymerase chain reaction: implications for hepatitis C virus replication in infected tissue. T Takehara N Hayashi E Mita H Hagiwara K Ueda K Katayama A Kasahara H Fusamoto T Kamada, Hepatology 1992 15 387 390 1312054
182. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. T Laskus EA Operskalski M Radkowski J Wilkinson WJ Mack M deGiacomo L Al-Harthi Z Chen J Xu A Kovacs, J Infect Dis 2007 195 124 133 10.1086/509897 17152016 (Pubitemid 44958234)
183. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. RE Lanford D Chavez FV Chisari C Sureau, J Virol 1995 69 8079 8083 7494326
184. Hepatitis C virus RNA localization in human carotid plaques. M Boddi R Abbate B Chellini B Giusti C Giannini G Pratesi L Rossi C Pratesi GF Gensini L Paperetti AL Zignego, J Clin Virol 2010 47 72 75 10.1016/j.jcv.2009.10.005 19896417
185. Analysis of hepatitis C virus (HCV) RNA in the lesions of lichen planus in patients with chronic hepatitis C: detection of anti-genomic- as well as genomic-strand HCV RNAs in lichen planus lesions. M Kurokawa T Hidaka H Sasaki I Nishikata K Morishita M Setoyama, J Dermatol Sci 2003 32 65 70 10.1016/S0923-1811(03)00049-5 12788531 (Pubitemid 36683049)
186. Lack of hepatitis C virus replication intermediate RNA in diseased skin tissue of chronic hepatitis C patients. A Mangia A Andriulli P Zenarola M Lomuto I Cascavilla R Quadri F Negro, J Med Virol 1999 59 277 280 10.1002/(SICI)1096- 9071(199911)59:3<277::AID-JMV33.0.CO;2-E 10502256 (Pubitemid 29468066)
187. Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C. M Inokuchi T Ito M Uchikoshi Y Shimozuma K Morikawa H Nozawa T Shimazaki K Hiroishi Y Miyakawa M Imawari, J Med Virol 2009 81 619 627 10.1002/jmv.21388 19235854
188. Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia. D Sansonno FA Tucci G Lauletta V De Re M Montrone L Troiani L Sansonno F Dammacco, Clin Exp Immunol 2007 147 241 248 17223964 (Pubitemid 46096001)
189. Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV RNA-negative patients with normal alanine aminotransferase levels. V Carreno M Pardo JM Lopez-Alcorocho E Rodriguez-Inigo J Bartolome I Castillo, J Infect Dis 2006 194 53 60 10.1086/504692 16741882
190. Analysis of B-lymphocyte differentiation in patients infected with hepatitis C virus. A Fournillier D Freida T Defrance P Merle C Trepo G Inchauspe, J Med Virol 2004 72 566 574 10.1002/jmv.20039 14981759 (Pubitemid 38296068)
191. Molecular evidence that the hepatitis C virus replicates in the oral mucosa. M Carrozzo R Quadri P Latorre M Pentenero S Paganin G Bertolusso S Gandolfo F Negro, J Hepatol 2002 37 364 369 10.1016/S0168-8278(02)00183-6 12175632 (Pubitemid 34969953)
192. Strand specific quantitative real-time PCR to study replication of hepatitis C virus genome. F Komurian-Pradel M Perret B Deiman M Sodoyer V Lotteau G Paranhos-Baccala P Andre, J Virol Methods 2004 116 103 106 10.1016/j.jviromet.2003.10.004 14715313 (Pubitemid 38056658)
193. Quantitative analysis of hepatitis C virus in peripheral blood and liver: replication detected only in liver. J Boisvert XS He R Cheung EB Keeffe T Wright HB Greenberg, J Infect Dis 2001 184 827 835 10.1086/323391 11550124 (Pubitemid 32881087)
194. Effects of delayed freezing of liver biopsies on the detection of hepatitis C virus RNA strands. A Madejon ML Manzano C Arocena I Castillo V Carreno, J Hepatol 2000 32 1019 1025 10.1016/S0168-8278(00)80107-5 10898323 (Pubitemid 30368096)
195. Detection of genomic- and minus-strand of hepatitis C virus RNA in the liver of chronic hepatitis C patients by strand-specific semiquantitative reverse-transcriptase polymerase chain reaction. F Negro K Krawczynski R Quadri L Rubbia-Brandt M Mondelli JP Zarski A Hadengue, Hepatology 1999 29 536 542 10.1002/hep.510290223 9918932 (Pubitemid 29088459)
196. Differences in hypervariable region 1 quasispecies of hepatitis C virus in human serum, peripheral blood mononuclear cells, and liver. M Okuda K Hino M Korenaga Y Yamaguchi Y Katoh K Okita, Hepatology 1999 29 217 222 10.1002/hep.510290117 9862869 (Pubitemid 29024005)
197. Specific detection of minus-strand hepatitis C virus RNA by reverse-transcription polymerase chain reaction on PolyA(+)-purified RNA. ST Takyar D Li Y Wang R Trowbridge EJ Gowans, Hepatology 2000 32 382 387 10.1053/jhep.2000.9094 10915746 (Pubitemid 30614671)
198. Significance of liver negative-strand HCV RNA quantitation in chronic hepatitis C. N Yuki S Matsumoto K Tadokoro K Mochizuki M Kato T Yamaguchi, J Hepatol 2006 44 302 309 10.1016/j.jhep.2005.10.014 16343680 (Pubitemid 43069211)
199. Detection of hepatitis-C virus and hepatitis-C virus replication in hepatocellular carcinoma by in situ hybridization. M Ohishi S Sakisaka M Harada H Koga E Taniguchi T Kawaguchi K Sasatomi M Sata T Kurohiji K Tanikawa, Scand J Gastroenterol 1999 34 432 438 10.1080/003655299750026470 10365906 (Pubitemid 29232381)
200. In situ simultaneous detection of hepatitis C virus RNA and hepatitis C virus-related antigens in hepatocellular carcinoma. D Sansonno V Cornacchiulo V Racanelli F Dammacco, Cancer 1997 80 22 33 10.1002/(SICI)1097-0142(19970701)80: 1<22::AID-CNCR43.0.CO;2-H 9210705 (Pubitemid 27270916)
201. Demonstration and distribution of HCV RNA sequences by in situ hybridization and HCV-related proteins by immunohistochemistry in the liver tissue of patients with chronic HCV infection. D Sansonno V Cornacchiulo AR Iacobelli P Gatti M Di Stasi F Dammacco, Pathobiology 1995 63 239 248 10.1159/000163956 8724205 (Pubitemid 26120357)
202. Detection of hepatitis C virus RNA by in situ hybridization. K Blight R Trowbridge R Rowland E Gowans, Liver 1992 12 286 289 1333032
203. Localization of hepatitis C virus RNA in human liver biopsies by in situ hybridization using thymine-thymine dimerized oligo DNA probes: improved method. H Endo G Yamada PK Nakane T Tsuji, Acta Med Okayama 1992 46 355 364 1332425
204. Detection by in situ hybridization of hepatitis C virus positive and negative RNA strands using digoxigenin-labeled cRNA probes in human liver cells. M Gastaldi A Massacrier R Planells A Robaglia-Schlupp I Portal-Bartolomei M Bourliere F Quilici J Fiteni E Mazzella P Cau, J Hepatol 1995 23 509 518 10.1016/0168-8278(95)80055-7 8583137
205. Detection of hepatitis C virus (HCV) RNA sequences in liver tissue by in situ hybridization. E Lamas P Baccarini C Housset D Kremsdorf C Brechot, J Hepatol 1992 16 219 223 10.1016/S0168-8278(05)80119-9 1336509 (Pubitemid 23013202)
206. Localization of hepatitis C viral RNA and capsid protein in human liver. G Yamada H Nishimoto H Endou T Doi M Takahashi T Tsuji H Yoshizawa M Nozawa T Koji PK Nakane, Dig Dis Sci 1993 38 882 887 10.1007/BF01295915 8387003 (Pubitemid 23144631)
207. Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection. D Sansonno F Dammacco, Hepatology 1993 18 240 245 10.1002/hep.1840180203 8340053 (Pubitemid 23225090)
208. Localization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus-infected patients with mixed cryoglobulinemia. D Sansonno V Cornacchiulo AR Iacobelli R Di Stefano M Lospalluti F Dammacco, Hepatology 1995 21 305 312 7843698
209. HCV-RNA detection using different PCR methods in sera, cryoglobulins and peripheral blood mononuclear cells of patients with mixed cryoglobulinemia. C de Maddalena G Zehender A Bianchi Bosisio G Monti A Monteverde F Invernizzi M Galli, Clin Exp Rheumatol 1995 13 Suppl 13 119 122 8730491
210. Immunohistochemical detection of the NS4 antigen of hepatitis C virus and its relation to histopathology. K Blight R Rowland PD Hall RR Lesniewski R Trowbridge JT LaBrooy EJ Gowans, Am J Pathol 1993 143 1568 1573 8256849 (Pubitemid 24058260)
211. Immunohistochemical detection of C-100 hepatitis C virus antigen in formaldehyde-fixed paraffin-embedded liver tissue. Correlation with serum, tissue and in situ RT-PCR results. L Benkoel P Biagini F Dodero X De Lamballerie P De Micco A Chamlian, Eur J Histochem 2004 48 185 190 15208090 (Pubitemid 38736135)
212. Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients. S Navas J Martin JA Quiroga I Castillo V Carreno, J Virol 1998 72 1640 1646 9445070 (Pubitemid 28116955)
213. Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. M Radkowski LF Wang HE Vargas J Rakela T Laskus, Transplantation 1998 66 664 666 10.1097/00007890- 199809150-00022 9753352 (Pubitemid 28433854)
214. Influence of extrahepatic viral infection on the natural history of hepatitis C. MI Barria J Vera-Otarola U Leon V Vollrath D Marsac A Riquelme M Lopez-Lastra A Soza, Ann Hepatol 2008 7 136 143 18626431 (Pubitemid 351845524)